Alcohol and alcoholism最新文献

Aims: This study compared individuals with hazardous alcohol consumption who used the web-based intervention "Ohne Alkohol mit Nathalie" (OAMN) with individuals who relied exclusively on traditional support to enhance the understanding of OAMN user characteristics.

Methods: A cross-sectional online survey included 2460 treatment-seeking participants with Alcohol Use Disorders Identification Test scores ≥8 indicating hazardous alcohol use. The OAMN group (n = 1825) included individuals who had used OAMN programs, while the non-OAMN group (n = 635) relied exclusively on traditional support. Analyses compared sociodemographic characteristics, psychiatric comorbidities, the extent to which OAMN was used as a standalone or complementary tool, alcohol consumption, and abstinence motives.

Results: Both groups were predominantly female and highly educated, but these characteristics were more pronounced among OAMN users. About one-third of OAMN users relied exclusively on the examined intervention, while two-thirds combined it with other forms of support. Non-OAMN users exhibited higher psychiatric comorbidities and had higher Alcohol Use Disorders Identification Test scores. Intrinsic motives were key drivers for abstinence in both groups, while these motives were more pronounced among OAMN users and extrinsic motives were more frequently reported by non-OAMN users.

Conclusion: These findings show that OAMN primarily attracts well-educated women and that it's used as both a standalone and complementary intervention. OAMN users were more likely to report intrinsic motives such as improving well-being and autonomy as key drivers for abstinence and less likely to report extrinsic motives such as external expectations and fear. These insights enhance understanding of the characteristics and abstinence motives of individuals engaging with OAMN.

Objective: Grocery stores are creating opportunities, such as a separate bar area and including beer and wine tasting events, to create a unique experience that caters to particular groups of clientele to encourage drinking. The goals of the study were to determine whether assortative drinking (i.e. the process of drinking alcohol in places where individuals have similar characteristics) is occurring at grocery stores, assess drink pacing (e.g. drinks per hour), and observe whether grocery stores engaged in responsible beverage service practices during special events and at their bars.

Method: We conducted unobtrusive observations at four grocery stores in Central Ohio to understand who attended special events and/or drinks at the bars located within grocery stores. Demographic characteristics and drinking quantity of the 96 patrons were recorded. Data were analyzed with bivariate statistics.

Major findings: Patrons drank, on average, 3.8 drinks per hour, although standard drink size could not be determined. The locations showed evidence of assortative drinking at the individual level by age and consumption of food. At the establishment level, assortative drinking appears to have occurred by gender, age, and race/ethnicity. Drinks per person per hour differed by location, type of drink, and presence of food.

Conclusions: Our work suggests a need to better understand these emerging alcohol establishments, which may create more opportunities to drink while bringing in new or different clientele to drink alcohol. The effects of these locations on alcohol-related problems are an important next step in understanding the full impact of drinking in these locations.

Aims: The goal of the present study was to determine the effect of prior experience with ethanol drinking and changes in session duration on the acquisition and maintenance of operant ethanol self-administration.

Methods: Adult male and female Long-Evans rats were trained to operantly self-administer ethanol. A subset of rats underwent 3 weeks of intermittent-access two-bottle choice drinking in the home cage prior to operant training. Controls were given access to two bottles of water. Once fully trained in 30-min operant sessions, the session duration was reduced to 15 min for all rats. Differences between 30- and 15-min sessions were also assessed in a separate group of rats trained to self-administer sucrose.

Results: No differences were observed in acquisition rates, the magnitude of responding for ethanol, or total ethanol consumed between rats allowed to drink ethanol in the home cage and those that remained ethanol naïve prior to operant training. A significant decrease in appetitive and consummatory behaviors was observed in rats trained to lever press for either ethanol or sucrose when session length was reduced from 30 to 15 min. Assessment of within-session drinking patterns suggests that this is driven primarily by missed drinking opportunities occurring during the second half of 30-min sessions.

Conclusions: These data suggest that prior short-term home cage ethanol drinking offers little advantage as an initiation procedure over no initiation procedure at all. Moreover, reducing operant session duration from 30-min to 15-min has the potential to decrease, rather than increase, levels of ethanol intake.

Aims: We described the age-specific trajectories of total alcohol consumption and the consumption of different types of beverages among adult Norwegian women as they age, and how these relate to education, lifestyle, and health-related factors.

Methods: This study included 76 382 women aged 31-70 years who participated in at least two of the three Norwegian Women and Cancer (NOWAC) study surveys conducted in 1991-97, 1998-2003, and 2004-11. Group-based trajectory modeling was used to identify the trajectories of self-reported alcohol consumption. Multinomial regression models were used to fit the adjusted odds ratios (ORs) of the associations between education, lifestyle, health-related factors, and the trajectory membership. Analysis was stratified into two subcohorts: women aged 31-49 years and women aged 50-70 years at enrolment.

Results: Five different trajectories of total alcohol consumption were identified among the two subcohorts: non-drinker stable (12.5%-23.6%), low stable (66.3%-60.1%), light increasing or light unstable (17.8%-12.1%), moderate to high or light to high (2.8%-2.7%), and high to moderate or moderate decreasing (.6%-1.4%). Trajectories were resembled by those of wine consumption. Compared to low stable drinkers, women who sustained or increased their total alcohol consumption showed higher ORs for higher education level, excellent self-rated health, former or current smoking status, and a body mass index (BMI) below 25 kg/m2.

Conclusion: While most women in this study maintained stable low-light levels of alcohol consumption, certain groups-such as women with higher education and better health-were more likely to increase their drinking with age. Women can particularly increase their drinking around the retirement age. The increasing trends of total alcohol consumption were reflected by those of wine. These findings provide information into groups and beverages that could be targeted in alcohol-reducing interventions.

Aims and methods: Hazardous alcohol use poses an increasing public health issue worldwide and it manifests as excessive consumption (acute or chronic), which may lead to addiction. The risk of alcohol-related pathologies correlates with the patterns of intake and increases with the amount of alcohol consumed. While the effects of alcohol consumption on ischemic stroke and ischemic heart disease are well documented, the impact on venous thromboembolism is less clear. Conflicting studies have reported that alcohol may be a risk factor for, or have a protective role against venous thromboembolism. Our narrative review aimed to assess the risk of unusual-site venous thrombosis in individuals with hazardous alcohol use, as it may stem from alcohol-related organ damage (e.g. liver cirrhosis, pancreatitis) as well as provide some suggestions for physicians.

Results: There appears to be a correlation between hazardous alcohol use and unusual-site thrombosis, though the underlying mechanisms are largely still unknown.

Conclusion: In subjects with hazardous alcohol use complicated by alcohol-related organ damage, physicians should be vigilant for potential thrombotic symptoms, and be prepared to diagnose and promptly initiate appropriate anticoagulation therapy.

Background: It seems that diet is one of the main triggers of migraine; one of the most studied is alcohol, and also, over the years, red wine has been shown to trigger headaches. Therefore, this systematic review and meta-analysis aims to examine the strength of the association between wine consumption and migraine.

Methods: In this systematic review and meta-analysis, a search of MEDLINE (via PubMed), Scopus, Cochrane, and Web of Science databases was conducted to assess the association between wine consumption and migraine, covering baseline to December 2023. Pooled Odds Ratio (p-OR) were calculated using the DerSimonian and Laird methods. This study was previously registered in PROSPERO (CRD42024511115). The risk of bias was evaluated using The Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies.

Results: Five studies were included in this systematic review, and only four of them were in the meta-analysis. Using the DerSimonian and Laird method, the p-OR for the effect of wine consumption on migraine was 0.63 (95% CI 0.36-1.09). The included studies after the risk of bias assessment showed a moderate risk of bias.

Conclusions: The findings of this systematic review and meta-analysis indicate that there is no conclusive evidence to support an increased or decreased risk of migraine associated with wine consumption.

Aims: This study aimed to evaluate national alcohol sales and their association with the number of maxillofacial fractures in Southern Finland.

Methods: Patient data of all facial fracture patients admitted to tertiary trauma centers (Helsinki University Hospital, Helsinki, Finland) from January 2014 to October 2020 were reviewed retrospectively. Information on alcohol sales in Finland was obtained from the Finnish Institute for Health and Welfare.

Results: The annual number of facial fractures increased, as did the number of facial fractures caused by interpersonal violence. Unexpectedly, we found a mostly inverse association between alcohol sales and facial fractures, although three months were associated positively: April, June, and November.

Conclusion: We conclude that although the significance of alcohol use in the etymology of facial fractures has been unmistakably proven neither population-level alcohol use nor interpersonal violence as an injury mechanism explains the increase in facial fractures. However, there are some associations between the seasonality of alcohol consumption and facial fractures, suggesting the same predisposing factors in both. Further, certain groups of users, exceeding a threshold of alcohol use, appear to be responsible for the traumatic presentations in emergency units. Elucidating the associations between alcohol use and facial fractures requires an assessment of patient-specific factors, rather than population-level alcohol use, for a detailed understanding and justification of alcohol policy.

Aims: We evaluated the safety, efficacy, and patient adherence to oral ANS-6637, a selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2), for treating alcohol use disorder (AUD).

Methods: A 3-arm, double-blind, randomized, proof-of-concept human laboratory study embedded in a 5-week multisite clinical trial tested 200 mg and 600 mg daily doses of ANS-6637 compared to placebo in treatment-seeking adults with AUD. After 1 week of medication, participants completed an alcohol cue reactivity session. Drinking and safety assessments were measured during treatment; other exploratory outcomes were measured 1 week after treatment ended.

Results: The study was terminated following enrollment of 43 of 81 planned participants due to clinically significant, reversible increases in liver enzymes in three women. Adverse events consistent with ALDH2 inhibition in the presence of alcohol (heart rate/palpitations, flushing, nausea) were dose dependent. Group differences in cue-elicited craving were not significant; effect sizes (Cohen's d) comparing the 200 mg and 600 mg doses to placebo were .71 and .06, respectively. Secondary endpoints did not differ significantly between groups; Cohen's d ranged from .31 to .57 for the 600 mg dose compared to placebo for continuous drinking outcomes.

Conclusions: Findings of liver toxicity with ANS-6637 led to early termination and reduced power to test hypotheses. Effect size estimates are consistent with the hypothesis that selective ALDH2 inhibition may reduce craving and drinking, however these estimates may be unreliable due to the small sample size. Additional research with non-hepatotoxic selective and reversible ALDH2 inhibitors is needed to evaluate this approach to AUD pharmacotherapy.

The study aimed to summarise the evidence of the association between preoperative alcohol consumption and postoperative complications in gastrointestinal surgeries. Comprehensive searches of MEDLINE, EMBASE, and Cochrane databases were undertaken to identify original studies investigating the association between preoperative alcohol consumption and postoperative complications occurring within 30 days of surgery. The primary outcome was 30-day mortality risk and secondary outcomes included postoperative complications such as surgical site infections and risk of anastomotic leak. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using a random effects model. In total, 3601 reports were identified and reviewed for eligibility, then data was extracted from 26 studies that met inclusion criteria. 13 studies were included in the meta-analysis. The total number of patients in the meta-analysis was 686 181 including 20 163 with a high alcohol intake. Clearly defined high preoperative alcohol consumption was associated with an increased risk of postoperative complications including 30-day mortality (OR = 1.56; 95% CI: 1.07-2.28). The risk of anastomotic leak was significantly increased in those undergoing colorectal surgery with a high alcohol intake, OR 2.17 (95% CI: 1.74-2.72). An increase in risk was also found for surgical site infections in those undergoing gastrointestinal surgery with high alcohol intake. (OR = 1.32; 95% CI: 1.15-1.53). Preoperative alcohol consumption was associated with an increased risk of 30-day mortality, anastomotic leak and surgical site infections. Preoperative modulation of alcohol intake may influence post-operative complications after gastrointestinal surgery.