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An analytical method for 3-dimensional calculation of the contaminant X-ray dose in water caused by clinical electron-beam irradiation 一种临床电子束辐照水中污染物x射线剂量三维计算的解析方法
Pub Date : 2020-02-03 DOI: 10.14312/2399-8172.2020-2
A. Iwasaki, S. Terashima, S. Kimura, K. Sutoh, K. Kamimura, Y. Hosokawa, M. Miyazawa
Purposes: In this paper, an analytical method for 3-dimensional (3D) calculation of the contaminant X-ray dose in water caused by clinical electron-beam irradiation is proposed in light of the two groups of Monte Carlo (MC) datasets reported by Wieslander and Knöös (2006). Methods: The dose calculation was performed based on Clarkson’s sector method. We used a plane called the isocenter plane, which is set perpendicular to the beam axis, containing the isocenter on it. On the isocenter plane, we defined the applicator field formed by an electron applicator and the cerrobend area field formed by a cerrobend insert if any, as well as other physical terms that are important for the dose calculations. The original sector method was modified to consider the following terms: (a) the vague beam-field margins formed by the dual-foil system; (b) the in-air dose distribution of the contaminant X-ray beam; (c) the X-ray spectrum change between the contaminant X-ray PDD datasets and the published radiotherapy X-ray PDD datasets; and (d) the contaminant X-ray attenuation for the cerrobent insert, if any. Results and conclusions: By comparing the calculated datasets of depth dose (DD) and off-axis dose (OAD) with the MC results for electron beams of E =6, 12, and 18 MeV, it can be concluded that the analytical calculation method is of practical use for various irradiation conditions. In particular, it should be noted that the analytical method can give almost the same calculation results as the MC-based dose calculation algorithm used in a commercial treatment planning system (TPS). highlights Based on Clarkson’s sector method, we developed an analytical method for calculation of the contaminant X-ray dose in water caused by clinical electron-beam irradiation. The analytical method was constructed by considering the following terms: (a) the vague beam-field margins formed by the dual-foil system; (b) the in-air dose distribution of the contaminant X-ray beam; (c) the X-ray spectrum change between the contaminant X-ray PDD datasets and the published radiotherapy X-ray PDD datasets; and (d) the contaminant X-ray attenuation for the cerrobent insert, if any. The dose calculation was performed in light of the two groups of Monte Carlo (MC) datasets reported by Wieslander and Knöös (2006). We conclude that the analytical method can achieve accurate dose calculations, even for beams with cerrobent inserts.
目的:本文根据Wieribrian和Knös(2006)报道的两组蒙特卡罗(MC)数据集,提出了一种三维(3D)计算临床电子束辐照引起的水中污染物X射线剂量的分析方法。方法:剂量计算采用克拉克森扇形法。我们使用了一个称为等中心平面的平面,该平面设置为垂直于束轴,并包含其上的等中心。在等中心平面上,我们定义了由电子施加器形成的施加器场和由卷探针插入物形成的卷探针面积场(如果有的话),以及对剂量计算很重要的其他物理术语。对原来的扇形法进行了修改,以考虑以下项:(a)由双箔系统形成的模糊束场边缘;(b) 污染物X射线束的空气中剂量分布;(c) 污染物X射线PDD数据集和公布的放射治疗X射线PDD数据集之间的X射线光谱变化;以及(d)用于所述cerrobent插件的污染物X射线衰减(如果有的话)。结果与结论:通过将深度剂量(DD)和离轴剂量(OAD)的计算数据集与E=6、12和18MeV电子束的MC结果进行比较,可以得出结论,该分析计算方法在各种辐照条件下具有实用性。特别地,应该注意的是,该分析方法可以给出与商业治疗计划系统(TPS)中使用的基于MC的剂量计算算法几乎相同的计算结果。亮点基于克拉克森扇形法,我们开发了一种计算临床电子束辐照引起的水中污染物X射线剂量的分析方法。该分析方法是通过考虑以下项来构建的:(a)由双箔系统形成的模糊束场边缘;(b) 污染物X射线束的空气中剂量分布;(c) 污染物X射线PDD数据集和公布的放射治疗X射线PDD数据集之间的X射线光谱变化;以及(d)用于所述cerrobent插件的污染物X射线衰减(如果有的话)。剂量计算是根据Wieribrian和Knös(2006)报告的两组蒙特卡罗(MC)数据集进行的。我们得出的结论是,该分析方法可以实现精确的剂量计算,即使是对于带有cerrobent插件的光束也是如此。
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引用次数: 0
Clinical pharmacology, use, and adverse reactions of intravenous iodinated contrast media in computed tomography 计算机断层扫描中静脉注射碘化造影剂的临床药理学、使用和不良反应
Pub Date : 2020-01-02 DOI: 10.14312/2399-8172.2020-1
D. Brillantino, T. Ferro, C. Brillantino, E. Rossi, R. Minelli, E. Bignardi, A. Tufano, R. Zeccolini, M. Zeccolini
Contrast media are substances used in radiology to improve the visualization of certain body structures subjected to analysis in a medical image. Contrast media are, then, diagnostic drugs because they increase the visibility of organs and tissues and allow the identification of details that otherwise could not be observed. With the introduction of multidetector computed tomography the number of patients undergoing contrast studies has grown exponentially in recent years. In computed tomography the formation of the radiographic image is obtained with the use of contrast media containing iodine atoms, exploiting the different attenuation that the X-ray beam presents in crossing the anatomical districts. The iodinated contrast media are a category of numerous substances formed by even complex molecules that vary considerably in their properties, uses and toxic effects. This article describes the clinical pharmacology, use and adverse reactions of intravenous iodinated contrast media used in computerized tomography, offering all doctors, even non-radiologists, the opportunity for rapid updating.
造影剂是放射学中用于改善医学图像中进行分析的某些身体结构的可视化的物质。因此,造影剂是诊断药物,因为它们可以增加器官和组织的可见性,并可以识别原本无法观察到的细节。随着多探测器计算机断层扫描的引入,近年来接受对比研究的患者数量呈指数级增长。在计算机断层扫描中,射线图像的形成是通过使用含有碘原子的造影剂来获得的,利用X射线束在穿过解剖区域时呈现的不同衰减。碘化造影剂是一类由复杂分子形成的众多物质,其性质、用途和毒性作用差异很大。本文介绍了计算机断层扫描中使用的静脉碘造影剂的临床药理学、使用和不良反应,为所有医生,甚至非放射科医生提供了快速更新的机会。
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引用次数: 0
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Journal of radiology and imaging
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