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The Integration of Social and Health Sectors in Scotland: An Analysis from the Prism of Different Public Policy Models. 苏格兰社会和卫生部门的整合:从不同公共政策模式的棱镜分析。
Q2 Medicine Pub Date : 2025-02-27 eCollection Date: 2025-03-01 DOI: 10.3390/jmahp13010008
Ricardo Correia de Matos, Generosa do Nascimento, Adalberto Campos Fernandes, Cristiano Matos

The integration of health and social care has been a key focus in Scotland, driven by demographic changes, rising healthcare costs, and the need for more efficient service delivery. The Public Bodies (Joint Working) (Scotland) Act 2014 sought to formalise this integration by restructuring governance and service provision to improve coordination between health and social care sectors. Despite these efforts, challenges remain in fully achieving the intended outcomes of the integration. This study analysed Scotland's integrated health and social care through the theoretical frameworks of public choice, institutionalism, and functionalism. The objective was to examine policy drivers, structural mechanisms, and governance implications, providing insights into the broader impact of integrated care reforms. A qualitative research approach was employed, synthesising data from peer-reviewed literature, government publications, and policy documents. The findings on integration were systematically examined through the lens of each public policy model, allowing for a nuanced analysis of how Scotland's approach to integration aligns with and diverges from these frameworks. A literature search was performed on PUBMED, Google Scholar, and Scottish government portals. While integration improved coordination and service delivery in some areas, limitations in funding allocation, workforce distribution, and governance autonomy limited its overall success. Scotland's integrated care model demonstrates potential benefits in reducing service fragmentation and improving patient-centred care; however, persistent challenges such as funding constraints, workforce shortages, and governance conflicts indicate that integration alone is not sufficient to resolve systemic healthcare inefficiencies. This study provides a perspective on Scotland's health and social care integration, offering valuable lessons for other European countries facing similar demographic and healthcare challenges.

在人口变化、医疗保健费用上升以及需要更有效地提供服务的推动下,保健和社会保健一体化一直是苏格兰的一个重点。《2014年公共机构(联合工作)(苏格兰)法》试图通过重组治理和服务提供,以改善卫生和社会保健部门之间的协调,使这种整合正式化。尽管作出了这些努力,但在充分实现一体化的预期成果方面仍然存在挑战。本研究通过公共选择、制度主义和功能主义的理论框架分析了苏格兰的综合卫生和社会保健。目的是研究政策驱动因素、结构机制和治理影响,为综合护理改革的广泛影响提供见解。采用了定性研究方法,综合了来自同行评审文献、政府出版物和政策文件的数据。通过每个公共政策模型的镜头系统地检查了关于整合的发现,允许对苏格兰的整合方法如何与这些框架保持一致和偏离进行细致入微的分析。在PUBMED、b谷歌Scholar和苏格兰政府门户网站上进行了文献检索。虽然集成改善了某些领域的协调和服务交付,但资金分配、劳动力分配和治理自主权方面的限制限制了其总体成功。苏格兰的综合护理模式在减少服务分散和改善以病人为中心的护理方面显示出潜在的好处;然而,资金限制、劳动力短缺和治理冲突等持续存在的挑战表明,仅靠整合不足以解决系统性医疗保健效率低下的问题。这项研究为苏格兰的健康和社会保健一体化提供了一个视角,为其他面临类似人口和保健挑战的欧洲国家提供了宝贵的经验教训。
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引用次数: 0
Musculoskeletal Magazine Advertising Focuses on White Individuals and Overlooks Minority Consumers. 《肌肉骨骼》杂志的广告聚焦于白人而忽略了少数族裔消费者。
Q2 Medicine Pub Date : 2025-02-04 eCollection Date: 2025-03-01 DOI: 10.3390/jmahp13010004
Wei Shao Tung, Kelsey A Rankin, Robert John Oris, Adithi Wijesekera, Daniel H Wiznia

Introduction: Demographic disparities in musculoskeletal (MSK) health exist in the US. Racial representation in advertising has been shown to influence consumer behavior and buying patterns. Direct-to-consumer advertising that does not target a racially diverse audience may exacerbate MSK disparities by failing to reach minorities. We explore the hypothesis that minorities are underrepresented in direct-to-consumer MSK advertisements in this cross-sectional analysis.

Methods: Using magazines from four databases, eight health-related magazine types were selected and advertisement categories were established. Racial distribution was analyzed using Pearson's Chi-squared and Chi-squared tests. Fisher's Exact test was used when >20% of cells had expected frequencies <5. Significance was set at α = 0.05.

Results: Of the advertisements featuring at least one model, 68.5% featured a white-presenting model, followed by 17.6% with a black model. Further, 92.7% of advertisements were monoethnic or monoracial with an overrepresentation of white models (p < 0.001). Black models were overrepresented as athletes (p < 0.001) and underrepresented in advertisements for pain relief (p < 0.001). Hispanic/Latinx and Asian models were underrepresented across all advertisement categories (p < 0.001).

Discussion: The causes of musculoskeletal health disparities are multifactorial. One potential influence is adjacent industries such as MSK health-related advertisements. When controlling for US population demographics, white models were overrepresented and minority race models were underrepresented, demonstrating racioethnic disparities in MSK advertising. Improving the racial and ethnic diversity of models within MSK advertisements may serve to improve patient perceptions of orthopaedic products and services and improve MSK disparities.

美国存在肌肉骨骼(MSK)健康的人口统计学差异。广告中的种族代表性已被证明会影响消费者的行为和购买模式。直接面向消费者的广告如果没有针对不同种族的受众,可能会因为未能触及少数族裔而加剧MSK的差异。在这个横断面分析中,我们探讨了少数民族在直接面向消费者的MSK广告中代表性不足的假设。方法:从4个数据库中选择8种与健康相关的杂志类型,建立广告分类。采用皮尔逊卡方检验和卡方检验分析种族分布。结果:在至少有一种模特的广告中,68.5%的广告是白人模特,其次是黑人模特,占17.6%。此外,92.7%的广告是单一种族或单一种族的,白人模特的比例过高(p < 0.001)。黑人模特作为运动员的比例过高(p < 0.001),而在止痛广告中的比例偏低(p < 0.001)。西班牙/拉丁裔和亚洲模特在所有广告类别中的代表性不足(p < 0.001)。讨论:肌肉骨骼健康差异的原因是多因素的。一个潜在的影响是邻近的行业,如MSK健康相关广告。在控制美国人口统计数据时,白人模型的代表性过高,少数族裔模型的代表性不足,这表明MSK广告中的种族差异。改善MSK广告中模特的种族和民族多样性可能有助于改善患者对骨科产品和服务的认知,并改善MSK差异。
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引用次数: 0
Assessing the Value of Further Investment in R&D Using Mixed Methods: A Case Study of Biosensor-Integrated Arteriovenous Grafts. 利用混合方法评估进一步研发投资的价值:以生物传感器集成动静脉移植物为例。
Q2 Medicine Pub Date : 2025-01-15 eCollection Date: 2025-03-01 DOI: 10.3390/jmahp13010001
Samuel Owusu Achiaw, Neil Hawkins, Olivia Wu, John Mercer

This study illustrates the utility of a mixed-methods approach in assessing the value of an example novel technology-biosensor-integrated self-reporting arteriovenous grafts (smart AVGs). Currently in preclinical development, the device will detect arteriovenous graft stenosis (surveillance-only use case) and treat stenosis (interventional use case). The approach to value assessment adopted in this study was multifaceted, with one stage informing the next and comprised a stakeholder engagement with clinical experts to explore the device's clinical value, a cost-utility analysis (CUA) from a US Medicare perspective to estimate pricing headroom, and an investment model estimating risk-adjusted net present value analysis (rNPVs) to determine commercial viability. The stakeholder engagement suggested that it would currently be difficult to establish the current value of the surveillance-only use case due to the lack of well-established interventions for preclinical stenosis. Based on this, the CUA focused on the interventional use case and estimated economically justifiable prices at assumed effectiveness levels. Using these prices, rNPVs were estimated over a range of scenarios. This value assessment informs early decision-making on health technology R&D by identifying the conditions (including clinical study success, potential market size and penetration, market access strategies, and assumptions associated with CUA) under which investment may be considered attractive.

本研究说明了混合方法在评估一种新型技术--集成生物传感器的自我报告动静脉移植物(智能动静脉移植物)--的价值方面的实用性。该设备目前处于临床前开发阶段,将用于检测动静脉移植物狭窄(仅用于监测)和治疗狭窄(用于介入)。本研究采用的价值评估方法是多方面的,一个阶段为下一阶段提供信息,包括与临床专家进行利益相关者接触以探讨该设备的临床价值、从美国医疗保险角度进行成本效用分析(CUA)以估算定价空间,以及投资模型估算风险调整后净现值分析(rNPV)以确定商业可行性。利益相关者的参与表明,由于缺乏完善的临床前狭窄干预措施,目前很难确定仅监测用例的当前价值。在此基础上,CUA 将重点放在干预用例上,并按照假定的有效性水平估算出经济上合理的价格。利用这些价格,对各种情况下的 rNPV 进行了估算。这种价值评估通过确定投资可能被认为具有吸引力的条件(包括临床研究的成功、潜在市场规模和渗透率、市场准入战略以及与 CUA 相关的假设),为医疗技术研发的早期决策提供信息。
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引用次数: 0
Managing Pharmaceutical Costs in Health Systems: A Review of Affordability, Accessibility and Sustainability Strategies. 管理医药成本在卫生系统:可负担性,可及性和可持续性战略的审查。
Q2 Medicine Pub Date : 2024-12-10 eCollection Date: 2024-12-01 DOI: 10.3390/jmahp12040031
Christos Ntais, Michael A Talias, John Fanourgiakis, Nikolaos Kontodimopoulos

Background: This paper reviews cost containment policies to control pharmaceutical expenditure either by regulating the pharmaceutical industry or targeting the demand side.

Methods: The method used was the narrative literature review of studies which assessed the effect of pharmaceutical cost containment policies.

Results: Governments worldwide have implemented a great variety of policy measures to manage pharmaceutical expenditure while ensuring fair access to essential medicines. Cost-sharing schemes, value-based pricing, reimbursement, reference pricing, payback mechanisms and the substitution of original drugs with generics and biosimilars are pivotal in these efforts, albeit with differing effectiveness across healthcare systems. Overall, it appears that any gains may be outweighed by the unfavorable effects of policies impacting patients. Although interventions have been created to improve physicians' prescribing practice, they often achieve very minor benefits and at considerable cost. Policy measures pertaining to the regulation of the supply side must be supported by thorough evaluation in order to ascertain costs and effects and guarantee that unintended consequences are minimized.

Conclusions: Policymakers frequently enact numerous laws and regulations to control pharmaceutical expenditure, even if there is limited evidence that they are cost-effective. The most crucial component of any policy's success, regardless of the one selected, is its evaluation. Further research is needed to develop context-specific guidance that balances cost containment, equity and sustainability.

背景:本文回顾了成本控制政策,以控制医药支出,无论是通过规范医药行业或针对需求方。方法:采用叙事性文献法对评价药品成本控制政策效果的研究进行综述。结果:世界各国政府已经实施了各种各样的政策措施来管理药品支出,同时确保公平获得基本药物。费用分摊计划、基于价值的定价、报销、参考定价、回报机制以及用仿制药和生物仿制药替代原药是这些努力的关键,尽管在不同的卫生保健系统中效果不同。总的来说,似乎任何收益都可能被影响患者的政策的不利影响所抵消。虽然干预措施是为了改善医生的处方实践,但它们往往收效甚微,而且成本相当高。与供应方面的管制有关的政策措施必须得到彻底评价的支持,以便确定成本和效果,并保证尽量减少意外后果。结论:决策者经常颁布大量的法律法规来控制药品支出,即使有有限的证据表明它们具有成本效益。任何政策成功的最关键因素,无论选择哪一项政策,都是对其进行评估。需要进行进一步研究,以制定针对具体情况的指导,平衡成本控制、公平和可持续性。
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引用次数: 0
Operational Efficiency of Public Hospitals in Greece During the COVID-19 Pandemic: A Comparative Analysis Using DEA and AHP Models. 新冠肺炎大流行期间希腊公立医院运营效率:基于DEA和AHP模型的比较分析
Q2 Medicine Pub Date : 2024-12-10 eCollection Date: 2024-12-01 DOI: 10.3390/jmahp12040030
Athanasios Mitakos, Panagiotis Mpogiatzidis

This study evaluates the efficiency of public hospitals in Greece during the COVID-19 epidemic in 2020, using Data Envelopment Analysis (DEA) and the Analytical Hierarchy Process (AHP). Faced with unprecedented pressure from increased demand for medical services, these hospitals had to adapt quickly while playing a crucial role in supporting local economies, similar to the effect of tourism on rural economies. This study reveals that, despite average efficiency scores of 83% for result-oriented models (BCC) and 65% for constant return models (CCR), inefficiencies of scale emerged under the pressures of the pandemic. The AHP, by incorporating qualitative criteria and decision-makers' preferences, offers a valuable perspective but shows little correlation with DEA's quantitative results. This research emphasizes the importance of utilizing integrated methods to formulate a more comprehensive assessment, adapted to the complex challenges of the healthcare sector during crisis periods.

本研究采用数据包络分析(DEA)和层次分析法(AHP)对2020年新冠肺炎疫情期间希腊公立医院的效率进行了评估。面对医疗服务需求增加带来的前所未有的压力,这些医院必须迅速适应,同时在支持地方经济方面发挥关键作用,类似于旅游业对农村经济的影响。这项研究表明,尽管结果导向模型(BCC)的平均效率得分为83%,不变回报模型(CCR)的平均效率得分为65%,但在大流行的压力下,规模效率低下出现了。AHP通过结合定性标准和决策者的偏好,提供了一个有价值的视角,但与DEA的定量结果几乎没有相关性。这项研究强调了利用综合方法制定更全面评估的重要性,以适应危机期间医疗保健部门的复杂挑战。
{"title":"Operational Efficiency of Public Hospitals in Greece During the COVID-19 Pandemic: A Comparative Analysis Using DEA and AHP Models.","authors":"Athanasios Mitakos, Panagiotis Mpogiatzidis","doi":"10.3390/jmahp12040030","DOIUrl":"10.3390/jmahp12040030","url":null,"abstract":"<p><p>This study evaluates the efficiency of public hospitals in Greece during the COVID-19 epidemic in 2020, using Data Envelopment Analysis (DEA) and the Analytical Hierarchy Process (AHP). Faced with unprecedented pressure from increased demand for medical services, these hospitals had to adapt quickly while playing a crucial role in supporting local economies, similar to the effect of tourism on rural economies. This study reveals that, despite average efficiency scores of 83% for result-oriented models (BCC) and 65% for constant return models (CCR), inefficiencies of scale emerged under the pressures of the pandemic. The AHP, by incorporating qualitative criteria and decision-makers' preferences, offers a valuable perspective but shows little correlation with DEA's quantitative results. This research emphasizes the importance of utilizing integrated methods to formulate a more comprehensive assessment, adapted to the complex challenges of the healthcare sector during crisis periods.</p>","PeriodicalId":73811,"journal":{"name":"Journal of market access & health policy","volume":"12 4","pages":"388-402"},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11676274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gatekeeping or Provider Choice for Sustainable Health Systems? A Literature Review on Their Impact on Efficiency, Access, and Quality of Services. 可持续卫生系统的把关还是提供者选择?它们对服务效率、可及性和质量影响的文献综述。
Q2 Medicine Pub Date : 2024-12-06 eCollection Date: 2024-12-01 DOI: 10.3390/jmahp12040029
Christos Ntais, Nikolaos Kontodimopoulos, Michael A Talias

As early as 1978, the World Health Organization set primary healthcare as the basis on which health systems should be built worldwide. However, the health systems of the different countries show considerable variations in terms of the implementation of gatekeeping from primary to secondary healthcare and direct access to specialists and hospital care. This literature review attempts to present the gatekeeping system with references to the UK, Sweden, the Netherlands, and Germany compared to the situation in Greece, where no gatekeeping system exists. Particular emphasis is placed on the impact of gatekeeping on the healthcare system's efficiency, equity of access, and the quality of the services provided. Evidence on the effects of gatekeeping is conflicting or limited by the low internal validity. Making the right gatekeeping implementation decisions is difficult in the absence of data. High-quality research studies on health outcomes, clinical efficacy, cost-effectiveness, quality of life, healthcare quality, utilisation of healthcare services, the burden in the healthcare system, and the opinions of patients, physicians, and policymakers are all necessary for developing policy.

早在1978年,世界卫生组织就将初级卫生保健作为建立世界卫生系统的基础。然而,不同国家的卫生系统在执行从初级到二级卫生保健的把关和直接获得专家和医院护理方面表现出相当大的差异。这篇文献综述试图以英国、瑞典、荷兰和德国的守门人制度为参照,与没有守门人制度的希腊的情况进行比较。特别强调把关对医疗保健系统的效率、公平获取和所提供服务质量的影响。把关效应的证据相互矛盾或受到内部效度低的限制。在缺乏数据的情况下,很难做出正确的把关实施决策。对健康结果、临床疗效、成本效益、生活质量、医疗保健质量、医疗保健服务的利用、医疗保健系统的负担以及患者、医生和决策者的意见进行高质量的研究,对于制定政策都是必要的。
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引用次数: 0
Adapting Efficiency Analysis in Health Systems: A Scoping Review of Data Envelopment Analysis Applications During the COVID-19 Pandemic. 在卫生系统中采用效率分析:COVID-19 大流行期间数据包络分析应用范围审查》。
Q2 Medicine Pub Date : 2024-10-22 eCollection Date: 2024-12-01 DOI: 10.3390/jmahp12040024
Athanasios Mitakos, Panagiotis Mpogiatzidis

Objective: To synthesize the current evidence base concerning the application of Data Envelopment Analysis (DEA) in healthcare efficiency during the COVID-19 pandemic using a scoping review of 13 primary studies. Methods: We consulted databases including Web of Science (WoS) and Scopus, as well as manual search entries up to September 2022. Included studies were primary applications of DEA for assessing healthcare efficiency during the COVID-19 pandemic. Key findings derived from thematic analysis of repeating pattern observations were extracted and tabulated for further synthesis, taking into consideration the variations in DMU definitions, the inclusion of undesirable outputs, the influence of external factors, and the infusion of advanced technologies in DEA. Results: The review observed a diverse application of DMUs, ranging from healthcare supply chains to entire national health systems. There was an evident shift towards incorporating undesirable outputs, such as mortality rates, in the DEA models amidst the pandemic. The influence of external and non-discretionary factors became more pronounced in DEA applications, highlighting the interconnected nature of global health challenges. Notably, several studies integrated advanced computational methods, including machine learning, into traditional DEA, paving the way for enhanced analytical capabilities. Conclusions: DEA, as an efficiency analysis tool, has exhibited adaptability and evolution in its application in the context of the COVID-19 healthcare crisis. By recognizing the multifaceted challenges posed by the pandemic, DEA applications have grown more comprehensive, integrating broader societal and health outcomes. This review provides pivotal insights that can inform policy and healthcare strategies, underscoring the importance of dynamic and comprehensive efficiency analysis methodologies during global health emergencies.

目的通过对 13 项主要研究进行范围界定,总结目前有关在 COVID-19 大流行期间将数据包络分析法 (DEA) 应用于提高医疗效率的证据基础。研究方法我们查阅了包括 Web of Science (WoS) 和 Scopus 在内的数据库,以及截至 2022 年 9 月的人工搜索条目。纳入的研究主要是在 COVID-19 大流行期间应用 DEA 评估医疗效率。考虑到 DMU 定义的差异、不良产出的纳入、外部因素的影响以及 DEA 中先进技术的注入,对重复模式观察的主题分析得出的主要结论进行了提取并制成表格,以便进一步综合。结果:审查发现,DMU 的应用多种多样,从医疗保健供应链到整个国家医疗保健系统,不一而足。在大流行病期间,DEA 模型明显转向将死亡率等不良产出纳入其中。在 DEA 应用中,外部因素和非自由裁量因素的影响变得更加明显,突出了全球卫生挑战的相互关联性。值得注意的是,一些研究将包括机器学习在内的先进计算方法融入传统的 DEA 中,为增强分析能力铺平了道路。结论:作为一种效率分析工具,DEA 在 COVID-19 医疗危机的应用中表现出了适应性和演变性。由于认识到大流行病所带来的多方面挑战,DEA 的应用已变得更加全面,整合了更广泛的社会和健康成果。本综述提供了可为政策和医疗保健战略提供参考的重要见解,强调了在全球卫生紧急情况下动态和综合效率分析方法的重要性。
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引用次数: 0
The Knowledge and Application of Economics in Healthcare in a High-Income Country Today: The Case of Belgium. 当今高收入国家在医疗保健领域的经济学知识和应用:比利时案例。
Q2 Medicine Pub Date : 2024-09-04 eCollection Date: 2024-09-01 DOI: 10.3390/jmahp12030021
Baudouin Standaert, Désirée Vandenberghe, Mark P Connolly, Johan Hellings

Healthcare is a huge business sector in many countries, focusing on the social function of delivering quality health when people develop illness. The system is essentially financed by public funds based on the solidarity principle. With a large financial outlay, the sector must use economic evaluation methods to achieve better efficiency. The objective of our study was to evaluate and to understand how health economics is used today, taking Belgium as an example of a high-income country. The evaluation started with a historical view of healthcare development and ended with potential projections for its future. A literature review focused on country-specific evaluation reports to identify the health economic methods used, with a search for potential gaps. The first results indicated that Belgium in 2021 devoted 11% of its GDP, 17% of its total tax revenue, and 30% of the national Social Security Fund to health-related activities, totalizing EUR 55.5 billion spending. The main health economic method used was a cost-effectiveness analysis linked to budget impact, assigning reimbursable monetary values to new products becoming available. However, these evaluation methods only impacted at most 20% of the money circulating in healthcare. The remaining 80% was subject to financial regulations (70%) and budgeting (10%), which could use many other techniques of an economic analysis. The evaluation indicated two potentially important changes in health economic use in Belgium. One was an increased focus on budgeting with plans, time frames, and quantified treatment objectives on specific disease problems. Economic models with simulations are very supportive in those settings. The other was the application of constrained optimization methods, which may become the new standard of practice when switching from fee-for-service to pay-per-performance as promoted by value-based healthcare and value-based health management. This economic refocusing to a more constrained approach may help to keep the healthcare system sustainable and affordable in the face of the many future challenges including ageing, climate change, migration, pandemics, logistical limitations, and financial instability.

在许多国家,医疗保健是一个庞大的商业部门,其重点是在人们患病时提供优质医疗服务的社会职能。该系统的资金主要来自基于团结原则的公共资金。由于财政支出巨大,该部门必须使用经济评估方法来提高效率。我们研究的目的是以比利时这个高收入国家为例,评估和了解当今卫生经济学的应用情况。评估以医疗保健发展的历史回顾开始,以对其未来的潜在预测结束。文献审查的重点是各国的评估报告,以确定所使用的卫生经济学方法,并寻找潜在的差距。初步结果显示,2021 年比利时将 11% 的国内生产总值、17% 的税收总额和 30% 的国家社会保障基金用于与医疗相关的活动,总支出达 555 亿欧元。所使用的主要卫生经济方法是与预算影响相关的成本效益分析,为新产品的上市分配可报销的货币价值。然而,这些评估方法最多只能影响 20% 的医疗保健流通资金。其余 80% 的资金受制于财务条例(70%)和预算编制(10%),可以使用许多其他经济分析技术。评估结果表明,比利时在卫生经济应用方面有两个潜在的重要变化。一是更加注重预算编制,包括计划、时间框架和针对具体疾病的量化治疗目标。在这种情况下,模拟经济模型非常有帮助。另一种是应用约束优化方法,这可能会成为从按服务收费转向按绩效付费的新实践标准,正如价值医疗和价值健康管理所提倡的那样。面对未来的诸多挑战,包括老龄化、气候变化、移民、大流行病、后勤限制和金融不稳定,这种将经济重点转向更具约束性的方法可能有助于保持医疗保健系统的可持续性和可负担性。
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引用次数: 0
Non-Medical Switching or Discontinuation Patterns among Patients with Non-Valvular Atrial Fibrillation Treated with Direct Oral Anticoagulants in the United States: A Claims-Based Analysis. 美国使用直接口服抗凝药治疗的非瓣膜性心房颤动患者的非医疗转换或停药模式:基于索赔的分析。
Q2 Medicine Pub Date : 2024-09-02 eCollection Date: 2024-09-01 DOI: 10.3390/jmahp12030020
Michael Ingham, Hela Romdhani, Aarti Patel, Veronica Ashton, Gabrielle Caron-Lapointe, Anabelle Tardif-Samson, Patrick Lefebvre, Marie-Hélène Lafeuille

This study assessed direct-acting oral anticoagulant (DOAC) switching/discontinuation patterns in patients with non-valvular atrial fibrillation (NVAF) in 2019, by quarter (Q1-Q4), and associated socioeconomic risk factors. Adults with NVAF initiating stable DOAC treatment (July 2018-December 2018) were selected from Symphony Health Solutions' Patient Transactional Datasets (April 2017-January 2021). Switching/discontinuation rates were reported in 2019 Q1-Q4, separately. Non-medical switching/discontinuation (NMSD) was defined as the difference between switching/discontinuation rates in Q1 and mean rates across Q2-Q4. The associations of socioeconomic factors with switching/discontinuation were assessed. Of 46,793 patients (78.7% ≥ 65 years; 52.6% male; 7.7% Black), 18.0% switched/discontinued their initial DOAC in Q1 vs. 8.8% on average in Q2-Q4, corresponding to an NMSD of 9.2%. During the quarter following the switch/discontinuation, more patients who switched/discontinued in Q1 remained untreated (Q1: 77.0%; Q2: 74.3%; Q3: 71.2%) and fewer reinitiated initial DOAC (Q1: 17.6%; Q2: 20.8%; Q3: 24.0%). Factors associated with the risk of switching/discontinuation in Q1 were race, age, gender, insurance type, and household income (all p < 0.05). More patients with NVAF switched/discontinued DOACs in Q1 vs. Q2-Q4, and more of them tended to remain untreated relative to those who switched/discontinued later in the year, suggesting a potential long-term impact of NMSD. Findings on factors associated with switching/discontinuation highlight potential socioeconomic discrepancies in treatment continuity.

本研究按季度(Q1-Q4)评估了2019年非瓣膜性心房颤动(NVAF)患者的直接作用口服抗凝剂(DOAC)转换/停药模式,以及相关的社会经济风险因素。从 Symphony Health Solutions 的患者交易数据集(2017 年 4 月至 2021 年 1 月)中选取了开始接受稳定 DOAC 治疗的 NVAF 成人患者(2018 年 7 月至 2018 年 12 月)。切换/停药率在 2019 年第一季度至第四季度分别报告。非医疗转换/停药率(NMSD)定义为第一季度转换/停药率与第二至第四季度平均转换/停药率之间的差值。评估了社会经济因素与转药/停药的关系。在 46,793 名患者(78.7% ≥ 65 岁;52.6% 为男性;7.7% 为黑人)中,18.0% 的患者在第一季度转换/停用了初始 DOAC,而第二至第四季度的平均转换/停用率为 8.8%,NMSD 为 9.2%。在换药/停药后的一个季度中,更多在第一季度换药/停药的患者仍未接受治疗(第一季度:77.0%;第二季度:74.3%;第三季度:71.2%),而重新启用初始 DOAC 的患者较少(第一季度:17.6%;第二季度:20.8%;第三季度:24.0%)。与第一季度转药/停药风险相关的因素有种族、年龄、性别、保险类型和家庭收入(所有因素的 p 均小于 0.05)。与第二至第四季度相比,第一季度有更多的 NVAF 患者更换/停用了 DOACs,而且其中有更多的患者倾向于不接受治疗,这表明 NMSD 可能会产生长期影响。关于换药/停药相关因素的研究结果突显了治疗连续性方面潜在的社会经济差异。
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引用次数: 0
Methods for Indirect Treatment Comparison: Results from a Systematic Literature Review 间接治疗比较方法:系统文献综述的结果
Q2 Medicine Pub Date : 2024-04-16 DOI: 10.3390/jmahp12020006
Bérengère Macabeo, Arthur Quenéchdu, Samuel Aballéa, Clément François, Laurent Boyer, Philippe Laramée
Introduction: Health technology assessment (HTA) agencies express a clear preference for randomized controlled trials when assessing the comparative efficacy of two or more treatments. However, an indirect treatment comparison (ITC) is often necessary where a direct comparison is unavailable or, in some cases, not possible. Numerous ITC techniques are described in the literature. A systematic literature review (SLR) was conducted to identify all the relevant literature on existing ITC techniques, provide a comprehensive description of each technique and evaluate their strengths and limitations from an HTA perspective in order to develop guidance on the most appropriate method to use in different scenarios. Methods: Electronic database searches of Embase and PubMed, as well as grey literature searches, were conducted on 15 November 2021. Eligible articles were peer-reviewed papers that specifically described the methods used for different ITC techniques and were written in English. The review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results: A total of 73 articles were included in the SLR, reporting on seven different ITC techniques. All reported techniques were forms of adjusted ITC. Network meta-analysis (NMA) was the most frequently described technique (in 79.5% of the included articles), followed by matching-adjusted indirect comparison (MAIC) (30.1%), network meta-regression (24.7%), the Bucher method (23.3%), simulated treatment comparison (STC) (21.9%), propensity score matching (4.1%) and inverse probability of treatment weighting (4.1%). The appropriate choice of ITC technique is critical and should be based on the feasibility of a connected network, the evidence of heterogeneity between and within studies, the overall number of relevant studies and the availability of individual patient-level data (IPD). MAIC and STC were found to be common techniques in the case of single-arm studies, which are increasingly being conducted in oncology and rare diseases, whilst the Bucher method and NMA provide suitable options where no IPD is available. Conclusion: ITCs can provide alternative evidence where direct comparative evidence may be missing. ITCs are currently considered by HTA agencies on a case-by-case basis; however, their acceptability remains low. Clearer international consensus and guidance on the methods to use for different ITC techniques is needed to improve the quality of ITCs submitted to HTA agencies. ITC techniques continue to evolve quickly, and more efficient techniques may become available in the future.
导言:卫生技术评估(HTA)机构明确表示,在评估两种或两种以上治疗方法的疗效比较时,首选随机对照试验。然而,在无法进行直接比较或在某些情况下无法进行直接比较时,往往需要进行间接治疗比较(ITC)。文献中介绍了大量的 ITC 技术。我们进行了一项系统性文献综述 (SLR),以确定现有 ITC 技术的所有相关文献,全面描述每种技术,并从 HTA 角度评估其优势和局限性,从而为在不同情况下使用最合适的方法提供指导。研究方法于 2021 年 11 月 15 日进行了 Embase 和 PubMed 电子数据库检索以及灰色文献检索。符合条件的文章均为经同行评审的论文,这些论文具体描述了不同 ITC 技术所使用的方法,并以英语撰写。综述按照《系统综述和元分析首选报告项目》(PRISMA)指南进行。结果:共有 73 篇文章被纳入 SLR,报告了七种不同的 ITC 技术。所有报告的技术都是调整后的ITC形式。网络荟萃分析(NMA)是最常见的技术(占收录文章的 79.5%),其次是匹配调整间接比较(MAIC)(30.1%)、网络荟萃回归(24.7%)、Bucher 方法(23.3%)、模拟治疗比较(STC)(21.9%)、倾向评分匹配(4.1%)和反向治疗加权概率(4.1%)。选择合适的 ITC 技术至关重要,应基于连接网络的可行性、研究之间和研究内部的异质性证据、相关研究的总体数量以及单个患者水平数据(IPD)的可用性。研究发现,MAIC 和 STC 是肿瘤学和罕见病领域越来越多开展的单臂研究的常用技术,而在没有 IPD 的情况下,Bucher 方法和 NMA 则是合适的选择。结论在缺乏直接比较证据的情况下,ITC 可提供替代证据。ITC 目前由 HTA 机构逐案考虑,但其可接受性仍然较低。需要就不同 ITC 技术的使用方法达成更明确的国际共识和指导,以提高提交给 HTA 机构的 ITC 的质量。ITC 技术仍在快速发展,未来可能会出现更高效的技术。
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Journal of market access & health policy
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