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The antagonistic effect of interferon-beta on the interferon-gamma-induced expression of HLA-DR antigen in a squamous cell carcinoma line. 干扰素- β对干扰素- γ诱导的鳞状细胞癌HLA-DR抗原表达的拮抗作用。
Pub Date : 1992-01-01
Y Naito, T Baba, H Suzuki, K Uyeno

We examined the effect of type I interferon (IFN) on IFN-gamma-induced HLA-DR antigen expression in A431 cells, a human squamous cell carcinoma line. A431 cells expressed HLA-DR antigen when stimulated with IFN-gamma, but not with IFN-beta. Simultaneous addition of IFN-gamma and IFN-beta to A431 cells resulted in significantly decreased HLA-DR antigen expression when compared to treatment with IFN-gamma alone. Kinetic studies revealed that IFN-beta was required concomitantly or prior to stimulation with IFN-gamma in order to down-regulate expression of HLA-DR antigens. IFN-alpha also inhibited IFN-gamma-induced HLA-DR antigen expression in A431 cells. Analysis of cytoplasmic mRNA showed that simultaneous treatment of A431 cells with IFN-gamma and IFN-beta resulted in a marked decrease of the level of DR alpha specific mRNA when compared to a level reached after treatment with IFN-gamma alone. These results suggest that type I IFN antagonize the IFN-gamma-induced HLA-DR antigen expression in human keratinocyte system, and that this antagonistic effect of type I IFN is confirmed as evidenced by a change in HLA-DR mRNA levels.

我们研究了I型干扰素(IFN)对干扰素γ诱导的人鳞状细胞癌A431细胞中HLA-DR抗原表达的影响。A431细胞在ifn - γ刺激下表达HLA-DR抗原,而在ifn - β刺激下不表达。与单独使用ifn - γ相比,同时向A431细胞中添加ifn - γ和ifn - β可显著降低HLA-DR抗原表达。动力学研究表明,为了下调HLA-DR抗原的表达,ifn - β需要同时或先于ifn - γ刺激。ifn - α也抑制ifn - γ诱导的HLA-DR抗原在A431细胞中的表达。细胞质mRNA分析显示,与单独使用ifn - γ处理相比,同时使用ifn - γ和ifn - β处理A431细胞导致DR α特异性mRNA水平显著降低。这些结果表明,I型IFN可以拮抗IFN- γ诱导的人角质细胞系统中HLA-DR抗原的表达,并且这种拮抗作用通过HLA-DR mRNA水平的变化得到证实。
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引用次数: 0
Modulation of alpha interferon levels by AZT treatment in HIV-seropositive patients. AZT治疗对hiv血清阳性患者α干扰素水平的调节作用。
Pub Date : 1992-01-01
E Buimovici-Klein, G F McKinley, M Lange, J A Sonnabend, V Mohan, M H Grieco, L Z Cooper

The effect of AZT on serum HIV p24 antigen and endogenous serum alpha interferon levels was studied in AIDS and ARC patients. Following administration of AZT there was a rapid decline in the serum levels of both HIV p24 antigen and alpha interferon. When AZT treatment was interrupted, the levels of both HIV p24 antigen and of interferon rapidly increased. These findings suggest that HIV or some other AZT sensitive microorganism is the inducer of interferon which is characteristically found in the serum of AIDS and symptomatic HIV infected patients. They also suggest that the rapid decline in interferon levels may underlie some of the symptomatic benefit that follows administration of AZT.

研究AZT对艾滋病和ARC患者血清HIV p24抗原和内源性血清α干扰素水平的影响。服用AZT后,血清中HIV p24抗原和α -干扰素水平均迅速下降。当AZT治疗中断时,HIV p24抗原和干扰素水平迅速升高。提示HIV或其他AZT敏感微生物是干扰素的诱导剂,干扰素存在于艾滋病和有症状的HIV感染者血清中。他们还认为,干扰素水平的迅速下降可能是AZT治疗后一些症状性获益的基础。
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引用次数: 0
Stimulation of IFN-alpha production in HLA-DR+, light density peripheral blood mononuclear cells by human immunodeficiency virus. 人免疫缺陷病毒对HLA-DR+、轻密度外周血单个核细胞ifn - α生成的刺激。
Pub Date : 1990-01-01
J F Toso, J J Ferbas, G Rappocciolo, J A Armstrong, M Ho, C R Rinaldo
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引用次数: 0
Response of rat myocardial mast cells to experimental ischemia. 大鼠心肌肥大细胞对实验性缺血的反应。
Pub Date : 1990-01-01
P G Krüger, T Ellingsen, T S Saetersdal

The effects of ischemia on mast cells in the rat heart were studied. After 5 hours morphological signs of mediator release: granule dissolution, were observed. After 4 weeks the number of mast cells was significantly increased in comparison with nonischemic. Furthermore, 4 weeks after ischemia there was an increased number of regenerating mast cells. An increase in the number of mast cells and morphological signs of granule synthesis in the ventricular or septal muscle of the sham operated controls indicates that the surgical procedure itself can affect the mast cells of the heart generally. Morphological signs of granule synthesis were observed within mast cells of all experimental groups, and the figure was highly increased after 4 weeks of ischemia.

研究了缺血对大鼠心脏肥大细胞的影响。5小时后,观察到介质释放的形态学迹象:颗粒溶解。4周后,肥大细胞数量较缺血时明显增加。此外,缺血4周后再生肥大细胞数量增加。假手术对照组肥大细胞数量的增加和室间隔肌颗粒合成的形态学迹象表明,手术本身可以普遍影响心脏肥大细胞。各实验组肥大细胞内均有颗粒合成的形态学迹象,缺血4周后,肥大细胞内颗粒合成的形态学特征明显增强。
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引用次数: 0
2',5'-Oligoadenylate (2-5A) binding protein (RNase L) changes in AIDS and mammalian cells/tissues. 2',5'-寡腺苷酸(2- 5a)结合蛋白(RNase L)在艾滋病和哺乳动物细胞/组织中的变化。
Pub Date : 1990-01-01
J M Wu, C C Chang, J W Chiao, C H Wang
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引用次数: 0
Interferon action on membrane-associated viruses: a minireview. 干扰素对膜相关病毒的作用综述。
Pub Date : 1990-01-01
R M Friedman
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引用次数: 0
Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes. HIV领导RNA、TAT和干扰素诱导酶的翻译调控。
Pub Date : 1990-01-01
R H Silverman, D N Sengupta

Every step in the replication cycle of HIV provides unique opportunities for controlling the progression of AIDS. In this regard, virus protein synthesis should be an important target for limiting HIV multiplication in cells. Molecular mechanisms in the regulation of HIV protein synthesis were therefore investigated in the context of interferon action. The interferon-inducible enzymes, 2-5A synthetase and dsRNA-dependent protein kinase, which can inhibit translation were activated by HIV-1 leader RNA. In cell-free systems, leader RNA and Tat protein of HIV inhibited and enhanced translation, respectively. An intriguing interplay of these viral and host factors were shown to influence the rate of translation in vitro. A model describing opposing actions of HIV Tat protein and interferon in HIV replication is represented.

艾滋病毒复制周期的每一步都为控制艾滋病的发展提供了独特的机会。在这方面,病毒蛋白合成应该是限制HIV在细胞中增殖的一个重要靶点。因此,在干扰素作用的背景下,研究了调节HIV蛋白合成的分子机制。可抑制翻译的干扰素诱导酶、2-5A合成酶和dsrna依赖性蛋白激酶被HIV-1先导RNA激活。在无细胞系统中,HIV的先导RNA和Tat蛋白分别抑制和增强翻译。一个有趣的相互作用,这些病毒和宿主因素被证明影响翻译的速度在体外。一个模型描述了HIV Tat蛋白和干扰素在HIV复制中的相反作用。
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引用次数: 0
Jack fruit lectin binding pattern in carcinoma of the uterine cervix. 杰克果凝集素在子宫颈癌中的结合模式。
Pub Date : 1990-01-01
P Remani, A Joy, K K Vijayan, A Ravindran, V M Haseena Beevi, D M Vasudevan, T Vijayakumar

A lectin was isolated and purified from the seeds of Jack Fruit (Artocarpus integrifolia) using a column of immobilized N-acetyl D-Galactosamine. The Jack Fruit lectin (JFL) was conjugated to horse radish peroxidase (HRP). The purified conjugate was used to study the binding properties of tissues from carcinomas of the uterine cervix. The binding to cancer tissues was compared with that of normal controls. The carcinomatous cells showed varying degrees of binding towards JFL in contrast to normal controls which generally had uniform binding. The nature and intensity of binding of the lectin with the cancer tissues suggest that this lectin may be used as a diagnostic marker in carcinoma of uterine cervix.

采用固定化n -乙酰基d -半乳糖胺柱从杰克果种子中分离纯化了一种凝集素。将杰克果凝集素(JFL)与马萝卜过氧化物酶(HRP)偶联。纯化的偶联物用于研究子宫颈癌组织的结合特性。将其与癌组织的结合与正常对照进行比较。与通常具有均匀结合的正常对照相比,癌细胞对JFL表现出不同程度的结合。该凝集素与癌组织结合的性质和强度提示该凝集素可作为宫颈癌的诊断标志物。
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引用次数: 0
Immunohistochemical demonstration of a thiamine diphosphate-binding protein in the brain of the adult rat. 成年大鼠脑中硫胺素二磷酸结合蛋白的免疫组织化学证明。
Pub Date : 1990-01-01
H Yoshioka, K Nishino, G Ohshio, T Kimura, T Sugiyama, T Kita

We recently purified a new thiamine diphosphate-binding protein (ThDP-BP) prepared from rat liver, and found immunoreactivity for ThDP-BP in neurons and other neuronal tissues. In this study, we examined the distribution of ThDP-BP in the rat neurons by the avidin-biotin complex technique. Strong immunoreactivity for ThDP-BP was found in the cerebral cortex, hippocampus, ependymal cells, nucleus III, nucleus V, and medial vestibular nucleus. Moderate immunoreactivity was noted in the olfactorius nucleus anterior and weak activity in the nucleus ruber. ThDP-BP may be useful in clarifying the pathogenesis of Wernicke encephalopathy and Leigh's disease.

我们最近从大鼠肝脏中纯化了一种新的硫胺素二磷酸结合蛋白(ThDP-BP),并在神经元和其他神经元组织中发现了ThDP-BP的免疫反应性。本研究采用亲和素-生物素复合物技术检测大鼠神经元中ThDP-BP的分布。在大脑皮层、海马、室管膜细胞、III核、V核和内侧前庭核中发现ThDP-BP具有较强的免疫反应性。嗅觉前核有中等程度的免疫反应性,而橡胶核的免疫反应性较弱。ThDP-BP可能有助于阐明韦尼克脑病和利氏病的发病机制。
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引用次数: 0
Relation of alpha and gamma interferon levels to development of AIDS in homosexual men. α和γ干扰素水平与男同性恋者艾滋病发展的关系。
Pub Date : 1990-01-01
C R Rinaldo, J A Armstrong, L A Kingsley, S Zhou, M Ho

Homosexual men who were human immunodeficiency virus (HIV) seropositive at enrollment into the Pittsburgh portion of the Multicenter AIDS Cohort Study had elevated titers of serum alpha and gamma interferon (IFN) within 24 months prior to development of AIDS. In contrast, subjects who developed AIDS relatively early after seroconversion to HIV during this study did not have increased levels of alpha or gamma IFN.

在多中心艾滋病队列研究的匹兹堡部分入组时,人类免疫缺陷病毒(HIV)血清阳性的男同性恋者在发生艾滋病前24个月内血清α和γ干扰素(IFN)滴度升高。相比之下,在这项研究中,血清转化为HIV后相对较早发展为艾滋病的受试者,α或γ干扰素水平没有增加。
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引用次数: 0
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Journal of Experimental Pathology
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