Pub Date : 2017-03-08DOI: 10.1186/s12952-017-0073-4
Sally Hunter, Carol Brayne
{"title":"Erratum to: Do anti-amyloid beta protein antibody cross reactivities confound Alzheimer disease research?","authors":"Sally Hunter, Carol Brayne","doi":"10.1186/s12952-017-0073-4","DOIUrl":"https://doi.org/10.1186/s12952-017-0073-4","url":null,"abstract":"","PeriodicalId":73849,"journal":{"name":"Journal of negative results in biomedicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12952-017-0073-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34795301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-03-01DOI: 10.1186/s12952-017-0069-0
Boubacar Efared, G Ebang-Atsame, Sani Rabiou, Abdoulsalam S Diarra, Layla Tahiri, Nawal Hammas, Mohamed Smahi, Bouchra Amara, Mohamed C Benjelloun, Mounia Serraj, Laila Chbani, Hinde El Fatemi
Objective: Bronchoalveolar lavage (BAL) is a diagnostic tool often used during the management of interstitial lung diseases (ILD). However, its diagnostic value in discrimination between entities comprising the very heterogenous group of ILD, is still a controversial issue. The objective of our study is to assess the diagnostic value of BAL in the management of ILD, by comparing the cytological findings in BAL fluid among the different diseases of this group.
Methods: It was a retrospective, observational study of 151 patients between January 2012 and December 2015. BAL fluid cytology was performed to analyse the distribution of leucocytes population subsets in patients with ILD.
Results: The mean age was 52.78 years; 74.83% were women. The analysis of the following main groups of diseases was performed : sarcoïdosis (n = 30), idiopathic pulmonary fibrosis (IPF; n = 22), other idiopathic interstitial pneumonia (non specific interstitial pneumonia, cryptogenic organising pneumonia and respiratory bronchiolitis interstitial lung disease; n = 20) and connective tissue disease (n = 14). Overall, out of 141 patients, 22% had sarcoïdosis, 15.6% had idiopathic pulmonary fibrosis (IPF), 14.18% had other idiopathic interstitial pneumonia (IIP) and 9.9% had connective tissue disease (CTD). Mixed alveolitis was common in the 4 groups, sarcoïdosis had higher proportion of lymphocytes and IPF had higher neutrophils count. However, there was no significant statistical difference of BAL cellular count among these diseases (p > 0.05). Also, the prevalence of studied diseases did not change with variation of BAL cellular count (p > 0.05).
Conclusion: Alone, the BAL cytological analysis has a limited value to provide substantial information that could lead to discriminate between diseases that form ILD. Thus, it must be always associated with other diagnostic methods.
{"title":"The diagnostic value of the bronchoalveolar lavage in interstitial lung diseases.","authors":"Boubacar Efared, G Ebang-Atsame, Sani Rabiou, Abdoulsalam S Diarra, Layla Tahiri, Nawal Hammas, Mohamed Smahi, Bouchra Amara, Mohamed C Benjelloun, Mounia Serraj, Laila Chbani, Hinde El Fatemi","doi":"10.1186/s12952-017-0069-0","DOIUrl":"https://doi.org/10.1186/s12952-017-0069-0","url":null,"abstract":"<p><strong>Objective: </strong>Bronchoalveolar lavage (BAL) is a diagnostic tool often used during the management of interstitial lung diseases (ILD). However, its diagnostic value in discrimination between entities comprising the very heterogenous group of ILD, is still a controversial issue. The objective of our study is to assess the diagnostic value of BAL in the management of ILD, by comparing the cytological findings in BAL fluid among the different diseases of this group.</p><p><strong>Methods: </strong>It was a retrospective, observational study of 151 patients between January 2012 and December 2015. BAL fluid cytology was performed to analyse the distribution of leucocytes population subsets in patients with ILD.</p><p><strong>Results: </strong>The mean age was 52.78 years; 74.83% were women. The analysis of the following main groups of diseases was performed : sarcoïdosis (n = 30), idiopathic pulmonary fibrosis (IPF; n = 22), other idiopathic interstitial pneumonia (non specific interstitial pneumonia, cryptogenic organising pneumonia and respiratory bronchiolitis interstitial lung disease; n = 20) and connective tissue disease (n = 14). Overall, out of 141 patients, 22% had sarcoïdosis, 15.6% had idiopathic pulmonary fibrosis (IPF), 14.18% had other idiopathic interstitial pneumonia (IIP) and 9.9% had connective tissue disease (CTD). Mixed alveolitis was common in the 4 groups, sarcoïdosis had higher proportion of lymphocytes and IPF had higher neutrophils count. However, there was no significant statistical difference of BAL cellular count among these diseases (p > 0.05). Also, the prevalence of studied diseases did not change with variation of BAL cellular count (p > 0.05).</p><p><strong>Conclusion: </strong>Alone, the BAL cytological analysis has a limited value to provide substantial information that could lead to discriminate between diseases that form ILD. Thus, it must be always associated with other diagnostic methods.</p>","PeriodicalId":73849,"journal":{"name":"Journal of negative results in biomedicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12952-017-0069-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34771551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-02-19DOI: 10.1186/s12952-017-0067-2
Ragheda Yaseen, Stefanie Blodkamp, Petra Lüthje, Friederike Reuner, Lena Völlger, H. Naim, M. von Köckritz-Blickwede
{"title":"Antimicrobial activity of HL-60 cells compared to primary blood-derived neutrophils against Staphylococcus aureus","authors":"Ragheda Yaseen, Stefanie Blodkamp, Petra Lüthje, Friederike Reuner, Lena Völlger, H. Naim, M. von Köckritz-Blickwede","doi":"10.1186/s12952-017-0067-2","DOIUrl":"https://doi.org/10.1186/s12952-017-0067-2","url":null,"abstract":"","PeriodicalId":73849,"journal":{"name":"Journal of negative results in biomedicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12952-017-0067-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45033400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-02-02DOI: 10.1186/s12952-017-0068-1
A. Kondkar, Nikhil B. Edward, Hatem A. Kalantan, Abdullah S. Al-kharashi, S. Altuwaijri, G. Mohamed, Tahira Sultan, Taif A Azad, K. Abu-Amero
{"title":"Lack of association between polymorphism rs540782 and primary open angle glaucoma in Saudi patients","authors":"A. Kondkar, Nikhil B. Edward, Hatem A. Kalantan, Abdullah S. Al-kharashi, S. Altuwaijri, G. Mohamed, Tahira Sultan, Taif A Azad, K. Abu-Amero","doi":"10.1186/s12952-017-0068-1","DOIUrl":"https://doi.org/10.1186/s12952-017-0068-1","url":null,"abstract":"","PeriodicalId":73849,"journal":{"name":"Journal of negative results in biomedicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12952-017-0068-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44796136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-26DOI: 10.1186/s12952-017-0066-3
S. Hunter, C. Brayne
{"title":"Do anti-amyloid beta protein antibody cross reactivities confound Alzheimer disease research?","authors":"S. Hunter, C. Brayne","doi":"10.1186/s12952-017-0066-3","DOIUrl":"https://doi.org/10.1186/s12952-017-0066-3","url":null,"abstract":"","PeriodicalId":73849,"journal":{"name":"Journal of negative results in biomedicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12952-017-0066-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42848961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-12-16DOI: 10.1186/s12952-016-0065-9
Anne Schaarschuch, C. Redies, N. Hertel
{"title":"Unspecific binding of cRNA probe to plaques in two mouse models for Alzheimer’s disease","authors":"Anne Schaarschuch, C. Redies, N. Hertel","doi":"10.1186/s12952-016-0065-9","DOIUrl":"https://doi.org/10.1186/s12952-016-0065-9","url":null,"abstract":"","PeriodicalId":73849,"journal":{"name":"Journal of negative results in biomedicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12952-016-0065-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65694500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-12-12DOI: 10.1186/s12952-016-0064-x
A. Cariaga-Martínez, R. Alelú-Paz
{"title":"False data, positive results in neurobiology: moving beyond the epigenetics of blood and saliva samples in mental disorders","authors":"A. Cariaga-Martínez, R. Alelú-Paz","doi":"10.1186/s12952-016-0064-x","DOIUrl":"https://doi.org/10.1186/s12952-016-0064-x","url":null,"abstract":"","PeriodicalId":73849,"journal":{"name":"Journal of negative results in biomedicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12952-016-0064-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65694490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-12-05DOI: 10.1186/s12952-016-0063-y
M. Ruiter, A. Doornbos, V. de Waard, R. D. de Winter, N. Attevelt, R. Steendam, C. D. de Vries
{"title":"Long-term effect of stents eluting 6-mercaptopurine in porcine coronary arteries","authors":"M. Ruiter, A. Doornbos, V. de Waard, R. D. de Winter, N. Attevelt, R. Steendam, C. D. de Vries","doi":"10.1186/s12952-016-0063-y","DOIUrl":"https://doi.org/10.1186/s12952-016-0063-y","url":null,"abstract":"","PeriodicalId":73849,"journal":{"name":"Journal of negative results in biomedicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12952-016-0063-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65694481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-11-02DOI: 10.1186/s12952-016-0062-z
G. Batty, B. Galobardes, J. Starr, M. Jeffreys, G. Davey Smith, Tom C. Russ
{"title":"Examining if being overweight really confers protection against dementia: Sixty-four year follow-up of participants in the Glasgow University alumni cohort study","authors":"G. Batty, B. Galobardes, J. Starr, M. Jeffreys, G. Davey Smith, Tom C. Russ","doi":"10.1186/s12952-016-0062-z","DOIUrl":"https://doi.org/10.1186/s12952-016-0062-z","url":null,"abstract":"","PeriodicalId":73849,"journal":{"name":"Journal of negative results in biomedicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12952-016-0062-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65694473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-10-26DOI: 10.1186/s12952-016-0061-0
Yaling Liu, E. Dutra, E. Reichenberger, I. Chen
{"title":"Dietary phosphate supplement does not rescue skeletal phenotype in a mouse model for craniometaphyseal dysplasia","authors":"Yaling Liu, E. Dutra, E. Reichenberger, I. Chen","doi":"10.1186/s12952-016-0061-0","DOIUrl":"https://doi.org/10.1186/s12952-016-0061-0","url":null,"abstract":"","PeriodicalId":73849,"journal":{"name":"Journal of negative results in biomedicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12952-016-0061-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65694430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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