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Abortion history and its association with current use of modern contraceptive methods in Luanda, Angola. 安哥拉罗安达的堕胎史及其与目前使用现代避孕方法的关系。
IF 1.8 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2018-07-16 eCollection Date: 2018-01-01 DOI: 10.2147/OAJC.S164736
Natalie Morris, Ndola Prata

Background: Women in sub-Saharan Africa often use abortion as a method of limiting their fertility and spacing births. However, it is not well understood whether having an abortion influences contraceptive behavior. The goal of this study was to examine associations between abortion history and use of a modern contraceptive method among women in Luanda, Angola.

Materials and methods: We analyzed data on 1,176 women aged 15-49 years from a 2012 cross-sectional study conducted in Luanda, Angola, which aimed to obtain general information on sexual and reproductive health indicators. The outcome and exposure were based on participant reports of past induced abortions and current use of a modern method. We used a modified Poisson regression with robust standard errors to estimate the relative risks of using a modern contraceptive method, given history of induced abortion.

Results: Among all respondents, 736 (62.6%) reported using a modern contraceptive method. The clear majority of the respondents (73.21%), regardless of abortion history, were using either no method, a traditional method, or condoms. Long-acting reversible contraceptive use was very low across all respondents (2.73%). The most common family planning method reported by women with a history of abortion was condoms (32.76%). Regression analysis demonstrated that women who had a history of abortion were 1.23 times more likely to use a modern contraceptive method as compared to those who never had an abortion (relative risk: 1.23; 95% CI: 1.10-1.36), after adjusting for potential confounders. Postregression estimations of predicted probabilities demonstrated that women with a history of abortion had an 80% probability of using a modern method (95% CI: 0.76-0.84), while those who never had an abortion had a 60% probability of using a modern method (95% CI: 0.59-0.61).

Conclusion: History of induced abortion was associated with use of a modern contraceptive method in our study population. The most common contraceptive used by women with a history of induced abortion was condoms, indicating that despite adoption of a modern method, many women are still at risk for an unintended pregnancy. Further research is needed to understand the causal factors underlying women's postabortion contraceptive choices.

背景:撒哈拉以南非洲地区的妇女经常将人工流产作为限制生育和生育间隔的一种方法。然而,人们对人工流产是否会影响避孕行为还不甚了解。本研究旨在探讨安哥拉罗安达妇女的人工流产史与使用现代避孕方法之间的关联:我们分析了2012年在安哥拉罗安达进行的一项横断面研究中1176名15-49岁女性的数据,该研究旨在获取有关性健康和生殖健康指标的一般信息。研究结果和暴露基于参与者对过去人工流产和目前使用现代方法的报告。我们使用带稳健标准误差的改良泊松回归法估算了在有人工流产史的情况下使用现代避孕方法的相对风险:在所有受访者中,有 736 人(62.6%)表示使用了现代避孕方法。绝大多数受访者(73.21%),无论是否有人工流产史,都没有使用任何避孕方法、传统避孕方法或避孕套。在所有受访者中,长效可逆避孕药的使用率非常低(2.73%)。有人工流产史的妇女最常用的计划生育方法是避孕套(32.76%)。回归分析表明,在对潜在的混杂因素进行调整后,与从未做过人工流产的妇女相比,有过人工流产史的妇女使用现代避孕方法的可能性要高出 1.23 倍(相对风险:1.23;95% CI:1.10-1.36)。对预测概率的回归估算表明,有过人工流产史的妇女使用现代避孕方法的概率为 80%(95% CI:0.76-0.84),而从未有过人工流产史的妇女使用现代避孕方法的概率为 60%(95% CI:0.59-0.61):结论:在我们的研究人群中,人工流产史与使用现代避孕方法有关。有人工流产史的妇女最常使用的避孕药具是安全套,这表明尽管采用了现代避孕方法,许多妇女仍有意外怀孕的风险。要了解妇女人工流产后选择避孕方法的因果关系,还需要进一步的研究。
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引用次数: 0
Does courtesy bias affect how clients report on objective and subjective measures of family planning service quality? A comparison between facility- and home-based interviews. 礼貌偏差是否会影响客户对计划生育服务质量的客观和主观衡量标准的报告?机构访谈与家庭访谈的比较。
Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2018-05-03 eCollection Date: 2017-01-01 DOI: 10.2147/OAJC.S153443
Waqas Hameed, Muhammad Ishaque, Xaher Gul, Junaid-Ur-Rehman Siddiqui, Sharmeen Hussain, Wajahat Hussain, Aftab Ahmed, Asma Balal

Purpose: Despite a general understanding that exit interviews being conducted at service providers' facilities may influence clients' responses favorably to health professionals, there is very little evidence available that demonstrates the extent to which this problem exists. This study aimed at assessing and comparing clients' perceptions of the quality of family planning services and their satisfaction levels between facility- and home-based interviews.

Methods: A cross-sectional survey was conducted among clients receiving family planning services across three service delivery channels - nongovernmental organization (NGO) clinics, social franchise (SF) centers, and outreach camps. The survey took place from December 2015 to January 2016 in 70 districts across all four provinces of Pakistan. A total of 2,807 clients were interviewed, of whom 1,404 clients were interviewed at health facilities after receiving services and 1,403 were interviewed at their homes within 3 days of method uptake.

Results: Overall, we found no significant differences between the characteristics of study participants interviewed at health facilities or at home. The findings suggested that experiences reported in exit surveys at facilities were strongly biased positively. This was true for both experiential (service quality) and perception-based (satisfaction) questions in the context of SF centers, while at NGO clinics the interview location only affected clients' responses regarding service quality. However, in outreach settings, clients are more likely to share bad experiences in exit interviews than in home-based interviews on objectively asked questions (service quality).

Conclusion: Our study indicates signs of courtesy bias and possibly the Hawthorne effect in exit interviews. Program implementers could opt for home-based interviews for women receiving services at NGO clinics or SF center, whereas exit interviews could be used in outreach settings.

目的:尽管人们普遍认为,在服务机构进行的离职面谈可能会影响客户对医疗专业人员的良好反应,但能证明这一问题存在程度的证据却少之又少。本研究旨在评估和比较服务对象对计划生育服务质量的看法,以及他们对在医疗机构和家庭进行的访谈的满意程度:在三种服务提供渠道--非政府组织(NGO)诊所、社会特许经营(SF)中心和外展营地--接受计划生育服务的客户中进行了横断面调查。调查于 2015 年 12 月至 2016 年 1 月在巴基斯坦所有四个省的 70 个地区进行。共有 2,807 名客户接受了访谈,其中 1,404 名客户是在接受服务后在医疗机构接受的访谈,1,403 名客户是在接受方法后 3 天内在家中接受的访谈:总体而言,我们发现在医疗机构或在家中接受访谈的研究参与者的特征没有明显差异。研究结果表明,在医疗机构进行的离职调查报告的经历偏向于正面。在自费医疗中心,体验性问题(服务质量)和感知性问题(满意度)都是如此,而在非政府组织诊所,访谈地点只影响客户对服务质量的回答。然而,在外联环境中,就客观提问的问题(服务质量)而言,与在家访谈相比,客户更有可能在离职访谈中分享不好的经历:我们的研究表明,离职访谈中存在礼节性偏差的迹象,也可能存在霍桑效应。对于在非政府组织诊所或自立基金中心接受服务的妇女,计划实施者可以选择上门访谈,而在外联环境中则可以使用退出访谈。
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引用次数: 0
Drospirenone-containing oral contraceptives and venous thromboembolism: an analysis of the FAERS database. 含螺环酮的口服避孕药和静脉血栓栓塞:FAERS数据库的分析。
Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2018-04-11 eCollection Date: 2018-01-01 DOI: 10.2147/OAJC.S161737
David Madigan, Jennifer Shin

Introduction: Substantial evidence suggests that drospirenone-containing oral contraceptives may cause a higher risk of venous thrombotic events than earlier-generation oral contraceptives.

Methods: To gain insight into recent real-world implications, we conducted an analysis using the US Food and Drug Administration's Adverse Event Reporting System.

Results: Venous thrombotic events continue to be reported at a much higher rate with drospirenone-containing oral contraceptives than the general background. The disproportionality has been rising since 2010. The same behavior is not seen with levonorgestrel-containing oral contraceptives.

Conclusion: Our results are consistent with decreased physician and patient awareness of risks associated with drospirenone-containing oral contraceptives.

大量证据表明,含螺环酮的口服避孕药可能比早期口服避孕药引起静脉血栓事件的风险更高。方法:为了深入了解最近对现实世界的影响,我们使用美国食品和药物管理局的不良事件报告系统进行了分析。结果:静脉血栓事件的报道继续与含屈螺酮口服避孕药比一般背景高得多。自2010年以来,这一比例一直在上升。含有左炔诺孕酮的口服避孕药没有出现同样的行为。结论:我们的结果与医生和患者对含螺环酮的口服避孕药风险的认知下降是一致的。
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引用次数: 8
Domestic violence: a hidden barrier to contraceptive use among women in Nigeria. 家庭暴力:尼日利亚妇女使用避孕药具的一个隐藏障碍。
Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2018-01-25 eCollection Date: 2018-01-01 DOI: 10.2147/OAJC.S154733
Ghose Bishwajit, Sanni Yaya

Background: The nonuse of family planning methods remains a major public health concern in the low-and-middle-income countries, especially due to its impact on unwanted pregnancy, high rate of abortion, and transmission of sexually transmitted diseases. Various demographic and socioeconomic factors have been reported to be associated with the nonuse of family planning methods. In the present study, we aimed at assessing the influence of domestic violence (DV) on contraceptive use among ever married women in Nigeria.

Methods: Data on 22,275 women aged between 15 and 49 years were collected from the most recent Nigeria Demographic and Health Survey conducted in 2013. The outcome variable was contraceptive utilization status, and the main exposure variable was DV, which was assessed by the self-reported experience of physical and psychological abuse. Complex survey method was employed to account for the multistage design of the survey. Data analyses were performed by using bivariate and multivariable techniques.

Results: The mean age of the participants was 31.33±8.26. More than four fifths (84%) of the participants reported that they were not using any contraceptive methods at all. Lifetime prevalence of psychological and physical abuse was, respectively, 19.0% (95% CI =18.0-20.1) and 14.1% (95% CI =13.3-14.9). Women who reported physical abuse were 28% (adjusted odds ratio [AOR] =1.275; 95% CI =1.030-1.578), and those reported both physical and psychological abuse had 52% (AOR =1.520; 95% CI =1.132-2.042) higher odds of not using any contraception.

Conclusion: The rate of contraception nonuse was considerably high and was found to be significantly associated with DV. Thus, the high prevalence of DV may compromise the effectiveness of the family planning programs in the long run. Evidence-based intervention strategies should be developed to protect the health and reproductive rights of the vulnerable women and to reduce DV by giving the issue a wider recognition in public policy making.

背景:在低收入和中等收入国家,不使用计划生育方法仍然是一个主要的公共卫生问题,特别是因为它对意外怀孕、高堕胎率和性传播疾病的传播产生了影响。据报道,各种人口和社会经济因素与不使用计划生育方法有关。在本研究中,我们旨在评估家庭暴力(DV)对尼日利亚已婚妇女使用避孕药具的影响。方法:从2013年进行的最新尼日利亚人口与健康调查中收集了22,275名年龄在15至49岁之间的妇女的数据。结果变量为避孕药具利用状况,主要暴露变量为家庭暴力,通过自我报告的身体和心理虐待经历来评估家庭暴力。考虑到调查的多阶段设计,采用了复杂的调查方法。数据分析采用双变量和多变量技术。结果:参与者平均年龄为31.33±8.26岁。超过五分之四(84%)的参与者报告说他们根本没有使用任何避孕方法。心理和身体虐待的终生患病率分别为19.0% (95% CI =18.0-20.1)和14.1% (95% CI =13.3-14.9)。报告身体虐待的妇女占28%(调整后的优势比[AOR] =1.275;95% CI =1.030-1.578),同时报告身体和心理虐待的占52% (AOR =1.520;95% CI =1.132-2.042)不采取任何避孕措施的几率更高。结论:不使用避孕药具的比例较高,且与家庭暴力有显著关系。因此,从长远来看,家庭暴力的高流行率可能会损害计划生育方案的有效性。应制定以证据为基础的干预战略,以保护弱势妇女的健康和生殖权利,并通过在公共政策制定中更广泛地承认家庭暴力问题来减少家庭暴力。
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引用次数: 17
A pilot study on the functional performance and acceptability of an innovative female condom (Wondaleaf®) in Malaysia. 一项关于马来西亚创新女用避孕套(Wondaleaf®)的功能性能和可接受性的试点研究。
Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2018-01-24 eCollection Date: 2018-01-01 DOI: 10.2147/OAJC.S152505
Rachel Sing-Kiat Ting, Ee-Lynn Wong, Jessie Koh-Sing Tnay

Background: Female condom (FC) has been available for over 30 years, but it still lacks wide acceptability. To overcome misdirection and invagination occurring in FC and to provide a wider area of protection, Wondaleaf® (WL), a new-generation adhesive FC, was recently invented. This pioneering study sought to assess the acceptability and functional performance of WL among Malaysian women.

Methods: A mixed method survey was conducted in three cities of Malaysia, recruiting sexually active heterosexual women, aged 18-50, by snowball sampling method. Participants were provided with WL and initially surveyed to rate its performance in five coital usages over 2 months. After that, the participants underwent a second survey to rate their satisfaction and acceptability toward WL. Descriptive statistics on clinical failure rates were tabulated with correlational analysis performed to identify major variables contributing to WL's functional performance and acceptability.

Results: Out of the 51 enrolled participants, 31 women completed the required surveys. WL's total clinical failure rate was 2.60% (out of 155 condom uses) with above-average ratings of functional performance. The ease of use significantly correlated with ratings of no slippage and no misdirection. The confidence in WL's safety features significantly correlated with a sense of empowerment and protection.

Conclusion: WL has a relatively low risk of clinical failures and an overall favorable acceptability among Malaysian women. However, this study also showed that its future usage largely depends on partner acceptability. It may have the potential of complementing the existing barrier toward contraceptive use. Further studies are needed to understand the global acceptability of WL.

背景:女用避孕套(FC)问世已有30多年,但仍缺乏广泛的接受度。为了克服在FC中发生的误导和内陷,并提供更广泛的保护区域,最近发明了新一代粘合剂FC Wondaleaf®(WL)。这项开创性的研究旨在评估马来西亚妇女对WL的可接受性和功能表现。方法:采用混合调查方法,在马来西亚三个城市招募18-50岁的性活跃异性恋女性,采用滚雪球抽样法。参与者被提供了WL,并在最初的调查中评估其在两个月内五次性交中的表现。之后,参与者进行了第二次调查,以评估他们对WL的满意度和可接受性。将临床失败率的描述性统计数据制成表格,并进行相关分析,以确定影响WL功能表现和可接受性的主要变量。结果:在51名参与者中,31名女性完成了要求的调查。WL的总临床失败率为2.60%(在155个避孕套使用中),其功能性能评分高于平均水平。易用性与无滑动和无误导的评级显著相关。对WL安全特性的信心与赋权感和保护感显著相关。结论:WL临床失败的风险相对较低,在马来西亚妇女中具有良好的总体可接受性。然而,这项研究也表明,它的未来使用在很大程度上取决于伴侣的接受程度。它可能具有补充现有避孕措施使用障碍的潜力。需要进一步的研究来了解WL的全球可接受性。
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引用次数: 9
Contraceptive use and preferences of young married women in Kerala, India. 印度喀拉拉邦年轻已婚妇女的避孕使用和偏好。
Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2018-01-05 eCollection Date: 2018-01-01 DOI: 10.2147/OAJC.S152178
Jissa Vinoda Thulaseedharan

Background: As in other states of India, female sterilization is the most widely used contraceptive method in Kerala where women have higher levels of education compared to most other states in India. This paper describes the use and preferences of contraceptive methods among young married women in Trivandrum district, Kerala, India.

Subjects and methods: A community-based cross-sectional survey was carried out among 203 young married women (18-28 years) during January-March 2015 using multistage cluster sampling method. Statistical analysis was mainly descriptive, and chi-squared test was used to test the statistical significance of the relationship between sociodemographic factors and contraceptive use.

Results: The average age at marriage for women was 21.3 years, and 23% of women had more than one child. Current use of any contraceptive methods was 58%. Female sterilization was preferred by 13% and it was significantly higher among women aged 25-28 years than in those aged 18-24 years (20% vs 2.6%, p<0.001). Female sterilization was significantly lower among women with higher levels of education than in women with an education level of plus two or below (5.8% vs 19%, p=0.006). Women were mostly in favor of female sterilization (91%), and a significantly lower proportion of highly educated women preferred female sterilization than women with an education of 12 years or below (85% vs 95.7%, p=0.008).

Conclusion: A considerable number of females in the age group 25-28-years opting for sterilization and the unique preference for female sterilization when the family size is complete show the predominant reliance on female sterilization among young women. Higher education delays sterilization in young women due to delayed marriage and childbirth. Women empowerment, proper information and assuring availability and accessibility to different methods can gradually change the dominant preference for female-oriented permanent method of contraception.

背景:与印度其他邦一样,女性绝育是喀拉拉邦最广泛使用的避孕方法,与印度大多数其他邦相比,喀拉拉邦的女性受教育程度更高。本文描述了在Trivandrum地区,喀拉拉邦,印度年轻已婚妇女避孕方法的使用和偏好。研究对象与方法:采用多阶段整群抽样方法,于2015年1 - 3月对203名18-28岁的青年已婚妇女进行社区横断面调查。统计分析以描述性分析为主,采用卡方检验检验社会人口学因素与避孕药具使用之间的关系是否具有统计学意义。结果:女性平均结婚年龄为21.3岁,23%的女性有一个以上的孩子。目前使用任何避孕方法的占58%。13%的女性倾向于绝育,25-28岁的女性明显高于18-24岁的女性(20% vs 2.6%, pp=0.006)。女性多数支持女性绝育(91%),高学历女性选择女性绝育的比例明显低于受教育12年及以下的女性(85% vs 95.7%, p=0.008)。结论:25-28岁年龄组中有相当多的女性选择绝育,且家庭规模完整时对女性绝育的独特偏好显示了年轻女性对女性绝育的主要依赖。由于晚婚晚育,高等教育推迟了年轻妇女的绝育。赋予妇女权力、适当的信息和确保不同方法的可得性和可获得性可以逐渐改变对面向女性的永久避孕方法的主要偏好。
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引用次数: 29
A practical alternative to calculating unmet need for family planning. 计算计划生育未满足需求的实际替代方案。
Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2017-07-26 eCollection Date: 2017-01-01 DOI: 10.2147/OAJC.S137705
Irit Sinai, Susan Igras, Rebecka Lundgren

The standard approach for measuring unmet need for family planning calculates actual, physiological unmet need and is useful for tracking changes at the population level. We propose to supplement it with an alternate approach that relies on individual perceptions and can improve program design and implementation. The proposed approach categorizes individuals by their perceived need for family planning: real met need (current users of a modern method), perceived met need (current users of a traditional method), real no need, perceived no need (those with a physiological need for family planning who perceive no need), and perceived unmet need (those who realize they have a need but do not use a method). We tested this approach using data from Mali (n=425) and Benin (n=1080). We found that traditional method use was significantly higher in Benin than in Mali, resulting in different perceptions of unmet need in the two countries. In Mali, perceived unmet need was much higher. In Benin, perceived unmet need was low because women believed (incorrectly) that they were protected from pregnancy. Perceived no need - women who believed that they could not become pregnant despite the fact that they were fecund and sexually active - was quite high in both countries. We posit that interventions that address perceptions of unmet need, in addition to physiological risk of pregnancy, will more likely be effective in changing behavior. The suggested approach for calculating unmet need supplements the standard calculations and is helpful for designing programs to better address women's and men's individual needs in diverse contexts.

衡量计划生育未满足需求的标准方法计算实际的、生理上未满足的需求,对跟踪人口水平的变化很有用。我们建议用另一种方法来补充它,这种方法依赖于个人的感知,可以改进程序的设计和实施。所提出的方法根据个人对计划生育的感知需求对个人进行分类:真正满足的需求(当前使用现代方法的用户),感知到的满足需求(当前使用传统方法的用户),真正不需要,感知到的不需要(那些对计划生育有生理需求但认为不需要的人),以及感知到的未满足需求(那些意识到自己有需求但没有使用某种方法的人)。我们使用马里(n=425)和贝宁(n=1080)的数据对该方法进行了检验。我们发现,贝宁的传统方法使用率明显高于马里,导致两国对未满足需求的看法不同。在马里,未满足的需求要高得多。在贝宁,认为未满足的需求很低,因为妇女(错误地)认为她们不会怀孕。认为没有必要怀孕的妇女——尽管她们生育能力强,性生活活跃——在这两个国家都相当高。我们认为,除了怀孕的生理风险外,解决未满足需求认知的干预措施更有可能有效地改变行为。所建议的计算未满足需求的方法补充了标准计算,并有助于设计方案,以更好地解决不同背景下女性和男性的个人需求。
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引用次数: 14
"Side effects affected my daily activities a lot": a qualitative exploration of the impact of contraceptive side effects in Bangladesh. “副作用对我的日常活动影响很大”:对孟加拉国避孕副作用影响的定性探索。
Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2017-07-10 eCollection Date: 2017-01-01 DOI: 10.2147/OAJC.S140214
Aparna Jain, Laura Reichenbach, Iqbal Ehsan, Ubaidur Rob

Purpose: In a country like Bangladesh that has made great progress in contraceptive use with one of the lowest levels of fertility and highest levels of contraceptive use, understanding what factors influence women's decisions to discontinue a contraceptive method and not switch to a new method is critical in designing interventions and programs that will help enable Bangladesh to reach its FP2020 goals. Research on side effects has focused on physical manifestations like headaches, moodiness, abdominal pain, and menstrual irregularities. While physical effects alone may stop women from continuing a contraceptive method, less is known about how side effects influence women's daily activities and lives. The purpose of this study is to understand the ways that side effects affect Bangladeshi women's participation in different social settings.

Methods: Thirty-five in-depth interviews with married women who recently discontinued or switched to a different contraceptive method were conducted in Sylhet and Khulna Divisions. Interviews explored reasons for discontinuation including experience of side effects and impact of side effects on women's lives.

Results: Key themes emerged including that side effects are not only experienced physically but are barriers to women's participation in many aspects of their lives. The spheres of life that most commonly appeared to be influenced by side effects include religion, household, and sexual intimacy irrespective of method used or residence.

Conclusion: Family planning providers need to be aware of these additional consequences associated with contraceptive side effects to provide tailored counseling that recognizes these issues and helps women to mitigate them. For Bangladesh to achieve its FP2020 goals, understanding the broader context in which family planning decisions are made vis-à-vis side effects is critical to design programs and interventions that meet all the needs of women beyond just their fertility intentions.

目的:在像孟加拉国这样在避孕药具使用方面取得巨大进展、生育率最低和避孕药具使用率最高的国家之一,了解哪些因素影响妇女决定停止使用一种避孕方法而不改用一种新方法,对于设计干预措施和方案至关重要,这些干预措施和方案将有助于孟加拉国实现其《2020年可持续发展目标》的目标。对副作用的研究主要集中在身体表现上,比如头痛、情绪低落、腹痛和月经不规律。虽然身体上的影响可能会阻止妇女继续使用避孕方法,但对副作用如何影响妇女的日常活动和生活所知甚少。本研究的目的是了解副作用影响孟加拉国妇女参与不同社会环境的方式。方法:在Sylhet和Khulna区对最近停止或改用不同避孕方法的已婚妇女进行了35次深入访谈。采访探讨了停药的原因,包括副作用的经历和副作用对妇女生活的影响。结果:出现的关键主题包括副作用不仅在身体上经历,而且是妇女参与生活许多方面的障碍。最常受到副作用影响的生活领域包括宗教、家庭和性亲密关系,无论使用的方法或居住地如何。结论:计划生育提供者需要意识到这些与避孕副作用相关的额外后果,并提供量身定制的咨询,以识别这些问题并帮助妇女减轻这些问题。孟加拉国要实现《2020年计划生育计划》的目标,就必须了解计划生育决策的更广泛背景(参见-à-vis副作用),这对于设计方案和干预措施至关重要,这些方案和干预措施不仅能满足妇女的生育意愿,还能满足她们的所有需求。
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引用次数: 17
Hormonal contraception in women with polycystic ovary syndrome: choices, challenges, and noncontraceptive benefits. 多囊卵巢综合征妇女的激素避孕:选择、挑战和非避孕益处。
Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2017-02-02 eCollection Date: 2017-01-01 DOI: 10.2147/OAJC.S85543
Anderson Sanches de Melo, Rosana Maria Dos Reis, Rui Alberto Ferriani, Carolina Sales Vieira

Polycystic ovary syndrome (PCOS) is an endocrine disorder among women of reproductive age characterized by chronic anovulation and polycystic ovary morphology and/or hyperandrogenism. Management of clinical manifestations of PCOS, such as menstrual irregularities and hyperandrogenism symptoms, includes lifestyle changes and combined hormonal contraceptives (CHCs). CHCs contain estrogen that exerts antiandrogenic properties by triggering the hepatic synthesis of sex hormone-binding globulin that reduces the free testosterone levels. Moreover, the progestogen present in CHCs and in progestogen-only contraceptives suppresses luteinizing hormone secretion. In addition, some types of progestogens directly antagonize the effects of androgens on their receptor and also reduce the activity of the 5α reductase enzyme. However, PCOS is related to clinical and metabolic comorbidities that may limit the prescription of CHCs. Clinicians should be aware of risk factors, such as age, smoking, obesity, diabetes, systemic arterial hypertension, dyslipidemia, and a personal or family history, of a venous thromboembolic event or thrombophilia. This article reports a narrative review of the available evidence of the safety of hormonal contraceptives in women with PCOS. Considerations are made for the possible impact of hormonal contraceptives on endocrine, metabolic, and cardiovascular health.

多囊卵巢综合征(PCOS)是一种以慢性无排卵和多囊卵巢形态和/或雄激素过多为特征的育龄妇女内分泌疾病。多囊卵巢综合征的临床表现,如月经不规律和雄激素分泌亢进症状,包括生活方式的改变和联合激素避孕药(CHCs)的管理。CHCs含有雌激素,通过触发肝脏合成性激素结合球蛋白来降低游离睾酮水平,从而发挥抗雄激素特性。此外,孕激素存在于CHCs和孕激素避孕药抑制黄体生成素的分泌。此外,某些类型的孕激素直接拮抗雄激素对其受体的作用,并降低5α还原酶的活性。然而,多囊卵巢综合征与临床和代谢合并症有关,这可能限制了CHCs的处方。临床医生应该意识到静脉血栓栓塞事件或血栓形成的危险因素,如年龄、吸烟、肥胖、糖尿病、全身性动脉高血压、血脂异常、个人或家族史。这篇文章报道了一篇关于激素避孕药在多囊卵巢综合征妇女中安全性的现有证据的叙述性综述。考虑到激素避孕药对内分泌、代谢和心血管健康的可能影响。
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引用次数: 33
Oral contraceptive and acute intestinal ischemia with mesenteric venous thrombosis: a case report. 口服避孕药合并急性肠缺血并发肠系膜静脉血栓1例。
Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2017-01-27 eCollection Date: 2017-01-01 DOI: 10.2147/OAJC.S124625
Aude Béliard, Lucie Verreth, Pascale Grandjean

Background: Venous thrombosis is a serious complication of combined contraceptive usage. However, mesenteric venous thrombosis and intestinal necrosis are infrequently seen in women using oral contraceptives, and in such cases diagnosis is often delayed.

Case presentation: We report the case of a 38-year-old obese female patient who presented with acute abdominal pain. A bowel infection was first diagnosed and treated with antibiotics. Contrast-enhanced tomography of the abdomen revealed diffuse ischemia of the small intestine with superior mesenteric thrombosis. Laparotomy with segmental resection of both small and large bowel was performed. No predisposing factor of mesenteric venous thrombosis was demonstrated except association of the combined contraceptive with obesity.

Conclusion: This report highlights the need for clinicians to suspect venous mesenteric thrombosis in women of reproductive age with acute abdominal pain and poor physical findings. Detailed personal history including prescriptions should help to quickly and accurately determine the problem.

背景:静脉血栓形成是联合使用避孕药的严重并发症。然而,在使用口服避孕药的妇女中,肠系膜静脉血栓形成和肠坏死并不常见,在这种情况下,诊断往往被推迟。病例介绍:我们报告一个38岁的肥胖女性患者谁提出了急性腹痛。最初诊断为肠道感染,并使用抗生素治疗。腹部造影显示小肠弥漫性缺血伴肠系膜上血栓形成。施行剖腹手术并节段性切除小肠和大肠。除联合避孕药与肥胖相关外,未发现肠系膜静脉血栓形成的易感因素。结论:本报告强调临床医生有必要怀疑育龄妇女急性腹痛和身体检查不佳的肠系膜静脉血栓形成。详细的个人病史,包括处方,应该有助于快速准确地确定问题。
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引用次数: 4
期刊
Open access journal of contraception
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