G. Com, Haripriya Santhanam, Berrin Ergun-Longmire
Pediatric Pulmonology Medicine, University of Florida, Pensacola, FL, USA; Department of Pediatric and Adolescent Medicine, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI, USA Contributions: (I) Conception and design: All authors (II) Administrative support: none; (III) Provision of study materials or patients: None; (IV) Collection and assembly of data: All authors; (V) Data analysis and interpretation: All authors; (VI) Manuscript writing: All authors; (VII) Final Approval of manuscript: All authors. Correspondence to: Berrin Ergun-Longmire, MD. Department of Pediatric and Adolescent Medicine, Western Michigan University Homer Stryker M.D. School of Medicine, 1000 Oakland Drive, Kalamazoo, MI 49008, USA. Email: berrin.ergun-longmire@med.wmich.edu.
{"title":"Respiratory system abnormalities in Prader-Willi syndrome: a literature review","authors":"G. Com, Haripriya Santhanam, Berrin Ergun-Longmire","doi":"10.21037/pm-21-102","DOIUrl":"https://doi.org/10.21037/pm-21-102","url":null,"abstract":"Pediatric Pulmonology Medicine, University of Florida, Pensacola, FL, USA; Department of Pediatric and Adolescent Medicine, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI, USA Contributions: (I) Conception and design: All authors (II) Administrative support: none; (III) Provision of study materials or patients: None; (IV) Collection and assembly of data: All authors; (V) Data analysis and interpretation: All authors; (VI) Manuscript writing: All authors; (VII) Final Approval of manuscript: All authors. Correspondence to: Berrin Ergun-Longmire, MD. Department of Pediatric and Adolescent Medicine, Western Michigan University Homer Stryker M.D. School of Medicine, 1000 Oakland Drive, Kalamazoo, MI 49008, USA. Email: berrin.ergun-longmire@med.wmich.edu.","PeriodicalId":74411,"journal":{"name":"Pediatric medicine (Hong Kong, China)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47981834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The impact of COVID-19 on the practice of pediatric cardiology: a narrative review","authors":"C. Chen, R. Grignani, Y. Lim, S. Quek","doi":"10.21037/pm-21-64","DOIUrl":"https://doi.org/10.21037/pm-21-64","url":null,"abstract":"","PeriodicalId":74411,"journal":{"name":"Pediatric medicine (Hong Kong, China)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44470597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: This review focuses on the role of anti-neutrophil antibodies in neonatal and pediatric neutropenias with particular regard to laboratory tests useful to detect them. Background: Neutropenia is a common medical problem for infants and children that can predispose them to the risk of bacterial infections. There are many causes for pediatric neutropenia, but at birth and for the first years of life, neutropenia is often attributable to immune mechanisms, either by the presence of auto or alloantibodies directed against human neutrophil antigens (HNA). The detection of these antibodies is a useful diagnostic tool to define immune-mediated neutropenia, which includes a variety of clinical conditions. Methods: PubMed was used to carry out a literature search for the last 10 years. In addition, pivotal papers on this topic, before 2010, were also considered. Conclusions: The detection and identification of anti-neutrophil antibodies with the techniques currently available are often laborious, difficult, and performed in specialized laboratories. Moreover, since neutrophils are fragile cells and difficult to preserve, several advances in laboratory procedures have been developed in the last years. The recent availability of new commercial assays, which do not require fresh cells, may represent an important step forward in neutrophil serology, as it could improve the standardization and availability of serological and genomic tests that can also be used in non-specialized laboratories. However, these assays still need to complete the necessary validations before replacing classical serological methods. 13
{"title":"Laboratory testing for the diagnosis of neonatal and pediatric immune neutropenias: a narrative review","authors":"A. Cattaneo, L. Porretti","doi":"10.21037/pm-21-43","DOIUrl":"https://doi.org/10.21037/pm-21-43","url":null,"abstract":"Objectives: This review focuses on the role of anti-neutrophil antibodies in neonatal and pediatric neutropenias with particular regard to laboratory tests useful to detect them. Background: Neutropenia is a common medical problem for infants and children that can predispose them to the risk of bacterial infections. There are many causes for pediatric neutropenia, but at birth and for the first years of life, neutropenia is often attributable to immune mechanisms, either by the presence of auto or alloantibodies directed against human neutrophil antigens (HNA). The detection of these antibodies is a useful diagnostic tool to define immune-mediated neutropenia, which includes a variety of clinical conditions. Methods: PubMed was used to carry out a literature search for the last 10 years. In addition, pivotal papers on this topic, before 2010, were also considered. Conclusions: The detection and identification of anti-neutrophil antibodies with the techniques currently available are often laborious, difficult, and performed in specialized laboratories. Moreover, since neutrophils are fragile cells and difficult to preserve, several advances in laboratory procedures have been developed in the last years. The recent availability of new commercial assays, which do not require fresh cells, may represent an important step forward in neutrophil serology, as it could improve the standardization and availability of serological and genomic tests that can also be used in non-specialized laboratories. However, these assays still need to complete the necessary validations before replacing classical serological methods. 13","PeriodicalId":74411,"journal":{"name":"Pediatric medicine (Hong Kong, China)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46124973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lihua Yu, Jiale Liu, Minjie Luo, D. Lin, Li Wu, Lulu Huang, Yajie Zhang, J. Zi, Jingxin Zhang, Xuebin Liao, J. Guan, Xinde Zhao, Ming Zhou, Yong Yang, Junde Zhang, Wangming Zhang, Lihua Yang
{"title":"Diagnosis and outcomes of pediatric central nervous system tumors in China: a single-center retrospective analysis from 2015 to 2020","authors":"Lihua Yu, Jiale Liu, Minjie Luo, D. Lin, Li Wu, Lulu Huang, Yajie Zhang, J. Zi, Jingxin Zhang, Xuebin Liao, J. Guan, Xinde Zhao, Ming Zhou, Yong Yang, Junde Zhang, Wangming Zhang, Lihua Yang","doi":"10.21037/pm-21-67","DOIUrl":"https://doi.org/10.21037/pm-21-67","url":null,"abstract":"","PeriodicalId":74411,"journal":{"name":"Pediatric medicine (Hong Kong, China)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48309480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Weiwei Du, Ye Lu, Fan Yang, Q. Lu, Zhiheng Li, Jun Lu, Shaoyan Hu
Background: To explore the clinical, histological, and molecular characteristics of childhood medulloblastoma (MB) and its prognosis. Methods: The authors analyzed clinical and pathological data from MB patients at Children’s Hospital of Soochow University who were diagnosed by pathology after surgical resection between November 2011 and October 2020. Results: A total of 40 patients were considered (20 males and 20 females), where the median age at MB onset was 81 months (5–163 months). Of these, complete resection was performed for 26 cases (26/40, 65%) and subtotal resection performed for 14 cases (14/40, 35%). Pathology after resection indicated that in 8 cases the MB had already metastasized. All 40 children were histologically classified, identifying: 32 cases of classic type (32/40, 80%), 6 cases of desmoplastic/nodular type (6/40, 15%), and 2 cases of anaplastic type (2/40, 5%). Molecular typing tests were performed on 19 children, identifying: 1 case in the wingless-activated (WNT-activated) group (1/19, 5.3%), 6 cases in the sonic hedgehog-activated (SHH-activated) group (6/19, 31.6%), 7 cases in Group 3 (7/19, 36.8%), and 5 cases in Group 4 (5/19, 26.3%). Of the 40 patients, 29 received a combined treatment of surgery, radiotherapy, and chemotherapy, and the median follow-up time was 25 months (1–102 months). The 3-year overall survival rate (OS) and event-free survival rate (EFS) were (64.3±10.4)% and (61.8±10.3)%, respectively. Univariate analyses showed that age, clinical stage, pathological subtype, and radiotherapy were potentially relevant variables in patient prognosis (P<0.05). Cox regression analysis showed that age and tumor metastasis were independent risk factors for poor prognosis of children with MB (P<0.05). Conclusions: Metastasis and age at initial diagnosis are unfavorable factors in the prognosis of childhood MB patients; however, radiotherapy could improve the prognosis of MB patients. 8
{"title":"Clinical characteristics and prognosis of pediatric medulloblastoma: a case study of 40 patients at children’s hospital of Soochow university","authors":"Weiwei Du, Ye Lu, Fan Yang, Q. Lu, Zhiheng Li, Jun Lu, Shaoyan Hu","doi":"10.21037/pm-21-59","DOIUrl":"https://doi.org/10.21037/pm-21-59","url":null,"abstract":"Background: To explore the clinical, histological, and molecular characteristics of childhood medulloblastoma (MB) and its prognosis. Methods: The authors analyzed clinical and pathological data from MB patients at Children’s Hospital of Soochow University who were diagnosed by pathology after surgical resection between November 2011 and October 2020. Results: A total of 40 patients were considered (20 males and 20 females), where the median age at MB onset was 81 months (5–163 months). Of these, complete resection was performed for 26 cases (26/40, 65%) and subtotal resection performed for 14 cases (14/40, 35%). Pathology after resection indicated that in 8 cases the MB had already metastasized. All 40 children were histologically classified, identifying: 32 cases of classic type (32/40, 80%), 6 cases of desmoplastic/nodular type (6/40, 15%), and 2 cases of anaplastic type (2/40, 5%). Molecular typing tests were performed on 19 children, identifying: 1 case in the wingless-activated (WNT-activated) group (1/19, 5.3%), 6 cases in the sonic hedgehog-activated (SHH-activated) group (6/19, 31.6%), 7 cases in Group 3 (7/19, 36.8%), and 5 cases in Group 4 (5/19, 26.3%). Of the 40 patients, 29 received a combined treatment of surgery, radiotherapy, and chemotherapy, and the median follow-up time was 25 months (1–102 months). The 3-year overall survival rate (OS) and event-free survival rate (EFS) were (64.3±10.4)% and (61.8±10.3)%, respectively. Univariate analyses showed that age, clinical stage, pathological subtype, and radiotherapy were potentially relevant variables in patient prognosis (P<0.05). Cox regression analysis showed that age and tumor metastasis were independent risk factors for poor prognosis of children with MB (P<0.05). Conclusions: Metastasis and age at initial diagnosis are unfavorable factors in the prognosis of childhood MB patients; however, radiotherapy could improve the prognosis of MB patients. 8","PeriodicalId":74411,"journal":{"name":"Pediatric medicine (Hong Kong, China)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47527405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To provide a narrative review of the current outcomes and future trends in paediatric and congenital cardiac surgery in a historical and multidisciplinary context. To present the paradigm shift in treating congenital heart disease that translate into improved outcomes. To identify current problems with directions of research. Background: Congenital heart disease (CHD) is the most common birth defect affecting approximately 1 neonate in every 120–166 births. More than half of CHD-patients need cardiac surgery in their lifetime; and half of the surgeries are required within the first six months of life. Methods: Narrative overview of the literature combining with current outcome data available from international databases is presented in comparison to the programme development of a newly-established tertiary-care centre. Conclusion: Congenital cardiac surgery is reconstructive surgery that aims for restoring biventricular circulation, when possible. Single-stage primary complete repair has become the central philosophy since the 1980s. In about thirty percent, physiologic and anatomical reasons do not permit repair by a single operation; these patients endure staged-repairs. Another 15% of CHD patients will require subsequent reoperations— mostly re-replacements of non-growing and/or deranged prostheses. Owing to advances of multidisciplinary treatment, CHD survival to adulthood now reaches 90–95% in high-income countries from less than 20% in the presurgical era. Treating CHD patients is a commitment for life. Research for viable and growing prostheses may solve the significant public health aspects currently associated with reoperations.
{"title":"Current outcomes and future trends in paediatric and congenital cardiac surgery: a narrative review","authors":"L. Kiraly","doi":"10.21037/pm-21-47","DOIUrl":"https://doi.org/10.21037/pm-21-47","url":null,"abstract":"Objective: To provide a narrative review of the current outcomes and future trends in paediatric and congenital cardiac surgery in a historical and multidisciplinary context. To present the paradigm shift in treating congenital heart disease that translate into improved outcomes. To identify current problems with directions of research. Background: Congenital heart disease (CHD) is the most common birth defect affecting approximately 1 neonate in every 120–166 births. More than half of CHD-patients need cardiac surgery in their lifetime; and half of the surgeries are required within the first six months of life. Methods: Narrative overview of the literature combining with current outcome data available from international databases is presented in comparison to the programme development of a newly-established tertiary-care centre. Conclusion: Congenital cardiac surgery is reconstructive surgery that aims for restoring biventricular circulation, when possible. Single-stage primary complete repair has become the central philosophy since the 1980s. In about thirty percent, physiologic and anatomical reasons do not permit repair by a single operation; these patients endure staged-repairs. Another 15% of CHD patients will require subsequent reoperations— mostly re-replacements of non-growing and/or deranged prostheses. Owing to advances of multidisciplinary treatment, CHD survival to adulthood now reaches 90–95% in high-income countries from less than 20% in the presurgical era. Treating CHD patients is a commitment for life. Research for viable and growing prostheses may solve the significant public health aspects currently associated with reoperations.","PeriodicalId":74411,"journal":{"name":"Pediatric medicine (Hong Kong, China)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45262613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yan Su, Shuai Zhu, Jing Qin, M. Ge, Yuan-qi Ji, Jian Gong, Tong Yu, Libing Fu, Zhikai Liu, Xiao-li Ma
Background: Medulloblastoma (MB) is the most common malignant pediatric brain tumor. This study systematically summarized the clinical characteristics and prognosis of children with MB respectively. Univariate survival analysis identified age <3 years and the absence of radiotherapy as poor prognostic factors (both P<0.05). Conclusions: Survival outcomes were good among patients with MB (MB) in our center. Young age and the omission of radiotherapy may be predictive of poor outcomes.
{"title":"Clinical features and prognostic analysis of children with medulloblastoma in a single center in China","authors":"Yan Su, Shuai Zhu, Jing Qin, M. Ge, Yuan-qi Ji, Jian Gong, Tong Yu, Libing Fu, Zhikai Liu, Xiao-li Ma","doi":"10.21037/pm-21-34","DOIUrl":"https://doi.org/10.21037/pm-21-34","url":null,"abstract":"Background: Medulloblastoma (MB) is the most common malignant pediatric brain tumor. This study systematically summarized the clinical characteristics and prognosis of children with MB respectively. Univariate survival analysis identified age <3 years and the absence of radiotherapy as poor prognostic factors (both P<0.05). Conclusions: Survival outcomes were good among patients with MB (MB) in our center. Young age and the omission of radiotherapy may be predictive of poor outcomes.","PeriodicalId":74411,"journal":{"name":"Pediatric medicine (Hong Kong, China)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44281136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Motoichiro Sakurai, Yuko Sakurai, Y. Wada, Yuuki Tani, K. Mizuno
A hospital-dedicated human milk bank was established in Japan at Koto Toyosu Hospital, Showa University in 2014. After a 3-year trial-and-error period, the Japanese Human Milk Bank Association was established in 2017. The supply of donor human milk (DHM) from the Japanese Human Milk Bank Association to various facilities nationwide has increased recently. However, as of 2021, there is only one human milk bank in Japan and the supply is limited. Therefore, there is an urgent need to understand the status of usage of DHM in the neonatal intensive care unit. Moreover, it is globally rare to build a database aimed at understanding the background and prognosis of all children supplied with DHM. In this paper, we have introduced the database and reported on aspects such as the salient points considered in building this database. The fundamental policy of this database included the following: (I) accessibility from the neonatal intensive care unit, (II) a simple input method, (III) reliability and continuity, (IV) safeguarding anonymity, (V) enriched search functionality, and (VI) enabling administration by the person in charge at each facility. In accordance with these six policies, the main items such as patient clinical information, DHM usage amount, and prognosis were set. In addition, the database was built to enable detailed search. The database was completed and became operational in November 2020. The input format was simplified as much as possible by adopting a selection-from-options approach. Enriched search functionality was implemented considering the function as a database in each facility. This database has enabled the proper operation of the human milk bank, and it would likely contribute further to perinatal care outcomes.
{"title":"An attempt at building a database of children using donor human milk in Japan","authors":"Motoichiro Sakurai, Yuko Sakurai, Y. Wada, Yuuki Tani, K. Mizuno","doi":"10.21037/pm-21-31","DOIUrl":"https://doi.org/10.21037/pm-21-31","url":null,"abstract":"A hospital-dedicated human milk bank was established in Japan at Koto Toyosu Hospital, Showa University in 2014. After a 3-year trial-and-error period, the Japanese Human Milk Bank Association was established in 2017. The supply of donor human milk (DHM) from the Japanese Human Milk Bank Association to various facilities nationwide has increased recently. However, as of 2021, there is only one human milk bank in Japan and the supply is limited. Therefore, there is an urgent need to understand the status of usage of DHM in the neonatal intensive care unit. Moreover, it is globally rare to build a database aimed at understanding the background and prognosis of all children supplied with DHM. In this paper, we have introduced the database and reported on aspects such as the salient points considered in building this database. The fundamental policy of this database included the following: (I) accessibility from the neonatal intensive care unit, (II) a simple input method, (III) reliability and continuity, (IV) safeguarding anonymity, (V) enriched search functionality, and (VI) enabling administration by the person in charge at each facility. In accordance with these six policies, the main items such as patient clinical information, DHM usage amount, and prognosis were set. In addition, the database was built to enable detailed search. The database was completed and became operational in November 2020. The input format was simplified as much as possible by adopting a selection-from-options approach. Enriched search functionality was implemented considering the function as a database in each facility. This database has enabled the proper operation of the human milk bank, and it would likely contribute further to perinatal care outcomes.","PeriodicalId":74411,"journal":{"name":"Pediatric medicine (Hong Kong, China)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43264333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Instituto de Investigação do Medicamento (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Lisbon, Portugal; Departamento de Ciências Farmacêuticas e do Medicamento, Faculdade de Farmácia, Universidade de Lisboa, Lisbon, Portugal Contributions: (I) Conception and design: Both authors; (II) Administrative support: None; (III) Provision of study materials or patients: None; (IV) Collection and assembly of data: Both authors; (V) Data analysis and interpretation: None; (VI) Manuscript writing: Both authors; (VII) Final Approval of manuscript: Both authors. Correspondence to: Dora Brites. Faculdade de Farmácia, Universidade de Lisboa, Lisbon, Portugal. Email: dbrites@ff.ulisboa.pt.
{"title":"Bilirubin neurotoxicity: a narrative review on long lasting, insidious, and dangerous effects","authors":"D. Brites, Rui F. M. Silva","doi":"10.21037/pm-21-37","DOIUrl":"https://doi.org/10.21037/pm-21-37","url":null,"abstract":"Instituto de Investigação do Medicamento (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Lisbon, Portugal; Departamento de Ciências Farmacêuticas e do Medicamento, Faculdade de Farmácia, Universidade de Lisboa, Lisbon, Portugal Contributions: (I) Conception and design: Both authors; (II) Administrative support: None; (III) Provision of study materials or patients: None; (IV) Collection and assembly of data: Both authors; (V) Data analysis and interpretation: None; (VI) Manuscript writing: Both authors; (VII) Final Approval of manuscript: Both authors. Correspondence to: Dora Brites. Faculdade de Farmácia, Universidade de Lisboa, Lisbon, Portugal. Email: dbrites@ff.ulisboa.pt.","PeriodicalId":74411,"journal":{"name":"Pediatric medicine (Hong Kong, China)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48405368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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