Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)最新文献

Objectives: To determine if selected serum biomarkers are superior to the acute patient physiologic and laboratory evaluation (APPLE) complete score in predicting 30-day mortality in a non-homogeneous disease population of critically ill dogs.

Design: Prospective cohort study comparing the serum biomarkers adiponectin, leptin, C-reactive protein, and S100A12 concentrations between surviving and nonsurviving critically ill dogs.

Setting: University small animal teaching hospital.

Animals: Seventy critically ill dogs were prospectively recruited, and an APPLE complete score was calculated within 24 hours of being admitted to the intensive care unit. Logistic regression models were fit to estimate the association between biomarkers and 30-day survival. Results were interpreted at the 5% level of significance.

Measurements and main results: Leptin was the only biomarker that was significantly correlated with the APPLE complete score (P < 0.001). Only the APPLE complete score (P = 0.003) and illness duration of < 1 day (P = 0.043) were significantly associated with outcome.

Conclusion: Based on the results of this study, there appears to be no benefit in using biomarkers over the APPLE score for disease severity stratification. Serum leptin concentration was significantly correlated with disease severity as determined by APPLE scoring. Longer duration of illness prior to admission was associated with a higher risk of death. APPLE scores were highest in dogs with infectious and immune-mediated diseases and bite wounds.

Objective: To measure tissue oxygen saturation (StO₂ ) in a population of dogs with naturally occurring shock and to evaluate the relationship of StO₂ with an established veterinary severity scoring system (Acute Patient Physiologic and Laboratory Evaluation) and patient survival.

Design: Prospective observational study.

Setting: University teaching hospital.

Animals: Twenty-five adult dogs presenting in shock, as determined by the presence of hypotension, the calculated shock index, and hyperlactatemia.

Interventions: StO₂ was measured prior to any therapeutic interventions. Blood samples were also collected for measurement of plasma lactate, complete blood count, and a serum biochemical profile. Abdominal and thoracic focused assessment with sonography was also performed.

Measurements and main results: Dogs enrolled in this study had lower mean (±SD) StO₂ values (65.12 ± 17.7%) than previously reported in experimental models of canine hemorrhagic shock. There was a moderate correlation between lower StO₂ and increasing Acute Patient Physiologic and Laboratory Evaluation scores. A single StO₂ value, assessed prior to therapeutic intervention, was not a sensitive predictor of mortality in this population.

Conclusions: Dogs with naturally occurring shock have lower mean StO₂ values than those previously reported in dogs with experimentally induced shock. A lower initial StO₂ was associated with worse disease severity but was not a significant predictor of survival in this population.

Objective: To describe the management and resolution of acute liver failure (ALF) in two dogs following ingestion of cheese tree (Glochidion ferdinandi) roots.

Case summaries: A 2-year-old male entire Bullmastiff and a 5-year-old female neutered German Shepherd dog were presented for acute-onset lethargy and vomiting after chewing on tree roots of a cheese tree. Both dogs developed clinical abnormalities consistent with ALF, including hepatic encephalopathy, marked increase in alanine aminotransferase activity and bilirubin concentration, and prolonged coagulation times. Treatment included administration of intravenous fluids, hepatoprotectants, vitamin K₁ , antibiotics, lactulose, antacids, antiemetics, and multiple fresh frozen plasma transfusions. Follow-up examinations performed 30 days after initial presentation revealed the dogs to be clinically healthy with serum biochemical and coagulation profiles within reference intervals.

New or unique information: This is the first report describing ALF in two dogs following ingestion of cheese tree (G. ferdinandi) roots. In this clinical setting, despite a poor prognosis, survival and recovery of adequate liver function were possible with medical management.

Objective: To review the sources, adverse effects, diagnosis, treatment, and prevention of psychogenic stress in hospitalized human and veterinary patients.

Data sources: Data were collected by searching PubMed for veterinary and human literature from the past 10 years.

Human data synthesis: Psychogenic stress has been linked to immune suppression; gastrointestinal, cardiovascular, and cutaneous diseases; delayed wound healing; alterations in pain perception; and neurologic impairment. Sources of psychogenic stress include environmental alterations such as excessive noise and light, social and physical factors, sleep disruption, drugs, and underlying disease. Nonpharmacologic options for stress reduction include environmental and treatment modifications, music therapy, and early mobilization. Pharmacologic options include sedation with benzodiazepines and dexmedetomidine. Trazodone and melatonin have been examined for use in sleep promotion but are not currently recommended as standard treatments in ICU.

Veterinary data synthesis: Activation of the stress response in veterinary patients is largely the same as in people, as are the affected body systems. Possible sources of stress can include social, physical, and environmental factors. No gold standard currently exists for the identification and quantification of stress. A combination of physical examination findings and the results of serum biochemistry, CBC, and biomarker testing can be used to support the diagnosis. Stress scales can be implemented to identify stressed patients and assess severity. Nonpharmacologic treatment options include low-stress handling, pheromones, environmental modifications, and sleep promotion. Pharmacologic options include trazodone, benzodiazepines, dexmedetomidine, and melatonin.

Conclusion: The prevalence and clinical significance of psychogenic stress in hospitalized veterinary patients is unknown. Future studies are needed to specifically examine the causative factors of psychogenic stress and the effects of various therapies on stress reduction. The recognition and reduction of psychogenic stress in veterinary patients can lead to improvements in patient care and welfare.

Objective: To characterize the clinical features of the acute respiratory distress syndrome (ARDS), risk factors, and outcome in dogs and cats. The study also aimed to evaluate the current veterinary criteria for the diagnosis of ARDS by comparison of clinical diagnostic criteria with necropsy findings.

Design: Retrospective study.

Animals: Fifty-four client-owned animals, 46 dogs and 8 cats.

Interventions: Medical records were reviewed for patients with the diagnosis of ARDS based on previously published clinical criteria or necropsy diagnosis. Signalment, clinical findings, and outcome were recorded.

Measurements and main results: Animals were grouped according to a clinical or necropsy diagnosis: 43/54 (80%) were diagnosed with ARDS based on clinical criteria (group 1) and 11/54 (20%) were diagnosed with ARDS based on necropsy only (group 2). In group 1, 22/43 (51%) had a necropsy, which confirmed ARDS in 12/22 (54%). Direct (pulmonary) causes of ARDS were more common than indirect causes in dogs, while cats had a similar occurrence of direct and indirect causes. The most common risk factors identified in dogs were aspiration pneumonia (42%), systemic inflammatory response syndrome (SIRS) (29%), and shock (29%). All cats diagnosed clinically with ARDS had SIRS with or without sepsis. Of the animals with a clinical diagnosis of ARDS, 49% received mechanical ventilation and 58% received treatment (with or without mechanical ventilation) for 24 hours or longer. The overall case fatality rate was 84% in dogs and 100% in cats.

Conclusions and clinical relevance: As described in human literature, pneumonia was the most common risk factor in dogs with ARDS, whereas it was SIRS for the cat population. The high mortality rate and discrepancy between the clinical diagnosis and necropsy findings may highlight limitations in the clinical criteria for the diagnosis of ARDS and treatment in dogs and cats.

Objective: To describe computed tomographic (CT) features of intra-abdominal hypertension (IAH) in 3 dogs with abdominal distension.

Case summary: Three dogs with anorexia, distended abdomen, or labored breathing were presented for CT imaging. All 3 dogs were premedicated with IV butorphanol (0.2 mg/kg). A Foley urinary catheter was aseptically placed and the transvesical technique was used to obtain intra-abdominal pressure (IAP). The IAP measurements were obtained with the dogs in a standing position after a stabilization period of 5 minutes. The mean IAP values for each of the 3 dogs were 26.0, 12.0, and 13.0 mm Hg. Anesthesia was induced with IV propofol (2.0-4.0 mg/kg, to effect) in all 3 dogs and maintained with sevoflurane in 2 dogs. Compression of the caudal vena cava and elevation of the diaphragm were observed in all 3 dogs, whereas renal compression and the extension of peritoneal fluid to the vaginal canal and cavity were seen in the dog with the highest IAP.

New or unique information provided: Compression of the caudal vena cava, direct renal compression, and the extension of peritoneal fluid into the vaginal canal and vaginal cavity are consistent with a diagnosis of IAH. Measurement of IAP and detection of these CT features should alert clinicians to the possible presence of IAH in veterinary patients.