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Neurology perspectives最新文献

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Stroke machine learning for discharge planning: A pilot implementation study 用于出院规划的脑卒中机器学习：试点实施研究
Neurology perspectives
Pub Date : 2025-01-30 DOI: 10.1016/j.neurop.2025.100183
S. Bacchi , R. Goh , J. Kovoor , S. Gluck , L. Oakden-Rayner , S. Koblar , T. Kleinig , J. Jannes
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引用次数: 0
Late-onset myoclonic epilepsy in Down syndrome (LOMEDS) and efficacy of perampanel 唐氏综合征迟发性肌阵挛性癫痫（LOMEDS）和perampanel的疗效
Neurology perspectives
Pub Date : 2025-01-30 DOI: 10.1016/j.neurop.2025.100184
Nazaret Peláez Vina , D.D. Bórquez , E.N. Moral , M. Cáceres
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引用次数: 0
Ibero-American consensus statement on migraine treatment 伊比利亚-美洲偏头痛治疗共识声明
Neurology perspectives
Pub Date : 2025-01-01 DOI: 10.1016/j.neurop.2024.100182
José Miguel Láinez , Oscar Pradilla , Pablo Irimia , Fidel Sobrino , Michel Volcy , Pedro Kowaks , Ildefonso Rodríguez Leyva , Fiorella Martín , Lucía Zavala , Alex Espinoza

Introduction and objectives

Migraine is the most common reason for neurology outpatient consultation; more than 80% of patients with migraine suffer some degree of associated disability. Migraine is an underdiagnosed disorder and patients frequently receive inappropriate treatment, which is why it is necessary to establish recommendations to improve patient management. The objective of this document is to establish a consensus position on the pharmacological treatment of migraine, including general measures and detailed analysis of the different options for the treatment of attacks and their prevention, from the perspective of Ibero-American countries.

Methods and results

Based on the recommendation documents published by the scientific societies of different Ibero-American countries, 2 surveys were prepared; through the application of the Delphi methodology and discussions in subsequent meetings, a document was developed in consensus format, supported by evidence from the literature and expert recommendations.

Conclusions

A series of recommendations were agreed upon for the treatment of episodic migraine and chronic migraine, both for the acute management of attacks and for their prevention. These recommendations are based on the consensus process and a literature review, and are adapted to the regional conditions of the Ibero-American countries.
前言和目的偏头痛是神经科门诊就诊最常见的原因；超过80%的偏头痛患者患有某种程度的相关残疾。偏头痛是一种未被充分诊断的疾病，患者经常接受不适当的治疗，这就是为什么有必要建立改善患者管理的建议。本文件的目的是从伊比利亚-美洲国家的角度，就偏头痛的药物治疗建立共识立场，包括一般措施和对治疗发作及其预防的不同选择的详细分析。方法与结果以伊比利亚-美洲不同国家科学学会发表的建议文件为基础，编制了2项调查；通过德尔菲方法的应用和随后会议的讨论，在文献和专家建议的证据支持下，以协商一致的形式制定了一份文件。结论针对发作性偏头痛和慢性偏头痛的急性发作管理和预防提出了一系列治疗建议。这些建议是根据协商一致进程和文献审查提出的，并根据伊比利亚-美洲国家的区域条件加以调整。
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引用次数: 0
Survey on first-line therapeutic management of relapsing–remitting multiple sclerosis in clinical practice in Spain 西班牙临床实践中复发-缓解型多发性硬化症一线治疗管理的调查
Neurology perspectives
Pub Date : 2025-01-01 DOI: 10.1016/j.neurop.2024.100178
M. Llaneza , G. Fontes , L. Benedito-Palos , E. Moral

Introduction

Current therapies for relapsing–remitting multiple sclerosis (RRMS) help reduce morbidity and delay disease progression. However, the available information on factors influencing decision-making regarding first-line treatment remain poorly understood.

Methods

Based on a review of the literature and the experience of a scientific committee made up by 2 neurologists, an ad hoc survey was developed and distributed to Spanish neurologists. It included 22 questions related to the first-line therapeutic management of RRMS.

Results

Sixty neurologists (mean age: 45.6 years, 60% women, mean of 16.0 years of experience, mean of 93.8 patients with RRMS attended/month) participated in the study. Neurologists considered that the 3 most important treatment characteristics (1–8 points, with higher scores denoting greater relevance) in treatment decision-making were efficacy in disease control (7.8 ± 0.5), safety/tolerability (6.7 ± 0.9), and improvements in patient quality of life (5.0 ± 1.5); regarding patient characteristics, the 3 most important (1–7 points) were disease activity (6.9 ± 0.5), intention to become pregnant (5.0 ± 1.0), and level of disability (4.3 ± 1.8). Dimethyl fumarate (32.6%) was the most frequently prescribed treatment, followed by teriflunomide (24.8%) and glatiramer acetate (17.6%). According to over 87% of the specialists, the latter drug was considered the most appropriate treatment for patients with liver disorders, who intended to become pregnant, and who presented low disease activity.

Conclusions

Our study provides evidence on the first-line therapeutic management of non-aggressive forms of RRMS and the factors influencing decision-making in routine clinical practice.
当前治疗复发缓解型多发性硬化症（RRMS）有助于降低发病率和延缓疾病进展。然而，关于影响一线治疗决策因素的现有信息仍然知之甚少。方法基于文献回顾和由2名神经科医生组成的科学委员会的经验，制定了一项特别调查，并向西班牙神经科医生分发。它包括22个与RRMS一线治疗管理相关的问题。结果60名神经科医生（平均年龄45.6 岁，60%为女性，平均经验16.0 年，平均93.8例RRMS患者/月参加）参与了研究。神经科医师认为治疗决策中最重要的3个治疗特征（1-8分，得分越高相关性越大）是疾病控制的有效性（7.8±0.5）、安全性/耐受性（6.7±0.9）和患者生活质量的改善（5.0±1.5）；在患者特征方面，最重要的3个（1-7分）是疾病活动性（6.9±0.5）、怀孕意向（5.0±1.0）和残疾程度（4.3±1.8）。富马酸二甲酯（32.6%）是最常用的治疗方法，其次是特立氟米特（24.8%）和醋酸格拉替雷默（17.6%）。根据超过87%的专家，后一种药物被认为是肝病患者最合适的治疗方法，这些患者打算怀孕，疾病活动性低。结论本研究为非侵袭性RRMS的一线治疗管理及临床常规决策的影响因素提供了依据。
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引用次数: 0
20886. EFECTIVIDAD DEL TRATAMIENTO CON TOXINA BOTULÍNICA Y ANTICUERPOS MONOCLONALES ANTI-CGRP EN LA MIGRAÑA ASOCIADA A LA MENSTRUACIÓN 20886. 用肉毒杆菌毒素和单克隆抗cgrp药物治疗与培训有关的移民的效果
Neurology perspectives
Pub Date : 2024-11-01 DOI: 10.1016/S2667-0496(24)00052-8
L. Gómez Dabó, R. Mas de les Valls, V. Gallardo Gómez-Dabó, A. Alpuente, M. Torres Ferrús, E. Caronna, E. Giné Ciprés, P. Pozo Rosich
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引用次数: 0
21619. PATRONES DE METABOLISMO CEREBRAL EN EL CONTINUUM DE LA ENFERMEDAD DE ALZHEIMER EN EL SÍNDROME DE DOWN 21619. 阿尔茨海默氏症在唐氏综合症连续体中的脑部代谢模式
Neurology perspectives
Pub Date : 2024-11-01 DOI: 10.1016/S2667-0496(24)00079-6
J. Arriola Infante, A. Morcillo Nieto, S. Zsadanyi, M. Franquesa Mullerat, L. Vaqué Alcázar, M. Rozalem Aranha, J. Arranz Martínez, Í. Rodríguez Baz, L. Maure Blesa, L. Videla Toro, I. Barroeta Espar, L. del Hoyo Soriano, B. Benejam, S. Fernández González, A. Sanjuán Hernández, N. Zhu, J. García Castro, S. Rubio Guerra, E. Vera Campuzano, J. Selma González, A. Bejanin
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引用次数: 0
21071. UTILIDAD DE LA DETERMINACIÓN DE PROADRENOMODULINA EN EL CÓDIGO ICTUS: ESTUDIO PRESTO 21071. 确定proadrenomodulin在现行法典中的作用：本研究
Neurology perspectives
Pub Date : 2024-11-01 DOI: 10.1016/S2667-0496(24)00138-8
C. Sanabria Gago, R. Berbegal Serralta, J. Alonso Maroto, V. Escribano Hernández, B. Colino Galián, E. Salgado Barbado, M. Sobrado Sanz, C. Ramos Marín, Á. Ximénez-Carrillo Rico, E. de la Fuente Sanz, A. González Martínez, C. Sánchez Rodríguez, A. Somovillla, J. Vivancos Mora, S. Trillo Senín
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引用次数: 0
21118. IDENTIFICACIÓN DE RUTAS METABÓLICAS AFECTADAS EN LA ENFERMEDAD DE ALZHEIMER Y POTENCIALES BIOMARCADORES A PARTIR DEL ESTUDIO PROTEÓMICO EN LCR 21118. 从LCR蛋白质组学研究中确定受阿尔茨海默病影响的代谢途径和潜在的生物标志物
Neurology perspectives
Pub Date : 2024-11-01 DOI: 10.1016/S2667-0496(24)00077-2
C. Peña Bautista, L. Álvarez Sánchez, Á. Balaguer, L. Raga, L. García Vallés, M. Baquero, C. Cháfer Pericás
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引用次数: 0
20820. LOS NIVELES DE P-TAU217 EN SANGRE PREDICEN LAS TRAYECTORIAS COGNITIVAS A 10 AÑOS EN ANCIANOS COGNITIVAMENTE SANOS DEL PROYECTO VALLECAS 20820. 血液中的P-TAU217水平预测了认知能力较强的老年人在山谷项目中的认知能力可达10年
Neurology perspectives
Pub Date : 2024-11-01 DOI: 10.1016/S2667-0496(24)00099-1
E. Valeriano Lorenzo, D. García, S. Wagner, A. Ruiz, A. Pastor, B. Frades, M. Valentí, M. Riccardi, M. Zea Sevilla, M. Antón, T. del Ser, P. Sánchez Juan
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引用次数: 0
20779. OPTIMIZACIÓN DE ALGORITMO DE INDICACIÓN DE MONITORIZACIÓN HOLTER PROLONGADA EN DOMICILIO TRAS ICTUS CRIPTOGÉNICO-ESUS 20779. 通过隐生孢子虫对房屋进行监测的旅馆指标算法的优化
Neurology perspectives
Pub Date : 2024-11-01 DOI: 10.1016/S2667-0496(24)00133-9
J. Marta Enguita, P. de la Riva Juez, A. de Arce Borda, N. Díez González, F. González López, A. Vinagre Aragón, R. Laspiur Gandara, A. López de Turiso, F. Zubia Olaskoaga, C. del Bosque Martín, M. Martínez Zabaleta
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