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Anaphylaxis due to cashew nut allergy associated with acute pancreatitis without abdominal pain: a case report. 腰果过敏引起的过敏性反应与急性胰腺炎无腹痛:一个病例报告。
Pub Date : 2025-10-01 DOI: 10.2185/jrm.2024-056
Shin Toki, Ryo Sugitate, Mariko Shimizu, Atsushi Matsui

Objective: Although gastrointestinal symptoms are common immediate reactions to food allergies (FA), the relationship between acute pancreatitis (AP) and FA remains unclear.

Patient: A 3-year-old boy developed vomiting, dyspnea, and urticaria 30 min after eating a cashew nut (CN) and was diagnosed with anaphylaxis.

Results: The patient was diagnosed with AP based on markedly elevated serum pancreatic amylase activity (1,847 IU/L) and mild pancreatic enlargement on abdominal ultrasonography, despite the absence of abdominal pain. All symptoms resolved immediately after intramuscular adrenaline injection, and serum pancreatic amylase activity normalized after 3 days. CN allergy was diagnosed based on blood tests showing elevated serum levels of CN- and Ana o 3-specific immunoglobulin E.

Conclusions: This is the first reported case of AP associated with anaphylaxis due to a CN allergy. AP should be considered in patients with FA who present with gastrointestinal symptoms, even if vomiting is the only symptom and abdominal pain is absent. AP associated with anaphylaxis may resolve rapidly with appropriate treatment.

目的:虽然胃肠道症状是食物过敏(FA)常见的直接反应,但急性胰腺炎(AP)与FA之间的关系尚不清楚。患者:一名3岁男孩在食用腰果(CN) 30分钟后出现呕吐、呼吸困难和荨麻疹,被诊断为过敏反应。结果:患者无腹痛,但血清胰淀粉酶活性明显升高(1847 IU/L),腹部超声检查胰腺轻度增大,诊断为AP。肌内注射肾上腺素后症状立即消失,血清胰淀粉酶活性3天后恢复正常。CN过敏的诊断是基于血液检查显示血清CN-和Ana o -特异性免疫球蛋白e水平升高。结论:这是第一例报道的AP与CN过敏引起的过敏反应相关的病例。出现胃肠道症状的FA患者应考虑AP,即使呕吐是唯一症状且没有腹痛。与过敏反应相关的AP可以通过适当的治疗迅速解决。
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引用次数: 0
Investigating the impact of remote visits on patients in hospitals with restricted visiting conditions. 调查远程就诊对就诊条件受限的医院患者的影响。
Pub Date : 2025-10-01 DOI: 10.2185/jrm.2025-014
Yuko Sugimoto, Mitsuru Chiba, Hideaki Andoh

Objective: Following the novel coronavirus disease 2019 (COVID-19) outbreak that began in 2020, contact between hospitalized patients and their families was significantly restricted to prevent infection. In May 2023, COVID-19 was classified as a Class 5 infectious disease by the Japanese Ministry of Health, Labour and Welfare. Although restrictions have gradually been lifted in some areas, at the time of writing this report, our hospital has not lifted all visit restrictions. Understandably, patients in this situation experience mental distress due to a lack of support from family, friends, or partners. Although remote visits have been introduced as an alternative to in-person visits, their effectiveness remains unclear. In this study, we report three cases in which we examine the impact of remote visits via electronic devices on patients who were unable to receive in-person visits.

Patients: Among the inpatients referred to our hospital's palliative care team from April 2022 to March 2023, three who requested remote visits due to psychological distress caused by the inability to see their families were enrolled in this study.

Results: The degree of psychological distress in all cases reduced after conducting remote visits. However, cancer-related pain (in two patients) and postoperative wound pain (in one patient) showed no significant differences in severity. In one patient, anxiety was evoked following a remote visit. This was attributed to the patient's realization of their isolation from their family.

Conclusion: For patients whose family members are unable to conduct in-person visits due to visit restrictions for various reasons, remote visits may help alleviate psychological distress. Since remote visits can cause adverse emotional reactions in some cases, monitoring the mental status during and after remote visits is necessary.

目的:自2020年新型冠状病毒病(COVID-19)暴发以来,为预防感染,住院患者与家属的接触受到严格限制。2023年5月,新冠肺炎被日本厚生劳动省列为5类传染病。虽然部分地区的限制已逐步解除,但在撰写本报告时,我院尚未全部解除探视限制。可以理解,在这种情况下,由于缺乏家人、朋友或伴侣的支持,患者会经历精神痛苦。虽然已采用远程访问作为面对面访问的替代方法,但其有效性仍不清楚。在本研究中,我们报告了三个案例,其中我们检查了通过电子设备远程访问对无法接受亲自访问的患者的影响。患者:在2022年4月至2023年3月转诊至我院姑息治疗团队的住院患者中,有3名因无法见家人而产生心理困扰,要求远程就诊的患者被纳入本研究。结果:远程访视后,所有患者的心理困扰程度均有所降低。然而,癌症相关疼痛(2例)和术后伤口疼痛(1例)在严重程度上没有显著差异。在一名患者中,焦虑是在远程访问后引起的。这是由于患者意识到他们与家人的隔离。结论:对于家属因各种原因无法亲临就诊的患者,远程就诊有助于缓解心理困扰。由于远程访问在某些情况下会引起不良情绪反应,因此监测远程访问期间和之后的精神状态是必要的。
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引用次数: 0
Bone marrow donors: experience among adolescents and young adults. 骨髓捐献者:青少年和青壮年的经验。
Pub Date : 2025-10-01 DOI: 10.2185/jrm.2024-043
Kotomi Sato, Masahiro Haraguchi

Objective: Recent treatment advancements have improved the survival rates of patients with hematological malignancies, making hematopoietic stem cell transplantation (HSCT) a key curative option. However, despite ongoing awareness efforts, the number of bone marrow donor registrations has not significantly increased over time, possibly because of the impact of recent infectious disease outbreaks. This may affect patients requiring allogeneic HSCT. This study explored the experiences of adolescent and young adult (AYA) bone marrow donors.

Patient and methods: Using a qualitative descriptive research design, we conducted semi-structured interviews with six AYA individuals who had experience as bone marrow donors. The study was approved by the institutional ethics committee (022-03), and no conflicts of interest were disclosed.

Results: Seven categories and 23 subcategories were identified in this analysis. Participants reported a strong sense of duty as donors, but faced challenges such as family opposition, lack of understanding from employers, and concerns about the impact on work and family life. Despite these difficulties, donors often experienced personal growth and fulfillment through donation.

Conclusion: Nurses should recognize AYA bone marrow donors as a population that requires support, and consider strategies to increase the understanding and registration among this crucial demographic group.

目的:最近的治疗进展提高了血液系统恶性肿瘤患者的生存率,使造血干细胞移植(HSCT)成为关键的治疗选择。然而,尽管不断努力提高认识,骨髓捐赠者登记的数量并没有随着时间的推移而显著增加,这可能是由于最近传染病爆发的影响。这可能会影响到需要同种异体造血干细胞移植的患者。本研究探讨了青少年和青壮年(AYA)骨髓捐赠者的经历。患者和方法:采用定性描述性研究设计,我们对6名有过骨髓捐赠经历的AYA个体进行了半结构化访谈。该研究得到了机构伦理委员会(022-03)的批准,没有披露任何利益冲突。结果:在本分析中确定了7类和23个亚类。参与者表示,作为捐赠者,他们有强烈的责任感,但也面临着一些挑战,比如家庭的反对、雇主的不理解,以及担心对工作和家庭生活的影响。尽管有这些困难,捐赠者经常通过捐赠经历个人成长和成就感。结论:护士应该认识到AYA骨髓捐赠者是一个需要支持的人群,并考虑提高这一关键人口群体的认识和登记的策略。
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引用次数: 0
A case of small intestinal perforation within inguinal hernia after low-energy indirect trauma. 低能量间接创伤腹股沟疝致小肠穿孔1例。
Pub Date : 2025-10-01 DOI: 10.2185/jrm.2025-029
Yuki Ohnishi, Jun Ebiko, Yasuhiro Suyama, Hiroyuki Otsuka

Objective: We present a case of small intestinal perforation within an inguinal hernia following low-energy indirect trauma.

Patient: A 55-year-old man with a known right inguinal hernia which had no prior indication for surgery developed acute right groin pain after sudden braking caused his scooter handlebar to strike his right thigh.

Results: Physical examination and computed tomography (CT) scan of the abdomen and pelvis revealed multiple pockets of extraluminal air within the hernia sac, as well as gas bubbles in the surrounding intestinal contents. Based on these findings, we made a diagnosis of small intestinal perforation within the inguinal hernia.

Conclusion: Small intestinal perforation within an inguinal hernia is an uncommon but potentially life-threatening complication requiring emergent surgical intervention. Delays in diagnosis and management can lead to peritonitis, abscess formation, sepsis, and prolonged hospitalization. Therefore, clinicians should maintain a high index of suspicion for intestinal perforation in patients with inguinal hernias, even in the absence of direct trauma or subsequent low-energy injuries.

目的:我们报告一例低能量间接创伤后腹股沟疝小肠穿孔。患者:一名55岁男性,患有已知的右腹股沟疝,先前没有手术指征,在突然刹车导致他的摩托车把手撞击右大腿后,出现急性右腹股沟疼痛。结果:腹部及骨盆体格检查及CT扫描显示疝囊内多腔外空气,周围肠内容物可见气泡。基于这些发现,我们诊断为腹股沟疝内小肠穿孔。结论:腹股沟疝小肠穿孔是一种罕见但可能危及生命的并发症,需要紧急手术干预。诊断和治疗的延误可导致腹膜炎、脓肿形成、败血症和延长住院时间。因此,即使没有直接创伤或随后的低能量损伤,临床医生也应保持对腹股沟疝患者肠穿孔的高度怀疑。
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引用次数: 0
Incidental diagnosis of Fabry disease by detecting mulberry bodies in a Bangladeshi male with infertility and residing in Japan: a case report highlighting clinical and economic challenges. 在一名居住在日本的孟加拉国男性不育症患者中,通过检测桑葚体偶然诊断法布里病:一个突出临床和经济挑战的病例报告。
Pub Date : 2025-07-01 DOI: 10.2185/jrm.2024-050
Kosuke Kojo, Kaori Mase, Hisato Suzuki, Miwa Arita, Chie Yokoyama, Yu Yamada, Akiko Kawasaki

Objective: Fabry disease is rarely reported in South Asian countries, except India. Here, we report a case of Fabry disease incidentally discovered in a Bangladeshi male.

Case report: A 31-year-old Bangladeshi male presented to our hospital in Japan for the evaluation of potential male infertility, during which hypospermia and asthenozoospermia were identified. No structural or endocrine abnormalities were observed; however, mulberry bodies were incidentally detected during urine microscopy. Reduced α-galactosidase activity and a known genetic mutation confirmed the diagnosis of Fabry disease. The patient was provided with information regarding Japan's subsidy program for rare diseases, through which he could access enzyme replacement therapy.

Conclusion: Fabry disease is likely to be underdiagnosed in developing countries because of limited medical resources and awareness. Although early detection has improved in developed countries, high treatment costs remain a challenge. This case highlights the need to balance equitable access to treatment for rare disorders, such as Fabry disease, with the maintenance of a sustainable healthcare system, regardless of the patient's nationality or socioeconomic status.

目的:除印度外,法布里病在南亚国家报道较少。在此,我们报告一例法布里病偶然发现在一名孟加拉男性。病例报告:一名31岁的孟加拉男性到我们日本医院评估潜在的男性不育症,在此期间发现了低精子症和弱精子症。未见结构或内分泌异常;然而,在尿液显微镜中偶然发现了桑葚体。α-半乳糖苷酶活性降低和已知的基因突变证实了法布里病的诊断。向患者提供了有关日本罕见病补贴方案的信息,通过该方案,他可以获得酶替代疗法。结论:由于发展中国家的医疗资源和认识有限,法布里病很可能被误诊。尽管发达国家的早期检测有所改善,但高昂的治疗费用仍然是一个挑战。该病例突出表明,无论患者的国籍或社会经济地位如何,都需要平衡公平获得法布里病等罕见疾病治疗与维持可持续的医疗保健系统之间的关系。
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引用次数: 0
Meaning of the use of type-B continuous employment support facilities for individuals with mental disabilities and difficulties in transitioning to employment. 使用乙类持续就业支援设施对有精神残疾及就业过渡困难人士的意义。
Pub Date : 2025-07-01 DOI: 10.2185/jrm.2024-058
Koichi Yoshimura

Objective: The purpose of this study was to clarify the meaning of the use of type-B continuous employment support facilities by individuals with mental disabilities and to examine the factors that make their transition to general employment difficult based on previous studies. This study sought to obtain insight into the role of nurses in employment-related disability welfare services.

Materials and methods: A literature search was conducted using the web version of the Igaku Chuo Zasshi (Index Medicus of Japan) and Medical Online search system. Sentences describing the meaning of Type B continuous employment support facilities were extracted, and the resulting data were collected and categorized. Factors that made the transition to regular employment difficult were summarized descriptively based on the extracted data.

Results: The use of type-B continuous employment support facilities by those with mental disabilities meant the following: [awareness as a member of society], [increased sense of self-efficacy], [attempts to stabilize psychiatric symptoms], and [independence in daily living]. The following factors complicated the transition of individuals with mental disabilities to regular employment: they found illness management challenging because of their psychiatric symptoms, which caused difficulties in continuing to work. They also perceived their workplace environment negatively, complaining that their coworkers did not understand their psychiatric symptoms.

Conclusions: Individuals with mental disabilities found meaning in utilizing B-type continuous employment support facilities beyond simply aiming for a transition to general employment. However, numerous factors complicate the transition to full employment. One is that individuals with mental disabilities find it challenging to manage their psychiatric symptoms. Hence, our findings suggest an increasing need for collaboration with nursing professionals and for providing high-level nursing care.

目的:本研究的目的是在以往研究的基础上,阐明精神障碍个体使用b类持续就业支持设施的意义,并探讨使他们难以过渡到一般就业的因素。本研究旨在了解护士在与就业有关的残疾福利服务中的角色。材料和方法:使用日本《医学索引》(Igaku Chuo Zasshi)网络版和Medical Online检索系统进行文献检索。提取描述B类连续就业支持设施含义的句子,并收集结果数据并进行分类。根据提取的数据,描述性地总结了使向正规就业过渡困难的因素。结果:精神障碍患者使用b型持续就业支持设施意味着:[作为社会成员的意识],[自我效能感的增强],[稳定精神症状的尝试]和[日常生活的独立性]。以下因素使精神残疾者向正常就业的过渡变得复杂:他们发现疾病管理具有挑战性,因为他们的精神症状使他们难以继续工作。他们还消极地看待工作环境,抱怨同事不理解他们的精神症状。结论:精神残疾个体发现利用b型持续就业支持设施的意义,而不仅仅是为了过渡到一般就业。然而,许多因素使向充分就业的过渡复杂化。其中之一是,有精神残疾的人发现控制他们的精神症状是一项挑战。因此,我们的研究结果表明,越来越需要与护理专业人员合作,提供高水平的护理。
{"title":"Meaning of the use of type-B continuous employment support facilities for individuals with mental disabilities and difficulties in transitioning to employment.","authors":"Koichi Yoshimura","doi":"10.2185/jrm.2024-058","DOIUrl":"https://doi.org/10.2185/jrm.2024-058","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to clarify the meaning of the use of type-B continuous employment support facilities by individuals with mental disabilities and to examine the factors that make their transition to general employment difficult based on previous studies. This study sought to obtain insight into the role of nurses in employment-related disability welfare services.</p><p><strong>Materials and methods: </strong>A literature search was conducted using the web version of the <i>Igaku Chuo Zasshi</i> (Index Medicus of Japan) and Medical Online search system. Sentences describing the meaning of Type B continuous employment support facilities were extracted, and the resulting data were collected and categorized. Factors that made the transition to regular employment difficult were summarized descriptively based on the extracted data.</p><p><strong>Results: </strong>The use of type-B continuous employment support facilities by those with mental disabilities meant the following: [awareness as a member of society], [increased sense of self-efficacy], [attempts to stabilize psychiatric symptoms], and [independence in daily living]. The following factors complicated the transition of individuals with mental disabilities to regular employment: they found illness management challenging because of their psychiatric symptoms, which caused difficulties in continuing to work. They also perceived their workplace environment negatively, complaining that their coworkers did not understand their psychiatric symptoms.</p><p><strong>Conclusions: </strong>Individuals with mental disabilities found meaning in utilizing B-type continuous employment support facilities beyond simply aiming for a transition to general employment. However, numerous factors complicate the transition to full employment. One is that individuals with mental disabilities find it challenging to manage their psychiatric symptoms. Hence, our findings suggest an increasing need for collaboration with nursing professionals and for providing high-level nursing care.</p>","PeriodicalId":73939,"journal":{"name":"Journal of rural medicine : JRM","volume":"20 3","pages":"161-169"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe fever thrombocytopenia syndrome proceeding east. 严重发热血小板减少综合征向东发展。
Pub Date : 2025-07-01 DOI: 10.2185/jrm.2025-011
Youichi Yanagawa, Hiroki Nagasawa, Yoshio Shimizu

Severe fever thrombocytopenia syndrome (SFTS) is a tick-borne viral hemorrhagic fever prevalent throughout Asia. In 2024, our hospital in eastern Shizuoka reported three consecutive cases of SFTS, the first such cluster identified in this region. Since April 2013, the confirmed area of infection has expanded from Kyushu to Shizuoka, which currently marks the easternmost limit. As global warming progresses, the spread of SFTS is projected to increase.

严重发热血小板减少综合征(SFTS)是一种流行于亚洲各地的蜱传病毒性出血热。2024年,我们静冈县东部医院连续报告了三例SFTS病例,这是该地区首次发现此类聚集性病例。自2013年4月以来,确诊的感染地区已从九州扩大到静冈县,这是目前的最东端。随着全球变暖的进展,预计SFTS的传播将会增加。
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引用次数: 0
The magnitude and risk factors of intimate partner violence during pregnancy in rural Tanzanian communities: an analytical cross-sectional study. 坦桑尼亚农村社区怀孕期间亲密伴侣暴力的程度和风险因素:一项分析性横断面研究。
Pub Date : 2025-07-01 DOI: 10.2185/jrm.2024-047
Fabiola Vincent Moshi, Keiko Nakamura, Yuri Tashiro, Ayano Miyashita, Hideko Sato, Mayumi Ohnishi

Objective: This study aimed to determine the prevalence and risk factors of intimate partner violence during pregnancy in rural Tanzania.

Method: An analytical cross-sectional study was conducted among 360 randomly selected postnatal mothers in rural Tanzania between March and April 2024 to determine the prevalence and risk factors of intimate partner violence during pregnancy. Data were collected using a pre-tested, semi-structured questionnaire. Bivariate and multivariable logistic regression analyses were performed using Statistical Package for Social Sciences (SPSS) version 25 to identify risk factors. Statistical significance was assessed at a 95% confidence interval (CI), with associations reported as Adjusted Odds Ratios (AOR).

Results: During pregnancy, 70.3% of women experienced at least one form of violence, with 45.6% suffering from two or more forms. Overall, 112 postnatal mothers (31.1%, 95% CI=26.4%-36.2%) experienced intimate partner violence during pregnancy. Significant factors included the health facility attended; Kondoa (AOR=0.262, P=0.017), Mpwapwa (AOR=0.197, P=0.001), Manyoni (AOR=0.086, P<0.001), and Sokoine (AOR=0.122, P<0.001) compared to Makole Health Center; rural residence (AOR=3.653, P=0.001), woman's autonomy in choosing partner (AOR=2.757, P=0.046); dowry payment (AOR=2.809, P=0.013); male partner's alcohol use (AOR=2.125, P=0.025), and a history of abortion (AOR=2.910, P=0.005).

Conclusion: A high proportion of women experienced intimate partner violence during pregnancy. Residing in rural areas, autonomy in partner selection, bride price payment, male partner alcohol use, prior experience of abortion exacerbated the prevalence. The study advocates for widespread educational campaigns to raise awareness about the detrimental impact of intimate partner violence, especially during the vulnerable period of pregnancy.

目的:本研究旨在确定坦桑尼亚农村怀孕期间亲密伴侣暴力的患病率和危险因素。方法:对2024年3月至4月在坦桑尼亚农村随机抽取的360名产后母亲进行横断面分析研究,以确定怀孕期间亲密伴侣暴力的发生率及其危险因素。数据收集使用预测试,半结构化问卷。使用社会科学统计软件包(SPSS)版本25进行双变量和多变量logistic回归分析,以确定风险因素。以95%置信区间(CI)评估统计学显著性,并以调整优势比(AOR)报告相关性。结果:在怀孕期间,70.3%的妇女至少经历过一种形式的暴力,45.6%的妇女遭受过两种或两种以上形式的暴力。总体而言,112名产后母亲(31.1%,95% CI=26.4%-36.2%)在怀孕期间经历过亲密伴侣暴力。重要因素包括就诊的保健设施;Kondoa (AOR=0.262, P=0.017)、Mpwapwa (AOR=0.197, P=0.001)、Manyoni (AOR=0.086, PPP=0.001)、女性择偶自主性(AOR=2.757, P=0.046);嫁妆支付(AOR=2.809, P=0.013);男性伴侣饮酒(AOR=2.125, P=0.025)和流产史(AOR=2.910, P=0.005)。结论:怀孕期间遭受亲密伴侣暴力的妇女比例很高。居住在农村地区、自主选择伴侣、支付彩礼、男性伴侣酗酒、以前有过堕胎经历,都加剧了这一现象的流行。这项研究主张开展广泛的教育运动,以提高人们对亲密伴侣暴力的有害影响的认识,特别是在孕期的脆弱时期。
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引用次数: 0
A case of intracranial hemorrhage due to rupture of aneurysm of the distal posterior cerebral artery associated with dural arteriovenous fistulas of the falcine sinus. 脑后动脉远端动脉瘤破裂并发镰窦硬脑膜动静脉瘘颅内出血1例。
Pub Date : 2025-07-01 DOI: 10.2185/jrm.2024-044
Akira Tempaku

Objective: This report describes a rare case of a dural arteriovenous fistula of the falcine sinus associated with a flow-related aneurysm.

Patient and methods: A 68-year-old man presented with severe headache secondary to an intracranial hemorrhage. The bleeding was caused by a dural arteriovenous fistula (dAVF) of the falcine sinus with a flow-related aneurysm of the dural branch of the right posterior cerebral artery.

Results: Trans arterial obliteration of the aneurysm and its feeder using glue and trans venous embolization of the draining portions using a coil were successfully performed.

Conclusion: The unusual coexistence of a flow-related aneurysm on the feeder of the dAVF resulted in a unique hemorrhage.

目的:本文报告一例罕见的镰状窦硬脑膜动静脉瘘合并血流相关动脉瘤。患者和方法:一名68岁男性,以颅内出血继发的严重头痛为主因。出血是由镰窦硬脑膜动静脉瘘(dAVF)引起的,并伴有大脑右后动脉硬脑膜分支的血流相关动脉瘤。结果:经动脉用胶水封堵动脉瘤及其喂养器,经静脉用线圈栓塞引流部分均成功。结论:血流相关动脉瘤罕见地共存于dAVF馈线上,导致了一次独特的出血。
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引用次数: 0
Effect of surgery on breast cancer-specific mortality in older adults with endocrine receptor-positive and HER2-negative breast cancer. 手术对内分泌受体阳性和her2阴性乳腺癌老年人乳腺癌特异性死亡率的影响
Pub Date : 2025-07-01 DOI: 10.2185/jrm.2025-009
Misako Yatsuyanagi, Tomoyuki Shimada

Objective: Standard treatment modalities, including surgery, are desirable, even in older adults with breast cancer. However, frailty and comorbidities may limit surgery. This study aimed to evaluate whether endocrine therapy (ET) is associated with a lower survival rate than a standard surgical regimen.

Patients and methods: In this retrospective observational study, older adults (aged ≥75 years) diagnosed with nonmetastatic hormone receptor-positive, HER2-negative, primary breast cancer who were treated between 2006 and 2022 were evaluated in the ET (n=33) and surgery (n=95) groups. Survival status and cause of death were analyzed by estimating the overall survival (OS) and breast cancer-specific survival (BCSS) rates. Univariate and multivariate analyses were performed to identify survival-associated factors. Propensity score matching (PSM) was used to reduce the effect of selection bias.

Results: The median ages of the ET and surgery groups were 84.6 and 80.4 years, respectively, and their mortality rates were 12.5% and 17.2%, respectively. OS and BCSS were significantly higher in the surgery group than in the ET group (hazard ratio [HR] 0.27, P=0.0014 and HR 0.66, P=0.029, respectively). Age, performance status, and treatment regimen proved to have a significant effect on OS and BCSS in univariate analysis. Only age and treatment affected OS; however, no factors were shown to affect BCSS in multivariate analysis. After PSM, the OS rates were higher in the surgery group than in the ET group (HR 0.23, P<0.001); however, no differences in BCSS rates were found.

Conclusion: ET may be an appropriate treatment option for older adults with breast cancer without sufficient life expectancies.

目的:标准的治疗方式,包括手术,是可取的,即使是老年乳腺癌患者。然而,虚弱和合并症可能限制手术。本研究旨在评估内分泌治疗(ET)是否与低于标准手术方案的生存率相关。患者和方法:在这项回顾性观察性研究中,在2006年至2022年期间接受治疗的诊断为非转移激素受体阳性、her2阴性的原发性乳腺癌的老年人(年龄≥75岁)分为ET组(n=33)和手术组(n=95)进行评估。通过估算总生存率(OS)和乳腺癌特异性生存率(BCSS)分析患者的生存状况和死亡原因。进行单因素和多因素分析以确定与生存相关的因素。采用倾向得分匹配(PSM)来降低选择偏倚的影响。结果:ET组和手术组的中位年龄分别为84.6岁和80.4岁,死亡率分别为12.5%和17.2%。手术组OS和BCSS明显高于ET组(风险比[HR] 0.27, P=0.0014;风险比[HR] 0.66, P=0.029)。单因素分析表明,年龄、运动状态和治疗方案对OS和BCSS有显著影响。只有年龄和治疗影响OS;然而,在多变量分析中没有发现影响BCSS的因素。PSM后,手术组的OS率高于ET组(HR 0.23, p)。结论:ET可能是预期寿命不足的老年乳腺癌患者的合适治疗选择。
{"title":"Effect of surgery on breast cancer-specific mortality in older adults with endocrine receptor-positive and HER2-negative breast cancer.","authors":"Misako Yatsuyanagi, Tomoyuki Shimada","doi":"10.2185/jrm.2025-009","DOIUrl":"10.2185/jrm.2025-009","url":null,"abstract":"<p><strong>Objective: </strong>Standard treatment modalities, including surgery, are desirable, even in older adults with breast cancer. However, frailty and comorbidities may limit surgery. This study aimed to evaluate whether endocrine therapy (ET) is associated with a lower survival rate than a standard surgical regimen.</p><p><strong>Patients and methods: </strong>In this retrospective observational study, older adults (aged ≥75 years) diagnosed with nonmetastatic hormone receptor-positive, HER2-negative, primary breast cancer who were treated between 2006 and 2022 were evaluated in the ET (n=33) and surgery (n=95) groups. Survival status and cause of death were analyzed by estimating the overall survival (OS) and breast cancer-specific survival (BCSS) rates. Univariate and multivariate analyses were performed to identify survival-associated factors. Propensity score matching (PSM) was used to reduce the effect of selection bias.</p><p><strong>Results: </strong>The median ages of the ET and surgery groups were 84.6 and 80.4 years, respectively, and their mortality rates were 12.5% and 17.2%, respectively. OS and BCSS were significantly higher in the surgery group than in the ET group (hazard ratio [HR] 0.27, <i>P</i>=0.0014 and HR 0.66, <i>P</i>=0.029, respectively). Age, performance status, and treatment regimen proved to have a significant effect on OS and BCSS in univariate analysis. Only age and treatment affected OS; however, no factors were shown to affect BCSS in multivariate analysis. After PSM, the OS rates were higher in the surgery group than in the ET group (HR 0.23, <i>P</i><0.001); however, no differences in BCSS rates were found.</p><p><strong>Conclusion: </strong>ET may be an appropriate treatment option for older adults with breast cancer without sufficient life expectancies.</p>","PeriodicalId":73939,"journal":{"name":"Journal of rural medicine : JRM","volume":"20 3","pages":"225-232"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Journal of rural medicine : JRM
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