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Advances in prostaglandin, thromboxane, and leukotriene research最新文献

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SB 209247, a high affinity LTB4 receptor antagonist demonstrating potent antiinflammatory activity. SB 209247，一种高亲和力LTB4受体拮抗剂，具有有效的抗炎活性。
Advances in prostaglandin, thromboxane, and leukotriene research
Pub Date : 1995-01-01
H M Sarau, J J Foley, D B Schmidt, M N Tzimas, L D Martin, R A Daines, P A Chambers, W D Kingsbury, D E Griswold
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引用次数: 0
Novel mode of monocyte 5-lipoxygenase stimulation. 单核细胞5-脂氧合酶刺激的新模式。
Advances in prostaglandin, thromboxane, and leukotriene research
Pub Date : 1995-01-01
I Weide, T Simmet
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引用次数: 0
Endothelin regulates PGE2 formation in rat mesangial cells through induction of prostaglandin endoperoxide synthase-2. 内皮素通过诱导前列腺素内过氧化物合酶-2调节大鼠系膜细胞PGE2的形成。
Advances in prostaglandin, thromboxane, and leukotriene research
Pub Date : 1995-01-01
E Coroneos, M Kester, P Thomas, M J Dunn

Endothelin-1 stimulates vascular smooth muscle and mesangial cells to release prostaglandin E2 which attenuates the vasoconstrictor and mitogenic effects of endothelin. The role of endothelin-1 to regulate prostaglandin endoperoxide synthase (PGHS)-1 and -2 gene expression and protein synthesis was evaluated in cultured mesangial cells. Endothelin induced mRNA and protein expression for PGHS-2 but not for PGHS-1. A direct correlation was observed between the mass of immunoprecipitated PGHS protein and PGE2 synthetic enzymatic activity.

内皮素-1刺激血管平滑肌和系膜细胞释放前列腺素E2，从而减弱内皮素的血管收缩和有丝分裂作用。在培养的系膜细胞中观察内皮素-1调控前列腺素内过氧化物合成酶(PGHS)-1和-2基因表达及蛋白合成的作用。内皮素诱导PGHS-2 mRNA和蛋白表达，而PGHS-1无表达。免疫沉淀PGHS蛋白的质量与PGE2合成酶活性之间存在直接相关性。
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引用次数: 0
Genomic organization and regulation of the human thromboxane synthase gene. 人血栓素合成酶基因的基因组组织和调控。
Advances in prostaglandin, thromboxane, and leukotriene research
Pub Date : 1995-01-01
R F Shen, S J Baek, K D Lee, L Zhang, T Fleischer
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引用次数: 0
Leukotriene-deficient mice generated by targeted disruption of the 5-lipoxygenase gene. 靶向破坏5-脂氧合酶基因产生白三烯缺乏小鼠。
Advances in prostaglandin, thromboxane, and leukotriene research
Pub Date : 1995-01-01
C D Funk, X S Chen, U Kurre, G Griffis
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引用次数: 0
Structures, properties and distributions of prostanoid receptors. 前列腺素受体的结构、性质和分布。
Advances in prostaglandin, thromboxane, and leukotriene research
Pub Date : 1995-01-01
S Narumiya
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引用次数: 0
Cyclooxygenase in rat pleural hypersensitivity reactions. 环加氧酶在大鼠胸膜超敏反应中的作用。
Advances in prostaglandin, thromboxane, and leukotriene research
Pub Date : 1995-01-01
A R Moore, D Willis, D Gilroy, A Tomlinson, I Appleton, D A Willoughby
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引用次数: 0
Airway hyperresponsiveness induced by 13-hydroxyoctadecadienoic acid (13-HODE) is mediated by sensory neuropeptides. 13-羟基十八烯二烯酸(13-HODE)诱导气道高反应性是由感觉神经肽介导的。
Advances in prostaglandin, thromboxane, and leukotriene research
Pub Date : 1995-01-01
F Engels, A H van Houwelingen, T L Buckley, M J van de Velde, P A Henricks, F P Nijkamp
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引用次数: 0
Blood cell-vascular wall interactions and the production of coronary contracting sulfidopeptide leukotrienes in isolated, cell- perfused, rabbit heart. 离体细胞灌注兔心脏中血细胞-血管壁相互作用和冠状动脉收缩硫多肽白三烯的产生。
Advances in prostaglandin, thromboxane, and leukotriene research
Pub Date : 1995-01-01
A Sala, G Rossoni, C Buccellati, T Testa, F Berti, J Maclouf, G Folco
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引用次数: 0
The rationale for prostaglandin E1 (alpha-alprostadil) in the management of male impotence. 前列腺素E1 (α -前列地尔)治疗男性阳痿的基本原理。
Advances in prostaglandin, thromboxane, and leukotriene research
Pub Date : 1995-01-01
H Porst
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引用次数: 0
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