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Evidence-based treatment for opioid use disorder is widely unavailable and often discouraged by providers of residential substance use services in North Carolina 在北卡罗来纳州,以证据为基础的阿片类药物使用障碍治疗普遍缺乏,住院药物使用服务提供者通常也不鼓励这种治疗。
N/A PSYCHOLOGY, CLINICAL Pub Date : 2024-08-22 DOI: 10.1016/j.josat.2024.209474

Introduction

Opioid agonist treatment (OAT) is the only treatment for opioid use disorder (OUD) proven to reduce overdose mortality, yet access to this evidence-based treatment remains poor. The purpose of this cross-sectional audit study was to assess OAT availability at residential substance use services in North Carolina.

Methods

We conducted a state-wide inventory of residential substance use service providers in North Carolina and subsequently called all providers identified, posing as uninsured persons who use heroin, seeking treatment services. Program characteristics, as reported in phone calls, were systematically recorded. We used Fisher's exact tests to assess what program characteristics were associated with OAT availability and with staff making discouraging comments about OAT. We used unsupervised agglomerative clustering to identify facilities with similar characteristics.

Results

Of the 94 treatment providers identified, we successfully contacted and collected data from 66. Of those, only 7 (10.6 %) provide OAT on site; an additional 9 (13.6 %) allow OAT through an outside or community-based prescriber. Only 8 (12.1 %) providers were licensed to provide residential substance use treatment. Staff from 33 (50.0 %) providers made negative, discouraging, or stigmatizing remarks about OAT—for example, that OAT substitutes one addiction for another or does not constitute “true recovery.” OAT availability was positively associated with a provider holding a state license for any substance use-related service (41.9 % vs 8.6 %, p = 0.002) and offering 12-step programming (36.1 % vs. 10/0 %, p = 0.020). OAT availability was negatively associated with faith-based programming (6.1 % vs 42.4 %, p = 0.001), dress codes (5.3 % vs 50.0 %, p < 0.001), and mandates that residents work in a provider-owned and -operated commercial enterprise (5.0 % vs 32.6 %, p = 0.026). Cluster analysis revealed that the most common (n = 21) type of service provider in North Carolina is an unlicensed, faith-based organization that prohibits OAT, imposes a dress code, and mandates that residents work, often in provider-owned and -operated commercial enterprises.

Conclusion

Evidence-based treatments for OUD are largely unavailable at providers of residential substance use services in North Carolina. The prohibition of OAT occurs most often among providers who are unlicensed and impose labor and/or 12-step mandates on residents. Changes to state licensure requirements and exemptions may help improve OAT availability.

导言:阿片类药物激动剂治疗(OAT)是唯一被证明能降低阿片类药物使用障碍(OUD)过量死亡率的治疗方法,但获得这种循证治疗的机会仍然很少。这项横断面审计研究的目的是评估北卡罗来纳州药物使用寄宿服务机构是否提供阿片类激动剂治疗:我们对北卡罗来纳州的住院药物使用服务提供者进行了一次全州范围的清查,随后打电话给所有被确认的提供者,假扮成没有保险的海洛因使用者寻求治疗服务。我们系统地记录了电话中报告的项目特征。我们使用费雪精确检验来评估哪些项目特征与是否提供 OAT 以及工作人员是否对 OAT 发表不鼓励性评论有关。我们使用无监督聚类法来识别具有相似特征的机构:在确定的 94 家治疗机构中,我们成功联系并收集了 66 家机构的数据。其中,只有 7 家(10.6%)在现场提供 OAT;另外 9 家(13.6%)允许通过外部或社区处方提供 OAT。只有 8 家(12.1%)医疗机构获得了提供住院药物使用治疗的许可。有 33 家(50.0%)提供机构的工作人员对 OAT 发表了负面、不鼓励或污名化的言论--例如,OAT 用一种毒瘾替代另一种毒瘾,或并不构成 "真正的康复"。提供 OAT 与提供者持有州政府颁发的药物使用相关服务执照(41.9% 对 8.6%,p = 0.002)和提供 12 步计划(36.1% 对 10/0%,p = 0.020)呈正相关。提供 OAT 与基于信仰的计划(6.1% 对 42.4%,p = 0.001)、着装规范(5.3% 对 50.0%,p 结论:OAT 的提供与基于信仰的计划呈负相关:北卡罗来纳州的住院药物使用服务提供者大多无法提供基于证据的 OUD 治疗。禁止使用 OAT 的服务提供者大多没有执照,并对住院者强制执行劳动和/或 12 步疗法。修改州执照要求和豁免规定可能有助于改善 OAT 的可用性。
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引用次数: 0
Latine perspectives on the impact of family, perceptions of medication, health systems, incarceration, and housing on accessing opioid agonist therapy: A thematic analysis 拉美人关于家庭、对药物的看法、医疗系统、监禁和住房对获得阿片类激动剂治疗的影响的观点:专题分析。
N/A PSYCHOLOGY, CLINICAL Pub Date : 2024-08-22 DOI: 10.1016/j.josat.2024.209491

Introduction

Opioid-related overdose deaths rates among Latine individuals are increasing rapidly and, in Massachusetts, have exceeded rates among non-Hispanic White individuals. Yet Latine individuals are less likely to receive opioid agonist therapies (OAT) methadone and buprenorphine, which have been demonstrated to prevent opioid deaths. Amid climbing Latine overdose rates, we lack qualitative data from Spanish-speaking people who use opioids about their views on and access to OAT. In this paper, we sought to assess variables affecting Latine individuals' initiation of OAT.

Methods

We conducted 21 semi-structured interviews – half in Spanish – with Latine-identifying individuals recruited from four locations–three residential treatment sites and one city shelter–in Boston offering services to people who use drugs. We utilized thematic analysis to identify barriers and facilitators to starting and continuing OAT.

Results

The following themes – which cut across individual-, interpersonal-, and systems-level variables – emerged as core considerations shaping Latine participants' OAT engagement: (1) family, (2) medication desirability and accessibility, (3) health care resources, (4) housing stability, and (5) incarceration. First, family members were prominent interpersonal influences on participants' treatment decisions. For some participants, family introduced participants to opioids at young ages and later supported them in recovery. Second, engagement with OAT was shaped by individual-level opinions on the medications as well as by systems-level experiences with trying to access the medications. Participants identified benefits and drawbacks of methadone versus buprenorphine, with greater access difficulties for methadone. Third, the health care setting in Boston provided notable systems-level facilitators to OAT access, including outreach workers, Medicaid, and Spanish-speaking providers. Fourth, housing instability impeded some from accessing OAT while motivating others to initiate the medications. Finally, incarceration created systems-level barriers to OAT engagement. Most participants had been incarcerated in jail or prison but did not have access to OAT during incarceration or during their transition back to the community.

Conclusions

Approaches to increase OAT engagement among Latine individuals should consider integrating family into recovery pathways, tailoring information in Spanish, developing bilingual/bicultural staffing, ensuring supportive insurance coverage systems, addressing housing needs, and making OAT available for individuals involved in the legal system.

导言:拉丁裔人群中与阿片类药物过量相关的死亡率正在迅速上升,在马萨诸塞州,这一比率已经超过了非西班牙裔白人。然而,拉丁裔患者接受阿片类激动剂疗法(OAT)美沙酮和丁丙诺啡的可能性较低,而这两种疗法已被证明可预防阿片类药物致死。在拉美裔阿片类药物过量率不断攀升的情况下,我们缺乏来自西班牙语阿片类药物使用者的定性数据,无法了解他们对 OAT 的看法和使用情况。在本文中,我们试图评估影响拉美人开始使用 OAT 的变量:我们对波士顿四个为吸毒者提供服务的地点--三个住院治疗点和一个城市庇护所--招募的拉丁裔人士进行了 21 次半结构式访谈,其中一半用西班牙语进行。我们利用主题分析来确定开始和继续接受 OAT 的障碍和促进因素:以下主题跨越了个人、人际和系统层面的变量,是影响 Latine 参与者参与 OAT 的核心因素:(1)家庭;(2)药物的可取性和可及性;(3)医疗保健资源;(4)住房稳定性;以及(5)监禁。首先,家庭成员对参与者的治疗决定具有显著的人际影响。对于一些参与者来说,家人在他们年幼时就向他们介绍了阿片类药物,后来又支持他们进行康复。其次,个人层面对药物的看法以及系统层面试图获得药物的经历影响了他们对 OAT 的参与。参与者们指出了美沙酮与丁丙诺啡的利弊,其中美沙酮的获取难度更大。第三,波士顿的医疗环境为获取 OAT 提供了显著的系统层面的便利,包括外展工作者、医疗补助(Medicaid)和讲西班牙语的医疗服务提供者。第四,住房的不稳定性阻碍了一些人获得 OAT,同时也促使另一些人开始服药。最后,监禁对参与 OAT 造成了系统层面的障碍。大多数参与者都曾被监禁在监狱或牢房中,但在监禁期间或重返社区的过渡时期却无法获得 OAT:增加拉丁裔患者参与 OAT 的方法应考虑将家庭纳入康复途径、定制西班牙语信息、发展双语/文化工作人员队伍、确保支持性保险覆盖系统、解决住房需求以及为涉及法律系统的患者提供 OAT。
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引用次数: 0
Housing and supportive services for young mothers experiencing substance use disorder and homelessness: Cost-effectiveness analysis of a randomized trial 为患有药物使用障碍和无家可归的年轻母亲提供住房和支持性服务:随机试验的成本效益分析。
N/A PSYCHOLOGY, CLINICAL Pub Date : 2024-08-15 DOI: 10.1016/j.josat.2024.209494

Background

Mothers experiencing homelessness and caring for young children struggle with high rates of substance use and mental health problems. A comprehensive supportive housing intervention was implemented to assist young mothers experiencing substance use disorder (SUD) and homelessness. The cost-effectiveness of this intensive intervention could inform future dissemination.

Methods

A cost-effectiveness analysis was conducted alongside a randomized controlled trial that lasted from May 2015 to October 2018. Mothers experiencing homelessness between the ages of 18–24 years with a SUD were randomly assigned to housing+support services (HOU + SS) (n = 80), housing-only (HOU) (n = 80), or services as usual SAU (n = 80). Using incremental cost-effectiveness ratios (ICERs), the study compared the costs of HOU + SS and HOU to SAU for three outcomes: housing stability (percent days of stable housing), substance use (percent days of substance use), and depressive symptoms (Beck Depression Inventory score). Direct intervention costs of HOU + SS and HOU from both payor and societal perspectives were estimated. Cost data were collected from detailed study financial records. Outcomes were taken from 6-month assessments.

Results

The average societal cost of HOU + SS per participant was $5114 [CI 95 %, $4949-5278], while the average societal cost of HOU was $3248 [CI 95 %, $ 3,140–$3341] (2019 U.S. dollars). The calculated ICERs show that HOU was more cost-effective than HOU + SS and SAU for housing outcome. For illicit drug use, HOU + SS was more cost-effective than HOU. Finally, for depressive symptoms, neither HOU + SS or HOU were more cost effective than SAU.

Conclusion

While HOU is more cost-effective for increasing housing, HOU + SS is more cost-effective for reducing illicit drug use. However, housing without improvements in substance use may not be sustainable, and supportive services are likely essential for improved well-being overall beyond the housing outcome alone.

背景:无家可归并需要照顾年幼子女的母亲在药物使用和心理健康问题上的发病率很高。我们实施了一项全面的支持性住房干预措施,以帮助经历药物使用障碍(SUD)和无家可归的年轻母亲。这种强化干预措施的成本效益可为今后的推广提供参考:成本效益分析与一项随机对照试验同时进行,该试验从 2015 年 5 月持续到 2018 年 10 月。年龄在 18-24 岁之间、患有 SUD 的无家可归母亲被随机分配到住房+支持服务(HOU + SS)(n = 80)、纯住房(HOU)(n = 80)或常规服务 SAU(n = 80)。该研究使用增量成本效益比(ICER)比较了 "HOU + SS "和 "HOU "与 "SAU "在三种结果上的成本:住房稳定性(稳定住房天数百分比)、药物使用(药物使用天数百分比)和抑郁症状(贝克抑郁量表评分)。从支付方和社会角度估算了 "HOU+SS "和 "HOU "的直接干预成本。成本数据来自详细的研究财务记录。结果来自 6 个月的评估:每位参与者的 HOU + SS 平均社会成本为 5114 美元 [CI 95 %,4949-5278 美元],而 HOU 的平均社会成本为 3248 美元 [CI 95 %,3248-3341 美元](2019 年美元)。计算得出的 ICER 表明,在住房结果方面,HOU 比 HOU + SS 和 SAU 更具成本效益。在非法药物使用方面,HOU + SS 的成本效益高于 HOU。最后,在抑郁症状方面,"HOU+SS "和 "HOU "的成本效益均低于 "SAU":结论:在增加住房方面,"住有所居 "的成本效益更高,而在减少非法药物使用方面,"住有所居 "+"社会服务 "的成本效益更高。然而,如果住房问题没有得到改善,药物使用问题就可能无法持续,而且除了住房问题之外,支持性服务对于改善整体福祉也很可能是必不可少的。
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引用次数: 0
A scoping review of social determinants of health's impact on substance use disorders over the life course 对健康的社会决定因素在整个生命过程中对药物使用失调的影响进行范围界定。
N/A PSYCHOLOGY, CLINICAL Pub Date : 2024-08-15 DOI: 10.1016/j.josat.2024.209484

Background

Substance use is a public crisis in the U.S. Substance use can be understood as a series of events in the life course, from initiation to mortality. Social Determinants of Health (SDoH) have increasingly been recognized as essential contributors to individuals' health. This scoping review aims to examine available evidence of SDoH impact on the life course of substance use disorder (SUD).

Methods

This study identified peer-reviewed articles that reported longitudinal studies with SDoH factors as independent variables and substance use and disorders as dependent variables from PubMed, Embase, and Web of Science. The reported associations between SDoH and substance use stages over the life course were narratively and graphically summarized.

Results

Among the 50 studies identified, ten revealed parental monitoring/support and early childhood education as protective factors, while negative peer influences and neighborhood instability were risk factors of substance use initiation. Nineteen articles reported factors associated with escalation in substance use, including unemployment, neighborhood vulnerability, negative peer influence, violence/trauma, and criminal justice system (CJS) involvement. Ten articles suggested that employment, social support, urban living, and low-barrier medication treatment facilitated treatment participation, while stigma and CJS involvement had negative impact on treatment trajectory. Social support and employment could foster progress in recovery and CJS involvement and unstable housing deterred recovery. Four studies suggested that unemployment, unstable housing, CJS involvement, and lack of social support were associated with overdose and mortality.

Conclusions

This review underscores the influence of social networks and early life experiences on the life course of SUD. Future SDoH research should investigate overdose and mortality and the impact of broader upstream SDoH on SUD. Interventions addressing these social factors are needed to mitigate their detrimental effects on the trajectories of SUD over the life course.

背景:药物使用是美国的一个公共危机。药物使用可以理解为生命过程中从开始到死亡的一系列事件。健康的社会决定因素(SDoH)越来越被认为是个人健康的重要因素。本范围界定综述旨在研究 SDoH 对药物使用障碍(SUD)的生命过程产生影响的现有证据:本研究从 PubMed、Embase 和 Web of Science 中筛选出同行评议文章,这些文章报道了以 SDoH 因素为自变量、以药物使用和障碍为因变量的纵向研究。对所报告的 SDoH 与生命过程中药物使用阶段之间的关联进行了叙述性总结和图表总结:在已确定的 50 项研究中,有 10 项研究显示父母的监督/支持和早期儿童教育是保护因素,而消极的同伴影响和邻里关系不稳定则是开始使用药物的风险因素。19篇文章报告了与药物使用升级相关的因素,包括失业、邻里关系不稳定、负面同伴影响、暴力/创伤和刑事司法系统(CJS)介入。有 10 篇文章指出,就业、社会支持、城市生活和低门槛药物治疗有助于参与治疗,而污名化和刑事司法系统参与则会对治疗轨迹产生负面影响。社会支持和就业可以促进康复的进展,而 CJS 的介入和不稳定的住房则会阻碍康复。四项研究表明,失业、住房不稳定、CJS 参与和缺乏社会支持与用药过量和死亡率有关:本综述强调了社会网络和早期生活经历对 SUD 生命历程的影响。未来的 SDoH 研究应调查用药过量和死亡率以及更广泛的上游 SDoH 对 SUD 的影响。需要针对这些社会因素采取干预措施,以减轻其对 SUD 生命历程轨迹的不利影响。
{"title":"A scoping review of social determinants of health's impact on substance use disorders over the life course","authors":"","doi":"10.1016/j.josat.2024.209484","DOIUrl":"10.1016/j.josat.2024.209484","url":null,"abstract":"<div><h3>Background</h3><p>Substance use is a public crisis in the U.S. Substance use can be understood as a series of events in the life course, from initiation to mortality. Social Determinants of Health (SDoH) have increasingly been recognized as essential contributors to individuals' health. This scoping review aims to examine available evidence of SDoH impact on the life course of substance use disorder (SUD).</p></div><div><h3>Methods</h3><p>This study identified peer-reviewed articles that reported longitudinal studies with SDoH factors as independent variables and substance use and disorders as dependent variables from PubMed, Embase, and Web of Science. The reported associations between SDoH and substance use stages over the life course were narratively and graphically summarized.</p></div><div><h3>Results</h3><p>Among the 50 studies identified, ten revealed parental monitoring/support and early childhood education as protective factors, while negative peer influences and neighborhood instability were risk factors of substance use initiation. Nineteen articles reported factors associated with escalation in substance use, including unemployment, neighborhood vulnerability, negative peer influence, violence/trauma, and criminal justice system (CJS) involvement. Ten articles suggested that employment, social support, urban living, and low-barrier medication treatment facilitated treatment participation, while stigma and CJS involvement had negative impact on treatment trajectory. Social support and employment could foster progress in recovery and CJS involvement and unstable housing deterred recovery. Four studies suggested that unemployment, unstable housing, CJS involvement, and lack of social support were associated with overdose and mortality.</p></div><div><h3>Conclusions</h3><p>This review underscores the influence of social networks and early life experiences on the life course of SUD. Future SDoH research should investigate overdose and mortality and the impact of broader upstream SDoH on SUD. Interventions addressing these social factors are needed to mitigate their detrimental effects on the trajectories of SUD over the life course.</p></div>","PeriodicalId":73960,"journal":{"name":"Journal of substance use and addiction treatment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949875924001966/pdfft?md5=b7b9f7f38cfd366ada7fc37cf241266d&pid=1-s2.0-S2949875924001966-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141997039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
“Like the Wild West”: Health care provider perspectives on impacts of recreational cannabis legalization on patients and providers at a tertiary psychiatric hospital in Ontario, Canada "就像狂野的西部加拿大安大略省一家三级精神病医院的医疗服务提供者对娱乐性大麻合法化对患者和服务提供者影响的看法。
N/A PSYCHOLOGY, CLINICAL Pub Date : 2024-08-15 DOI: 10.1016/j.josat.2024.209487

Introduction

Legalization has increased cannabis availability in Canada. Research shows complex relationships between cannabis use and mental health, and a need for health care providers to engage with patients about cannabis use. Providers have noted gaps in knowledge and research on the medical effects of cannabis as barriers to service delivery. It is unclear how providers and patients in mental health care settings have been impacted by legalization.

Methods

From June 1 to July 2, 2021, we conducted a qualitative study involving semi-structured interviews with 20 health care providers in a range of roles (e.g., physicians, pharmacists, nurses) within a psychiatric hospital setting. Participants responded to open-ended questions with follow-up probes on various topics related to cannabis legalization. Topics included impacts on patient mental and physical health, clinical impacts, education and training, legal cannabis retail system and the medical cannabis access system.

Results

Thematic analysis identified several themes in the data. Participants reported that legalization has had some positive impacts relating to clinical care and cannabis safety. They also expressed concerns with increased rates of cannabis use, risks to mental health and ongoing challenges engaging with patients about cannabis. Participants made recommendations for medical educators and regulators (e.g., updated curriculums, clinical guidelines), the mental health care sector (e.g., implementation of standardized screening), government (e.g., public health campaigns, safe use guidelines), the medical cannabis access system (e.g., increased regulation, research), and the legal cannabis system (e.g., zoning changes, point-of-sale information).

Conclusions

This study begins to address the paucity of data on impacts of legalization from mental health service delivery settings. Findings show that although legalization has had some positive impacts, there are ongoing patient concerns and unmet provider needs. More research is needed to understand the experiences of providers delivering care to populations experiencing mental health and/or substance use concerns who use cannabis in the post-legalization era.

导言:大麻合法化增加了加拿大的大麻供应量。研究表明,使用大麻与心理健康之间存在复杂的关系,医疗服务提供者需要与患者就使用大麻的问题进行沟通。医疗服务提供者指出,有关大麻医疗效果的知识和研究方面的差距是提供服务的障碍。目前还不清楚合法化对精神健康护理机构的提供者和患者产生了怎样的影响:2021 年 6 月 1 日至 7 月 2 日,我们进行了一项定性研究,对一家精神病院内 20 名不同角色的医疗服务提供者(如医生、药剂师、护士)进行了半结构式访谈。参与者回答了开放式问题,并就与大麻合法化相关的各种话题进行了追问。主题包括对患者身心健康的影响、临床影响、教育和培训、合法大麻零售系统和医用大麻准入系统:专题分析确定了数据中的几个主题。参与者报告称,合法化对临床护理和大麻安全产生了一些积极影响。他们也表达了对大麻使用率上升、精神健康风险以及与患者就大麻问题进行交流所面临的持续挑战的担忧。参与者对医学教育者和监管者(如更新课程、临床指南)、精神卫生保健部门(如实施标准化筛查)、政府(如公共卫生运动、安全使用指南)、医用大麻准入系统(如加强监管、研究)以及合法大麻系统(如改变分区、销售点信息)提出了建议:本研究开始解决精神健康服务提供环境中有关合法化影响的数据匮乏问题。研究结果表明,尽管合法化产生了一些积极影响,但患者的担忧和提供者的需求仍未得到满足。需要开展更多的研究,以了解在大麻合法化后的时代,医疗服务提供者为使用大麻的精神健康和/或药物使用人群提供医疗服务的经验。
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引用次数: 0
Improving thiamine prescribing in alcohol use disorder using electronic decision support in a large urban academic medical center: A pre-post intervention study 在一个大型城市学术医疗中心,利用电子决策支持改善酒精使用障碍患者的硫胺素处方:事后干预研究。
N/A PSYCHOLOGY, CLINICAL Pub Date : 2024-08-15 DOI: 10.1016/j.josat.2024.209485

Introduction

Thiamine is the only therapy for prevention and treatment of Wernicke Encephalopathy among patients with Alcohol Use Disorder (AUD). Despite this fact, up to 75 % of inpatients with AUD are not prescribed thiamine during hospitalization. Even fewer patients are prescribed high-dose thiamine which many experts recommend should be standard of care. Previous attempts to improve thiamine prescribing for inpatients have had limited success.

Methods

We conducted an evaluation of thiamine prescribing in the year before and year after an intervention to increase high-dose thiamine prescribing. Pre-post study analysis occurred on two distinct study cohorts: those with alcohol-related diagnoses and those with elevated alcohol levels. The intervention was new electronic health record-based decision support which encouraged high-dose thiamine when any thiamine order was sought. No educational support was provided. The primary outcome was prescription of high-dose thiamine before versus after intervention. Of those with alcohol-related diagnoses, the monthly percentage of thiamine treatment courses including high-dose thiamine were graphed on a control chart.

Results

We examined 5307 admissions with alcohol-related diagnoses (2285 pre- and 3022 post-intervention) and 698 admissions with elevated alcohol levels (319 pre- and 379 post-intervention). Among admissions with alcohol-related diagnoses, the intervention was associated with a higher proportion of admissions receiving high-dose thiamine prescriptions in the first 24 h (4.7 % vs. 1.1 %, adjusted odds ratio 4.50, CI 2.93 to 6.89, p < 0.001). A similar difference in high-dose thiamine was seen post-intervention among admissions with elevated alcohol levels (14.3 % vs. 2.5 %, adjusted odds ratio 6.43, CI 3.05 to 13.53, p < 0.001). The control chart among those with an alcohol-related diagnosis demonstrated special cause variation: the median percentage of thiamine treatment courses including high-dose thiamine improved from 8.2 % to 13.0 %.

Conclusions

Electronic decision support without educational interventions increased the use of high-dose thiamine among patients with alcohol-related diagnoses and with elevated alcohol levels during hospitalization. This increase occurred immediately in the month after the intervention and was sustained in the year-long study period after.

简介硫胺素是预防和治疗酗酒症(AUD)患者韦尼克脑病的唯一疗法。尽管如此,高达 75% 的 AUD 住院患者在住院期间并未获得硫胺素处方。许多专家建议应将高剂量硫胺素作为标准治疗方法,但获得高剂量硫胺素处方的患者却更少。以往改善住院患者硫胺素处方的尝试成效有限:我们对增加大剂量硫胺素处方的干预措施实施前后一年的硫胺素处方情况进行了评估。研究前和研究后的分析针对两个不同的研究群体:与酒精相关的诊断和酒精水平升高的人群。干预措施是基于电子健康记录的新决策支持,鼓励在开具任何硫胺素处方时使用大剂量硫胺素。没有提供教育支持。主要结果是干预前后大剂量硫胺素处方的对比。在诊断为酒精相关的患者中,包括大剂量硫胺素在内的硫胺素治疗疗程的月百分比在对照表上进行了标注:我们检查了 5307 例与酒精相关的入院诊断(干预前 2285 例,干预后 3022 例)和 698 例酒精水平升高的入院诊断(干预前 319 例,干预后 379 例)。在诊断为酒精相关的入院患者中,干预后在最初 24 小时内接受大剂量硫胺素处方的比例更高(4.7% 对 1.1%,调整后的几率比为 4.50,CI 为 2.93 至 6.89,P 结论:在没有教育干预的情况下,电子决策支持增加了入院患者的比例:在没有教育干预措施的情况下,电子决策支持增加了酒精相关诊断患者和住院期间酒精水平升高的患者对大剂量硫胺素的使用。这种增加在干预后的一个月内立即出现,并在随后长达一年的研究期间持续。
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引用次数: 0
Perinatal substance use treatment and criminal legal system referral trends 围产期药物使用治疗和刑事法律系统转介趋势。
N/A PSYCHOLOGY, CLINICAL Pub Date : 2024-08-14 DOI: 10.1016/j.josat.2024.209492

Introduction

To guide improvements in treatment for pregnant persons with substance use disorders within the criminal legal system, treatment programs must first determine the primary substances of concern for this population. The objective of this study is to compare trends in specific substance use upon admission to treatment in pregnancy, based upon whether referrals originated from the criminal legal system or from another referral source.

Methods

This research accessed data on perinatal substance use (1995–2021) and referral sources from the Treatment Episode Data Set-Admissions (TEDS-A). Analyses use multiple logistic regressions to evaluate trends in primary substance use leading to treatment admission during pregnancy.

Results

Approximately 1 % (N = 536,948) of all substance use treatment admissions in TEDS-A were for pregnant people. Between 1995 and 2021, the percentage of treatment admissions increased for primary methamphetamine use (10 % to 27 %), primary opioid use (21 % to 38 %), and primary cannabis use (9 % to 18 %), and decreased for primary cocaine use (32 % to 6 %) and primary alcohol use (26 % to 11 %). By 2021, treatment admissions referred from criminal legal agencies were more likely to primarily be for primary methamphetamine use (33 % vs 25 %) and less likely to be for primary opioid use (22 % vs 42 %) compared to other referral sources.

Conclusions

Trends in substance use treatment during pregnancy have changed substantially over the past few decades and emphasize the unique needs of patients referred to treatment by the criminal legal system. Treatment programs must therefore adapt to fluctuating trends in perinatal substance use. In particular, it is important to expand programs that prioritize treatment of methamphetamine use disorder for pregnant people referred through criminal legal agencies.

导言:为了指导改善对刑事法律系统中患有药物使用障碍的孕妇的治疗,治疗计划必须首先确定这一人群主要关注的药物。本研究的目的是根据转介是来自刑事法律系统还是其他转介来源,比较孕妇在接受治疗时使用特定药物的趋势:本研究从治疗事件数据集-入院治疗(TEDS-A)中获取了围产期药物使用(1995-2021 年)和转诊来源的数据。使用多重逻辑回归进行分析,以评估怀孕期间导致入院治疗的主要药物使用趋势:在 TEDS-A 收治的所有药物使用患者中,约有 1%(N=536,948)为孕妇。从 1995 年到 2021 年,主要使用甲基苯丙胺(10% 到 27%)、主要使用阿片类药物(21% 到 38%)和主要使用大麻(9% 到 18%)的入院治疗比例有所上升,而主要使用可卡因(32% 到 6%)和主要使用酒精(26% 到 11%)的入院治疗比例有所下降。到 2021 年,与其他转介来源相比,刑事法律机构转介的接受治疗者更有可能主要是因为初次吸食甲基苯丙胺(33% 对 25%),而初次吸食阿片类药物(22% 对 42%)的可能性较小:在过去几十年中,孕期药物使用治疗的趋势发生了很大变化,并强调了由刑事法律系统转介到治疗机构的患者的独特需求。因此,治疗项目必须适应围产期药物使用的波动趋势。尤其重要的是,要扩大优先治疗通过刑事法律机构转介的孕妇甲基苯丙胺使用障碍的项目。
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引用次数: 0
Measurement invariance of the Perceived Stress Scale across race, sex, and time, and differential impacts on cocaine use treatment outcomes 不同种族、性别和时间的感知压力量表的测量不变性,以及对可卡因使用治疗结果的不同影响。
N/A PSYCHOLOGY, CLINICAL Pub Date : 2024-08-14 DOI: 10.1016/j.josat.2024.209493

Introduction

To understand the influence of phenotypic characteristics, such as stress, on substance use treatment outcomes, measures must function equivalently across groups to allow for interpretable comparisons of effects. The present study evaluated measurement invariance of the Perceived Stress Scale (PSS) across race, sex, and time, examined its association with cocaine use disorder (CUD) treatment outcomes, and tested whether associations were moderated by race and/or sex.

Methods

Data from four clinical trials evaluating behavioral and/or pharmacological treatments for cocaine use were combined providing a total sample of 302 participants with DSM-IV cocaine abuse/dependence (57.6 % Black, 42.4 % White, 43.7 % females, Mage = 40.22 years, SD = 9.26).

Results

Factor analyses support a two-factor model (i.e., general stress, self-efficacy to cope with stressors) that demonstrated configural, metric, and scalar invariance across race and sex and configural and metric invariance across time. End-of-treatment stress and coping were both related to treatment outcomes, but not treatment retention. Interactions between baseline and end-of-treatment stress and coping self-efficacy with race and sex predicting treatment retention and outcomes were not significant.

Conclusions

Results support the utility of the PSS to examine between-group differences among individuals with CUD and suggest that sociodemographic groups differ in the extent to which stress and self-efficacy to cope influence treatment outcomes.

导言:要了解压力等表型特征对药物使用治疗结果的影响,测量方法必须在不同群体间具有等效性,以便对效果进行可解释的比较。本研究评估了不同种族、性别和时间的感知压力量表(PSS)的测量不变性,考察了其与可卡因使用障碍(CUD)治疗结果的关联,并检验了关联是否受种族和/或性别的调节:将四项评估可卡因使用行为和/或药物治疗的临床试验数据合并在一起,共收集了 302 名患有 DSM-IV 可卡因滥用/依赖症的参与者样本(57.6% 为黑人,42.4% 为白人,43.7% 为女性,年龄 = 40.22 岁,SD = 9.26):因子分析支持一个双因子模型(即一般压力和应对压力的自我效能),该模型在配置、度量和标度上具有跨种族和性别的不变性,在配置和度量上具有跨时间的不变性。治疗结束时的压力和应对能力都与治疗结果有关,但与治疗保持率无关。基线与治疗末期压力和应对自我效能与种族和性别之间的交互作用对治疗保持率和治疗结果的预测并不显著:研究结果表明,压力和应对自我效能对治疗结果的影响程度因社会人口群体而异。
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引用次数: 0
Cannabis use disorder and substance use treatment among U.S. adults 美国成年人中的大麻使用障碍和药物使用治疗。
N/A PSYCHOLOGY, CLINICAL Pub Date : 2024-08-14 DOI: 10.1016/j.josat.2024.209486

Introduction

Recent expansion of cannabis legalization in multiple states calls for reexamination of the prevalence of cannabis use, cannabis use disorder (CUD), and the associations between CUD severity and substance use treatment. We used Andersen's behavioral model of healthcare use as the conceptual/analytic framework for examining treatment use.

Methods

We used data from the 2022 National Survey on Drug Use and Health (NSDUH; N = 47,100, age 18+) to describe the prevalence of past-year cannabis use, CUD and CUD severity, other substance use disorders, and substance use treatment. We compared sociodemographic, mental health, healthcare use, and cannabis and other substance use characteristics by CUD severity. Finally, we used logistic regression models to examine the associations between CUD severity and substance use treatment.

Results

Of the U.S. adult population, 23.0 % used cannabis in the past year; 7.0 % had a CUD (3.9 % mild, 1.9 % moderate, and 1.2 % severe CUD); and 4.7 % received substance use treatment. Of past-year cannabis users, 30.3 % had CUD (16.9 % mild, 8.4 % moderate, and 5.0 % severe CUD), and 9.6 % received substance use treatment. Cannabis users had 3–4 times higher rates of other substance use disorders than nonusers. Of those with CUD, 38.4 % had moderate/severe mental illness, 52.4 % had other substance use disorders, and 16.5 % received substance use treatment. Among all cannabis users, moderate (aOR [adjusted odds ratios] = 1.48, 95 % CI = 1.03–2.13) and severe (aOR = 2.57, 95 % CI = 1.60–4.11) CUDs were associated with greater odds of substance use treatment. Among cannabis users without nicotine dependence and alcohol, opioid, tranquilizer/sedative, and stimulant use disorders, only severe CUD (aOR = 6.03, 95 % CI = 3.37–10.78) was associated with greater odds of substance use treatment.

Conclusions

This study shows increased prevalence of cannabis use and CUD among U.S. adults, and with or without other substance use disorders, CUD was associated with greater odds of substance use treatment. However, the overall low rate of treatment use among those with CUD is concerning. Healthcare providers need to provide education for both medical and recreational users on the development of tolerance and dependence. Harm reduction strategies to minimize the negative consequences of CUD are also needed.

导言:最近,大麻合法化在多个州得到推广,这要求我们重新审视大麻使用的流行率、大麻使用障碍(CUD)以及 CUD 严重程度与药物使用治疗之间的关联。我们将安德森的医疗保健使用行为模型作为研究治疗使用情况的概念/分析框架:我们使用 2022 年全国药物使用和健康调查(NSDUH;N = 47,100 人,18 岁以上)的数据来描述上一年大麻使用、CUD 和 CUD 严重程度、其他药物使用障碍以及药物使用治疗的流行情况。我们按 CUD 严重程度比较了社会人口学、心理健康、医疗保健使用以及大麻和其他药物使用特征。最后,我们使用逻辑回归模型研究了 CUD 严重程度与药物使用治疗之间的关联:在美国成年人口中,23.0% 在过去一年中使用过大麻;7.0% 患有 CUD(3.9% 轻度、1.9% 中度和 1.2% 重度 CUD);4.7% 接受过药物使用治疗。在过去一年的大麻使用者中,30.3% 的人患有 CUD(16.9% 轻度、8.4% 中度和 5.0%重度 CUD),9.6% 的人接受了药物使用治疗。吸食大麻者罹患其他药物使用障碍的比例是未吸食者的 3-4 倍。在患有 CUD 的人群中,38.4% 的人患有中度/重度精神疾病,52.4% 的人患有其他药物使用障碍,16.5% 的人接受过药物使用治疗。在所有大麻使用者中,中度(aOR [调整赔率比] = 1.48,95 % CI = 1.03-2.13)和重度(aOR = 2.57,95 % CI = 1.60-4.11)CUD 与接受药物使用治疗的几率更大相关。在没有尼古丁依赖和酒精、阿片类药物、镇定剂/镇静剂和兴奋剂使用障碍的大麻使用者中,只有重度 CUD(aOR = 6.03,95 % CI = 3.37-10.78)与药物使用治疗的更大几率相关:本研究表明,美国成年人中大麻使用和 CUD 的流行率有所上升,无论是否患有其他药物使用障碍,CUD 都与药物使用治疗的几率增大有关。然而,CUD 患者接受治疗的总体比例较低,令人担忧。医疗保健提供者需要向医疗和娱乐使用者提供关于耐受性和依赖性发展的教育。此外,还需要采取减少危害的策略,将 CUD 的负面影响降至最低。
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引用次数: 0
Methadone treatment utilization and overdose trends among Medicaid beneficiaries in New Jersey before and during the COVID-19 pandemic 在 COVID-19 大流行之前和期间,新泽西州医疗补助受益人使用美沙酮治疗和用药过量的趋势。
N/A PSYCHOLOGY, CLINICAL Pub Date : 2024-08-07 DOI: 10.1016/j.josat.2024.209476

Introduction

The COVID-19 pandemic disrupted the traditional mode of methadone maintenance treatment (MMT) delivery through the imposition of lockdowns and social distancing measures. In response, policy makers granted flexibilities to providers delivering MMT to change their practices to maintain patient participation while accommodating the measures imposed to prevent the spread of COVID-19. This study examines the utilization of MMT and overdoses of patients receiving MMT during the COVID-19 pandemic in one mid-Atlantic state.

Materials and methods

We analyzed Medicaid claims data for 2018–2020, calculating weekly trends for starts, discontinuations, and medically-treated overdoses for beneficiaries receiving MMT who had been continuously enrolled in Medicaid for the previous 12 months, to account for changes in the composition of the Medicaid population following the COVID-19 public health emergency (PHE). We completed data analyses from January to June 2022.

Results

We observed countervailing trends in new starts, which experienced an immediate, non-significant dip of −22.47 per 100,000 Medicaid beneficiaries (95%CI, −50.99 to 6.04) at the outset of the pandemic followed by an increasing upward trend of 1.41 per 100,000 beneficiaries per week (95%CI, 0.37 to 2.46), and in discontinuations, which also experienced an immediate dip of −3.23 per 1000 MMT enrollees (95%CI, −4.49 to −1.97) followed by an increasing upward trend of 0.14 per 1000 MMT enrollees per week (95%CI, 0.09 to 0.19). The net result of these shifts was a stable, slowly increasing rate of MMT treatment of 0.02 % per week before and after the PHE. We also found no statistically significant association of the PHE with medically-treated overdoses among beneficiaries enrolled in MMT (trend change = 0.02 overdoses per 10,000 MMT enrollees, 95%CI, −0.05 to 0.09).

Conclusions

New Jersey achieved overall stability in MMT treatment prevalence following the pandemic's onset, while some changes in treatment dynamics took place. This outcome may reflect that the extensive flexibilities granted to providers of MMT by the state and federal government successfully maintained access to MMT for Medicaid beneficiaries through the pandemic without increasing risk of medically-treated overdose. These findings should inform policy makers developing the post-COVID-19 legal and regulatory landscape.

导言:COVID-19 的流行扰乱了美沙酮维持治疗(MMT)的传统模式,因为美沙酮维持治疗采取了封锁和社会隔离措施。作为回应,政策制定者给予提供美沙酮维持治疗的医疗机构灵活性,让他们改变做法,以维持病人的参与,同时适应为防止 COVID-19 传播而采取的措施。本研究调查了大西洋中部一个州在 COVID-19 大流行期间 MMT 的使用情况以及接受 MMT 的患者的过量用药情况:我们分析了 2018-2020 年的医疗补助(Medicaid)报销数据,计算了接受 MMT 治疗的受益人的开始、中断和药物治疗过量的每周趋势,这些受益人在过去 12 个月中连续加入了医疗补助(Medicaid),以考虑到 COVID-19 公共卫生突发事件(PHE)后医疗补助人口组成的变化。我们完成了 2022 年 1 月至 6 月的数据分析:结果:我们观察到新病例有相反的趋势,在大流行开始时,每 10 万名医疗补助受益人中的新病例立即下降了 22.47 例(95%CI,-50.99 至 6.04),但并不显著,随后呈上升趋势,每 10 万名医疗补助受益人中的新病例每周上升 1.41 例(95%CI,-50.99 至 6.04)。在停药方面,也经历了每 1000 名 MMT 注册者-3.23(95%CI,-4.49 至-1.97)的直接下降,随后呈上升趋势,每周每 1000 名 MMT 注册者 0.14(95%CI,0.09 至 0.19)。这些变化的净结果是,在公共健康教育前后,MMT 治疗率保持稳定并缓慢上升,每周为 0.02%。我们还发现,在接受 MMT 治疗的受益人中,公共健康教育与药物治疗过量之间没有统计学意义上的关联(趋势变化 = 每 10,000 名接受 MMT 治疗的人中有 0.02 例药物治疗过量,95%CI,-0.05 至 0.09):结论:大流行开始后,新泽西州的 MMT 治疗普及率总体保持稳定,但治疗动态发生了一些变化。这一结果可能反映出,州政府和联邦政府给予美沙酮治疗提供者的广泛灵活性,成功地在大流行期间维持了医疗补助受益人获得美沙酮治疗的机会,而没有增加药物治疗过量的风险。这些发现应为政策制定者在制定 19COVID 后的法律法规时提供参考。
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引用次数: 0
期刊
Journal of substance use and addiction treatment
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