Pub Date : 2024-07-18DOI: 10.1007/s44258-024-00025-3
Allan Sun, Arian Nasser, Chaohao Chen, Y. Zhao, Haimei Zhao, Zihao Wang, Wenlong Cheng, Pierre Qian, L. Ju
{"title":"Strategic reuse of rapid antigen tests for coagulation status assessment: an integrated machine learning approach","authors":"Allan Sun, Arian Nasser, Chaohao Chen, Y. Zhao, Haimei Zhao, Zihao Wang, Wenlong Cheng, Pierre Qian, L. Ju","doi":"10.1007/s44258-024-00025-3","DOIUrl":"https://doi.org/10.1007/s44258-024-00025-3","url":null,"abstract":"","PeriodicalId":74169,"journal":{"name":"Med-X","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141827717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-03DOI: 10.1007/s44258-024-00022-6
David T. She, M. Nai, C. T. Lim
{"title":"Atomic force microscopy in the characterization and clinical evaluation of neurological disorders: current and emerging technologies","authors":"David T. She, M. Nai, C. T. Lim","doi":"10.1007/s44258-024-00022-6","DOIUrl":"https://doi.org/10.1007/s44258-024-00022-6","url":null,"abstract":"","PeriodicalId":74169,"journal":{"name":"Med-X","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141272197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-21DOI: 10.1007/s44258-024-00020-8
Han-Sem Kim, Tanza Baby, Jung-Hwan Lee, U. Shin, Hae-Won Kim
{"title":"Biomaterials-enabled electrical stimulation for tissue healing and regeneration","authors":"Han-Sem Kim, Tanza Baby, Jung-Hwan Lee, U. Shin, Hae-Won Kim","doi":"10.1007/s44258-024-00020-8","DOIUrl":"https://doi.org/10.1007/s44258-024-00020-8","url":null,"abstract":"","PeriodicalId":74169,"journal":{"name":"Med-X","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141114692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-03DOI: 10.1007/s44258-024-00021-7
Yu Yong, Yicong Cai, Jiawei Lin, Lin Ma, HongBin Han, Fenfang Li
{"title":"Advancement in modulation of brain extracellular space and unlocking its potential for intervention of neurological diseases","authors":"Yu Yong, Yicong Cai, Jiawei Lin, Lin Ma, HongBin Han, Fenfang Li","doi":"10.1007/s44258-024-00021-7","DOIUrl":"https://doi.org/10.1007/s44258-024-00021-7","url":null,"abstract":"","PeriodicalId":74169,"journal":{"name":"Med-X","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141014715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-18DOI: 10.1007/s44258-024-00017-3
Shuai Shao, Sha Deng, Na Li, Zheng-Zhu Zhang, Hangyu Zhang, Bo Liu
{"title":"Mapping the distribution of tension across paxillin upon shear stress with FRET-based biosensor","authors":"Shuai Shao, Sha Deng, Na Li, Zheng-Zhu Zhang, Hangyu Zhang, Bo Liu","doi":"10.1007/s44258-024-00017-3","DOIUrl":"https://doi.org/10.1007/s44258-024-00017-3","url":null,"abstract":"","PeriodicalId":74169,"journal":{"name":"Med-X","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140233205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-29DOI: 10.1007/s44258-024-00015-5
Keziah Jacob Souza, Deepak K. Agrawal
{"title":"Employing toehold-mediated DNA strand displacement reactions for biomedical applications","authors":"Keziah Jacob Souza, Deepak K. Agrawal","doi":"10.1007/s44258-024-00015-5","DOIUrl":"https://doi.org/10.1007/s44258-024-00015-5","url":null,"abstract":"","PeriodicalId":74169,"journal":{"name":"Med-X","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140486913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01Epub Date: 2024-07-03DOI: 10.1007/s44258-024-00024-4
Cih Cheng, Eric J Williamson, George T-C Chiu, Bumsoo Han
Hydrogels with particulates, including proteins, drugs, nanoparticles, and cells, enable the development of new and innovative biomaterials. Precise control of the spatial distribution of these particulates is crucial to produce advanced biomaterials. Thus, there is a high demand for manufacturing methods for particle-laden hydrogels. In this context, 3D printing of hydrogels is emerging as a promising method to create numerous innovative biomaterials. Among the 3D printing methods, inkjet printing, so-called drop-on-demand (DOD) printing, stands out for its ability to construct biomaterials with superior spatial resolutions. However, its printing processes are still designed by trial and error due to a limited understanding of the ink behavior during the printing processes. This review discusses the current understanding of transport processes and hydrogel behaviors during inkjet printing for particulate-laden hydrogels. Specifically, we review the transport processes of water and particulates within hydrogel during ink formulation, jetting, and curing. Additionally, we examine current inkjet printing applications in fabricating engineered tissues, drug delivery devices, and advanced bioelectronics components. Finally, the challenges and opportunities for next-generation inkjet printing are also discussed.
{"title":"Engineering biomaterials by inkjet printing of hydrogels with functional particulates.","authors":"Cih Cheng, Eric J Williamson, George T-C Chiu, Bumsoo Han","doi":"10.1007/s44258-024-00024-4","DOIUrl":"10.1007/s44258-024-00024-4","url":null,"abstract":"<p><p>Hydrogels with particulates, including proteins, drugs, nanoparticles, and cells, enable the development of new and innovative biomaterials. Precise control of the spatial distribution of these particulates is crucial to produce advanced biomaterials. Thus, there is a high demand for manufacturing methods for particle-laden hydrogels. In this context, 3D printing of hydrogels is emerging as a promising method to create numerous innovative biomaterials. Among the 3D printing methods, inkjet printing, so-called drop-on-demand (DOD) printing, stands out for its ability to construct biomaterials with superior spatial resolutions. However, its printing processes are still designed by trial and error due to a limited understanding of the ink behavior during the printing processes. This review discusses the current understanding of transport processes and hydrogel behaviors during inkjet printing for particulate-laden hydrogels. Specifically, we review the transport processes of water and particulates within hydrogel during ink formulation, jetting, and curing. Additionally, we examine current inkjet printing applications in fabricating engineered tissues, drug delivery devices, and advanced bioelectronics components. Finally, the challenges and opportunities for next-generation inkjet printing are also discussed.</p><p><strong>Graphical abstract: </strong></p>","PeriodicalId":74169,"journal":{"name":"Med-X","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11222244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141556455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01Epub Date: 2024-10-01DOI: 10.1007/s44258-024-00028-0
Gwangmook Kim, Hyunah Ahn, Joshua Chaj Ulloa, Wei Gao
The rapid advancement in personalized healthcare has driven the development of wearable biomedical devices for real-time biomarker monitoring and diagnosis. Traditional invasive blood-based diagnostics are painful and limited to sporadic health snapshots. To address these limitations, microneedle-based sensing platforms have emerged, utilizing interstitial fluid (ISF) as an alternative biofluid for continuous health monitoring in a minimally invasive and painless manner. This review aims to provide a comprehensive overview of microneedle sensor technology, covering microneedle design, fabrication methods, and sensing strategy. Additionally, it explores the integration of monitoring electronics for continuous on-body monitoring. Representative applications of microneedle sensing platforms for both monitoring and therapeutic purposes are introduced, highlighting their potential to revolutionize personalized healthcare. Finally, the review discusses the remaining challenges and future prospects of microneedle technology.
{"title":"Microneedle sensors for dermal interstitial fluid analysis.","authors":"Gwangmook Kim, Hyunah Ahn, Joshua Chaj Ulloa, Wei Gao","doi":"10.1007/s44258-024-00028-0","DOIUrl":"10.1007/s44258-024-00028-0","url":null,"abstract":"<p><p>The rapid advancement in personalized healthcare has driven the development of wearable biomedical devices for real-time biomarker monitoring and diagnosis. Traditional invasive blood-based diagnostics are painful and limited to sporadic health snapshots. To address these limitations, microneedle-based sensing platforms have emerged, utilizing interstitial fluid (ISF) as an alternative biofluid for continuous health monitoring in a minimally invasive and painless manner. This review aims to provide a comprehensive overview of microneedle sensor technology, covering microneedle design, fabrication methods, and sensing strategy. Additionally, it explores the integration of monitoring electronics for continuous on-body monitoring. Representative applications of microneedle sensing platforms for both monitoring and therapeutic purposes are introduced, highlighting their potential to revolutionize personalized healthcare. Finally, the review discusses the remaining challenges and future prospects of microneedle technology.</p><p><strong>Graphical abstract: </strong></p>","PeriodicalId":74169,"journal":{"name":"Med-X","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11445365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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