Pub Date : 2024-02-01DOI: 10.1097/ju9.0000000000000115
Mario I. Fernández, Alberto Bustamante
{"title":"Editorial Comment: Office-Based Transperineal Laser Ablation for Benign Prostatic Hyperplasia Under Local Anaesthesia: 2-Year Results from a Dose Range Confirmatory Trial","authors":"Mario I. Fernández, Alberto Bustamante","doi":"10.1097/ju9.0000000000000115","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000115","url":null,"abstract":"","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":"50 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139965620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.1097/ju9.0000000000000085
J. Kikuchi
{"title":"Editorial Comment: Case Report: Sacral Neuromodulation with Suspected Neuromuscular Blockade Secondary to a Butyrylcholinesterase (BCHE) Variant","authors":"J. Kikuchi","doi":"10.1097/ju9.0000000000000085","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000085","url":null,"abstract":"","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":" 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138620237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.1097/ju9.0000000000000086
Ryan Terlecki, Ethan Matz, Connor Policastro
{"title":"Editorial Comment: Postoperative Oral Care Pathways Are Not Required at the Time of Buccal Mucosa Harvest","authors":"Ryan Terlecki, Ethan Matz, Connor Policastro","doi":"10.1097/ju9.0000000000000086","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000086","url":null,"abstract":"","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":"620 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139024572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.1097/ju9.0000000000000091
Amy Zheng, Susan M. MacDonald
{"title":"Reply to Editorial Comment: Pelvic Floor Dysfunction: A Common Cause of Chronic Orchialgia","authors":"Amy Zheng, Susan M. MacDonald","doi":"10.1097/ju9.0000000000000091","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000091","url":null,"abstract":"","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":"770 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139018704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.1097/ju9.0000000000000099
John W. Davis
{"title":"JU Open Plus: Updates on the American Urological Association Family of Journals","authors":"John W. Davis","doi":"10.1097/ju9.0000000000000099","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000099","url":null,"abstract":"","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":"33 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139026102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.1097/ju9.0000000000000084
Michael A. Liss
{"title":"Editorial Comment: Microbiomes in Post-DRE Urine Samples Are Linked to Prostate Cancer Risk","authors":"Michael A. Liss","doi":"10.1097/ju9.0000000000000084","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000084","url":null,"abstract":"","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":" 690","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138610754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.1097/ju9.0000000000000082
E. D. Crawford, R. Martin, Caleb D. Phillips, Whitney N. Stanton, A. van Bokhoven, M. S. Lucia, Paul Arangua, Francisco G. La Rosa, Zachary Grasmick, Ryan Terlecki, Margaret F. Meagher, Daisaku Hirano, J. C. Nickel, P. Werahera
Bacterial species including Cutibacterium acnes (C. acnes) have been associated with different inflammatory and neoplastic conditions in prostate cancer (PCa) tissue samples, but their clinical impact is unknown. Using next-generation sequencing (NGS)–based clinical reports, we investigated the differential abundance and incidence of microbiomes in post–digital rectal exam (DRE) urine samples from patients with PCa and a matched control group at low risk of PCa. A total of 200 post-DRE urine samples were analyzed, 100 from patients with histopathologically confirmed PCa and 100 from men at very low risk of PCa with PSA <1.5 ng/mL as controls. Bacterial and fungal communities were characterized by NGS of 16S and internal transcribed spacer (ITS) loci, respectively, with species' relative abundances provided on physicians' clinical reports. The differential abundance and incidence of species between cancer and control groups were evaluated. Microbes were reported in 39% and 56% of PCa and control group samples, respectively. C. acnes had a significantly higher relative abundance in patients with PCa vs controls (P < .05), and C. acnes incidence rates were also nominally higher in patients with PCa as compared with controls (12.82% and 7.27%, respectively). By contrast, Finegoldia magna (F. magna) had a significantly higher relative abundance (P < .05) and incidence rate (P < .05) in controls as compared with patients with PCa. C. acnes was among the most prevalent bacterial species in PCa urine samples. F. magna identified in the low-risk group is responsible for production of equol, a soy metabolite associated with lowering risk of PCa, suggesting a role in prostate cancer chemoprevention.
{"title":"Microbiomes in Post–Digital Rectal Exam Urine Samples are Linked to Prostate Cancer Risk","authors":"E. D. Crawford, R. Martin, Caleb D. Phillips, Whitney N. Stanton, A. van Bokhoven, M. S. Lucia, Paul Arangua, Francisco G. La Rosa, Zachary Grasmick, Ryan Terlecki, Margaret F. Meagher, Daisaku Hirano, J. C. Nickel, P. Werahera","doi":"10.1097/ju9.0000000000000082","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000082","url":null,"abstract":"\u0000 \u0000 \u0000 Bacterial species including Cutibacterium acnes (C. acnes) have been associated with different inflammatory and neoplastic conditions in prostate cancer (PCa) tissue samples, but their clinical impact is unknown. Using next-generation sequencing (NGS)–based clinical reports, we investigated the differential abundance and incidence of microbiomes in post–digital rectal exam (DRE) urine samples from patients with PCa and a matched control group at low risk of PCa.\u0000 \u0000 \u0000 \u0000 A total of 200 post-DRE urine samples were analyzed, 100 from patients with histopathologically confirmed PCa and 100 from men at very low risk of PCa with PSA <1.5 ng/mL as controls. Bacterial and fungal communities were characterized by NGS of 16S and internal transcribed spacer (ITS) loci, respectively, with species' relative abundances provided on physicians' clinical reports. The differential abundance and incidence of species between cancer and control groups were evaluated.\u0000 \u0000 \u0000 \u0000 Microbes were reported in 39% and 56% of PCa and control group samples, respectively. C. acnes had a significantly higher relative abundance in patients with PCa vs controls (P < .05), and C. acnes incidence rates were also nominally higher in patients with PCa as compared with controls (12.82% and 7.27%, respectively). By contrast, Finegoldia magna (F. magna) had a significantly higher relative abundance (P < .05) and incidence rate (P < .05) in controls as compared with patients with PCa.\u0000 \u0000 \u0000 \u0000 \u0000 C. acnes was among the most prevalent bacterial species in PCa urine samples. F. magna identified in the low-risk group is responsible for production of equol, a soy metabolite associated with lowering risk of PCa, suggesting a role in prostate cancer chemoprevention.\u0000","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":" 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138619754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cellular mechanisms of stricture progression after repeated transurethral interventions are unclear. We hypothesize that urethral injury and mechanical stretch cause tears on the urethral epithelial cell lining leading to leaking epithelium and urine extravasation. Urinary bacteria traverse the epithelial lining and may promote fibrogenesis through inflammation due to microbial activity. Our objective was to perform a case-control study of the urobiome from patients with urethral stricture disease or healthy controls using 16S rRNA and shotgun metagenomic sequencing profiling to elucidate the clinical relevance of the urobiome in urinary stricture progression. First catch urine samples from patients and healthy volunteers were collected and pelleted urine was used for DNA extraction, followed by high throughput 16S rRNA and shotgun metagenomic sequencing. Sequencing data were used to determine microbial taxa and functions associated with urethral stricture disease. Sequencing results revealed that the lower urinary tract urobiome was significantly different between urethral stricture disease cases and healthy controls. In particular, taxonomic and metabolic profiles point toward anaerobic biofilm formation by antibiotic-resistant species of Klebsiella, which is a known uropathogen. Importantly, no patients in the study exhibited signs or symptoms of clinical infection. Our findings suggest a role for biofilm formation by uropathogens such as Klebsiella spp. in developing an inflammatory environment and consequent fibrosis progression. Future studies will elucidate specific mechanisms of Klebsiella-induced fibrosis. Our data suggest that targeting specific bacteria or biofilm formation may be beneficial for urethral stricture disease detection and prevention of progression.
{"title":"Uropathogenic Dysbiosis Pattern is Associated With Urethral Fibrosis","authors":"Michael Witthaus, Saager Chawla, Dhruvi Puri, Kyoko Sakamoto, Jill Buckley, Aaron Miller, Mahadevan Rajasekaran","doi":"10.1097/ju9.0000000000000089","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000089","url":null,"abstract":"Cellular mechanisms of stricture progression after repeated transurethral interventions are unclear. We hypothesize that urethral injury and mechanical stretch cause tears on the urethral epithelial cell lining leading to leaking epithelium and urine extravasation. Urinary bacteria traverse the epithelial lining and may promote fibrogenesis through inflammation due to microbial activity. Our objective was to perform a case-control study of the urobiome from patients with urethral stricture disease or healthy controls using 16S rRNA and shotgun metagenomic sequencing profiling to elucidate the clinical relevance of the urobiome in urinary stricture progression.\u0000 \u0000 \u0000 \u0000 First catch urine samples from patients and healthy volunteers were collected and pelleted urine was used for DNA extraction, followed by high throughput 16S rRNA and shotgun metagenomic sequencing. Sequencing data were used to determine microbial taxa and functions associated with urethral stricture disease.\u0000 \u0000 \u0000 \u0000 Sequencing results revealed that the lower urinary tract urobiome was significantly different between urethral stricture disease cases and healthy controls. In particular, taxonomic and metabolic profiles point toward anaerobic biofilm formation by antibiotic-resistant species of Klebsiella, which is a known uropathogen. Importantly, no patients in the study exhibited signs or symptoms of clinical infection.\u0000 \u0000 \u0000 \u0000 Our findings suggest a role for biofilm formation by uropathogens such as Klebsiella spp. in developing an inflammatory environment and consequent fibrosis progression. Future studies will elucidate specific mechanisms of Klebsiella-induced fibrosis. Our data suggest that targeting specific bacteria or biofilm formation may be beneficial for urethral stricture disease detection and prevention of progression.","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":"125 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138608918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.1097/ju9.0000000000000072
Justin P. Mehr, Kyle A. Blum, William S. Jones, Neha Maithel, Martin J. Citardi, Steven Canfield
Metastatic neoplasms to the sinonasal tract are rare. Here, we report the case of a 74-year-old woman with no notable oncological history, presenting to the emergency department with a 3-week history of intermittent epistaxis. CT and MRI revealed a right-sided sinonasal tract mass with histopathological analysis revealing cells of clear cell renal cell carcinoma origin. Full-body CT revealed a 4.9-cm L renal mass for which cytoreductive nephrectomy was performed after immunotherapy. The patient experienced recurrence of the sinonasal mass 14 months from initial discovery, for which they continue to follow with our multidisciplinary cancer care team.
转移到鼻窦的肿瘤是罕见的。在这里，我们报告一个74岁的女性病例，没有明显的肿瘤病史，以3周的间歇性鼻出血史就诊于急诊科。CT和MRI显示右侧鼻窦炎肿块，组织病理分析显示透明细胞肾细胞癌起源细胞。全身CT显示4.9 cm L肾肿块，免疫治疗后行细胞减减性肾切除术。患者从最初发现的14个月后鼻窦肿块复发，因此他们继续跟随我们的多学科癌症护理团队。
{"title":"A Case of Metastatic Renal Cell Carcinoma to the Maxillary Sinus Initially Presenting as Recurrent Epistaxis","authors":"Justin P. Mehr, Kyle A. Blum, William S. Jones, Neha Maithel, Martin J. Citardi, Steven Canfield","doi":"10.1097/ju9.0000000000000072","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000072","url":null,"abstract":"\u0000 Metastatic neoplasms to the sinonasal tract are rare. Here, we report the case of a 74-year-old woman with no notable oncological history, presenting to the emergency department with a 3-week history of intermittent epistaxis. CT and MRI revealed a right-sided sinonasal tract mass with histopathological analysis revealing cells of clear cell renal cell carcinoma origin. Full-body CT revealed a 4.9-cm L renal mass for which cytoreductive nephrectomy was performed after immunotherapy. The patient experienced recurrence of the sinonasal mass 14 months from initial discovery, for which they continue to follow with our multidisciplinary cancer care team.","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":" 42","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138616757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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