Pub Date : 2022-10-17DOI: 10.14218/jerp.2022.00047
Ashok Kumar, A. Rana, B. Parashar, Ankit Kumar, D. Semwal
{"title":"Anti-diarrheal Activity of the Aqueous Extract of Stem Bark of Myrica nagi in Albino Rats","authors":"Ashok Kumar, A. Rana, B. Parashar, Ankit Kumar, D. Semwal","doi":"10.14218/jerp.2022.00047","DOIUrl":"https://doi.org/10.14218/jerp.2022.00047","url":null,"abstract":"","PeriodicalId":73746,"journal":{"name":"Journal of exploratory research in pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44356455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-21DOI: 10.14218/jerp.2022.00031
W. A. Wannes, M. Tounsi
In Tunisian folk medicine, several herbs are prescribed for reducing renal damage and to avoid kidney related complications. These can be of immense value in combating renal damage. In this review, we provide a descrip-tion of the current literature on the use of indigenous herbs as alternative medicine for treating renal damage. The aim of this review was to collect information on promising active phytoconstituents such as organosulfur compounds, polyphenols, terpenes, alkaloids phenylpropanoids, and polysaccharides from Tunisian plants that have been scientifically examined for their nephroprotective capacities. Twenty-nine Tunisian medicinal plants have been reported for their significant nephroprotective activities against renal toxicities in animal models. Lamiaceae was the most commonly used Tunisian plant family used for renal protection. The leaves were maximally used for nephroprotection compared to the other plant parts. Nephrotoxicity is commonly the result of several nephrotoxins. Many studies have focussed on drug-caused renal failure which is one of the major problems in medical practice. Other studies focused on other important nephrotoxicity factors, including drugs and industrial chemicals. This literature review highlights the use of some medicinal plants as nephroprotective agents. To defend against this nephrotoxicity, some medicinal plants, known as nephroprotective agents, have been highlighted in this review. nephroprotective renal the potent nephroprotective effect of luteolin was determined against cisplatin-induced nephrotoxicity in rats. Additionally, the renal protective potential of naringeninn and quercetin was studied in cadmium-induced oxidative renal dysfunction in rats. an 4 days. Results showed that aspirin induced an increase in serum biochemical parameters as well as oxidative stress in kidney. There was an increase in TBARS and a decrease in SOD, CAT, and GPx in kidney. Administration of P. halepensis essential oil corrected these parameters. Hamrouni et al . found that the essential oil of Tunisian halepensis was acterized predominance of monoterpene hydrocarbons, vinifera seeds and skin against doxorubicin-induced renal toxicity in rats. the ethanol extract from V. vinifera and skin 8 days and doxorubicin mg/ days later. Results showed that doxorubicin induced renal toxicity by affecting the renal architecture and plasma creatinine. Dox- orubicin also induced oxidative stress characterized by an increase in MDA, calcium, and H 2 O 2 and a decrease in CAT and SOD. Un- expectedly, doxorubicin increased peroxidase and decreased carbonyl protein and plasma urea. Treatment with V. vinifera extract counteracted almost all adverse effects induced by doxorubicin.
{"title":"Tunisian Nephroprotective Plants: A Review","authors":"W. A. Wannes, M. Tounsi","doi":"10.14218/jerp.2022.00031","DOIUrl":"https://doi.org/10.14218/jerp.2022.00031","url":null,"abstract":"In Tunisian folk medicine, several herbs are prescribed for reducing renal damage and to avoid kidney related complications. These can be of immense value in combating renal damage. In this review, we provide a descrip-tion of the current literature on the use of indigenous herbs as alternative medicine for treating renal damage. The aim of this review was to collect information on promising active phytoconstituents such as organosulfur compounds, polyphenols, terpenes, alkaloids phenylpropanoids, and polysaccharides from Tunisian plants that have been scientifically examined for their nephroprotective capacities. Twenty-nine Tunisian medicinal plants have been reported for their significant nephroprotective activities against renal toxicities in animal models. Lamiaceae was the most commonly used Tunisian plant family used for renal protection. The leaves were maximally used for nephroprotection compared to the other plant parts. Nephrotoxicity is commonly the result of several nephrotoxins. Many studies have focussed on drug-caused renal failure which is one of the major problems in medical practice. Other studies focused on other important nephrotoxicity factors, including drugs and industrial chemicals. This literature review highlights the use of some medicinal plants as nephroprotective agents. To defend against this nephrotoxicity, some medicinal plants, known as nephroprotective agents, have been highlighted in this review. nephroprotective renal the potent nephroprotective effect of luteolin was determined against cisplatin-induced nephrotoxicity in rats. Additionally, the renal protective potential of naringeninn and quercetin was studied in cadmium-induced oxidative renal dysfunction in rats. an 4 days. Results showed that aspirin induced an increase in serum biochemical parameters as well as oxidative stress in kidney. There was an increase in TBARS and a decrease in SOD, CAT, and GPx in kidney. Administration of P. halepensis essential oil corrected these parameters. Hamrouni et al . found that the essential oil of Tunisian halepensis was acterized predominance of monoterpene hydrocarbons, vinifera seeds and skin against doxorubicin-induced renal toxicity in rats. the ethanol extract from V. vinifera and skin 8 days and doxorubicin mg/ days later. Results showed that doxorubicin induced renal toxicity by affecting the renal architecture and plasma creatinine. Dox- orubicin also induced oxidative stress characterized by an increase in MDA, calcium, and H 2 O 2 and a decrease in CAT and SOD. Un- expectedly, doxorubicin increased peroxidase and decreased carbonyl protein and plasma urea. Treatment with V. vinifera extract counteracted almost all adverse effects induced by doxorubicin.","PeriodicalId":73746,"journal":{"name":"Journal of exploratory research in pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48077724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-16DOI: 10.14218/jerp.2022.00045
A. Chehad, N. Boutrid, H. Rahmoune
Managing chronic pediatric skin disorders is challenging due to a lack of approved medication and the relative weakness of research studies for this age group. Ustekinumab is a human monoclonal antibody that targets the p40 subunit shared by IL12 and IL23 and thereby modulates the inflammatory reaction triggered by the Th1 and Th17 pathways, respectively. Currently, in dermatology, ustekinumab is the only IL12/IL23 inhibitor approved by regulatory authorities to treat moderate to severe psoriasis in adults, adolescents, and children of age six years and older. Although off-label and not supported by strong evidence, the therapeutic use of ustekinumab has been gradually extended to various other dermatoses. The reported adverse events of this biologic in pediatric patients were generally consistent with those in adults. However, its long-term safety remains to be confirmed. In this review, we discuss the existing evidence on the mechanisms of ustekinumab action, the current regulatory authority-approved indications, off-label use in pediatric cutaneous disorders, and the most reported adverse events related to this drug.
{"title":"Ustekinumab in Pediatric Dermatology: An Updated Review","authors":"A. Chehad, N. Boutrid, H. Rahmoune","doi":"10.14218/jerp.2022.00045","DOIUrl":"https://doi.org/10.14218/jerp.2022.00045","url":null,"abstract":"Managing chronic pediatric skin disorders is challenging due to a lack of approved medication and the relative weakness of research studies for this age group. Ustekinumab is a human monoclonal antibody that targets the p40 subunit shared by IL12 and IL23 and thereby modulates the inflammatory reaction triggered by the Th1 and Th17 pathways, respectively. Currently, in dermatology, ustekinumab is the only IL12/IL23 inhibitor approved by regulatory authorities to treat moderate to severe psoriasis in adults, adolescents, and children of age six years and older. Although off-label and not supported by strong evidence, the therapeutic use of ustekinumab has been gradually extended to various other dermatoses. The reported adverse events of this biologic in pediatric patients were generally consistent with those in adults. However, its long-term safety remains to be confirmed. In this review, we discuss the existing evidence on the mechanisms of ustekinumab action, the current regulatory authority-approved indications, off-label use in pediatric cutaneous disorders, and the most reported adverse events related to this drug.","PeriodicalId":73746,"journal":{"name":"Journal of exploratory research in pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47070873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bioequivalence Studies of Two Brands of Linagliptin Tablets in Healthy Adults Under Fed and Fasted Conditions","authors":"Xin Li, Fang Yuan, Bing Xu, Keqing Yao, Guiying Xiao, Yuan Li, Ping Zhang, Shengqing Tu","doi":"10.14218/jerp.2022.00035","DOIUrl":"https://doi.org/10.14218/jerp.2022.00035","url":null,"abstract":"","PeriodicalId":73746,"journal":{"name":"Journal of exploratory research in pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46810800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-07DOI: 10.14218/jerp.2022.00048
P. Bignardi
The emergence of COVID-19 led to the development of various vaccines at an unprecedented rate. Due to massive vaccination, the pandemic has started to change, reducing the cases and deaths re-lated to COVID-19. Despite the massive contribution of vaccines, drugs, such as antivirals, are still essential in the containment of severe cases and deaths from COVID-19. However, this same ra-pidity in vaccine development was not observed in the antiviral agents’ discovery against SARS-CoV-2. Studies showed that viral load from upper respiratory tract spec-imen swabs in COVID-19 seems to decline during the first week of infection, extending the decline to the end of the second week, and may extend until the end of the third week. 1,2 Nevertheless, suc-cessfully cultivating SARS-CoV-2 occurs between the first and the fifth days of symptom onset and peaks on the third day. 1 Although a study has found a cultivable virus in 9%
{"title":"Clinical Trials Approaching Antiviral Agents Use Against SARS-CoV-2: Reliable Studies or Drug’s Cemetery?","authors":"P. Bignardi","doi":"10.14218/jerp.2022.00048","DOIUrl":"https://doi.org/10.14218/jerp.2022.00048","url":null,"abstract":"The emergence of COVID-19 led to the development of various vaccines at an unprecedented rate. Due to massive vaccination, the pandemic has started to change, reducing the cases and deaths re-lated to COVID-19. Despite the massive contribution of vaccines, drugs, such as antivirals, are still essential in the containment of severe cases and deaths from COVID-19. However, this same ra-pidity in vaccine development was not observed in the antiviral agents’ discovery against SARS-CoV-2. Studies showed that viral load from upper respiratory tract spec-imen swabs in COVID-19 seems to decline during the first week of infection, extending the decline to the end of the second week, and may extend until the end of the third week. 1,2 Nevertheless, suc-cessfully cultivating SARS-CoV-2 occurs between the first and the fifth days of symptom onset and peaks on the third day. 1 Although a study has found a cultivable virus in 9%","PeriodicalId":73746,"journal":{"name":"Journal of exploratory research in pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43593809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.14218/jerp.2022.00054
M. Hahn, S. Roll
{"title":"A Collaborative Approach in Pharmacogenetic Testing: Actionable Genotypes of Antidepressants and Their Avoidance in a Retrospective Study","authors":"M. Hahn, S. Roll","doi":"10.14218/jerp.2022.00054","DOIUrl":"https://doi.org/10.14218/jerp.2022.00054","url":null,"abstract":"","PeriodicalId":73746,"journal":{"name":"Journal of exploratory research in pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45503895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-16DOI: 10.14218/jerp.2022.00029
Sarfuddin Azmi, Mohammad Mustafa, Shoaib Shoaib, M. K. Hussain
{"title":"Structures, Functions and Therapeutic Potential of Cyclotides","authors":"Sarfuddin Azmi, Mohammad Mustafa, Shoaib Shoaib, M. K. Hussain","doi":"10.14218/jerp.2022.00029","DOIUrl":"https://doi.org/10.14218/jerp.2022.00029","url":null,"abstract":"","PeriodicalId":73746,"journal":{"name":"Journal of exploratory research in pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47262144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-15DOI: 10.14218/jerp.2022.00021
N. R. Joshi, Sandip Mule, Vishnu A. Gore, Ravindra D. Suryawanshi, G. Pawar, S. Bembalkar, R. Pawar
{"title":"Synthesis and Biological Study of Novel Schiff Base (1-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl) methylene) hydrazine) Ligand and Metal Complexes","authors":"N. R. Joshi, Sandip Mule, Vishnu A. Gore, Ravindra D. Suryawanshi, G. Pawar, S. Bembalkar, R. Pawar","doi":"10.14218/jerp.2022.00021","DOIUrl":"https://doi.org/10.14218/jerp.2022.00021","url":null,"abstract":"","PeriodicalId":73746,"journal":{"name":"Journal of exploratory research in pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46592391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-12DOI: 10.14218/jerp.2022.00033
Sanmoy Pathak, Joshuah Fialho, D. Nandi
{"title":"Plant-based Immunomodulators and Their Potential Therapeutic Actions","authors":"Sanmoy Pathak, Joshuah Fialho, D. Nandi","doi":"10.14218/jerp.2022.00033","DOIUrl":"https://doi.org/10.14218/jerp.2022.00033","url":null,"abstract":"","PeriodicalId":73746,"journal":{"name":"Journal of exploratory research in pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43290204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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