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Alcohol to-go sales policies at on-premise drinking establishments near large public US universities during the COVID-19 pandemic 在 COVID-19 大流行期间,美国大型公立大学附近的店内酒水销售政策
IF 2.8 4区 医学 Q3 SUBSTANCE ABUSE Pub Date : 2024-04-18 DOI: 10.1093/alcalc/agae023
Erika M Rosen, Andrew Walker, Pamela J Trangenstein, Cassidy R LoParco, Melvin D Livingston, Adam E Barry, Matthew E Rossheim
Aims Sweeping policy changes during the COVID-19 pandemic increased alcohol availability through permitted to-go sales, potentially posing unique risks to college students. While to-go sales may make binge drinking more convenient, little remains known about these practices. Therefore, this study aimed to assess whether drinking establishments’ to-go sales practices are associated with their other operational practices and state policy. Method This cross-sectional analysis included 221 randomly selected bars, nightclubs, and restaurants within two miles of a large public university. Telephone interviews assessed establishment practices, and the Alcohol Policy Information System provided state alcohol to-go laws. Regression models tested whether establishment to-go sales practices were associated with their business practices (logistic regression) and state policy (generalized estimating equations). Results Nearly one-half (44.8%) of drinking establishments sold alcohol to-go. Establishments with higher vodka prices had nearly 30% higher odds of selling spirits to-go (aOR = 1.29) and establishments offering happy hours specials had more than twice the odds of selling beer (aOR = 2.22), wine (aOR = 2.53), and spirits to-go (aOR = 2.60). Additionally, establishments that implemented physical distance requirements had higher odds of selling wine to-go (aOR = 3.00). State to-go laws were associated with higher odds of selling wine (aOR = 3.99) and spirits to-go (aOR = 5.43) in the full sample and beer to-go (aOR = 4.92) in urban counties. Conclusions Establishments that sell alcohol to-go tend to engage in other practices designed to drive sales. Evaluations of alcohol to-go sales laws on risky consumption among priority populations, including college students, are urgently needed to inform decisions about how to appropriately regulate sales.
目的 在 COVID-19 大流行期间,大范围的政策变化通过允许外带销售增加了酒精的供应量,这可能会给大学生带来独特的风险。虽然外带销售可能会使狂饮变得更加方便,但人们对这些做法仍然知之甚少。因此,本研究旨在评估饮酒场所的即饮即售行为是否与其他经营行为和国家政策相关。方法 这项横断面分析包括在一所大型公立大学两英里范围内随机抽取的221家酒吧、夜总会和餐馆。电话访谈评估了场所的经营行为,酒精政策信息系统提供了各州的酒精外带法律。回归模型检验了场所的外带酒销售行为是否与其经营行为(逻辑回归)和州政策(广义估计方程)相关。结果 近二分之一(44.8%)的饮酒场所出售外带酒。伏特加价格较高的酒馆出售烈酒外带的几率高出近 30%(aOR = 1.29),提供欢乐时光特价的酒馆出售啤酒(aOR = 2.22)、葡萄酒(aOR = 2.53)和烈酒外带(aOR = 2.60)的几率是其他酒馆的两倍多。此外,实施物理距离要求的场所销售外带葡萄酒的几率更高(aOR = 3.00)。在全部样本中,各州的待售酒类法律与销售葡萄酒(aOR = 3.99)和烈性酒(aOR = 5.43)的几率较高有关,而在城市各县,销售啤酒(aOR = 4.92)的几率较高。结论 出售外带酒类的场所往往会采取其他旨在促进销售的做法。亟需评估酒类外卖销售法律对重点人群(包括大学生)风险消费的影响,以便为如何适当规范酒类外卖销售提供决策依据。
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引用次数: 0
Reductions in World Health Organization risk drinking level are associated with improvements in sleep problems among individuals with alcohol use disorder 降低世界卫生组织规定的危险饮酒量与改善饮酒障碍患者的睡眠问题有关
IF 2.8 4区 医学 Q3 SUBSTANCE ABUSE Pub Date : 2024-04-12 DOI: 10.1093/alcalc/agae022
Christian C Garcia, Dylan K Richards, Felicia R Tuchman, Kevin A Hallgren, Henry R Kranzler, Henri-Jean Aubin, Stephanie S O’Malley, Karl Mann, Arnie Aldridge, Michaela Hoffman, Raymond F Anton, Katie Witkiewitz
Aims Among individuals with alcohol use disorder (AUD), sleep disturbances are pervasive and contribute to the etiology and maintenance of AUD. However, despite increased attention toward the relationship between alcohol use and sleep, limited empirical research has systematically examined whether reductions in drinking during treatment for AUD are associated with improvements in sleep problems. Methods We used data from a multisite, randomized, controlled trial that compared 6 months of treatment with gabapentin enacarbil extended-release with placebo for adults with moderate-to-severe AUD (N = 346). The Timeline Follow-back was used to assess WHO risk drinking level reductions and the Pittsburgh Sleep Quality Index was used to assess sleep quality over the prior month at baseline and the end of treatment. Results Sleep problem scores in the active medication and placebo groups improved equally. Fewer sleep problems were noted among individuals who achieved at least a 1-level reduction (B = −0.99, 95% confidence interval (CI) [−1.77, −0.20], P = .014) or at least a 2-level reduction (B = −0.80, 95% CI [−1.47, −0.14], P = .018) in WHO risk drinking levels at the end of treatment. Reductions in drinking, with abstainers excluded from the analysis, also predicted fewer sleep problems at the end of treatment (1-level: B = −1.01, 95% CI [−1.83, −0.20], P = .015; 2-level: B = −0.90, 95% CI [−1.59, −0.22], P = .010). Conclusions Drinking reductions, including those short of abstinence, are associated with improvements in sleep problems during treatment for AUD. Additional assessment of the causal relationships between harm-reduction approaches to AUD and improvements in sleep is warranted.
研究目的 在酒精使用障碍(AUD)患者中,睡眠障碍是一种普遍现象,也是导致酒精使用障碍的病因之一。然而,尽管人们越来越关注饮酒与睡眠之间的关系,但系统性地研究治疗 AUD 期间减少饮酒是否与改善睡眠问题相关的实证研究却很有限。方法 我们使用了一项多地点随机对照试验的数据,该试验比较了中重度 AUD 成人(N = 346)接受 6 个月加巴喷丁恩那卡比缓释剂与安慰剂治疗的效果。基线和治疗结束时,采用时间轴跟踪回溯法评估世卫组织风险饮酒水平的降低情况,采用匹兹堡睡眠质量指数评估前一个月的睡眠质量。结果 有效药物组和安慰剂组的睡眠问题评分改善程度相当。治疗结束时,WHO风险饮酒水平至少降低1级(B = -0.99,95% 置信区间(CI)[-1.77, -0.20],P = .014)或至少降低2级(B = -0.80,95% CI [-1.47, -0.14],P = .018)的患者睡眠问题较少。在分析中排除禁酒者的情况下,饮酒量的减少也预示着治疗结束时睡眠问题的减少(1 级,B = -1.01, 95 CI [-1.47, -0.14]):B=-1.01,95% CI [-1.83,-0.20],P=0.015;2 级B=-0.90,95% CI [-1.59,-0.22],P = .010)。结论 减少饮酒(包括未戒酒)与 AUD 治疗期间睡眠问题的改善有关。有必要对减少危害治疗 AUD 与改善睡眠之间的因果关系进行进一步评估。
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引用次数: 0
Pulmonary symptoms associated with heavy alcohol consumption among people living with HIV: an analysis of the NHANES 1999–2010 与艾滋病病毒感染者大量饮酒有关的肺部症状:对 1999-2010 年国家健康调查(NHANES)的分析
IF 2.8 4区 医学 Q3 SUBSTANCE ABUSE Pub Date : 2024-04-06 DOI: 10.1093/alcalc/agae021
Moses New-Aaron, Mohleen Kang, Samantha M Yeligar
Aim This matched case–control study aimed to provide epidemiologic evidence of increased burden of respiratory symptoms and pulmonary function decline among people living with human immunodeficiency virus (HIV) and a history of heavy alcohol consumption. Methods Cases were participants with HIV (PWH; n = 75, 33%), and controls were participants without HIV (PWoH; n = 150, 67%). PWH were matched to PWoH by age and sex in the ratio of 1:2. Eligible participants responded to the respiratory health National Health and Nutrition Examination Survey questionnaire [prolonged coughs (≥3 months), bringing up of phlegm (≥3 months), and a history of wheezing or whistling in the chest (past year)]. The effects of both alcohol and HIV on participants’ pulmonary function were determined using linear regression analysis. Results History of heavy alcohol consumption was more prevalent among PWH (40%) compared to PWoH (27%). PWH who had a history of heavy alcohol consumption had a higher prevalence of coughing most days (45% vs. 4%, P = .0010), bringing up phlegm most days (31% vs. 0%, P = .0012), and wheezing or whistling in the chest (40% vs. 20%, P = .058) compared to participants who did not heavily consume alcohol. Furthermore, a history of heavy alcohol consumption was associated with decreased forced expiratory volume (ml) in 1 s/forced vital capacity among PWH (β = − 0.098 95% C.I. −0.16, −0.04, P = .03) after adjusting for having smoked at least 100 cigarettes in life. Conclusion A history of heavy alcohol use increased respiratory symptoms and suppressed pulmonary function among people living with HIV. This study provides epidemiological evidence of the respiratory symptom burden of people living with HIV who have a history of heavy alcohol consumption.
目的 这项配对病例对照研究旨在提供流行病学证据,证明有大量饮酒史的人类免疫缺陷病毒(HIV)感染者呼吸道症状和肺功能下降的负担加重。方法 病例为感染 HIV 的参与者(PWH;n = 75,33%),对照组为未感染 HIV 的参与者(PWoH;n = 150,67%)。PWH与PWoH的年龄和性别比例为1:2。符合条件的参与者回答了呼吸系统健康全国健康与营养调查问卷[长期咳嗽(≥3 个月)、咳痰(≥3 个月)、喘息或胸部啸叫史(过去一年)]。通过线性回归分析确定了酒精和艾滋病病毒对参与者肺功能的影响。结果 与艾滋病感染者(27%)相比,有大量饮酒史的艾滋病感染者比例更高(40%)。与没有大量饮酒的参与者相比,有大量饮酒史的艾滋病感染者在大多数日子里咳嗽(45% 对 4%,P = .0010)、大多数日子里咳痰(31% 对 0%,P = .0012)以及胸部喘息或呼啸(40% 对 20%,P = .058)的发生率更高。此外,在对一生中至少吸过 100 支烟进行调整后,大量饮酒史与吸烟者 1 秒钟内用力呼气量(毫升)/用力呼吸量减少有关(β = - 0.098 95% C.I. -0.16,-0.04,P = .03)。结论 大量饮酒史会加重 HIV 感染者的呼吸道症状并抑制肺功能。这项研究为有大量饮酒史的艾滋病病毒感染者的呼吸道症状负担提供了流行病学证据。
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引用次数: 0
How frequently is alcohol advertised on television in Canada?: A cross-sectional study 加拿大电视上的酒类广告频率如何?横断面研究
IF 2.8 4区 医学 Q3 SUBSTANCE ABUSE Pub Date : 2024-04-04 DOI: 10.1093/alcalc/agae020
Elise Pauzé, Adena Pinto, Monique Potvin Kent
Aims Alcohol marketing is a commercial driver of alcohol use, including among youth. This study sought to quantify and characterize alcohol advertising on broadcast television in Canada. Methods Open-source television program logs for January to December 2018 submitted to the Canadian Radio-television and Telecommunications Commission by 147 stations with alcohol advertisements were analyzed. Results Overall, 501 628 alcohol advertisements were broadcast. Four companies accounted for 83% of advertisements, namely, Anheuser-Busch in Bev (33.7%), Molson Coors (22.7%), Diageo (16.1%), and Arterra Wines Canada (10.8%). On conventional stations, advertising was highest on French-language stations [Median (Mdn) = 3224; interquartile range (IQR) = 2262] followed by those with programming in foreign/mixed languages (Mdn = 2679; IQR = 219) and English-language stations (Mdn = 1955; IQR = 1563). On speciality stations, advertising was most frequent on those primarily focused on sports programming (Mdn = 8036; IQR = 7393), movies and scripted shows (Mdn = 7463; IQR = 5937), and cooking (Mdn = 5498; IQR = 4032). On weekdays, 33% of alcohol ads aired from 6 to 9 a.m. and 3 to 9 p.m. and on weekends, 52% aired from 6 a.m. to 9 p.m. when children or adolescents are more likely to be watching television. On youth-oriented stations (n = 4), 7937 alcohol advertisements were broadcast with most airing from 9 p.m. to midnight (44–45%) or 12–6 a.m. (50%) on both weekdays and weekends. Conclusions While few alcohol advertisements were broadcast on youth-oriented stations, young people in Canada are likely exposed to such advertising on programming intended for older or general audiences (e.g. sports). More research is needed to ascertain the extent to which broadcast television constitutes a source of alcohol advertising exposure among youth and to inform policies aimed at protecting them from the influence of such exposure.
目的 酒精营销是包括青少年在内的酒精使用的商业驱动力。本研究旨在量化和描述加拿大广播电视中的酒精广告。方法 分析了147个电视台向加拿大广播电视和电信委员会提交的2018年1月至12月的开放源电视节目日志,其中有酒精广告。结果 共播出了 501 628 个酒类广告。四家公司的广告占 83%,即 Anheuser-Busch in Bev(33.7%)、Molson Coors(22.7%)、Diageo(16.1%)和 Arterra Wines Canada(10.8%)。在传统广播电台中,法语广播电台的广告投放最多[中位数 (Mdn) = 3224;四分位数间距 (IQR) = 2262],其次是外语/混合语广播电台(中位数 = 2679;IQR = 219)和英语广播电台(中位数 = 1955;IQR = 1563)。在专业电台中,以体育节目(Mdn = 8036;IQR = 7393)、电影和剧本节目(Mdn = 7463;IQR = 5937)以及烹饪节目(Mdn = 5498;IQR = 4032)为主的电台最常出现广告。在工作日,33%的酒类广告在上午 6 点至 9 点和下午 3 点至 9 点播出,而在周末,52%的酒类广告在上午 6 点至晚上 9 点播出,此时儿童或青少年更有可能在看电视。在面向青少年的电视台(n = 4)中,共播出了 7937 个酒类广告,其中大部分在晚上 9 点至午夜(44%-45%)或凌晨 12 点至 6 点(50%)播出,播出时间均为工作日和周末。结论 虽然在面向青少年的电台中播出的酒类广告很少,但加拿大的青少年很可能在面向老年人或普通观众的节目(如体育节目)中接触到此类广告。需要开展更多的研究,以确定广播电视在多大程度上成为青少年接触酒精广告的来源,并为旨在保护青少年免受此类广告影响的政策提供信息。
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引用次数: 0
Positive allosteric modulators of the GABAB receptor: a new class of ligands with therapeutic potential for alcohol use disorder GABAB 受体的正性异构调节剂:一类具有治疗酒精使用障碍潜力的新型配体
IF 2.8 4区 医学 Q3 SUBSTANCE ABUSE Pub Date : 2024-04-03 DOI: 10.1093/alcalc/agae018
Giancarlo Colombo
Background Positive allosteric modulators (PAMs) of the GABAB receptor constitute a new class of GABAB-receptor ligands. GABAB PAMs reproduce several pharmacological effects of the orthosteric GABAB receptor agonist, baclofen, although displaying a better safety profile. Aims This paper reviews the reducing or, frequently, even suppressing effects of all GABAB PAMs tested to date on multiple alcohol-related behaviours in laboratory rodents exposed to validated experimental models of human alcohol use disorder. Results Acute or repeated treatment with CGP7930, GS39783, BHF177, rac-BHFF, ADX71441, CMPPE, COR659, ASP8062, KK-92A, and ORM-27669 reduced excessive alcohol drinking, relapse- and binge-like drinking, operant alcohol self-administration, reinstatement of alcohol seeking, and alcohol-induced conditioned place preference in rats and mice. Conclusions These effects closely mirrored those of baclofen; notably, they were associated to remarkably lower levels of tolerance and toxicity. The recent transition of ASP8062 to clinical testing will soon prove whether these highly consistent preclinical data translate to AUD patients.
背景 GABAB 受体的正性异位调节剂(PAMs)是一类新的 GABAB 受体配体。GABAB PAMs 可再现正交 GABAB 受体激动剂巴氯芬的多种药理作用,但具有更好的安全性。目的 本文回顾了迄今为止测试过的所有 GABAB PAMs 对暴露于人类酒精使用障碍验证实验模型的实验室啮齿动物的多种酒精相关行为的降低甚至抑制作用。结果 使用 CGP7930、GS39783、BHF177、rac-BHFF、ADX71441、CMPPE、COR659、ASP8062、KK-92A 和 ORM-27669 对大鼠和小鼠进行急性或重复治疗可减少过度饮酒、复饮和狂饮、操作性酒精自我给药、酒精寻求的恢复和酒精诱导的条件性位置偏好。结论 这些效果与巴氯芬的效果非常相似;值得注意的是,这些效果与明显较低的耐受性和毒性有关。ASP8062 最近已进入临床试验阶段,不久将证明这些高度一致的临床前数据是否适用于 AUD 患者。
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引用次数: 0
Keeping you connected or keeping you addicted? Weekly use of social media platforms is associated with hazardous alcohol use and problem gambling among adults. 让你保持联系还是让你沉迷其中?成年人每周使用社交媒体平台与危险饮酒和问题赌博有关。
IF 2.8 4区 医学 Q3 SUBSTANCE ABUSE Pub Date : 2024-03-16 DOI: 10.1093/alcalc/agae024
Iina Savolainen, Atte Oksanen

Aims: A wide variety of social media platforms exist, each offering tailored solutions to attract specific target audiences based on their social media needs and interests. This diversity may pose a risk factor for the development or perpetuation of harmful behaviors. Research has established a connection between social media use and increased health risk behaviors. This six-wave exploratory longitudinal study investigated the associations between active social media use, hazardous alcohol use, and problem gambling among adult social media users.

Methods: Data were collected via surveys in 6-month intervals, starting in March-April 2021 (T1: N = 1530; Mage = 46.67; SD = 16.42; 50.33% male). Of the T1 respondents, 58.10% participated in T6 (n = 889). Measures included the frequency of use of different social media platforms, the 3-item Alcohol Use Disorders Identification Test (AUDIT-C), and the Problem Gambling Severity Index (PGSI). Hybrid multilevel regression models were used for analyses.

Results: We found positive within-person effects of weekly Facebook use and between-person effects of weekly use of Facebook, TikTok, and gambling-related online communities on drinking. These results suggest an increase in hazardous alcohol consumption over time among the platforms' active users. Weekly Instagram use had a negative between-person effect on hazardous alcohol use. Individuals using TikTok or gambling communities weekly were more prone to problem gambling compared to non-weekly users.

Conclusions: There are risks involved in the active use of some social media services among adult users. Prevention work, including digital health interventions, should be targeted according to the appropriate user group.

目的:社交媒体平台种类繁多,每个平台都根据特定目标受众的社交媒体需求和兴趣提供量身定制的解决方案,以吸引他们。这种多样性可能会成为有害行为发展或延续的风险因素。研究证实,社交媒体的使用与健康风险行为的增加之间存在联系。这项为期六周的探索性纵向研究调查了成年社交媒体用户中社交媒体的活跃使用、危险饮酒和问题赌博之间的关联:从 2021 年 3-4 月开始,每隔 6 个月通过调查收集数据(T1:N = 1530;Mage = 46.67;SD = 16.42;50.33% 为男性)。在 T1 受访者中,58.10% 的人参加了 T6(n = 889)。测量指标包括使用不同社交媒体平台的频率、三项目酒精使用障碍识别测试(AUDIT-C)和问题赌博严重程度指数(PGSI)。分析采用混合多层次回归模型:结果:我们发现,每周使用 Facebook 对饮酒有积极的人内效应,每周使用 Facebook、TikTok 和赌博相关网络社区对饮酒有积极的人际效应。这些结果表明,随着时间的推移,这些平台的活跃用户的危险饮酒量有所增加。每周使用 Instagram 对危险饮酒具有负的人际效应。与非每周使用TikTok或赌博社区的用户相比,每周使用TikTok或赌博社区的用户更容易出现赌博问题:结论:成人用户积极使用某些社交媒体服务存在风险。预防工作,包括数字健康干预,应根据适当的用户群体有针对性地进行。
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引用次数: 0
Exploring the relationship between solitary drinking and living without other adults on alcohol consumption during the COVID-19 pandemic. 探索 COVID-19 大流行期间独自饮酒与无其他成年人陪伴生活对酒精消费的影响。
IF 2.8 4区 医学 Q3 SUBSTANCE ABUSE Pub Date : 2024-03-16 DOI: 10.1093/alcalc/agae013
Yvette Mojica-Perez, Bree Willoughby, Dan Anderson-Luxford, Claire Wilkinson, Emmanuel Kuntsche, Sarah Callinan, Alison Ritter

Aims: The COVID-19 pandemic presents the opportunity to learn about solitary drinking as many people were forced to spend time at home. The aim of this study is to examine the relationship between solitary drinking and living without other adults on alcohol consumption.

Methods: A longitudinal study with four survey waves (between May and November 2020) obtained seven-day drinking diary data from Australian adults living in New South Wales. In May, a convenience sample of 586 participants (Mage = 35.3, SD = 14.8; 65.3% women) completed the first wave. Participants then completed a survey in June (n = 319, 54.4% response rate), July/August (n = 225, 38.4% response rate), and November (n = 222, 37.9% response rate). Information about alcohol consumption including risky drinking (more than four drinks on one occasion), household structure, solitary drinking, and demographics were collected. We conducted random-effects panel bivariate and multivariable regression analyses predicting the number of standard drinks and risky drinking.

Results: Participants with solitary drinking occasions consumed more and had more risky drinking occasions than participants with no solitary drinking occasions, which was also found to be the case during lockdown. Living without other adults was associated with less consumption and less risky drinking than living with other adults. However, participants who lived without other adults and had frequent solitary drinking occasions (solitary drinking in >50% drinking occasions) reported more consumption than participants without a solitary drinking occasion.

Conclusions: Individuals who consume alcohol alone and live without other adults or spend long periods of time at home may be more at risk of alcohol-related harm.

目的:COVID-19 大流行为了解独饮提供了机会,因为许多人被迫在家中度过。本研究旨在探讨独自饮酒与没有其他成年人陪伴的生活对酒精消费的影响:一项纵向研究共进行了四次调查(2020 年 5 月至 11 月),从居住在新南威尔士州的澳大利亚成年人那里获得了七天饮酒日记数据。5 月,方便抽样的 586 名参与者(年龄 = 35.3,SD = 14.8;65.3% 为女性)完成了第一波调查。随后,参与者分别于 6 月(样本数 = 319,回复率为 54.4%)、7 月/8 月(样本数 = 225,回复率为 38.4%)和 11 月(样本数 = 222,回复率为 37.9%)完成了调查。我们收集了包括危险饮酒(一次饮酒超过四杯)、家庭结构、单独饮酒和人口统计学特征在内的饮酒信息。我们对标准饮酒次数和风险饮酒进行了随机效应面板双变量和多变量回归分析:结果:与没有单独饮酒经历的参与者相比,有单独饮酒经历的参与者的饮酒量更大,风险饮酒的次数也更多。与与其他成年人一起生活的参与者相比,与其他成年人一起生活的参与者的饮酒量和风险饮酒量更少。然而,与没有单独饮酒场合的参与者相比,在没有其他成年人陪伴的情况下经常单独饮酒(单独饮酒占饮酒场合的50%以上)的参与者报告的饮酒量更高:结论:独自饮酒、没有其他成年人陪伴或长时间呆在家中的人可能更容易受到酒精相关伤害。
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引用次数: 0
Isolation and loneliness as pathways to heavy drinking early in the pandemic. 隔离和孤独是导致大流行病早期大量饮酒的途径。
IF 2.8 4区 医学 Q3 SUBSTANCE ABUSE Pub Date : 2024-03-16 DOI: 10.1093/alcalc/agae012
Michael Fendrich, Jessica Becker, Beth S Russell, Crystal L Park

Introduction: social isolation and forced quarantines during the early phases of the COVID-19 pandemic coincided with a steep and persistent rise in alcohol consumption among US adults. While the association between loneliness and drinking is well established, less is known about the impact of social isolation (a known correlate of loneliness) and the interplay between these two variables in relation to drinking.

Methods: we recruited US adults using the MTurk platform for an online survey in early April 2020. The initial survey was followed up with a second wave, 30 days later in mid to late May. Data from the current analyses focus on this second wave of data collection.

Results: we found significant direct effects on heavy drinking for both social isolation (c' = 0.495; P < .01) and loneliness (b = 0.071; P < .05). We also found a significant indirect path from social isolation to heavy drinking through social isolation's impact on elevating loneliness (a = 0.919; P < .001). The indirect effect of social isolation on the composite measure of heavy drinking was 0.0652 (0.919 × 0.071) and was significant at the 0.05 level after bootstrapping estimates of the variance were constructed.

Conclusions: those most isolated early in the pandemic were at increased risk for heavy drinking, in part because their social isolation led to increased loneliness. Post-pandemic research is needed to explore whether the relationships that stemmed from social isolation during the pandemic led to a persistent pattern of behavioral risk that maintained high rates of heavy drinking.

导言:在 COVID-19 大流行的早期阶段,社会隔离和强制隔离与美国成年人饮酒量的急剧和持续上升相吻合。虽然孤独与饮酒之间的关系已得到证实,但人们对社会隔离(孤独的一个已知相关因素)的影响以及这两个变量与饮酒之间的相互作用却知之甚少。方法:2020 年 4 月初,我们利用 MTurk 平台招募美国成年人进行在线调查。30 天后,即 5 月中下旬,我们又进行了第二次调查。结果:我们发现社会隔离对大量饮酒有显著的直接影响(c' = 0.495; P 结论:大流行早期最孤立的人群大量饮酒的风险增加,部分原因是他们的社会隔离导致孤独感增加。大流行后需要进行研究,以探讨大流行期间社会隔离所产生的关系是否会导致持续的行为风险模式,从而维持较高的大量饮酒率。
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引用次数: 0
Associations between alcohol taxes and varied health outcomes among women of reproductive age and infants. 酒精税与育龄妇女和婴儿各种健康结果之间的关系。
IF 2.8 4区 医学 Q3 SUBSTANCE ABUSE Pub Date : 2024-03-16 DOI: 10.1093/alcalc/agae015
Meenakshi S Subbaraman, Alex Schulte, Nancy F Berglas, William C Kerr, Sue Thomas, Ryan Treffers, Guodong Liu, Sarah C M Roberts

Objective: No studies have examined whether alcohol taxes may be relevant for reducing harms related to pregnant people's drinking.

Method: We examined how beverage-specific ad valorem, volume-based, and sales taxes are associated with outcomes across three data sets. Drinking outcomes came from women of reproductive age in the 1990-2020 US National Alcohol Surveys (N = 11 659 women $le$ 44 years); treatment admissions data came from the 1992-2019 Treatment Episode Data Set: Admissions (N = 1331 state-years; 582 436 pregnant women admitted to treatment); and infant and maternal outcomes came from the 2005-19 Merative Marketscan® database (1 432 979 birthing person-infant dyads). Adjusted analyses for all data sets included year fixed effects, state-year unemployment and poverty, and accounted for clustering by state.

Results: Models yield no robust significant associations between taxes and drinking. Increased spirits ad valorem taxes were robustly associated with lower rates of treatment admissions [adjusted IRR = 0.95, 95% CI: 0.91, 0.99]. Increased wine and spirits volume-based taxes were both robustly associated with lower odds of infant morbidities [wine aOR = 0.98, 95% CI: 0.96, 0.99; spirits aOR = 0.99, 95% CI: 0.98, 1.00] and lower odds of severe maternal morbidities [wine aOR = 0.91, 95% CI: 0.86, 0.97; spirits aOR = 0.95, 95% CI: 0.92, 0.97]. Having an off-premise spirits sales tax was also robustly related to lower odds of severe maternal morbidities [aOR = 0.78, 95% CI: 0.64, 0.96].

Conclusions: Results show protective associations between increased wine and spirits volume-based and sales taxes with infant and maternal morbidities. Policies that index tax rates to inflation might yield more public health benefits, including for pregnant people and infants.

目的:没有研究酒精税是否能减少孕妇饮酒的危害:尚未有研究探讨酒税是否有助于减少与孕妇饮酒有关的危害:我们通过三个数据集研究了特定饮料从价税、从量税和销售税与饮酒结果之间的关系。饮酒结果来自 1990-2020 年美国全国酒精调查中的育龄妇女(N = 11 659 名 44 岁以下妇女);入院治疗数据来自 1992-2019 年治疗事件数据集:入院治疗数据来自 1992-2019 年治疗事件数据集:入院治疗(N = 1331 州-年;582 436 名孕妇入院治疗);婴儿和产妇结局数据来自 2005-19 年 Merative Marketscan® 数据库(1 432 979 个分娩者-婴儿二元组)。所有数据集的调整分析均包括年份固定效应、州年失业率和贫困率,并考虑了各州的聚类情况:模型结果表明,税收与饮酒之间没有明显的联系。烈性酒从价税的增加与较低的治疗入院率密切相关[调整后 IRR = 0.95,95% CI:0.91, 0.99]。葡萄酒和烈性酒从量税的增加与婴儿发病率的降低[葡萄酒 aOR = 0.98,95% CI:0.96, 0.99;烈性酒 aOR = 0.99,95% CI:0.98, 1.00]和孕产妇严重发病率的降低[葡萄酒 aOR = 0.91,95% CI:0.86, 0.97;烈性酒 aOR = 0.95,95% CI:0.92, 0.97]密切相关。征收酒类销售税也与降低孕产妇严重发病率密切相关[aOR = 0.78, 95% CI: 0.64, 0.96]:结果显示,葡萄酒和烈性酒数量税和销售税的增加与婴儿和孕产妇发病率之间存在保护性联系。将税率与通货膨胀率挂钩的政策可能会产生更多的公共健康益处,包括对孕妇和婴儿的益处。
{"title":"Associations between alcohol taxes and varied health outcomes among women of reproductive age and infants.","authors":"Meenakshi S Subbaraman, Alex Schulte, Nancy F Berglas, William C Kerr, Sue Thomas, Ryan Treffers, Guodong Liu, Sarah C M Roberts","doi":"10.1093/alcalc/agae015","DOIUrl":"10.1093/alcalc/agae015","url":null,"abstract":"<p><strong>Objective: </strong>No studies have examined whether alcohol taxes may be relevant for reducing harms related to pregnant people's drinking.</p><p><strong>Method: </strong>We examined how beverage-specific ad valorem, volume-based, and sales taxes are associated with outcomes across three data sets. Drinking outcomes came from women of reproductive age in the 1990-2020 US National Alcohol Surveys (N = 11 659 women $le$ 44 years); treatment admissions data came from the 1992-2019 Treatment Episode Data Set: Admissions (N = 1331 state-years; 582 436 pregnant women admitted to treatment); and infant and maternal outcomes came from the 2005-19 Merative Marketscan® database (1 432 979 birthing person-infant dyads). Adjusted analyses for all data sets included year fixed effects, state-year unemployment and poverty, and accounted for clustering by state.</p><p><strong>Results: </strong>Models yield no robust significant associations between taxes and drinking. Increased spirits ad valorem taxes were robustly associated with lower rates of treatment admissions [adjusted IRR = 0.95, 95% CI: 0.91, 0.99]. Increased wine and spirits volume-based taxes were both robustly associated with lower odds of infant morbidities [wine aOR = 0.98, 95% CI: 0.96, 0.99; spirits aOR = 0.99, 95% CI: 0.98, 1.00] and lower odds of severe maternal morbidities [wine aOR = 0.91, 95% CI: 0.86, 0.97; spirits aOR = 0.95, 95% CI: 0.92, 0.97]. Having an off-premise spirits sales tax was also robustly related to lower odds of severe maternal morbidities [aOR = 0.78, 95% CI: 0.64, 0.96].</p><p><strong>Conclusions: </strong>Results show protective associations between increased wine and spirits volume-based and sales taxes with infant and maternal morbidities. Policies that index tax rates to inflation might yield more public health benefits, including for pregnant people and infants.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"59 3","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10945295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140142614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identifying excessive chronic alcohol use with phosphatidylethanol in patients with suspected severe injury-results from the IDART study. 用磷脂酰乙醇识别疑似重伤患者长期过度饮酒--IDART 研究的结果。
IF 2.8 4区 医学 Q3 SUBSTANCE ABUSE Pub Date : 2024-03-16 DOI: 10.1093/alcalc/agae014
Benedicte M Jørgenrud, Camilla C Bråthen, Jo Steinson Stenehjem, Thomas Kristiansen, Leiv Arne Rosseland, Stig Tore Bogstrand

Introduction: Acute and chronic alcohol use are well-known risk factors for accidents and injuries, and concurrent psychoactive drug use can increase injury risk further. Phosphatidylethanol (PEth) 16:0/18:1 is a biomarker used to determine alcohol consumption the previous 3-4 weeks. The aim was to investigate the prevalence of chronic alcohol use in trauma patients, as determined by PEth 16:0/18:1 concentrations, and how excessive chronic alcohol use relate to demographic variables, injury mechanisms and drug use.

Setting: Patients received at Norwegian trauma hospitals from March 2019 to February 2020. The study is part of the Impairing Drugs and Alcohol as Risk factors for Traumatic Injuries study.

Methods: All patients aged ≥ 16 years received with trauma team were included in the study. Data on injury date and mechanism, gender and age was registered. Blood samples were analyzed for 22 psychoactive medicinal and illicit drugs, ethanol and phosphatidylethanol 16:0/18:1. Regression analyses were conducted to assess associations between alcohol use and gender, age, injury mechanism and drug use.

Results and conclusion: Of the 4845 patients included in the study, 10% had PEth 16:0/18:1 concentration ≥ 600 nM (~430 ng/mL), indicative of excessive chronic alcohol use. Being male, between 44-61 years old, involved in violence, and testing positive for medicinal drugs was associated with excessive chronic alcohol use.Excessive chronic alcohol use was common among males, middle-aged, patients with violence as injury mechanism and those with medicinal drug use. These findings emphasize the need to detect and treat excessive chronic alcohol use among trauma patients.

引言急性和慢性饮酒是众所周知的事故和伤害风险因素,同时使用精神活性药物会进一步增加伤害风险。磷脂酰乙醇(PEth)16:0/18:1是一种生物标志物,用于确定前3-4周的饮酒量。该研究旨在通过磷脂酰乙醇(PEth)16:0/18:1的浓度确定外伤患者长期饮酒的普遍程度,以及过度长期饮酒与人口统计学变量、受伤机制和药物使用之间的关系:研究对象:2019年3月至2020年2月期间在挪威创伤医院接受治疗的患者。该研究是作为创伤性损伤风险因素的损害性药物和酒精研究的一部分:所有年龄≥16岁、在创伤团队接受治疗的患者均纳入研究。登记受伤日期和机制、性别和年龄等数据。对血液样本中的 22 种精神药物和违禁药物、乙醇和磷脂酰乙醇 16:0/18:1 进行分析。进行了回归分析,以评估酒精使用与性别、年龄、受伤机制和药物使用之间的关联:在研究的 4845 名患者中,10% 的患者 PEth 16:0/18:1 浓度≥ 600 nM(约 430 ng/mL),这表明患者长期过度饮酒。男性、44-61岁、参与暴力事件、药物检测呈阳性与长期过度饮酒有关。长期过度饮酒常见于男性、中年、以暴力为伤害机制的患者和使用药物的患者。这些发现强调了发现和治疗创伤患者长期过度饮酒的必要性。
{"title":"Identifying excessive chronic alcohol use with phosphatidylethanol in patients with suspected severe injury-results from the IDART study.","authors":"Benedicte M Jørgenrud, Camilla C Bråthen, Jo Steinson Stenehjem, Thomas Kristiansen, Leiv Arne Rosseland, Stig Tore Bogstrand","doi":"10.1093/alcalc/agae014","DOIUrl":"10.1093/alcalc/agae014","url":null,"abstract":"<p><strong>Introduction: </strong>Acute and chronic alcohol use are well-known risk factors for accidents and injuries, and concurrent psychoactive drug use can increase injury risk further. Phosphatidylethanol (PEth) 16:0/18:1 is a biomarker used to determine alcohol consumption the previous 3-4 weeks. The aim was to investigate the prevalence of chronic alcohol use in trauma patients, as determined by PEth 16:0/18:1 concentrations, and how excessive chronic alcohol use relate to demographic variables, injury mechanisms and drug use.</p><p><strong>Setting: </strong>Patients received at Norwegian trauma hospitals from March 2019 to February 2020. The study is part of the Impairing Drugs and Alcohol as Risk factors for Traumatic Injuries study.</p><p><strong>Methods: </strong>All patients aged ≥ 16 years received with trauma team were included in the study. Data on injury date and mechanism, gender and age was registered. Blood samples were analyzed for 22 psychoactive medicinal and illicit drugs, ethanol and phosphatidylethanol 16:0/18:1. Regression analyses were conducted to assess associations between alcohol use and gender, age, injury mechanism and drug use.</p><p><strong>Results and conclusion: </strong>Of the 4845 patients included in the study, 10% had PEth 16:0/18:1 concentration ≥ 600 nM (~430 ng/mL), indicative of excessive chronic alcohol use. Being male, between 44-61 years old, involved in violence, and testing positive for medicinal drugs was associated with excessive chronic alcohol use.Excessive chronic alcohol use was common among males, middle-aged, patients with violence as injury mechanism and those with medicinal drug use. These findings emphasize the need to detect and treat excessive chronic alcohol use among trauma patients.</p>","PeriodicalId":7407,"journal":{"name":"Alcohol and alcoholism","volume":"59 3","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10945293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140142616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Alcohol and alcoholism
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