Pub Date : 2023-10-01DOI: 10.3171/2023.7.FOCVID2379
Mohamed Macki, Vardhaan S Ambati, Christine Park, Michael Tawil, Abraham Dada, Alysha Jamieson, Sean Wilkinson, Timothy Chryssikos, Praveen V Mummaneni
A 60-year-old male with renal cell carcinoma (RCC) presented with back pain, weakness, and bowel and bladder urgency. MRI demonstrated a cauda equina tumor at L2. Following L1-3 laminectomies, intraoperative ultrasound localized the tumor. After dural opening, a vascular tumor was adherent to the cauda equina. Intraoperative nerve stimulation helped to identify the nerve rootlets. Tumor was removed in a piecemeal fashion. Tumor dissection caused periodic spasms in L1-3 distributions. A neuromonitoring checklist was used to recover motor evoked potential signals with elevated mean arterial pressures. Hemostasis was challenging with the vascular tumor. Intraoperative ultrasound confirmed tumor debulking. Pathology confirmed metastatic RCC.
{"title":"Surgical resection of lumbar intradural metastatic renal cell carcinoma.","authors":"Mohamed Macki, Vardhaan S Ambati, Christine Park, Michael Tawil, Abraham Dada, Alysha Jamieson, Sean Wilkinson, Timothy Chryssikos, Praveen V Mummaneni","doi":"10.3171/2023.7.FOCVID2379","DOIUrl":"https://doi.org/10.3171/2023.7.FOCVID2379","url":null,"abstract":"<p><p>A 60-year-old male with renal cell carcinoma (RCC) presented with back pain, weakness, and bowel and bladder urgency. MRI demonstrated a cauda equina tumor at L2. Following L1-3 laminectomies, intraoperative ultrasound localized the tumor. After dural opening, a vascular tumor was adherent to the cauda equina. Intraoperative nerve stimulation helped to identify the nerve rootlets. Tumor was removed in a piecemeal fashion. Tumor dissection caused periodic spasms in L1-3 distributions. A neuromonitoring checklist was used to recover motor evoked potential signals with elevated mean arterial pressures. Hemostasis was challenging with the vascular tumor. Intraoperative ultrasound confirmed tumor debulking. Pathology confirmed metastatic RCC.</p>","PeriodicalId":74299,"journal":{"name":"Neurosurgical focus: Video","volume":"9 2","pages":"V22"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49685913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.3171/2023.6.FOCVID2386
Lea Scherschinski, Ethan A Winkler, Charuta G Furey, Timothy C Gooldy, Joshua S Catapano, Michael T Lawton
Spinal cord ependymomas comprise 25% of all intramedullary tumors and are typically treated with resection. A man in his mid-60s presented with imbalance and sensory deficits in both lower extremities, and a spinal thoracic intramedullary ependymoma spanning the levels T2 and T3 was diagnosed. After a laminectomy was performed, the tumor was microsurgically resected, and the patient demonstrated no neurological deficits on postoperative examination. Subsequent MRI showed complete resection of the tumor. This video showcases a thoracic intramedullary ependymoma resected using careful microdissection into the median raphe as a safe entry zone to preserve neurological function.
{"title":"Thoracic laminectomy and midline myelotomy for resection of a spinal ependymoma.","authors":"Lea Scherschinski, Ethan A Winkler, Charuta G Furey, Timothy C Gooldy, Joshua S Catapano, Michael T Lawton","doi":"10.3171/2023.6.FOCVID2386","DOIUrl":"https://doi.org/10.3171/2023.6.FOCVID2386","url":null,"abstract":"<p><p>Spinal cord ependymomas comprise 25% of all intramedullary tumors and are typically treated with resection. A man in his mid-60s presented with imbalance and sensory deficits in both lower extremities, and a spinal thoracic intramedullary ependymoma spanning the levels T2 and T3 was diagnosed. After a laminectomy was performed, the tumor was microsurgically resected, and the patient demonstrated no neurological deficits on postoperative examination. Subsequent MRI showed complete resection of the tumor. This video showcases a thoracic intramedullary ependymoma resected using careful microdissection into the median raphe as a safe entry zone to preserve neurological function.</p>","PeriodicalId":74299,"journal":{"name":"Neurosurgical focus: Video","volume":"9 2","pages":"V15"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49685918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.3171/2023.6.FOCVID2377
Serdar Rahmanov, Yücel Doğruel, Abuzer Güngör, Uğur Türe
The surgical management of ventral upper cervical meningiomas poses significant challenges due to their deep location and limited accessibility. These tumors have the potential to compress or involve nearby neurovascular structures, leading to various neurological complications including inferior cranial nerve palsy, motor deficits, and sensory disturbances such as hypoesthesia, paresthesia, and impaired coordination. To address this issue, surgical intervention through an anterolateral or far lateral approach has been recognized as the optimal treatment strategy. In this video, the authors present a detailed demonstration of the operative technique using an anterolateral upper cervical approach to safely resect a ventrally located C1-2 meningioma.
{"title":"Anterolateral upper cervical approach for ventral C1-C2 meningioma.","authors":"Serdar Rahmanov, Yücel Doğruel, Abuzer Güngör, Uğur Türe","doi":"10.3171/2023.6.FOCVID2377","DOIUrl":"https://doi.org/10.3171/2023.6.FOCVID2377","url":null,"abstract":"<p><p>The surgical management of ventral upper cervical meningiomas poses significant challenges due to their deep location and limited accessibility. These tumors have the potential to compress or involve nearby neurovascular structures, leading to various neurological complications including inferior cranial nerve palsy, motor deficits, and sensory disturbances such as hypoesthesia, paresthesia, and impaired coordination. To address this issue, surgical intervention through an anterolateral or far lateral approach has been recognized as the optimal treatment strategy. In this video, the authors present a detailed demonstration of the operative technique using an anterolateral upper cervical approach to safely resect a ventrally located C1-2 meningioma.</p>","PeriodicalId":74299,"journal":{"name":"Neurosurgical focus: Video","volume":"9 2","pages":"V8"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49685899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.3171/2023.7.FOCVID2366
Marianna Di Costanzo, Pietro Spennato, Francesca Vitulli, Maria Allegra Cinalli, Maria De Liso, Claudio Ruggiero, Giuseppe Cinalli
Epidermoid cysts are rare, benign neoplasms that account for less than 1% of all intraspinal tumors. The most common localization is in the lumbar area, and one-third of the tumors are intramedullary. In this video, the authors present removal of a thoracic intramedullary epidermoid tumor in a 6-year-old boy, carrier of a 22q11 gene duplication and affected by psychomotor retardation. He presented a 1-year history of progressive gait impairment. No history of lumbar puncture or trauma was reported. The procedure was performed under neurophysiological monitoring, and it was uneventful with complete recovery of neurological function. Technical nuances are illustrated.
{"title":"Removal of a thoracic intramedullary epidermoid tumor in a child.","authors":"Marianna Di Costanzo, Pietro Spennato, Francesca Vitulli, Maria Allegra Cinalli, Maria De Liso, Claudio Ruggiero, Giuseppe Cinalli","doi":"10.3171/2023.7.FOCVID2366","DOIUrl":"https://doi.org/10.3171/2023.7.FOCVID2366","url":null,"abstract":"<p><p>Epidermoid cysts are rare, benign neoplasms that account for less than 1% of all intraspinal tumors. The most common localization is in the lumbar area, and one-third of the tumors are intramedullary. In this video, the authors present removal of a thoracic intramedullary epidermoid tumor in a 6-year-old boy, carrier of a 22q11 gene duplication and affected by psychomotor retardation. He presented a 1-year history of progressive gait impairment. No history of lumbar puncture or trauma was reported. The procedure was performed under neurophysiological monitoring, and it was uneventful with complete recovery of neurological function. Technical nuances are illustrated.</p>","PeriodicalId":74299,"journal":{"name":"Neurosurgical focus: Video","volume":"9 2","pages":"V17"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49685906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.3171/2023.7.FOCVID2351
Joseph Yunga Tigre, Adam Levy, Eva M Wu, James Boddu, Vignessh Kumar, Allan D Levi, S Shelby Burks
Large ventrally located spinal meningiomas are typically resected via a posterolateral or lateral approach. Optimal outcomes are associated with good preoperative functional status (i.e., modified McCormick grade < 4), while recurrence rates may be predicted by degree and quality of resection (i.e., low Simpson grade). This video describes the operative techniques for resection of a large ventral C2 intradural extramedullary meningioma in a 71-year-old male presenting with hemibody sensory loss and abnormal gait. A paramedian approach was performed, allowing for adequate exposure and gross-total resection. The patient was discharged on postoperative day 2 and showed near-complete resolution of sensory deficits.
{"title":"Surgical resection of an intradural extramedullary spinal tumor.","authors":"Joseph Yunga Tigre, Adam Levy, Eva M Wu, James Boddu, Vignessh Kumar, Allan D Levi, S Shelby Burks","doi":"10.3171/2023.7.FOCVID2351","DOIUrl":"https://doi.org/10.3171/2023.7.FOCVID2351","url":null,"abstract":"<p><p>Large ventrally located spinal meningiomas are typically resected via a posterolateral or lateral approach. Optimal outcomes are associated with good preoperative functional status (i.e., modified McCormick grade < 4), while recurrence rates may be predicted by degree and quality of resection (i.e., low Simpson grade). This video describes the operative techniques for resection of a large ventral C2 intradural extramedullary meningioma in a 71-year-old male presenting with hemibody sensory loss and abnormal gait. A paramedian approach was performed, allowing for adequate exposure and gross-total resection. The patient was discharged on postoperative day 2 and showed near-complete resolution of sensory deficits.</p>","PeriodicalId":74299,"journal":{"name":"Neurosurgical focus: Video","volume":"9 2","pages":"V9"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49685912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.3171/2023.7.FOCVID2393
Joseph S Bell, Ulrich Batzdorf, Langston T Holly
This video depicts the resection of three separate intradural extramedullary spinal tumors performed under the same anesthetic. Neuromonitoring was used to identify motor nerve roots, and laminoplasty was performed at the thoracolumbar junction to preserve alignment and minimize the risk of postoperative CSF leak.
{"title":"Tandem resection of multiple spinal schwannomas.","authors":"Joseph S Bell, Ulrich Batzdorf, Langston T Holly","doi":"10.3171/2023.7.FOCVID2393","DOIUrl":"https://doi.org/10.3171/2023.7.FOCVID2393","url":null,"abstract":"<p><p>This video depicts the resection of three separate intradural extramedullary spinal tumors performed under the same anesthetic. Neuromonitoring was used to identify motor nerve roots, and laminoplasty was performed at the thoracolumbar junction to preserve alignment and minimize the risk of postoperative CSF leak.</p>","PeriodicalId":74299,"journal":{"name":"Neurosurgical focus: Video","volume":"9 2","pages":"V21"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49685915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.3171/2023.7.FOCVID2361
Brandon M Wilkinson, Disep I Ojukwu, Timothy Dawson, Cheerag Upadhyaya, Michael A Galgano
The majority of spinal nerve sheath tumors are within the intradural/extramedullary compartment. A subset of these tumors develop extraforaminal components that gradually expand into potential spaces. Herein, the authors provide a 2D video demonstrating the technical nuances concerning resection of cervical dumbbell schwannomas with extraspinal extension. Although nerve sheath tumors with large extraforaminal extension are often associated with complications and pose unique challenges to surgeons, circumferential exposure with intradural exploration allows for gross-total resection and nerve root preservation, without need for adjuvant treatments. The use of intraoperative ultrasound, neurophysiological monitoring, Doppler imaging, and meticulous surgical techniques aided to circumvent complications.
{"title":"Technical nuances for the resection of cervical dumbbell schwannomas.","authors":"Brandon M Wilkinson, Disep I Ojukwu, Timothy Dawson, Cheerag Upadhyaya, Michael A Galgano","doi":"10.3171/2023.7.FOCVID2361","DOIUrl":"https://doi.org/10.3171/2023.7.FOCVID2361","url":null,"abstract":"<p><p>The majority of spinal nerve sheath tumors are within the intradural/extramedullary compartment. A subset of these tumors develop extraforaminal components that gradually expand into potential spaces. Herein, the authors provide a 2D video demonstrating the technical nuances concerning resection of cervical dumbbell schwannomas with extraspinal extension. Although nerve sheath tumors with large extraforaminal extension are often associated with complications and pose unique challenges to surgeons, circumferential exposure with intradural exploration allows for gross-total resection and nerve root preservation, without need for adjuvant treatments. The use of intraoperative ultrasound, neurophysiological monitoring, Doppler imaging, and meticulous surgical techniques aided to circumvent complications.</p>","PeriodicalId":74299,"journal":{"name":"Neurosurgical focus: Video","volume":"9 2","pages":"V14"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49685916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.3171/2023.7.FOCVID2378
Daniel M Aaronson, Brandon Laing, Randall Treffy, Saman Shabani
In this video, the authors present the resection of a large thoracolumbar intradural ependymoma in a 33-year-old female. The patient underwent T9-L3 laminectomies, intradural tumor resection, and posterior instrumented fixation and fusion. The surgical procedure aimed to relieve the mass effect, obtain a diagnosis, prevent further neurological decline, and achieve a potential curative resection. The pathology confirmed a myxopapillary ependymoma, a rare tumor with a preference for the conus medullaris, cauda equina, or filum terminale. The video provides insights into the case, surgical steps, clinical outcomes, and background information on myxopapillary ependymomas and treatment options.
{"title":"Resection of a large thoracolumbar intradural ependymoma: a 2D operative video.","authors":"Daniel M Aaronson, Brandon Laing, Randall Treffy, Saman Shabani","doi":"10.3171/2023.7.FOCVID2378","DOIUrl":"https://doi.org/10.3171/2023.7.FOCVID2378","url":null,"abstract":"<p><p>In this video, the authors present the resection of a large thoracolumbar intradural ependymoma in a 33-year-old female. The patient underwent T9-L3 laminectomies, intradural tumor resection, and posterior instrumented fixation and fusion. The surgical procedure aimed to relieve the mass effect, obtain a diagnosis, prevent further neurological decline, and achieve a potential curative resection. The pathology confirmed a myxopapillary ependymoma, a rare tumor with a preference for the conus medullaris, cauda equina, or filum terminale. The video provides insights into the case, surgical steps, clinical outcomes, and background information on myxopapillary ependymomas and treatment options.</p>","PeriodicalId":74299,"journal":{"name":"Neurosurgical focus: Video","volume":"9 2","pages":"V16"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49685908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.3171/2023.7.FOCVID2394
Jennifer L Perez, Maria D Astudillo Potes, Juliana C Rotter, Megan C Everson, Aditya Raghunathan, Michelle J Clarke
Spinal subependymomas (SE) are rare, often indolent benign tumors presenting most frequently as intramedullary tumors in the cervical spine or cervicothoracic junction. When symptomatic, patients often present with years of sensory changes, weakness, paresthesias, or bowel and bladder dysfunction. Preoperatively, SE are difficult to distinguish radiographically from ependymomas or astrocytomas; however, it is important to make the distinction intraoperatively as complete resection can be curative. Here the authors present a rare case of recurrent, symptomatic cervical subependymoma which underwent gross-total resection and discussion of management strategies and outcomes of all SE at their institution.
{"title":"Surgical resection of recurrent intramedullary subependymoma of the cervical spinal cord.","authors":"Jennifer L Perez, Maria D Astudillo Potes, Juliana C Rotter, Megan C Everson, Aditya Raghunathan, Michelle J Clarke","doi":"10.3171/2023.7.FOCVID2394","DOIUrl":"https://doi.org/10.3171/2023.7.FOCVID2394","url":null,"abstract":"<p><p>Spinal subependymomas (SE) are rare, often indolent benign tumors presenting most frequently as intramedullary tumors in the cervical spine or cervicothoracic junction. When symptomatic, patients often present with years of sensory changes, weakness, paresthesias, or bowel and bladder dysfunction. Preoperatively, SE are difficult to distinguish radiographically from ependymomas or astrocytomas; however, it is important to make the distinction intraoperatively as complete resection can be curative. Here the authors present a rare case of recurrent, symptomatic cervical subependymoma which underwent gross-total resection and discussion of management strategies and outcomes of all SE at their institution.</p>","PeriodicalId":74299,"journal":{"name":"Neurosurgical focus: Video","volume":"9 2","pages":"V7"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49685914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.3171/2023.7.FOCVID2317
Jun-Hoe Kim, Chun Kee Chung
Although resection is the gold standard treatment for spinal ependymoma, permanent neurological deterioration has been reported postoperatively in 20%-27% of patients. Despite thorough dissection of the tumor from its surroundings, conventional longitudinally directed midline myelotomy can lead to injury to the dorsal column, possibly due to deformation of the posterior median septum as the tumor grows. To address this issue, the authors have been performing precise midline myelotomy through the anatomical posterior median septum by directly dissecting the dorsal column. This video presents the principles and application of this technique.
{"title":"The precise midline myelotomy through anatomical posterior median septum by dissecting dorsal column in microsurgical resection of ependymoma (2-dimensional operative video).","authors":"Jun-Hoe Kim, Chun Kee Chung","doi":"10.3171/2023.7.FOCVID2317","DOIUrl":"https://doi.org/10.3171/2023.7.FOCVID2317","url":null,"abstract":"<p><p>Although resection is the gold standard treatment for spinal ependymoma, permanent neurological deterioration has been reported postoperatively in 20%-27% of patients. Despite thorough dissection of the tumor from its surroundings, conventional longitudinally directed midline myelotomy can lead to injury to the dorsal column, possibly due to deformation of the posterior median septum as the tumor grows. To address this issue, the authors have been performing precise midline myelotomy through the anatomical posterior median septum by directly dissecting the dorsal column. This video presents the principles and application of this technique.</p>","PeriodicalId":74299,"journal":{"name":"Neurosurgical focus: Video","volume":"9 2","pages":"V5"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10580751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49685917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}