Pub Date : 2026-01-01Epub Date: 2026-01-19DOI: 10.1007/s00292-025-01516-9
Philipp Ströbel
{"title":"[Research and healthcare in transition: the 108th DGP annual congress in Leipzig].","authors":"Philipp Ströbel","doi":"10.1007/s00292-025-01516-9","DOIUrl":"https://doi.org/10.1007/s00292-025-01516-9","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":"47 Suppl 1","pages":"1-5"},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145999881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01Epub Date: 2025-12-10DOI: 10.1007/s00292-025-01503-0
Martin-Leo Hansmann
Background: Hematopathology is rapidly advancing. Combining structural, molecular, and dynamic analyses enables a deeper understanding of immune reactions and malignant lymphomas.
Materials and methods: Three-dimensional (3D) imaging uses fluorescence-stained tissue sections with confocal microscopy. Four-dimensional (4D) live tissue slices allow real-time visualization of immune cell movement. Drugs can be tested directly on fresh samples.
Results: Three-dimensional images show key immune cell types; 4D imaging reveals cell-cell interactions. Nivolumab, for example, prolonged T cell contact with Hodgkin cells.
Conclusion: Four-dimensional technology improves early disease detection, treatment monitoring, and drug development, bridging between molecular findings and clinical applications.
{"title":"Taking imaging into the fourth dimension.","authors":"Martin-Leo Hansmann","doi":"10.1007/s00292-025-01503-0","DOIUrl":"10.1007/s00292-025-01503-0","url":null,"abstract":"<p><strong>Background: </strong>Hematopathology is rapidly advancing. Combining structural, molecular, and dynamic analyses enables a deeper understanding of immune reactions and malignant lymphomas.</p><p><strong>Materials and methods: </strong>Three-dimensional (3D) imaging uses fluorescence-stained tissue sections with confocal microscopy. Four-dimensional (4D) live tissue slices allow real-time visualization of immune cell movement. Drugs can be tested directly on fresh samples.</p><p><strong>Results: </strong>Three-dimensional images show key immune cell types; 4D imaging reveals cell-cell interactions. Nivolumab, for example, prolonged T cell contact with Hodgkin cells.</p><p><strong>Conclusion: </strong>Four-dimensional technology improves early disease detection, treatment monitoring, and drug development, bridging between molecular findings and clinical applications.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"59-61"},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145717070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01Epub Date: 2025-11-24DOI: 10.1007/s00292-025-01501-2
Lena Angerer, Tobias Zauner, Rupert Langer
Rare diseases of the gastrointestinal (GI) tract present a significant diagnostic challenge. This paper focusses on two particular groups of conditions: drug-induced injuries and parasitic infections. With aging populations and increased use of complex pharmacologic regimens-including immunosuppressants and biologics-drug-related GI pathology is nowadays more frequently encountered. However, the histologic changes are often non-specific and overlap with more common conditions such as inflammatory bowel disease (IBD), ischemia, autoimmune diseases, or infections. Key patterns include lymphocytic or neutrophilic inflammation, crypt apoptosis, crypt abscesses, and architectural distortion. Certain agents, such as mycophenolate, olmesartan, immune checkpoint inhibitors, or ion exchange resins (e.g. sodium polystyrene sulfonate/kayexalate, sevelamer), have distinct but subtle histopathologic signatures. Parasitic infections, although less frequent in high-income countries, remain relevant due to global travel and migration. Organisms such as Schistosoma, Strongyloides, or Giardia can mimic IBD, neoplasia, or cause unexpected eosinophilic or granulomatous inflammation. Parasite ova may require special stains and careful morphologic assessment to be identified. Importantly, some helminths have been associated with chronic complications including cancer or fibrosis, thus underscoring the need for accurate recognition. For the practicing pathologist, these rare but impactful conditions demand a high index of suspicion, especially in cases with atypical histology or poor clinical correlation. Using some illustrative cases, this paper highlights diagnostic strategies and key morphologic features to improve recognition and avoid misdiagnosis of these underappreciated entities.
{"title":"Rare non-neoplastic gastrointestinal diseases-drugs and bugs.","authors":"Lena Angerer, Tobias Zauner, Rupert Langer","doi":"10.1007/s00292-025-01501-2","DOIUrl":"10.1007/s00292-025-01501-2","url":null,"abstract":"<p><p>Rare diseases of the gastrointestinal (GI) tract present a significant diagnostic challenge. This paper focusses on two particular groups of conditions: drug-induced injuries and parasitic infections. With aging populations and increased use of complex pharmacologic regimens-including immunosuppressants and biologics-drug-related GI pathology is nowadays more frequently encountered. However, the histologic changes are often non-specific and overlap with more common conditions such as inflammatory bowel disease (IBD), ischemia, autoimmune diseases, or infections. Key patterns include lymphocytic or neutrophilic inflammation, crypt apoptosis, crypt abscesses, and architectural distortion. Certain agents, such as mycophenolate, olmesartan, immune checkpoint inhibitors, or ion exchange resins (e.g. sodium polystyrene sulfonate/kayexalate, sevelamer), have distinct but subtle histopathologic signatures. Parasitic infections, although less frequent in high-income countries, remain relevant due to global travel and migration. Organisms such as Schistosoma, Strongyloides, or Giardia can mimic IBD, neoplasia, or cause unexpected eosinophilic or granulomatous inflammation. Parasite ova may require special stains and careful morphologic assessment to be identified. Importantly, some helminths have been associated with chronic complications including cancer or fibrosis, thus underscoring the need for accurate recognition. For the practicing pathologist, these rare but impactful conditions demand a high index of suspicion, especially in cases with atypical histology or poor clinical correlation. Using some illustrative cases, this paper highlights diagnostic strategies and key morphologic features to improve recognition and avoid misdiagnosis of these underappreciated entities.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"51-58"},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12816097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145590045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01Epub Date: 2025-11-07DOI: 10.1007/s00292-025-01486-y
Sylvia Hartmann
{"title":"[Report of the Hematopathology Working Group of the German Society of Pathology].","authors":"Sylvia Hartmann","doi":"10.1007/s00292-025-01486-y","DOIUrl":"10.1007/s00292-025-01486-y","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"114-115"},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145460850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01Epub Date: 2025-10-28DOI: 10.1007/s00292-025-01484-0
T Braunschweig, K Schierle
{"title":"[Report of the Working Group on the History and Ethics of Pathology of the German Society of Pathology : 2025 Annual Meeting of the German Society of Pathology in Leipzig from 12-14 June 2025].","authors":"T Braunschweig, K Schierle","doi":"10.1007/s00292-025-01484-0","DOIUrl":"10.1007/s00292-025-01484-0","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"108-110"},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145395680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01Epub Date: 2025-10-30DOI: 10.1007/s00292-025-01490-2
Thomas F E Barth, Gunhild Mechtersheimer
{"title":"[Report of the Working Group on Bone, Joint, and Soft Tissue Pathology of the German Society of Pathology].","authors":"Thomas F E Barth, Gunhild Mechtersheimer","doi":"10.1007/s00292-025-01490-2","DOIUrl":"10.1007/s00292-025-01490-2","url":null,"abstract":"","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":"124-125"},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145411133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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