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Mood Responses to Passive and Active Motion Leg Cycling Exercise in Healthy Sedentary Young Adults. 久坐不动的健康年轻人对被动和主动运动腿部循环运动的情绪反应。
Pub Date : 2020-02-29 eCollection Date: 2020-01-01 DOI: 10.1155/2020/7282013
Vernon Bond, Tamrat Retta, Krishna Kumar, James Dorsey, Vasavi R Gorantla, Richard M Millis

Previous studies suggest that passive motion exercise (PME) may be useful for overcoming exercise limitations associated with a sedentary lifestyle, orthopedic disorders, and various other debilitating conditions. Negative mood response is one of the factors that limit a person's ability to exercise. Therefore, this study tests the hypothesis that the mood response associated with PME is not different than the mood response associated with active motion exercise (AME). Eight women and seven men participated in the study and were administrated the Profile of Mood States (POMS) during modes of PME and AME in a randomized order. Outcome of the POMS consisted of the total mood disturbance score [(feelings of tension + depression + fatigue + anger + confusion) - vigor]. ANOVA was used to determine significance of differences in total mood disturbance, oxygen uptake (V.O2), and middle cerebral blood flow velocity (MCAv) at baseline and immediately after 30-minute conditions of PME and AME. Postexercise total mood disturbance score was significantly decreased for both conditions (PME baseline 29.2 ± 5.2 vs. postexercise 16.4 ± 6.8, P < 0.05) and AME baseline 22.4 ± 4.4 vs. postexercise 13.1 ± 5.2, P < 0.05). These senses of changes in feelings were associated with significant physiological increases in V.O2 and MCAv during both PME and AME (P < 0.05). These results demonstrate that physiological and mood responses to passive and active motion cycling exercise are not different. Future studies should determine whether passive motion cycling exercise is a useful preventive medicine strategy for overcoming various disease-related exercise limitations and counteracting the adverse effects of sedentary lifestyles.

先前的研究表明,被动运动锻炼(PME)可能有助于克服与久坐不动的生活方式、骨科疾病和各种其他衰弱状况相关的运动限制。消极的情绪反应是限制一个人锻炼能力的因素之一。因此,本研究验证了与PME相关的情绪反应与主动运动锻炼(AME)相关的情绪反应没有差异的假设。八名女性和七名男性参与了这项研究,并按随机顺序在PME和AME模式下进行了情绪状态描述(POMS)。结果包括情绪障碍总分[(紧张感+抑郁感+疲劳感+愤怒感+困惑感)-活力]。采用方差分析(ANOVA)确定PME和AME在基线和30分钟后立即发生的总情绪障碍、氧摄食量(V.O2)和脑中血流速度(MCAv)的显著性差异。运动后两种情况的总情绪障碍评分均显著降低(PME基线29.2±5.2比运动后16.4±6.8,P < 0.05), AME基线22.4±4.4比运动后13.1±5.2,P < 0.05)。在PME和AME期间,这些感觉变化与V.O2和MCAv的显著生理增加相关(P < 0.05)。这些结果表明,被动和主动运动循环运动的生理和情绪反应没有不同。未来的研究应该确定被动运动自行车运动是否是一种有效的预防医学策略,以克服各种疾病相关的运动限制和抵消久坐不动的生活方式的不利影响。
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引用次数: 3
Determinants of Noncompletion of the Third Dose of Tetanus Toxoid Vaccine in Pregnant Women in Dschang Health District, Cameroon. 喀麦隆Dschang卫生区孕妇未完成第三剂破伤风类毒素疫苗接种的决定因素
Pub Date : 2020-02-25 eCollection Date: 2020-01-01 DOI: 10.1155/2020/1603518
Florent Ymele Fouelifack, Bruno Kenfack, Skinner Lekelem Nguefack, Jackson Jr Nforbewing Ndenkeh, Jeanne Hortence Fouedjio, Loic Dongmo Fouelifa, Pierre Marie Tebeu

Introduction. Tetanus vaccination plays an important role in the fight against neonatal mortality. Our study aimed to determine the noncompletion rate of the 3rd dose of tetanus toxoid vaccine (TTV) and to analyze the associated factors in pregnant women.

Methods: This was a cross-sectional study conducted in 2 hospitals of Dschang Health District and targeting all women at least in their second gestation coming for antenatal consultation. Upon informed consent by the participant, a prepared questionnaire was administered. The collected data was analyzed using SPSS v22.0 with results presented in means and proportions. Logistic regression was used at two levels to identify independently associated factors for noncompletion of the third dose of TTV with a significance set at 5%.

Results: A total of 380 pregnant women were recruited in this study of mean age 27 ± 5.2 yrs, 70% being married, more than 80% having at least secondary education, and 31.8% of them being students. It was noted that 172 (45.26%) of these women had not received the third dose of TTV. The analysis of the adjusted effects showed that not going to postnatal consultation (aOR = 6.75; 3.98-11.49, p < 0.0001), not accompanying her baby to vaccination (aOR = 3.784; 1.803-7.942, p < 0.0001), not accompanying her baby to vaccination (aOR = 3.784; 1.803-7.942, p < 0.0001), not accompanying her baby to vaccination (aOR = 3.784; 1.803-7.942.

Conclusion: Tetanus vaccination coverage is not yet optimal in Dschang Health District and is associated with marital status as well as postgestational behavior of the mothers. There is thus the need to put in place strategies that will provide social support to single mothers as well as encourage women to attend postnatal consultation and to accompany their own children for vaccination. Furthermore, community-based vaccination could capture some of the lost women thus optimizing the overall vaccination coverage.

介绍。破伤风疫苗接种在降低新生儿死亡率方面发挥着重要作用。本研究旨在确定孕妇破伤风类毒素疫苗(TTV)第三次接种不完成率,并分析其相关因素。方法:采用横断面研究方法,在昌市卫生区2家医院开展,调查对象为所有来产前会诊的二胎以上妇女。在参与者的知情同意下,一份准备好的问卷被执行。收集的数据采用SPSS v22.0进行分析,结果以均数和比例表示。在两个水平上使用逻辑回归来确定第三剂TTV未完成的独立相关因素,显著性设置为5%。结果:本研究共纳入孕妇380例,平均年龄27±5.2岁,已婚70%,中等及以上文化程度80%以上,学生占31.8%。值得注意的是,这些妇女中有172人(45.26%)没有接受第三剂TTV。调整后的效果分析显示,不去产后咨询(aOR = 6.75;3.98-11.49, p < 0.0001),未陪同婴儿接种疫苗(aOR = 3.784;1.803-7.942, p < 0.0001),未陪同婴儿接种疫苗(aOR = 3.784;1.803-7.942, p < 0.0001),未陪同婴儿接种疫苗(aOR = 3.784;1.803 - -7.942。结论:德昌卫生区破伤风疫苗接种率尚未达到最佳水平,破伤风疫苗接种率与产妇的婚姻状况和孕后行为有关。因此,有必要制定战略,向单身母亲提供社会支持,并鼓励妇女参加产后咨询和陪伴自己的孩子接种疫苗。此外,以社区为基础的疫苗接种可以弥补一些失去的妇女,从而优化总体疫苗接种覆盖率。
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引用次数: 3
Effects of Routine Checkups and Chronic Conditions on Middle-Aged Patients with Diabetes. 中年糖尿病患者常规体检与慢性病的关系
Pub Date : 2020-02-20 eCollection Date: 2020-01-01 DOI: 10.1155/2020/4043959
America E McGuffee, Kailyn Chillag, Amber Johnson, Regan Richardson, Hallie Williams, Jessica Hartos

Purpose. Middle-aged males and females with diabetes are more likely to have poor physical (PH) and mental health (MH); however, there is limited research determining the relationship between MH and PH and routine check-up in diabetic middle-aged adults, especially by gender. The purpose of this study was to determine whether PH and MH status differ by routine check-up in middle-aged (age 45-64) adults with diabetes in the general population. Methods. This cross-sectional analysis used data from the 2017 BRFSS conducted by the CDC for adults aged 45-64 who reported having diabetes in Florida (N = 1183), Kentucky (N = 617), Maryland (N = 731), New York (N = 593), and Ohio (N = 754). Multiple logistic regression by state and gender was used to determine the relationship between MH and PH status and routine check-up while controlling for health-related, socioeconomic, and demographic factors. Results. Across states, up to one-half reported good PH (32-50%), over one-half reported good MH (46-67%), and most reported having a routine check-up (87-93%). Adjusted analysis indicated that MH and PH were not significantly related to routine check-up, but both were inversely related to having diabetes plus two other health conditions. Conclusions. Overall, routine check-up was not related to good PH and MH in this target population; however, a number of health conditions were inversely related to good PH and MH status. In a primary care setting for this target population, there may be a low to moderate prevalence of good PH and MH and a high prevalence of having a routine check-up and having multiple health conditions. It is recommended to automatically screen this target population for PH, MH, other chronic conditions, and physical activity and treat concurrently.

目的。患有糖尿病的中年男性和女性更有可能身体(PH)和精神健康(MH)不佳;然而,确定中年糖尿病患者MH和PH与常规检查之间关系的研究有限,特别是按性别进行检查。本研究的目的是确定普通人群中患有糖尿病的中年(45-64岁)成年人的PH和MH状态是否通过常规检查有所不同。方法。该横断面分析使用了疾病预防控制中心对佛罗里达州(N = 1183)、肯塔基州(N = 617)、马里兰州(N = 731)、纽约州(N = 593)和俄亥俄州(N = 754)报告患有糖尿病的45-64岁成年人进行的2017年BRFSS数据。在控制健康相关、社会经济和人口因素的同时,采用州和性别的多元逻辑回归来确定MH和PH状态与常规检查的关系。结果。在各州,多达一半的人报告PH值良好(32-50%),超过一半的人报告MH良好(46-67%),大多数人报告进行了例行检查(87-93%)。调整后的分析表明,MH和PH与常规检查无显著相关,但两者与糖尿病和其他两种健康状况呈负相关。结论。总体而言,常规检查与该目标人群的良好PH和MH无关;然而,一些健康状况与良好的PH和MH状态呈负相关。在针对这一目标人群的初级保健环境中,良好PH和MH的患病率可能低至中等,而进行常规检查和患有多种健康状况的患病率可能很高。建议对这一目标人群进行PH、MH、其他慢性病和身体活动的自动筛查,并同时进行治疗。
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引用次数: 0
Self-Collected Specimens Revealed a Higher Vaccine- and Non-Vaccine-Type Human Papillomavirus Prevalences in a Cross-Sectional Study in Akuse. 在Akuse的一项横断面研究中,自我收集的标本显示了更高的疫苗型和非疫苗型人乳头瘤病毒患病率。
Pub Date : 2020-01-22 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8343169
Adolf K Awua, Alberto Severini, Edwin K Wiredu, Edwin A Afari, Vanessa A Zubach, Richard M K Adanu

Background: Population-specific epidemiologic data on human Papillomavirus infection, which are limited in most of the SubSaharan African countries, are necessary for effective cervical cancer prevention. This study aimed to generate population-specific data on human Papillomavirus infections, and determine which of these, self-collected and provider-collected specimens, gives a higher estimate of the prevalence of human Papillomaviruses, including vaccine and non-vaccine-type human Papillomavirus.

Methods: In this cross-sectional study, following a questionnaire-based collection of epidemiological data, self-, and provider-collected specimens, obtained from women 15-65 years of age, were analysed for human Papillomavirus types by a nested-multiplex polymerase chain reaction, and for cervical lesions by Pap testing. HPV data were categorised according to risk type and vaccine types for further analysis.

Results: The difference between the overall human Papillomavirus infection prevalences obtained with the self-collected specimens, 43.1% (95% CI of 38.0-51.0%) and that with the provider-collected samples, 23.3% (95% CI of 19.0-31.0%) were significant (p ≤ 0.001). The prevalence of quadrivalent vaccine-type human Papillomaviruses was 12.3% with self-collected specimens, but 6.0% with provider-collected specimens. For the nonavalent vaccine-types, the prevalences were 26.6% and 16.7% respectively. There were multiple infections involving both vaccine-preventable and nonvaccine preventable high-risk human Papillomavirus genotypes.

Conclusion: The Akuse subdistrict can, therefore, be said to have a high burden of human Papillomavirus infections, which included nonvaccine types, as detected with both self-collected and provider-collected specimens. These imply that self-collection is to be given a higher consideration as a means for a population-based high-risk human Papillomavirus infections burdens assessment/screening. Additionally, even with a successful implementation of the HPV vaccination, if introduced in Ghana, there is still the need to continue with the screening of women.

背景:大多数撒哈拉以南非洲国家关于人乳头瘤病毒感染的人口特异性流行病学数据有限,这对于有效预防宫颈癌是必要的。本研究旨在生成人类乳头瘤病毒感染的人群特异性数据,并确定其中哪种(自行收集的和提供者收集的)标本对人类乳头瘤病毒(包括疫苗型和非疫苗型人类乳头瘤病毒)的流行率给出更高的估计。方法:在这项横断面研究中,通过问卷调查收集流行病学数据,通过巢式多重聚合酶链反应分析从15-65岁妇女中获得的自我和提供者收集的标本,并通过巴氏试验分析人类乳头瘤病毒类型。HPV数据根据风险类型和疫苗类型进行分类,以便进一步分析。结果:人乳头瘤病毒总感染率自行采集标本43.1% (95% CI为38.0 ~ 51.0%),与提供者采集标本23.3% (95% CI为19.0 ~ 31.0%)差异有统计学意义(p≤0.001)。四价疫苗型人乳头瘤病毒在自行采集标本中的流行率为12.3%,而在提供者采集标本中的流行率为6.0%。非价型疫苗的患病率分别为26.6%和16.7%。有多种感染涉及疫苗可预防和非疫苗可预防的高危人乳头瘤病毒基因型。结论:因此,Akuse街道可以说是人类乳头瘤病毒感染的高负担区,其中包括非疫苗类型,通过自行收集和提供者收集的标本均可检测到。这意味着,作为基于人群的高危人乳头瘤病毒感染负担评估/筛查的手段,自我收集应得到更高的考虑。此外,即使成功实施了人乳头瘤病毒疫苗接种,如果在加纳实施,仍然需要继续对妇女进行筛查。
{"title":"Self-Collected Specimens Revealed a Higher Vaccine- and Non-Vaccine-Type Human Papillomavirus Prevalences in a Cross-Sectional Study in Akuse.","authors":"Adolf K Awua,&nbsp;Alberto Severini,&nbsp;Edwin K Wiredu,&nbsp;Edwin A Afari,&nbsp;Vanessa A Zubach,&nbsp;Richard M K Adanu","doi":"10.1155/2020/8343169","DOIUrl":"https://doi.org/10.1155/2020/8343169","url":null,"abstract":"<p><strong>Background: </strong>Population-specific epidemiologic data on human Papillomavirus infection, which are limited in most of the SubSaharan African countries, are necessary for effective cervical cancer prevention. This study aimed to generate population-specific data on human Papillomavirus infections, and determine which of these, self-collected and provider-collected specimens, gives a higher estimate of the prevalence of human Papillomaviruses, including vaccine and non-vaccine-type human Papillomavirus.</p><p><strong>Methods: </strong>In this cross-sectional study, following a questionnaire-based collection of epidemiological data, self-, and provider-collected specimens, obtained from women 15-65 years of age, were analysed for human Papillomavirus types by a nested-multiplex polymerase chain reaction, and for cervical lesions by Pap testing. HPV data were categorised according to risk type and vaccine types for further analysis.</p><p><strong>Results: </strong>The difference between the overall human Papillomavirus infection prevalences obtained with the self-collected specimens, 43.1% (95% CI of 38.0-51.0%) and that with the provider-collected samples, 23.3% (95% CI of 19.0-31.0%) were significant (<i>p</i> ≤ 0.001). The prevalence of quadrivalent vaccine-type human Papillomaviruses was 12.3% with self-collected specimens, but 6.0% with provider-collected specimens. For the nonavalent vaccine-types, the prevalences were 26.6% and 16.7% respectively. There were multiple infections involving both vaccine-preventable and nonvaccine preventable high-risk human Papillomavirus genotypes.</p><p><strong>Conclusion: </strong>The Akuse subdistrict can, therefore, be said to have a high burden of human Papillomavirus infections, which included nonvaccine types, as detected with both self-collected and provider-collected specimens. These imply that self-collection is to be given a higher consideration as a means for a population-based high-risk human Papillomavirus infections burdens assessment/screening. Additionally, even with a successful implementation of the HPV vaccination, if introduced in Ghana, there is still the need to continue with the screening of women.</p>","PeriodicalId":7388,"journal":{"name":"Advances in Preventive Medicine","volume":"2020 ","pages":"8343169"},"PeriodicalIF":0.0,"publicationDate":"2020-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8343169","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37937983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Compliance to Iron-Folic Acid Supplementation and Its Association with the Number of ANC Visits in Ethiopia: Systematic Review and Meta-Analysis. 铁叶酸补充依从性及其与埃塞俄比亚ANC就诊次数的关系:系统评价和荟萃分析
Pub Date : 2019-12-22 eCollection Date: 2019-01-01 DOI: 10.1155/2019/3602585
Yinager Workineh, Ayele Semachew, Emiru Ayalew, Worku Animaw Temesgen

Background: The World Health Organization recommended that 80% of communities in all countries should receive the standard dose of iron folic acid. But, in Ethiopia, this target was not yet achieved. The compliance of iron folic acid was also variable across each district. Therefore, the aim of this study was to assess women compliance with iron-folic acid supplementation and its association with a number of antenatal care visits in Ethiopia using systematic review and meta-analysis, 2018.

Methods: In the current meta-analysis, the target variables were searched from different electronic database system like PubMed, Google Scholar, Science Direct, and Cochrane Library. To predict the pooled prevalence of compliance with iron-folic acid supplementation in Ethiopia, all original studies were considered. All necessary data were extracted by using a standardized data extraction format. The data were analyzed by using STATA 14 statistical software. Heterogeneity between the studies was assessed by Cochrane Q and I 2 tests. A random effect model was computed to estimate the pooled compliance with iron-folic acid supplementation.

Results: Twelve full-text studies were included in the meta-analysis. The findings of this meta-analysis revealed that the pooled prevalence of compliance with iron-folic acid supplementation in Ethiopia was 43.63% (CI: 28.00, 59.25%). The women from the city administration had a high rate of compliance as compared with other regions of Ethiopia. The odds of having four or more antenatal care visit were the independent pooled predictor of compliance with iron-folic acid supplementation.

Conclusion: Current compliance with iron-folic supplementation was lower than the World health organization recommendation. Mothers from the city administration who utilized the antenatal care four and above times, had high level compliance with iron-folic acid supplementation. Therefore, we recommended that women should visit the antenatal clinic four times to compliance with the iron folic acid supplementation.

背景:世界卫生组织建议所有国家80%的社区应接受标准剂量的叶酸铁。但是,在埃塞俄比亚,这一目标尚未实现。叶酸铁的依从性也因地区而异。因此,本研究的目的是通过2018年的系统回顾和荟萃分析,评估埃塞俄比亚妇女对叶酸铁补充剂的依从性及其与产前保健就诊的关系。方法:在本次meta分析中,从PubMed、Google Scholar、Science Direct、Cochrane Library等不同的电子数据库系统中检索目标变量。为了预测埃塞俄比亚铁叶酸补充剂的总体依从性,我们考虑了所有的原始研究。使用标准化的数据提取格式提取所有必要的数据。采用STATA 14统计软件对数据进行分析。通过Cochrane Q和i2检验评估研究之间的异质性。计算了一个随机效应模型来估计铁叶酸补充的总体顺应性。结果:meta分析纳入了12项全文研究。本荟萃分析的结果显示,埃塞俄比亚补充叶酸铁的总患病率为43.63% (CI: 28.00, 59.25%)。与埃塞俄比亚其他地区相比,来自城市管理部门的妇女的遵守率很高。接受四次或四次以上产前检查的几率是叶酸铁补充依从性的独立综合预测因子。结论:目前叶酸铁补充剂的依从性低于世界卫生组织的建议。利用产前保健4次及以上的城市管理人员的母亲对补充叶酸铁的依从性较高。因此,我们建议妇女应该去产前诊所四次,以遵守补充叶酸铁。
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引用次数: 9
Nephrolepis exaltata Herbal Mask Increases Nasal IgA Levels and Pulmonary Function in Textile Factory Workers. 高肾松草药面罩增加纺织厂工人鼻IgA水平和肺功能。
Pub Date : 2019-12-09 eCollection Date: 2019-01-01 DOI: 10.1155/2019/5687135
Awal Prasetyo, Arindra Adi Rahardja, Dhiva Tsuroya Azzahro, Ika Pawitra Miranti, Indah Saraswati, Fathur Nur Kholis

Background: Chronic occupational exposure in textile workers lowers the pulmonary function and levels of sinonasal IgA. A Nephrolepis exaltata herbal mask can protect the respiratory tract. This study aims to understand the effect of this herbal mask on the IgA levels and pulmonary function in textile workers. Thirty employees were selected for this study.

Methods: The pre- and post-test randomized experimental control trials were conducted in a garment industry of Bawen, Semarang, Indonesia. The subjects that qualified to participate (n = 30) fulfilled the inclusion criteria i.e., 20-35 years old, healthy, and willing to be a research subject; and exclusion criteria i.e., having history of alcohol consumption, smoking, history of liver disease, autoimmune disease, cancer, pulmonary and heart disease and/or being pregnant. The subjects were then divided randomly into control group (n = 15), who used regular mask that was rewashed and changed every month for eight weeks, and treatment group (n = 15), who used Nephrolepis exaltata mask that was changed every two days for eight weeks. Pulmonary function tests were carried out using MIR Spirolab III before and after the experiment. IgA levels were measured by nasal wash method using ELISA.

Results: IgA levels of the treatment group before and after usage of mask were significantly different (p<0.001) compared to the control group. There were significant difference in FVC of the control group, but no significant difference was observed for FEV1 (p = 0.507) and PEF (p = 0.001). In the treatment group, all three parameters showed significant differences [FVC (p = 0.038), FEV1 (p = 0.004), and PEF (p = 0.001)]. The means of ΔFVC, ΔFEV1, and ΔPEF were significantly (p<0.05) higher in the treatment group with OR = 5.1 for higher IgA levels.

Conclusions: The herbal mask is better in increasing IgA and improving the pulmonary function compared to the regular mask.

背景:纺织工人的慢性职业暴露降低了肺功能和鼻窦IgA水平。高肾素草药面膜可以保护呼吸道。本研究旨在了解中药口罩对纺织工人IgA水平和肺功能的影响。本研究选取了30名员工。方法:采用试验前、试验后随机对照试验对印尼三宝垄市巴温市某服装行业进行调查。符合入选标准的受试者(n = 30),即年龄20-35岁,身体健康,愿意成为研究对象;排除标准是,有饮酒史,吸烟史,肝病史,自身免疫性疾病史,癌症史,肺病和心脏病史和/或怀孕史。然后将受试者随机分为对照组(n = 15)和治疗组(n = 15),对照组使用普通面膜,每月更换一次,为期8周;治疗组(n = 15)使用高效肾松(Nephrolepis exaltata)面膜,每两天更换一次,为期8周。实验前后分别用MIR Spirolab III进行肺功能检测。ELISA法洗鼻法检测IgA水平。结果:治疗组患者使用口罩前后IgA水平(pp = 0.507)、PEF水平(p = 0.001)差异有统计学意义。治疗组3个参数均有显著差异[FVC (p = 0.038)、FEV1 (p = 0.004)、PEF (p = 0.001)]。ΔFVC、ΔFEV1、ΔPEF的均值均有统计学意义(p < 0.05)。结论:中药口罩较普通口罩在增加IgA、改善肺功能方面效果更好。
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引用次数: 6
Effective Vaccine Management: The Case of a Rural District in Ghana 有效的疫苗管理:加纳农村地区的案例
Pub Date : 2019-10-13 DOI: 10.1155/2019/5287287
E. Osei, M. Ibrahim, Gregory Kofi Amenuvegbe
Background The Effective Vaccine Management (EVM) initiative provides the platform needed to monitor and assess the vaccine supply chain system to identify strengths and weaknesses of the system at all levels to enhance the development of improvement plan to strengthen the system. This valuation was carried out in the Tolon District of the Northern Region, Ghana. Methods A descriptive valuation of vaccine management was carried out in six vaccine stores in the Tolon District of Northern Ghana. We employed World Health Organization (WHO) assessment tools and procedures which consisted of desk reviews and interviews of cold chain managers to assess vaccine management practices in the district. Five out of the nine global assessment criteria were assessed and a minimum target level required for all criteria to meet the WHO standard was 80%. Results None of the facilities assessed met the WHO benchmark of 80% for all but one criteria assessed. With regards to temperature control, the scores ranged from 42% at Kasuliyili CHPS Centre to 77% at the district store with an average district score of 60%. Stock management ranged between 11% at Wantugu Health Centre and 75% at Nyankpala Health Centre with district average score of 32%. Effective vaccine distribution scores ranged between 13% at Kasuliyili CHPS and 46% at Nyankpala Health Centre with an average district score of 27%. Only Nyankpala Health Centre had an acceptable score of 84% for vaccine management, whereas the lowest score for this indicator was 5% at Tolon Health Centre store with district average score of 53%. Information management and supportive functions scores ranged from 0% at Tolon Health Centre to 26% at the district store with the district average score of 16%. Nineteen (90.5%) of vaccine users had poor knowledge regarding temperature control and vaccine distribution. Conclusion Effective vaccine management knowledge and practices are poor at Tonlon district and calls for urgent and pragmatic approaches such as training and re-training of vaccine users at all levels.
有效疫苗管理(EVM)倡议提供了监测和评估疫苗供应链系统所需的平台,以确定各级系统的优势和弱点,从而加强改进计划的制定,以加强系统。这一估价是在加纳北部地区的Tolon区进行的。方法对加纳北部Tolon地区6家疫苗商店的疫苗管理情况进行描述性评价。我们采用了世界卫生组织(世卫组织)的评估工具和程序,包括案头审查和冷链管理人员的访谈,以评估该地区的疫苗管理做法。对9项全球评估标准中的5项进行了评估,所有标准达到世卫组织标准所需的最低目标水平为80%。结果除一项标准外,所有设施均未达到WHO标准的80%。在温度控制方面,得分从卡苏利伊利卫生保健中心的42%到地区商店的77%不等,地区平均得分为60%。旺图古保健中心的库存管理为11%,尼扬帕拉保健中心为75%,地区平均得分为32%。卡苏利利卫生保健中心的有效疫苗分发得分为13%,尼扬帕拉卫生中心的有效疫苗分发得分为46%,平均地区得分为27%。只有尼扬帕拉保健中心在疫苗管理方面的可接受得分为84%,而托伦保健中心商店在该指标方面的最低得分为5%,地区平均得分为53%。信息管理和支持功能得分从Tolon保健中心的0%到地区商店的26%不等,地区平均得分为16%。19名(90.5%)疫苗使用者对温度控制和疫苗分发知识不了解。结论Tonlon地区有效的疫苗管理知识和实践较差,需要采取紧急和务实的措施,如对各级疫苗使用者进行培训和再培训。
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引用次数: 14
Bacterial Infections and Their Antibiotic Resistance Pattern in Ethiopia: A Systematic Review 埃塞俄比亚细菌感染及其抗生素耐药模式:系统综述
Pub Date : 2019-08-05 DOI: 10.1155/2019/4380309
Alemayehu Reta, Abebaw Bitew Kifilie, Abeba Mengist
Background Antibiotic resistance is a global challenge in the public health sector and also a major challenge in Ethiopia. It is truly difficult to report bacterial antibiotic resistance pattern in Ethiopia due to the absence of a review which is done comprehensively. The aim of this systematic review was to provide an overview of the works of literature on the antibiotic resistance pattern of the specific bacterial isolates that can be obtained from different clinical samples in the context of Ethiopia. Materials and Methods A web-based search using PubMed, Google Scholar, Hinari, Sci Hub, Scopus and the Directory of Open Access Journals was conducted from April to May 2018 for published studies without restriction in the year of publication. Works of literature potentially relevant to the study were identified by Boolean search technique using various keywords: Bacterial infection, antimicrobial resistance, antibiotic resistance, drug resistance, drug susceptibility, anti-bacterial resistance, Ethiopia. Study that perform susceptibility test from animal or healthy source using <10 isolates and methods other than prospective cross-sectional were excluded. Results The database search delivered a total of 3459 studies. After amendment for duplicates and inclusion and exclusion criteria, 39 articles were found suitable for the systematic review. All studies were prospective cross-sectional in nature. The review encompasses 12 gram-positive and 15 gram-negative bacteria with their resistance pattern for around 12 antibiotics. It covers most of the regions which are found in Ethiopia. The resistance pattern of the isolates ranged from 0% up to 100%. The overall resistance of M. tuberculosis for antituberculosis drugs ranges from 0% up to 32.6%. The percentage of resistance increases among previously treated tuberculosis cases. Neisseria gonorrhea, S. typhimurium, S. Virchow, Group A Streptococci (GAS), and Group B Streptococci (GBS) were highly susceptible for most of the tested antibiotics. Methicillin-Resistant Staphylococcus aureus was highly resistant to most of the antibiotics with a slightly increased susceptibility to gentamycin. Conclusions Total bacterial isolates obtained from a different source of sample and geographic areas were 28, including M. tuberculosis. Majority of the bacterial isolates were resistant to commonly used antibiotics. A continuous monitoring and studies on the multidrug-resistant bacterial isolates are important measures.
背景抗生素耐药性是公共卫生部门面临的全球性挑战,也是埃塞俄比亚面临的重大挑战。由于缺乏全面的审查,很难报告埃塞俄比亚的细菌抗生素耐药性模式。本系统综述的目的是概述埃塞俄比亚不同临床样本中可获得的特定细菌分离株的抗生素耐药性模式的文献工作。材料和方法2018年4月至5月,使用PubMed、Google Scholar、Hinari、Sci Hub、Scopus和开放获取期刊目录对发表当年的已发表研究进行了无限制的网络搜索。通过布尔搜索技术,使用各种关键词确定了可能与该研究相关的文献作品:细菌感染、抗微生物耐药性、抗生素耐药性、耐药性、药物敏感性、抗菌耐药性、埃塞俄比亚。排除了使用<10个分离株和前瞻性横断面以外的方法从动物或健康来源进行易感性测试的研究。结果数据库检索共提供3459项研究。在对重复项、纳入和排除标准进行修改后,发现39篇文章适合进行系统审查。所有研究均为前瞻性横断面研究。这篇综述包括12种革兰氏阳性菌和15种革兰氏阴性菌,它们对大约12种抗生素的耐药性模式。它覆盖了埃塞俄比亚的大部分地区。分离株的抗性模式从0%到100%不等。结核分枝杆菌对抗结核药物的总体耐药性在0%至32.6%之间。在既往治疗的结核病例中,耐药性的百分比增加。淋病奈瑟菌、鼠伤寒沙门氏菌、病毒链球菌、A组链球菌(GAS)和B组链球菌(GBS)对大多数测试抗生素高度敏感。耐甲氧西林金黄色葡萄球菌对大多数抗生素具有高度耐药性,对庆大霉素的易感性略有增加。结论从不同的样品来源和地理区域获得的细菌分离株总数为28株,其中包括结核分枝杆菌。大多数细菌分离株对常用抗生素具有耐药性。对多药耐药菌株进行持续监测和研究是重要措施。
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引用次数: 20
Prevalence Study of Dermatologic Manifestations among Diabetic Patients 糖尿病患者皮肤病表现的流行病学研究
Pub Date : 2019-07-01 DOI: 10.1155/2019/5293193
Zahra Azizian, E. Behrangi, Roshanak Hasheminasabzavareh, Hassan Kazemlo, R. Esmaeeli, P. Hassani
Background Diabetes mellitus (DM) is an interdisciplinary disorder that needs many different specialties' attention; however, the importance of dermatologists' knowledge has not been highlighted regarding this issue. As a result, we aim to assess the prevalence and variety of DM skin and nail manifestations in an effort to further acquaint dermatologists and other clinicians with diabetic dermatologic manifestations. Methods This was a cross-sectional study; subjects who had a diagnosis of DM, attending to the outpatient endocrinology clinics of Rassoul Akram Hospital, Tehran, Iran, were evaluated by one dermatologist for diabetic dermopathy. The results were recorded in prepared data sheets, and general descriptions of DM duration, DM type, DM control, and drug history as well as the demographic data were gathered. Results Among a total of 255 subjects, the prevalence of one or more identifiable skin conditions was 88.4%. 15.7% of the subjects had nail manifestations. Among cutaneous manifestations, acanthosis nigricans, acral erythema, and onychoschizia showed a significant relationship with the age and disease duration (p<0.05); and knuckle pebbles, eczema, facial erythema, and koilonychias had a meaningful relationship with FBS level and glycated hemoglobin, HbA1c (p<0.05). Conclusion This study provides an overview that facilitates earlier detection and treatment of DM. Also, this data can help physicians and endocrinologists to visualize DM control level.
糖尿病(DM)是一种跨学科的疾病,需要许多不同的专业的关注;然而,在这个问题上,皮肤科医生的知识的重要性并没有得到强调。因此,我们的目的是评估糖尿病皮肤和指甲表现的患病率和多样性,以进一步使皮肤科医生和其他临床医生熟悉糖尿病皮肤表现。方法采用横断面研究;在伊朗德黑兰Rassoul Akram医院内分泌科门诊就诊的诊断为糖尿病的受试者由一名皮肤科医生评估糖尿病性皮肤病。结果记录在准备好的数据表中,并收集糖尿病病程、糖尿病类型、糖尿病控制、用药史的一般描述以及人口统计学数据。结果在255名受试者中,一种或多种可识别皮肤状况的患病率为88.4%。15.7%的患者有指甲表现。皮肤表现中,黑棘皮、肢端红斑、甲裂与年龄、病程有显著相关性(p<0.05);FBS水平、糖化血红蛋白、HbA1c与指关节疙瘩、湿疹、面部红斑、口唾液炎有显著相关性(p<0.05)。结论本研究为糖尿病的早期发现和治疗提供了一个概述,并为医生和内分泌学家了解糖尿病的控制水平提供了帮助。
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引用次数: 12
Vitamin D as an Adjunctive Treatment to Standard Drugs in Pulmonary Tuberculosis Patients: An Evidence-Based Case Report 维生素D作为肺结核患者标准药物的辅助治疗:一项循证病例报告
Pub Date : 2019-06-20 DOI: 10.1155/2019/5181847
Diajeng A. Soeharto, Diana Ashilah Rifai, Stella Marsudidjadja, Aisha Emilirosy Roekman, Chadijah Karima Assegaf, M. Louisa
Background Vitamin D has a prominent role in the body's innate immunity as it is important in the maintenance of macrophages and monocytes and its function in defending against infections. In-vitro studies have established vitamin D's potential role in tuberculosis (TB) infection, in that it restricts Mycobacterium tuberculosis growth, thus implying the potential benefit of vitamin D as an adjunctive treatment for TB. However, clinical trials and reviews have contradicting findings regarding the true clinical efficacy of adjunctive vitamin D, particularly in reducing the sputum conversion rate (SCR). Objective This study aims to update the current evidence regarding vitamin D supplementation as an adjunctive treatment in achieving the smear sputum conversion rate (SCR) among pulmonary TB patients. Method A comprehensive search was conducted in October 2018 in PubMed-NCBI, MEDLINE-OVID, SCOPUS-Elsevier, and Cochrane. The selection of studies was done as per the predetermined inclusion and exclusion criteria of this EBCR and resulted in the inclusion of 11 eligible studies (8 RCTs and 3 systematic reviews). The selected studies were then critically appraised for their validity, importance, and applicability according to the CEBM (Centre for Evidence-Based Medicine) appraisal tools. Results Overall, most of the trials showed no statistically significant changes in terms of the proportion of TB patients with a negative sputum smear conversion in the group treated with an adjunctive therapy vs. the group treated with standard antituberculosis therapy alone. Only one trial showed significant results, which was conducted in a population of TB patients with vitamin D deficiency. Furthermore, overall the reviews showed no significant change in the 8-week sputum smear conversion after treatment within the group given vitamin D in comparison to those who were not. Conclusion Vitamin D as adjunctive therapy in TB patients shows no clinical improvement in terms of sputum conversion to antituberculosis management.
维生素D在机体先天免疫中起着重要作用,因为它在巨噬细胞和单核细胞的维持及其防御感染的功能中起着重要作用。体外研究已经确定了维生素D在结核病感染中的潜在作用,因为它限制了结核分枝杆菌的生长,从而暗示了维生素D作为结核病辅助治疗的潜在益处。然而,关于辅助维生素D的真正临床疗效,特别是在降低痰转换率(SCR)方面,临床试验和综述得出了相互矛盾的发现。目的本研究旨在更新目前关于补充维生素D作为辅助治疗在实现肺结核患者涂片痰转换率(SCR)方面的证据。方法于2018年10月在PubMed-NCBI、MEDLINE-OVID、SCOPUS-Elsevier和Cochrane中进行综合检索。研究的选择按照EBCR预先确定的纳入和排除标准进行,最终纳入了11项符合条件的研究(8项随机对照试验和3项系统评价)。然后根据CEBM(循证医学中心)评估工具对所选研究的有效性、重要性和适用性进行严格评估。结果:总体而言,大多数试验显示,在接受辅助治疗组与单独接受标准抗结核治疗组中,痰涂片转化为阴性的结核病患者比例没有统计学上的显著变化。只有一项试验显示了显著的结果,该试验是在维生素D缺乏的结核病患者群体中进行的。此外,总体评价显示,与未服用维生素D的组相比,服用维生素D的组在治疗后8周的痰涂片转换没有显著变化。结论维生素D作为结核病患者的辅助治疗在痰液转化为抗结核治疗方面无明显改善作用。
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引用次数: 17
期刊
Advances in Preventive Medicine
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