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The Role of Lactate for Sepsis in Polytrauma Patients, a Time related Analysis using the IBM Watson Trauma Pathway Explorer®. 乳酸盐在多重创伤患者脓毒症中的作用,使用IBM沃森创伤路径探索者®进行时间相关分析。
Pub Date : 2022-01-01 DOI: 10.26502/jsr.10020268
Philipp Vetter, Cédric Niggli, Jan Hambrecht, Philipp Niggli, Jindrich Vomela, Richard Chaloupka, Hans-Christoph Pape, Ladislav Mica

The Watson Trauma Pathway Explorer ® is an outcome prediction tool invented by the University Hospital of Zurich in collaboration with IBM®, representing an artificial intelligence application to predict the most adverse outcome scenarios in polytrauma patients: Systemic Inflammatory Respiratory Syndrome (SIRS), sepsis within 21 days and death within 72 h. The hypothesis was how lactate values woud be associated with the incidence of sepsis. Data from 3653 patients in an internal database, with ongoing implementation, served for analysis. Patients were split in two groups according to sepsis presence, and lactate values were measured at formerly defined time points from admission until 21 days after admission for both groups. Differences between groups were analyzed; time points with lactate as independent predictor for sepsis were identified. The predictive quality of lactate at 2 and 12 h after admission was evaluated. Threshold values between groups at all timepoints were calculated. Lactate levels differed from less than 2 h after admission until the end of the observation period (21 d). Lactate represented an independent predictor for sepsis from 12 to 48 h and 14 d to 21 d after admission relative to ISS levels. AUROC was poor at 2 and 12 h after admission with a slight improvement at the 12 h mark. Lactate levels decreased over time at a range of 2 [mmol/L] for 6-8 h after admission. These insights may allow for time-dependent referencing of lactate levels and anticipation of subsequent sepsis, although further parameters must be considered for a higher predictability.

Watson创伤路径探索者®是苏黎世大学医院与IBM®合作发明的一种结果预测工具,代表了一种人工智能应用程序,用于预测多发创伤患者最不利的结果情景:全身性炎症呼吸综合征(SIRS)、21天内的败血症和72小时内的死亡。该假设是乳酸值如何与败血症的发生率相关。来自内部数据库中3653名患者的数据,正在实施中,用于分析。根据脓毒症的存在将患者分为两组,并在入院至入院后21天的前定义时间点测量两组患者的乳酸值。分析各组间差异;确定了乳酸作为脓毒症独立预测因子的时间点。评估入院后2和12 h乳酸的预测质量。计算各组间各时间点的阈值。从入院后不到2小时到观察期结束(21天),乳酸水平有所不同。相对于ISS水平,乳酸水平是入院后12至48小时和14至21天脓毒症的独立预测因子。入院后2和12小时AUROC较差,12小时略有改善。入院后6-8小时,乳酸水平随时间下降,范围为2 [mmol/L]。这些见解可能允许乳酸水平的时间依赖参考和预测随后的败血症,尽管进一步的参数必须考虑更高的可预测性。
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引用次数: 1
Mesenteric Pseudocyst Following Blunt Abdominal Trauma: Report of a Case and Review of Literature 腹部钝性创伤后肠系膜假性囊肿1例报告及文献复习
Pub Date : 2022-01-01 DOI: 10.26502/jsr.10020258
Klaudia Gjinoska, O. Kostovski, A. Nikolovski, Daniela Bajdevska Dukoska, Agron Alimi, S. Antović
Mesenteric pseudocysts are rare intraabdominal lesions. A total of 29 similar case reports were retrieved via the Medline/PubMed search engine. They represent a subtype of mesenteric cysts displaying histological similarity to pancreatic pseudocysts which are usually surrounded by a thick fibrous wall without an inner epithelial lining. Mesenteric pseudocysts may present as any other expanding intraabdominal lesion. Accurate preoperative characterization of mesenteric cystic lesions remains challenging. Imaging diagnostics for most of the cases involve both ultrasound and computerized tomography. It is unclear whether routine MRI use would increase preoperative diagnostic accuracy and aid in preoperative planning. Total surgical excision of the pseudocyst has been the treatment of choice. Surgical removal has been achieved by means of open surgery, laparoscopy and the robotic system. It remains unclear to this date whether other treatment approaches are feasible. Other options such as debridement, marsupialization or partial excision have been considered inadequate due to concerns such as the possibility of malignant cell seeding, septic complications and risk of recurrence. We present the case of a posttraumatic mesenteric pseudocyst following blunt abdominal trauma in a 27 year old female, treated by surgical excision.
肠系膜假性囊肿是罕见的腹腔内病变。通过Medline/PubMed搜索引擎共检索到29例类似病例报告。它们是肠系膜囊肿的一种亚型,在组织学上与胰腺假性囊肿相似,假性囊肿通常被厚纤维壁包围,没有内上皮衬里。肠系膜假性囊肿可能表现为任何其他扩张的腹内病变。准确的术前肠系膜囊性病变特征仍然具有挑战性。大多数病例的影像学诊断包括超声和计算机断层扫描。目前尚不清楚常规MRI是否会提高术前诊断的准确性并有助于术前计划。假性囊肿的全手术切除一直是治疗的选择。手术切除是通过开放手术、腹腔镜和机器人系统实现的。目前尚不清楚其他治疗方法是否可行。其他选择,如清创、有袋术或部分切除被认为是不够的,因为考虑到恶性细胞播种的可能性、化脓性并发症和复发的风险。我们提出的情况下创伤后肠系膜假性囊肿钝性腹部创伤在一个27岁的女性,通过手术切除治疗。
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引用次数: 0
Closure Techniques and Suture Materials for Upper Blepharoplasty: An Extensive Narrative Literature Review 上睑成形术的闭合技术和缝合材料:广泛的叙事文献回顾
Pub Date : 2022-01-01 DOI: 10.26502/jsr.10020213
Ibrahim H Alawadh, Waleed M Alshehri, Nouf A Alshehri, Ahmed S Alsaleh, Ibrahim AlQuniabut, Sami A Alharethy
Closure Techniques and Suture Materials Upper Abstract Purpose Blepharoplasty is an operation performed for the correction of functional abnormalities and for esthetic appearance. Differences in various techniques include the wound closure technique and the suture materials used. In this review, we Few studies have been conducted on this subject; however, there are various suturing and non-suturing techniques available for upper blepharoplasty wound closure, and several materials are used for these suturing and non-suturing closure techniques. These techniques include suturing with different materials, such as an adhesive made of a polymer called cyanoacrylate and wound adhesive strips. The selection of the wound closure technique and material should be performed depending on the surgeon’s preference and experience.
摘要目的眼睑成形术是一种矫正功能异常和美观的手术。各种技术的差异包括伤口闭合技术和使用的缝合材料。在这篇综述中,我们很少有关于这一主题的研究;然而,上睑成形术的缝合和非缝合技术多种多样,缝合和非缝合缝合的材料也多种多样。这些技术包括用不同的材料缝合,比如用一种叫做氰基丙烯酸酯的聚合物制成的粘合剂和伤口胶条。伤口闭合技术和材料的选择应根据外科医生的喜好和经验进行。
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引用次数: 0
Anatomical Injury Clusters in Polytrauma Patients. 多发创伤患者的解剖损伤群。
Pub Date : 2022-01-01 DOI: 10.26502/jsr.10020270
Tanja Birri, Hans-Christoph Pape, Cyrill Dennler, Hans-Peter Simmen, Jindrich Vomela, Richard Chaloupka, Ladislav Mica

Polytrauma is a major cause of death in young adults. The trial was to identify clusters of interlinked anatomical regions to improve strategical operational planning in the acute situation. A total of 2219 polytrauma patients with an ISS (Injury Severity Score) ≥ 16 and an age ≥ 16 years was included into this retrospective cohort study. Pearson's correlation was performed amongst the AIS (Abbreviated Injury Scale) groups. The predictive quality was tested by ROC (Receiver Operating Curve) and their area under the curve. Independency was tested by the binary logistic regression, AIS ≥3 was taken as a significant injury. The analysis was conducted using IBM SPSS® 24.0. The highest predictive value was reached in the combination of thorax, abdomen, pelvis and spine injuries (ROC: abdomen for thorax 0.647, thorax for abdomen 0.621, pelvis for thorax 0.608, pelvis for abdomen 0.651, spine for thorax 0.617). The binary logistic regression revealed the anatomical regions thorax, abdomen pelvis and spine as per-mutative independent predictors for each other when a particular injury exceeded the AIS ≥3. The documented clusters of injuries in truncal trauma are crucial to define priorities in the polytrauma management.

多发创伤是年轻人死亡的主要原因。该试验旨在确定相互关联的解剖区域集群,以改善急性情况下的战略操作规划。本回顾性队列研究共纳入2219例ISS(损伤严重程度评分)≥16、年龄≥16岁的多发创伤患者。在AIS(简略伤害量表)组之间进行Pearson相关性分析。采用ROC (Receiver Operating Curve)及其曲线下面积检验预测质量。采用二元logistic回归检验独立性,以AIS≥3为显著性损伤。采用IBM SPSS®24.0进行分析。胸、腹、骨盆和脊柱联合损伤的预测值最高(ROC:腹部为0.647,胸部为0.621,骨盆为0.608,骨盆为0.651,脊柱为0.617)。二元logistic回归显示,当某一特定损伤超过AIS≥3时,胸腔、腹部、骨盆和脊柱解剖区域是相互独立的突变预测因子。记录的簇状损伤在躯干创伤是至关重要的,以确定优先的多创伤管理。
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引用次数: 0
Effects of Granulocyte Colony-Stimulating Factor Administration on Liver Hypertrophy After Portal Vein Embolization in a Rabbit Model 粒细胞集落刺激因子对兔门静脉栓塞后肝脏肥厚的影响
Pub Date : 2022-01-01 DOI: 10.26502/jsr.10020249
K. Nishio, K. Kimura, A. Yamamoto, R. Amano, G. Ohira, Ken Kageyama, Kotaro Miura, Naoki Kametani, T. Ishizawa
Background: Postoperative liver failure is one of the most frequent causes of perioperative mortality in hepatectomy patients, even with preoperative portal vein embolization (PVE). However, recent research has found that administration of granulocyte colony-stimulating factor (G-CSF) improves liver function and increases the survival rate of patients with decompensated liver cirrhosis. This study aimed to determine the effects of G-CSF administration on liver hypertrophy after PVE in a rabbit model. Methods: Eight rabbits were divided into an embolization only (PVE) group (n = 4) and an embolization with G-CSF administration (G-CSF) group (n = 4). The degree of nonembolized liver volume hypertrophy (DLV) and the immunohistochemistry for Ki67, RAM11, and CD34 levels were compared between the two groups to quantify macrophage and cell proliferation and the presence of CD34-positive cells in the liver. Results: The median DLV in the PVE group was 14.7%, compared to 18.8% in the G-CSF group. This was a significant difference (p = 0.042). The expression of both Ki67 and RAM11 in the nonembolized parts of the livers of the G-CSF group was significantly greater than in the nonembolized livers of the PVE group (p = 0.0003). There was no significant difference in CD34 expression in the nonembolized livers of the rabbits in the two groups. Conclusions: In our rabbit model, the DLV and cell proliferation in the G-CSF group were significantly greater than in the PVE group. This suggests that G-CSF administration with PVE prompts the proliferation of liver
背景:术后肝功能衰竭是肝切除术患者围手术期死亡的最常见原因之一,即使术前有门静脉栓塞(PVE)。然而,最近的研究发现,给予粒细胞集落刺激因子(G-CSF)可改善肝功能,提高失代偿期肝硬化患者的生存率。本研究旨在探讨G-CSF给药对兔PVE后肝脏肥厚的影响。方法:将8只家兔分为单独栓塞(PVE)组(n = 4)和联合G-CSF栓塞(G-CSF)组(n = 4),比较两组未栓塞肝体积肥大(DLV)程度和免疫组化检测Ki67、RAM11、CD34水平,定量分析肝内巨噬细胞和细胞增殖情况以及CD34阳性细胞的存在情况。结果:PVE组的中位DLV为14.7%,而G-CSF组为18.8%。差异有统计学意义(p = 0.042)。G-CSF组未栓塞肝脏中Ki67和RAM11的表达均显著高于PVE组未栓塞肝脏(p = 0.0003)。两组未栓塞家兔肝脏中CD34表达差异无统计学意义。结论:在我们的家兔模型中,G-CSF组的DLV和细胞增殖明显大于PVE组。这表明G-CSF与PVE联合使用可促进肝脏增殖
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引用次数: 0
Cost-effectiveness of Colorectal Screening in a European Country. A Comparison of Five Alternative Screening Strategies 欧洲国家结直肠筛查的成本效益。五种筛查策略的比较
Pub Date : 2022-01-01 DOI: 10.26502/jsr.10020253
Luís Lopes, M. Certo, Paula Veiga, J. Canena
Background: The implementation of an organized screening strategy should include a cost-effectiveness analysis for the governments to take decisions that promote health and better allocate resources which does not happen most of the times. This study aimed to evaluate the most cost-effective strategy for CRC screening in a European Country. Methods: A cost-effectiveness (CE) probabilistic Markov model was developed to compare the costs and the quality-adjusted life expectancy of 50-year-old average-risk individuals submitted to five alternative screening strategies based on colonoscopy, computed tomography (CT) and FIT, as well as no screening. We calculated the costs from the perspective of a third payer (Portuguese National Health Service) and populated the model with data from published literature. Probability of being cost-effective was estimated for different thresholds of willingness-to-pay. Results: Colonoscopy 3/10 years is the most cost-effective strategy for colorectal screening in Portugal, with an estimated ICER of 802 €/ QALY when compared with colonoscopy every 10 years. The FIT and CT colonography based strategies are dominated by colonoscopy-based strategies. Biennial FIT, the strategy currently being used in Portugal, showed the smallest gains in life years gained (498.3 days) the smallest reduction in the incidence of CRC (-37%) and the smallest reduction in CRC mortality (-57%) between all the screening strategies. The findings were robust to probabilistic sensitivity analysis. Conclusions: Colonoscopy based strategies offer the best value for the money in Portugal. Biennial FIT, the screening strategy in Portugal should be replaced by a colonoscopy-based strategy. Screening European Country. A Comparison of Five Alternative Screening Strategies.
背景:实施有组织的筛查战略应包括成本效益分析,以便政府作出促进健康和更好地分配资源的决定,而这在大多数情况下并不会发生。本研究旨在评估欧洲国家最具成本效益的CRC筛查策略。方法:建立成本-效果(CE)概率马尔可夫模型,比较50岁平均风险个体接受基于结肠镜检查、计算机断层扫描(CT)和FIT以及不进行筛查的五种替代筛查策略的成本和质量调整预期寿命。我们从第三支付方(葡萄牙国家卫生服务)的角度计算了成本,并用已发表文献的数据填充了模型。对不同的支付意愿阈值估计了具有成本效益的可能性。结果:在葡萄牙,3/10年的结肠镜检查是最具成本效益的结直肠筛查策略,与每10年的结肠镜检查相比,估计ICER为802€/ QALY。以FIT和CT结肠镜为基础的策略以结肠镜为基础的策略为主。目前在葡萄牙使用的两年期FIT策略显示,在所有筛查策略中,获得的生命年数最小(498.3天),CRC发病率降低最小(-37%),CRC死亡率降低最小(-57%)。结果对概率敏感性分析具有稳健性。结论:结肠镜检查为基础的策略提供了最好的价值在葡萄牙的钱。在葡萄牙,两年一次的FIT筛查策略应被结肠镜检查策略所取代。筛选欧洲国家。五种筛查策略的比较。
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引用次数: 0
Study to Compare Bilateral Lichtenstein Repair with Stoppa’s (Giant Prosthetic Reinforcement of The Visceral Sac) Repair in Cases of Bilateral Inguinal Hernia 双侧列支敦士登修复术与Stoppa修复术治疗双侧腹股沟疝的比较研究
Pub Date : 2022-01-01 DOI: 10.26502/jsr.10020264
J. Prakash, Rajiv Nandan Sahai
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引用次数: 0
Aberrant Left Subclavian Artery with Kommerell’s Diverticulum And Right Sided Aortic Arch: Hybrid Approach 左锁骨下动脉异常伴Kommerell憩室和右侧主动脉弓:混合入路
Pub Date : 2022-01-01 DOI: 10.26502/jsr.10020229
Juliette Strella, Q. Langouet, É. Marchand, J. Pucheux, A. Legras, Robert R. Martinez
Aberrant Left Subclavian Artery with Kommerell’s Diverticulum And Right Sided Aortic Arch: Hybrid Approach Abstract A 58 years-old woman presented a rare right-sided aortic arch with an aberrant left subclavian retro-esophageal artery, originates from Kommerell’s diverticulum. After left subclavian to carotid transposition, we implanted a thoracic endoprosthesis under ventricular fibrillation. Type IA symptomatic proximal endoleak was treated with a second endograft a week later. We shared here technical aspects and challenges of endovascular management, including precise preoperative imaging (CT angiography, lymphangio-MRI), the need of a hybrid operative room, conformable endoprosthesis and right ventricle overstimulation.
摘要一例58岁女性患者,右侧主动脉弓少见,左侧锁骨下食道后动脉异常,起源于Kommerell憩室。左锁骨下颈动脉转位后,我们在心室颤动下植入胸腔内假体。1周后进行第二次内移植术治疗IA型症状性近端内漏。我们在这里分享了血管内管理的技术方面和挑战,包括精确的术前成像(CT血管造影,淋巴管- mri),混合手术室的需求,符合要求的假体和右心室过度刺激。
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引用次数: 0
Mastectomy and Immediate Breast Reconstruction with Pre-Pectoral or Sub-Pectoral Implant: Assessing Clinical Practice, Post-Surgical Outcomes, Patient's Satisfaction and Cost. 乳房切除术和胸前或胸下植入物的即时乳房重建:评估临床实践,术后结果,患者满意度和成本。
Pub Date : 2022-01-01 DOI: 10.26502/jsr.10020250
Gilles Houvenaeghel, Monique Cohen, Laura Sabiani, Aurore Van Troy, Olivia Quilichini, Axelle Charavil, Max Buttarelli, Sandrine Rua, Agnès Tallet, Alexandre de Nonneville, Marie Bannier

Immediate breast reconstruction (IBR) rates increase during last years and implant-based reconstruction was the most commonly performed procedure. We examined data collected over 25 months to assess complication rate, duration of surgery, patient's satisfaction and cost, according to pre-pectoral or sub-pectoral implant-IBR. All patients who received an implant-IBR, from January 2020 to January 2022, were included. Results were compared between pre-pectoral and sub-pectoral implant-IBR in univariate and multivariate analysis. We performed 316 implant-IBR, 218 sub-pectoral and 98 (31%) pre-pectoral. Pre-pectoral implant-IBR was significantly associated with the year (2021: OR=12.08 and 2022: OR=76.6), the surgeons and type of mastectomy (SSM vs NSM: OR=0.377). Complications and complications Grade 2-3 rates were 12.9% and 10.1% for sub-pectoral implant-IBR respectively, without significant difference with pre-pectoral implant-IBR: 17.3% and 13.2%. Complications Grade 2-3 were significantly associated with age <50-years (OR=2.27), ASA-2 status (OR=3.63) and cup-size >C (OR=3.08), without difference between pre and sub-pectoral implant-IBR. Durations of surgery were significantly associated with cup-size C and >C (OR=1.72 and 2.80), with sentinel lymph-node biopsy and axillary dissection (OR=3.66 and 9.59) and with sub-pectoral implant-IBR (OR=2.088). Median hospitalization stay was 1 day, without difference between pre and sub-pectoral implant-IBR. Cost of surgery was significantly associated with cup-size > C (OR=2.216) and pre-pectoral implant-IBR (OR=8.02). Bad-medium satisfaction and IBR-failure were significantly associated with local recurrence (OR=8.820), post-mastectomy radiotherapy (OR=1.904) and sub-pectoral implant-IBR (OR=2.098).

Conclusion: Complications were not different between pre and sub-pectoral implant-IBR. Pre-pectoral implant-IBR seems a reliable and faster technique with better patient satisfaction but with higher cost.

即时乳房重建(IBR)率在过去几年中增加,以植入物为基础的重建是最常见的手术。我们检查了超过25个月收集的数据,根据胸前或胸下植入物ibr评估并发症发生率、手术时间、患者满意度和成本。所有在2020年1月至2022年1月期间接受植入式ibr的患者均被纳入研究。结果在单因素和多因素分析中比较了胸前和胸下植入式ibr。我们进行了316例植入式ibr, 218例胸下ibr和98例(31%)胸前ibr。胸前植入物- ibr与年份(2021年:OR=12.08, 2022年:OR=76.6)、外科医生和乳房切除术类型(SSM vs NSM: OR=0.377)显著相关。胸下ibr组的并发症和并发症2-3级发生率分别为12.9%和10.1%,与胸前ibr组的17.3%和13.2%无显著差异。并发症2-3级与年龄C显著相关(OR=3.08),胸前和胸下植入ibr无差异。手术时间与罩杯大小C和>C (OR=1.72和2.80)、前哨淋巴结活检和腋窝清扫(OR=3.66和9.59)以及胸下植入物- ibr (OR=2.088)显著相关。中位住院时间为1天,胸前和胸下植入ibr无差异。手术费用与罩杯尺寸> C (OR=2.216)和胸前植入物- ibr (OR=8.02)显著相关。不良介质满意度和ibr失败与局部复发(OR=8.820)、乳房切除术后放疗(OR=1.904)和胸下植入物- ibr (OR=2.098)显著相关。结论:胸前植入术与胸下植入术并发症无明显差异。胸前植入式ibr是一种可靠、快速的技术,患者满意度较高,但成本较高。
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引用次数: 0
Use of Voice Recordings in the Consultation of Patients Seeking Genital Gender-Affirming Surgery: An Opportunity for Broader Application Throughout Surgery? 在寻求生殖器性别确认手术的患者咨询中使用录音:在整个手术中广泛应用的机会?
Pub Date : 2022-01-01 DOI: 10.26502/jsr.10020269
Shannon M Smith, Jenna Stelmar, Grace Lee, Peter R Carroll, Maurice M Garcia

Introduction: It has been demonstrated that patient memory for medical information is often poor and inaccurate. The use of audio recordings for patient consultation has been described; however, to our knowledge this is the first reported use of audio recordings in consultation for gender-affirming surgery. Our aim was to determine whether, and specifically how, audio recording the consultation of patients presenting for genital gender-affirming surgery would be of benefit to patients.

Materials and methods: We began to offer all new patients the opportunity to have their consultations recorded. At the end of the consultation the recording was uploaded to a USB, which was given to the patient to keep. We then surveyed all patients who had received a copy of their recorded consultation to query the utility of having access to an audio recording of their consultation.

Results: 71/72 (98.6%) patients who were given the option to have their consultation recorded chose to do so. 50/71 (70%) of patients who had their consultation recorded responded to our survey. Patients reported that having access to a voice recording of their consultation was beneficial and was viewed overwhelmingly positively.

Conclusions: Routine audio recording of patient consultations is highly beneficial to patients, with little cost to providers, and should be considered as a valuable addition to the new patient consultation. This approach may have applications in broader clinical contexts where patients face numerous, complex, and nuanced management options. The study would benefit from continued application and a larger (multi-center, international) sample.

研究表明,病人对医疗信息的记忆往往很差,而且不准确。对患者咨询录音的使用进行了描述;然而,据我们所知,这是首次报道在性别确认手术咨询中使用录音。我们的目的是确定是否,特别是如何,录音咨询的患者呈现生殖器性别确认手术将有利于患者。材料和方法:我们开始为所有新患者提供咨询记录的机会。在咨询结束时,录音被上传到一个USB,并交给患者保存。然后,我们调查了所有收到咨询录音副本的患者,以询问获得咨询录音的效用。结果:71/72(98.6%)的患者选择了记录他们的咨询。有咨询记录的患者中有50/71(70%)对我们的调查做出了回应。患者报告说,获得他们咨询的录音是有益的,并且被压倒性地积极看待。结论:常规的患者问诊录音对患者非常有益,对提供者的成本很少,应被视为对新患者问诊的有价值的补充。这种方法可以在更广泛的临床环境中应用,在这些环境中,患者面临着众多、复杂和微妙的管理选择。该研究将受益于继续应用和更大的(多中心,国际)样本。
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引用次数: 2
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Journal of surgery and research
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