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Are We Consulting, Sharing Care, or Taking Over? A Conceptual Framework. 我们是咨询、分担护理还是接管?一个概念框架。
Q4 Nursing Pub Date : 2024-02-23 eCollection Date: 2024-01-01 DOI: 10.1089/pmr.2023.0079
José Pereira, Christopher Klinger, Hsien Seow, Denise Marshall, Leonie Herx

Background: Primary- and specialist-level palliative care services are needed. They should work collaboratively and synergistically. Although several service models have been described, these remain open to different interpretations and deployment.

Aim: This article describes a conceptual framework, the Consultation-Shared Care-Takeover (C-S-T) Framework, its evolution and its applications.

Design: An iterative process informed the development of the Framework. This included a symposium, literature searches, results from three studies, and real-life applications.

Results: The C-S-T Framework represents a spectrum anchored by the Consultation model at one end, the Takeover model at the other end, and the Shared Care model in the center. Indicators, divided into five domains, help differentiate one model from the other. The domains are (1) Scope (What aspects of care are addressed by the palliative care clinician?); (2) Prescriber (Who prescribes the treatments?); (3) Communication (What communication occurs between the palliative care clinician and the patient's attending clinician?); (4) Follow-up (Who provides the follow-up visits and what is their frequency?); and (5) Most responsible practitioner (MRP) (Who is identified as MRP?). Each model demonstrates strengths, limitations, uses, and roles.

Conclusions: The C-S-T Framework can be used to better describe, understand, assess, and monitor models being used by specialist palliative care teams in their interactions with primary care providers and other specialist services. Large studies are needed to test the application of the Framework on a broader scale in health care systems.

背景:需要初级和专科级别的姑息关怀服务。它们应协同合作,发挥协同效应。目的:本文描述了一个概念性框架,即 "咨询-共同照护-接管(C-S-T)框架",以及该框架的演变和应用:设计:该框架的开发采用了一个迭代过程。设计:迭代过程为该框架的开发提供了依据,其中包括一次研讨会、文献检索、三项研究的结果以及现实生活中的应用:结果:C-S-T 框架代表了一个光谱,一端是咨询模式,另一端是接管模式,中间是共享护理模式。指标分为五个领域,有助于区分不同模式。这五个领域分别是:(1)范围(姑息关怀临床医师负责哪些方面的关怀?每种模式都展示了其优势、局限性、用途和作用:C-S-T框架可用于更好地描述、理解、评估和监控姑息关怀专科团队在与初级医疗服务提供者和其他专科服务互动时所使用的模式。需要开展大型研究,以测试该框架在医疗保健系统中的广泛应用。
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引用次数: 0
Opioids and Immunosuppression: Clinical Evidence, Mechanisms of Action, and Potential Therapies. 阿片类药物与免疫抑制:临床证据、作用机制和潜在疗法。
Q4 Nursing Pub Date : 2024-02-02 eCollection Date: 2024-01-01 DOI: 10.1089/pmr.2023.0049
Jeffrey J Bettinger, Bruce C Friedman

Background: In addition to the more well-known adverse effects of opioids, such as constipation, mounting evidence supports underlying immunosuppressive effects as well.

Methods: In this study, we provide a narrative review of preclinical and clinical evidence of opioid suppression of the immune system as well as possible considerations for therapies.

Results: In vitro and animal studies have shown clear effects of opioids on inflammatory cytokine expression, immune cell activity, and pathogen susceptibility. Observational data in humans have so far supported preclinical findings, with multiple reports of increased rates of infections in various settings of opioid use. However, the extent to which this risk is due to the impact of opioids on the immune system compared with other risk factors associated with opioid use remains uncertain. Considering the data showing immunosuppression and increased risk of infection with opioid use, measures are needed to mitigate this risk in patients who require ongoing treatment with opioids. In preclinical studies, administration of opioid receptor antagonists blocked the immunomodulatory effects of opioids.

Conclusions: As selective antagonists of peripheral opioid receptors, peripherally acting mu-opioid receptor (MOR) antagonists may be able to protect against immune impairment while still allowing for opioid analgesia. Future research is warranted to further investigate the relationship between opioids and infection risk as well as the potential application of peripherally acting MOR antagonists to counteract these risks.

背景:除了众所周知的阿片类药物的不良反应(如便秘)外,越来越多的证据表明阿片类药物还具有潜在的免疫抑制作用:除了众所周知的阿片类药物的不良反应(如便秘)外,越来越多的证据表明阿片类药物还具有潜在的免疫抑制作用:在本研究中,我们对阿片类药物抑制免疫系统的临床前和临床证据以及可能的治疗方法进行了叙述性综述:体外和动物研究表明,阿片类药物对炎症细胞因子表达、免疫细胞活性和病原体易感性有明显影响。迄今为止,人类的观察数据支持了临床前的研究结果,有多份报告显示,在使用阿片类药物的各种情况下,感染率会增加。然而,与使用阿片类药物相关的其他风险因素相比,这种风险在多大程度上是由于阿片类药物对免疫系统的影响造成的,这一点仍不确定。考虑到有数据显示使用阿片类药物会导致免疫抑制和感染风险增加,因此需要采取措施来降低需要持续接受阿片类药物治疗的患者的这一风险。在临床前研究中,阿片受体拮抗剂可阻断阿片类药物的免疫调节作用:结论:作为外周阿片受体的选择性拮抗剂,外周作用的μ阿片受体(MOR)拮抗剂可能能够防止免疫功能受损,同时仍能发挥阿片类镇痛作用。未来的研究将进一步探讨阿片类药物与感染风险之间的关系,以及外周作用缪阿片受体(MOR)拮抗剂在抵消这些风险方面的潜在应用。
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引用次数: 0
Practices of and Perspectives on Palliative Sedation Among Palliative Care Physicians in Ontario, Canada: A Mixed-Methods Study 加拿大安大略省姑息治疗医生对姑息镇静的实践和看法:混合方法研究
Q4 Nursing Pub Date : 2024-02-01 DOI: 10.1089/pmr.2023.0081
Amy Nolen, D. Selby, Fahad Qureshi, Anneliese Mills
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引用次数: 0
Trajectories of Activities of Daily Living in the Last Eight Weeks of Life Among Patients With Terminal Cancer in a Palliative Care Unit: A Retrospective Study 姑息治疗病房的晚期癌症患者在生命最后八周的日常生活活动轨迹:回顾性研究
Q4 Nursing Pub Date : 2024-02-01 DOI: 10.1089/pmr.2023.0043
Ryohei Soeda, Aiko Ishikawa, Shunsuke Oyamada, Mana Mitsuhashi, Suzune Okano, Aiko Yokosawa, Teruo Okutsu, Tetsuya Tsuji
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引用次数: 0
The Hierarchy of Communication Needs: A Novel Communication Strategy for High Mistrust Settings Developed in a Brazilian COVID-ICU 沟通需求层次:在巴西 COVID-ICU 制定的高度不信任环境下的新型沟通策略
Q4 Nursing Pub Date : 2024-02-01 DOI: 10.1089/pmr.2023.0070
D. N. Forte, Mark Stoltenberg, Sabrina Correa da Costa Ribeiro, Ingrid Maria (Mia) Olsen de Almeida, Vicki Jackson, B. Daubman
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引用次数: 0
The Hierarchy of Communication Needs: A Novel Communication Strategy for High Mistrust Settings Developed in a Brazilian COVID-ICU 沟通需求层次:在巴西 COVID-ICU 制定的高度不信任环境下的新型沟通策略
Q4 Nursing Pub Date : 2024-02-01 DOI: 10.1089/pmr.2023.0070
D. N. Forte, Mark Stoltenberg, Sabrina Correa da Costa Ribeiro, Ingrid Maria (Mia) Olsen de Almeida, Vicki Jackson, B. Daubman
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引用次数: 0
Palliative Care Providers' and Administrators' Perspectives on Integrating Community-Based Palliative Care Using the Social Determinants of Health Framework 姑息关怀提供者和管理者对利用健康的社会决定因素框架整合社区姑息关怀的看法
Q4 Nursing Pub Date : 2024-02-01 DOI: 10.1089/pmr.2023.0048
Savannah Horvick, Nancy Dias
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引用次数: 0
Practices of and Perspectives on Palliative Sedation Among Palliative Care Physicians in Ontario, Canada: A Mixed-Methods Study 加拿大安大略省姑息治疗医生对姑息镇静的实践和看法:混合方法研究
Q4 Nursing Pub Date : 2024-02-01 DOI: 10.1089/pmr.2023.0081
Amy Nolen, D. Selby, Fahad Qureshi, Anneliese Mills
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引用次数: 0
Trajectories of Activities of Daily Living in the Last Eight Weeks of Life Among Patients With Terminal Cancer in a Palliative Care Unit: A Retrospective Study 姑息治疗病房的晚期癌症患者在生命最后八周的日常生活活动轨迹:回顾性研究
Q4 Nursing Pub Date : 2024-02-01 DOI: 10.1089/pmr.2023.0043
Ryohei Soeda, Aiko Ishikawa, Shunsuke Oyamada, Mana Mitsuhashi, Suzune Okano, Aiko Yokosawa, Teruo Okutsu, Tetsuya Tsuji
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引用次数: 0
Palliative Care Providers' and Administrators' Perspectives on Integrating Community-Based Palliative Care Using the Social Determinants of Health Framework 姑息关怀提供者和管理者对利用健康的社会决定因素框架整合社区姑息关怀的看法
Q4 Nursing Pub Date : 2024-02-01 DOI: 10.1089/pmr.2023.0048
Savannah Horvick, Nancy Dias
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引用次数: 0
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Palliative medicine reports
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