Pub Date : 2025-01-01DOI: 10.1016/j.neurop.2024.100182
José Miguel Láinez , Oscar Pradilla , Pablo Irimia , Fidel Sobrino , Michel Volcy , Pedro Kowaks , Ildefonso Rodríguez Leyva , Fiorella Martín , Lucía Zavala , Alex Espinoza
Introduction and objectives
Migraine is the most common reason for neurology outpatient consultation; more than 80% of patients with migraine suffer some degree of associated disability. Migraine is an underdiagnosed disorder and patients frequently receive inappropriate treatment, which is why it is necessary to establish recommendations to improve patient management. The objective of this document is to establish a consensus position on the pharmacological treatment of migraine, including general measures and detailed analysis of the different options for the treatment of attacks and their prevention, from the perspective of Ibero-American countries.
Methods and results
Based on the recommendation documents published by the scientific societies of different Ibero-American countries, 2 surveys were prepared; through the application of the Delphi methodology and discussions in subsequent meetings, a document was developed in consensus format, supported by evidence from the literature and expert recommendations.
Conclusions
A series of recommendations were agreed upon for the treatment of episodic migraine and chronic migraine, both for the acute management of attacks and for their prevention. These recommendations are based on the consensus process and a literature review, and are adapted to the regional conditions of the Ibero-American countries.
{"title":"Ibero-American consensus statement on migraine treatment","authors":"José Miguel Láinez , Oscar Pradilla , Pablo Irimia , Fidel Sobrino , Michel Volcy , Pedro Kowaks , Ildefonso Rodríguez Leyva , Fiorella Martín , Lucía Zavala , Alex Espinoza","doi":"10.1016/j.neurop.2024.100182","DOIUrl":"10.1016/j.neurop.2024.100182","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Migraine is the most common reason for neurology outpatient consultation; more than 80% of patients with migraine suffer some degree of associated disability. Migraine is an underdiagnosed disorder and patients frequently receive inappropriate treatment, which is why it is necessary to establish recommendations to improve patient management. The objective of this document is to establish a consensus position on the pharmacological treatment of migraine, including general measures and detailed analysis of the different options for the treatment of attacks and their prevention, from the perspective of Ibero-American countries.</div></div><div><h3>Methods and results</h3><div>Based on the recommendation documents published by the scientific societies of different Ibero-American countries, 2 surveys were prepared; through the application of the Delphi methodology and discussions in subsequent meetings, a document was developed in consensus format, supported by evidence from the literature and expert recommendations.</div></div><div><h3>Conclusions</h3><div>A series of recommendations were agreed upon for the treatment of episodic migraine and chronic migraine, both for the acute management of attacks and for their prevention. These recommendations are based on the consensus process and a literature review, and are adapted to the regional conditions of the Ibero-American countries.</div></div>","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"5 1","pages":"Article 100182"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143133576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.neurop.2024.100178
M. Llaneza , G. Fontes , L. Benedito-Palos , E. Moral
Introduction
Current therapies for relapsing–remitting multiple sclerosis (RRMS) help reduce morbidity and delay disease progression. However, the available information on factors influencing decision-making regarding first-line treatment remain poorly understood.
Methods
Based on a review of the literature and the experience of a scientific committee made up by 2 neurologists, an ad hoc survey was developed and distributed to Spanish neurologists. It included 22 questions related to the first-line therapeutic management of RRMS.
Results
Sixty neurologists (mean age: 45.6 years, 60% women, mean of 16.0 years of experience, mean of 93.8 patients with RRMS attended/month) participated in the study. Neurologists considered that the 3 most important treatment characteristics (1–8 points, with higher scores denoting greater relevance) in treatment decision-making were efficacy in disease control (7.8 ± 0.5), safety/tolerability (6.7 ± 0.9), and improvements in patient quality of life (5.0 ± 1.5); regarding patient characteristics, the 3 most important (1–7 points) were disease activity (6.9 ± 0.5), intention to become pregnant (5.0 ± 1.0), and level of disability (4.3 ± 1.8). Dimethyl fumarate (32.6%) was the most frequently prescribed treatment, followed by teriflunomide (24.8%) and glatiramer acetate (17.6%). According to over 87% of the specialists, the latter drug was considered the most appropriate treatment for patients with liver disorders, who intended to become pregnant, and who presented low disease activity.
Conclusions
Our study provides evidence on the first-line therapeutic management of non-aggressive forms of RRMS and the factors influencing decision-making in routine clinical practice.
{"title":"Survey on first-line therapeutic management of relapsing–remitting multiple sclerosis in clinical practice in Spain","authors":"M. Llaneza , G. Fontes , L. Benedito-Palos , E. Moral","doi":"10.1016/j.neurop.2024.100178","DOIUrl":"10.1016/j.neurop.2024.100178","url":null,"abstract":"<div><h3>Introduction</h3><div>Current therapies for relapsing–remitting multiple sclerosis (RRMS) help reduce morbidity and delay disease progression. However, the available information on factors influencing decision-making regarding first-line treatment remain poorly understood.</div></div><div><h3>Methods</h3><div>Based on a review of the literature and the experience of a scientific committee made up by 2 neurologists, an ad hoc survey was developed and distributed to Spanish neurologists. It included 22 questions related to the first-line therapeutic management of RRMS.</div></div><div><h3>Results</h3><div>Sixty neurologists (mean age: 45.6 years, 60% women, mean of 16.0 years of experience, mean of 93.8 patients with RRMS attended/month) participated in the study. Neurologists considered that the 3 most important treatment characteristics (1–8 points, with higher scores denoting greater relevance) in treatment decision-making were efficacy in disease control (7.8<!--> <!-->±<!--> <!-->0.5), safety/tolerability (6.7<!--> <!-->±<!--> <!-->0.9), and improvements in patient quality of life (5.0<!--> <!-->±<!--> <!-->1.5); regarding patient characteristics, the 3 most important (1–7 points) were disease activity (6.9<!--> <!-->±<!--> <!-->0.5), intention to become pregnant (5.0<!--> <!-->±<!--> <!-->1.0), and level of disability (4.3<!--> <!-->±<!--> <!-->1.8). Dimethyl fumarate (32.6%) was the most frequently prescribed treatment, followed by teriflunomide (24.8%) and glatiramer acetate (17.6%). According to over 87% of the specialists, the latter drug was considered the most appropriate treatment for patients with liver disorders, who intended to become pregnant, and who presented low disease activity.</div></div><div><h3>Conclusions</h3><div>Our study provides evidence on the first-line therapeutic management of non-aggressive forms of RRMS and the factors influencing decision-making in routine clinical practice.</div></div>","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"5 1","pages":"Article 100178"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143133607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/S2667-0496(24)00052-8
L. Gómez Dabó, R. Mas de les Valls, V. Gallardo Gómez-Dabó, A. Alpuente, M. Torres Ferrús, E. Caronna, E. Giné Ciprés, P. Pozo Rosich
{"title":"20886. EFECTIVIDAD DEL TRATAMIENTO CON TOXINA BOTULÍNICA Y ANTICUERPOS MONOCLONALES ANTI-CGRP EN LA MIGRAÑA ASOCIADA A LA MENSTRUACIÓN","authors":"L. Gómez Dabó, R. Mas de les Valls, V. Gallardo Gómez-Dabó, A. Alpuente, M. Torres Ferrús, E. Caronna, E. Giné Ciprés, P. Pozo Rosich","doi":"10.1016/S2667-0496(24)00052-8","DOIUrl":"10.1016/S2667-0496(24)00052-8","url":null,"abstract":"","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"4 ","pages":"Pages 4-5"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143129338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/S2667-0496(24)00077-2
C. Peña Bautista, L. Álvarez Sánchez, Á. Balaguer, L. Raga, L. García Vallés, M. Baquero, C. Cháfer Pericás
{"title":"21118. IDENTIFICACIÓN DE RUTAS METABÓLICAS AFECTADAS EN LA ENFERMEDAD DE ALZHEIMER Y POTENCIALES BIOMARCADORES A PARTIR DEL ESTUDIO PROTEÓMICO EN LCR","authors":"C. Peña Bautista, L. Álvarez Sánchez, Á. Balaguer, L. Raga, L. García Vallés, M. Baquero, C. Cháfer Pericás","doi":"10.1016/S2667-0496(24)00077-2","DOIUrl":"10.1016/S2667-0496(24)00077-2","url":null,"abstract":"","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"4 ","pages":"Page 13"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143129764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/S2667-0496(24)00099-1
E. Valeriano Lorenzo, D. García, S. Wagner, A. Ruiz, A. Pastor, B. Frades, M. Valentí, M. Riccardi, M. Zea Sevilla, M. Antón, T. del Ser, P. Sánchez Juan
{"title":"20820. LOS NIVELES DE P-TAU217 EN SANGRE PREDICEN LAS TRAYECTORIAS COGNITIVAS A 10 AÑOS EN ANCIANOS COGNITIVAMENTE SANOS DEL PROYECTO VALLECAS","authors":"E. Valeriano Lorenzo, D. García, S. Wagner, A. Ruiz, A. Pastor, B. Frades, M. Valentí, M. Riccardi, M. Zea Sevilla, M. Antón, T. del Ser, P. Sánchez Juan","doi":"10.1016/S2667-0496(24)00099-1","DOIUrl":"10.1016/S2667-0496(24)00099-1","url":null,"abstract":"","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"4 ","pages":"Page 20"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143131320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/S2667-0496(24)00133-9
J. Marta Enguita, P. de la Riva Juez, A. de Arce Borda, N. Díez González, F. González López, A. Vinagre Aragón, R. Laspiur Gandara, A. López de Turiso, F. Zubia Olaskoaga, C. del Bosque Martín, M. Martínez Zabaleta
{"title":"20779. OPTIMIZACIÓN DE ALGORITMO DE INDICACIÓN DE MONITORIZACIÓN HOLTER PROLONGADA EN DOMICILIO TRAS ICTUS CRIPTOGÉNICO-ESUS","authors":"J. Marta Enguita, P. de la Riva Juez, A. de Arce Borda, N. Díez González, F. González López, A. Vinagre Aragón, R. Laspiur Gandara, A. López de Turiso, F. Zubia Olaskoaga, C. del Bosque Martín, M. Martínez Zabaleta","doi":"10.1016/S2667-0496(24)00133-9","DOIUrl":"10.1016/S2667-0496(24)00133-9","url":null,"abstract":"","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"4 ","pages":"Pages 30-31"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143131412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/S2667-0496(24)00079-6
J. Arriola Infante, A. Morcillo Nieto, S. Zsadanyi, M. Franquesa Mullerat, L. Vaqué Alcázar, M. Rozalem Aranha, J. Arranz Martínez, Í. Rodríguez Baz, L. Maure Blesa, L. Videla Toro, I. Barroeta Espar, L. del Hoyo Soriano, B. Benejam, S. Fernández González, A. Sanjuán Hernández, N. Zhu, J. García Castro, S. Rubio Guerra, E. Vera Campuzano, J. Selma González, A. Bejanin
{"title":"21619. PATRONES DE METABOLISMO CEREBRAL EN EL CONTINUUM DE LA ENFERMEDAD DE ALZHEIMER EN EL SÍNDROME DE DOWN","authors":"J. Arriola Infante, A. Morcillo Nieto, S. Zsadanyi, M. Franquesa Mullerat, L. Vaqué Alcázar, M. Rozalem Aranha, J. Arranz Martínez, Í. Rodríguez Baz, L. Maure Blesa, L. Videla Toro, I. Barroeta Espar, L. del Hoyo Soriano, B. Benejam, S. Fernández González, A. Sanjuán Hernández, N. Zhu, J. García Castro, S. Rubio Guerra, E. Vera Campuzano, J. Selma González, A. Bejanin","doi":"10.1016/S2667-0496(24)00079-6","DOIUrl":"10.1016/S2667-0496(24)00079-6","url":null,"abstract":"","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"4 ","pages":"Page 13"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143148267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/S2667-0496(24)00138-8
C. Sanabria Gago, R. Berbegal Serralta, J. Alonso Maroto, V. Escribano Hernández, B. Colino Galián, E. Salgado Barbado, M. Sobrado Sanz, C. Ramos Marín, Á. Ximénez-Carrillo Rico, E. de la Fuente Sanz, A. González Martínez, C. Sánchez Rodríguez, A. Somovillla, J. Vivancos Mora, S. Trillo Senín
{"title":"21071. UTILIDAD DE LA DETERMINACIÓN DE PROADRENOMODULINA EN EL CÓDIGO ICTUS: ESTUDIO PRESTO","authors":"C. Sanabria Gago, R. Berbegal Serralta, J. Alonso Maroto, V. Escribano Hernández, B. Colino Galián, E. Salgado Barbado, M. Sobrado Sanz, C. Ramos Marín, Á. Ximénez-Carrillo Rico, E. de la Fuente Sanz, A. González Martínez, C. Sánchez Rodríguez, A. Somovillla, J. Vivancos Mora, S. Trillo Senín","doi":"10.1016/S2667-0496(24)00138-8","DOIUrl":"10.1016/S2667-0496(24)00138-8","url":null,"abstract":"","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"4 ","pages":"Page 32"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143148630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/S2667-0496(24)00050-4
A. González Martínez, M. García-Castillo, Á. Sierra-Mencía, A. Recio García, Á. Guerrero-Peral, A. Sánchez-Soblechero, E. Luque Buzo, A. Lozano-Ros, S. Urtiaga, M. González-Salaices, D. Toledo, A. Muñoz-Vendrell, S. Campoy, M. Huerta, G. Martín Ávila, J. Casas-Limón, S. Santos-Lasaosa, M. Polanco, V. González-Quintanilla, J. Pascual, A. González-Martínez
{"title":"20741. ¿SON LOS FÁRMACOS ANTI-CGRP UNA OPCIÓN EFECTIVA Y SEGURA PARA PACIENTES CON ENFERMEDADES AUTOINMUNES? RESULTADOS DEL PROYECTO MULTICÉNTRICO “IMMUNOCGRP STUDY” EN MIGRAÑA","authors":"A. González Martínez, M. García-Castillo, Á. Sierra-Mencía, A. Recio García, Á. Guerrero-Peral, A. Sánchez-Soblechero, E. Luque Buzo, A. Lozano-Ros, S. Urtiaga, M. González-Salaices, D. Toledo, A. Muñoz-Vendrell, S. Campoy, M. Huerta, G. Martín Ávila, J. Casas-Limón, S. Santos-Lasaosa, M. Polanco, V. González-Quintanilla, J. Pascual, A. González-Martínez","doi":"10.1016/S2667-0496(24)00050-4","DOIUrl":"10.1016/S2667-0496(24)00050-4","url":null,"abstract":"","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"4 ","pages":"Page 4"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/S2667-0496(24)00113-3
N. Guillén Soley, J. Sarto Alonso, D. Esteller Gauxax, I. Perales, J. Jose Ríos Guillermo, J. Augé, L. Naranjo, R. Ruiz García, J. Juncà Parella, A. Tort Merino, G. Fernández Villullas, A. Alberique, Y. González, A. Antonell, S. Borrego Écija, M. Castellví, B. Bosch, A. del Val Guardiola, R. Sánchez Valle, M. Balasa, A. Lladó
{"title":"21116. PROGRESIÓN CLÍNICA Y BIOMARCADORES PRONÓSTICOS EN LA ENFERMEDAD DE ALZHEIMER","authors":"N. Guillén Soley, J. Sarto Alonso, D. Esteller Gauxax, I. Perales, J. Jose Ríos Guillermo, J. Augé, L. Naranjo, R. Ruiz García, J. Juncà Parella, A. Tort Merino, G. Fernández Villullas, A. Alberique, Y. González, A. Antonell, S. Borrego Écija, M. Castellví, B. Bosch, A. del Val Guardiola, R. Sánchez Valle, M. Balasa, A. Lladó","doi":"10.1016/S2667-0496(24)00113-3","DOIUrl":"10.1016/S2667-0496(24)00113-3","url":null,"abstract":"","PeriodicalId":74283,"journal":{"name":"Neurology perspectives","volume":"4 ","pages":"Pages 24-25"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143129085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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