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Salivary RNA sequencing highlights a sex-specific developmental time course towards oral feeding maturation in the newborn 唾液RNA测序强调新生儿口服喂养成熟的性别特异性发育时间过程
Pub Date : 2021-01-01 DOI: 10.21037/pm-21-45
Prarthana Khanna, Kaley Jenney, A. Tai, Jill L. Maron
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引用次数: 1
A narrative review: treatment outcomes of central precocious puberty (CPP) 中枢性性性早熟(CPP)的治疗结果综述
Pub Date : 2021-01-01 DOI: 10.21037/pm-21-105
Berrin Ergun-Longmire, Patricia Vining-Maravolo, B. Graham, D. Greydanus
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引用次数: 0
Validity of anti-reflux formulas as a slightly thick liquid: effect of time, caloric density, and refrigerated storage on formula thickness 微稠液体防回流配方的有效性:时间、热量密度和冷藏对配方厚度的影响
Pub Date : 2021-01-01 DOI: 10.21037/pm-21-44
K. McGrattan, Abigail Spoden, Abbey Sterkowitz, M. Gosa, Michael J Beckstrand, K. Hernandez
Background: Advancements in neonatal medicine have resulted in an increased prevalence of infants suffering from swallowing deficits. One method to treat these deficits is to provide thickened liquids through the use of anti-reflux formulas. However, little is known regarding the impact of common clinical conditions such as time since mixing, caloric density, and refrigeration on the thickness of these anti-reflux formulas. The aim of the investigation was to test the effect of clinical variables on thickness of two commonly used U.S. anti-reflux formulas (Enfamil A.R.™ and Similac Spit-Up ® ) in their ready to feed and powder formulations. Methods: Thickness of two anti-reflux formulas (Enfamil A.R.™ and Similac Spit-Up ® ) was tested in their 20 kcal/oz ready to feed formulation and at graduated caloric densities of their powder formulations (20–30 kcal/oz). Thickness was determined using International Dysphagia Diet Standardization Initiative (IDDSI) flow testing methodology and quantified as residual volume and thickness category (thin, slightly thick, mildly thick, moderately thick). Repeated-measures and two-way ANOVA was used to test the effect of formula variables on thickness. Results: Time after mixing did not impact thickness of 20 kcal/oz ready to feed formulations (Enfamil A.R.™, slightly thick, 1.3, 1.1–1.5 mL) (Similac Spit-Up ® , thin, 0.7, 0.4–0.8 mL) though it did for Enfamil A.R.™ powder formulations as characterized by an increase in thickness from thin to slightly thick over 30 minutes. Increasing caloric density of Enfamil A.R.™ caused a stepwise increase in thickness, with thicknesses ranging from slightly thick to moderately thick at the end of the 30-minute testing period across 20–30 kcal/oz formulations. Similac Spit-Up ® did not exhibit any change in thickness based on caloric density. Both Enfamil A.R.™ and Similac Spit-Up ® showed non-significant trends of increased thickness when tested cold after three hours of refrigeration, followed by thinning close to baseline values once the formula was re-heated. Conclusions: Although Enfamil A.R.™ is a valid slightly thick liquid option in its ready to feed formulation, the validity of its powder formulation to reach slightly thick designation is dependent on its caloric density. Future investigations examining the safety of this practice are warranted.
背景:新生儿医学的进步导致婴儿吞咽缺陷的患病率增加。治疗这些缺陷的一种方法是通过使用抗反流配方提供增稠液体。然而,关于常见临床条件(如混合后的时间、热量密度和冷藏)对这些抗反流配方奶粉厚度的影响,我们知之甚少。本研究的目的是测试临床变量对两种常用美国抗反流配方奶粉(Enfamil A.R。™ 和Similac Spit Up®)。方法:两种抗反流配方奶粉(Enfamil A.R。™ 和Similac Spit Up®)在其20千卡/盎司的即食配方和粉末配方的分级热量密度(20-30千卡/oz)下进行了测试。使用国际吞咽困难饮食标准化倡议(IDDSI)流动测试方法测定厚度,并将其量化为残余体积和厚度类别(薄、稍厚、轻度厚、中度厚)。使用重复测量和双向方差分析来检验公式变量对厚度的影响。结果:混合后的时间不会影响20 kcal/oz即食配方奶粉的厚度(Enfamil A.R。™, 稍厚,1.3,1.1–1.5 mL)(Similac Spit Up®,薄,0.7,0.4–0.8 mL),尽管Enfamil A.R。™ 粉末制剂,其特征在于在30分钟内厚度从薄增加到稍厚。Enfamil A.R.不断增加的热量密度。™ 导致厚度逐步增加,在20–30 kcal/oz配方的30分钟测试期结束时,厚度从略厚到中等厚不等。Similac Spit Up®没有显示出基于热量密度的任何厚度变化。Enfamil A.R。™ Similac Spit Up®在冷藏三小时后冷态测试时显示出厚度增加的不显著趋势,随后在配方奶粉重新加热后变薄至接近基线值。结论:尽管安婴儿A.R。™ 在其即食配方中是一种有效的微稠液体选择,其粉末配方达到微稠指定的有效性取决于其热量密度。今后有必要对这种做法的安全性进行调查。
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引用次数: 1
Diagnosis and outcomes of pediatric central nervous system tumors in China: a single-center retrospective analysis from 2015 to 2020 中国儿童中枢神经系统肿瘤的诊断和预后:2015 - 2020年单中心回顾性分析
Pub Date : 2021-01-01 DOI: 10.21037/pm-21-67
Lihua Yu, Jiale Liu, Minjie Luo, D. Lin, Li Wu, Lulu Huang, Yajie Zhang, J. Zi, Jingxin Zhang, Xuebin Liao, J. Guan, Xinde Zhao, Ming Zhou, Yong Yang, Junde Zhang, Wangming Zhang, Lihua Yang
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引用次数: 0
Clinical characteristics and prognosis of pediatric medulloblastoma: a case study of 40 patients at children’s hospital of Soochow university 苏州大学儿童医院40例小儿髓母细胞瘤临床特点及预后分析
Pub Date : 2021-01-01 DOI: 10.21037/pm-21-59
Weiwei Du, Ye Lu, Fan Yang, Q. Lu, Zhiheng Li, Jun Lu, Shaoyan Hu
Background: To explore the clinical, histological, and molecular characteristics of childhood medulloblastoma (MB) and its prognosis. Methods: The authors analyzed clinical and pathological data from MB patients at Children’s Hospital of Soochow University who were diagnosed by pathology after surgical resection between November 2011 and October 2020. Results: A total of 40 patients were considered (20 males and 20 females), where the median age at MB onset was 81 months (5–163 months). Of these, complete resection was performed for 26 cases (26/40, 65%) and subtotal resection performed for 14 cases (14/40, 35%). Pathology after resection indicated that in 8 cases the MB had already metastasized. All 40 children were histologically classified, identifying: 32 cases of classic type (32/40, 80%), 6 cases of desmoplastic/nodular type (6/40, 15%), and 2 cases of anaplastic type (2/40, 5%). Molecular typing tests were performed on 19 children, identifying: 1 case in the wingless-activated (WNT-activated) group (1/19, 5.3%), 6 cases in the sonic hedgehog-activated (SHH-activated) group (6/19, 31.6%), 7 cases in Group 3 (7/19, 36.8%), and 5 cases in Group 4 (5/19, 26.3%). Of the 40 patients, 29 received a combined treatment of surgery, radiotherapy, and chemotherapy, and the median follow-up time was 25 months (1–102 months). The 3-year overall survival rate (OS) and event-free survival rate (EFS) were (64.3±10.4)% and (61.8±10.3)%, respectively. Univariate analyses showed that age, clinical stage, pathological subtype, and radiotherapy were potentially relevant variables in patient prognosis (P<0.05). Cox regression analysis showed that age and tumor metastasis were independent risk factors for poor prognosis of children with MB (P<0.05). Conclusions: Metastasis and age at initial diagnosis are unfavorable factors in the prognosis of childhood MB patients; however, radiotherapy could improve the prognosis of MB patients. 8
背景:探讨儿童髓母细胞瘤(MB)的临床、组织学和分子特征及其预后。方法:作者分析了2011年11月至2020年10月期间东吴大学儿童医院手术切除后经病理诊断为MB患者的临床和病理数据。结果:共考虑了40名患者(20名男性和20名女性),其中MB发病的中位年龄为81个月(5-163个月)。其中,完全切除26例(26/40,65%),次全切除14例(14/40,35%)。切除后病理学检查显示8例MB已经转移。所有40名儿童都进行了组织学分类,确定:经典型32例(32/40,80%),结缔组织增生性/结节型6例(6/40,15%),间变性型2例(2/40,5%)。对19名儿童进行了分子分型测试,确定:无翼激活(WNT激活)组1例(1/19,5.3%),声波刺猬激活(SHH激活)组6例(6/19,31.6%),第3组7例(7/19,36.8%),第4组5例(5/19,26.3%)。在40名患者中,29人接受了手术、放疗和化疗的联合治疗,中位随访时间为25个月(1-102个月)。3年总生存率(OS)和无事件生存率(EFS)分别为(64.3±10.4)%和(61.8±10.3)%。单因素分析显示年龄、临床分期、病理亚型、,Cox回归分析显示年龄和肿瘤转移是儿童MB预后不良的独立危险因素(P<0.05)。结论:转移和初诊年龄是影响儿童MB预后的不利因素;放疗可改善MB患者的预后。8.
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引用次数: 0
Current outcomes and future trends in paediatric and congenital cardiac surgery: a narrative review 儿科和先天性心脏手术的当前结果和未来趋势:叙述性回顾
Pub Date : 2021-01-01 DOI: 10.21037/pm-21-47
L. Kiraly
Objective: To provide a narrative review of the current outcomes and future trends in paediatric and congenital cardiac surgery in a historical and multidisciplinary context. To present the paradigm shift in treating congenital heart disease that translate into improved outcomes. To identify current problems with directions of research. Background: Congenital heart disease (CHD) is the most common birth defect affecting approximately 1 neonate in every 120–166 births. More than half of CHD-patients need cardiac surgery in their lifetime; and half of the surgeries are required within the first six months of life. Methods: Narrative overview of the literature combining with current outcome data available from international databases is presented in comparison to the programme development of a newly-established tertiary-care centre. Conclusion: Congenital cardiac surgery is reconstructive surgery that aims for restoring biventricular circulation, when possible. Single-stage primary complete repair has become the central philosophy since the 1980s. In about thirty percent, physiologic and anatomical reasons do not permit repair by a single operation; these patients endure staged-repairs. Another 15% of CHD patients will require subsequent reoperations— mostly re-replacements of non-growing and/or deranged prostheses. Owing to advances of multidisciplinary treatment, CHD survival to adulthood now reaches 90–95% in high-income countries from less than 20% in the presurgical era. Treating CHD patients is a commitment for life. Research for viable and growing prostheses may solve the significant public health aspects currently associated with reoperations.
目的:在历史和多学科背景下,对儿科和先天性心脏手术的当前结果和未来趋势进行叙述性回顾。介绍治疗先天性心脏病的模式转变,转化为改善的结果。确定当前的问题和研究方向。背景:先天性心脏病(CHD)是最常见的出生缺陷,大约每120-166例新生儿中就有1例。超过一半的冠心病患者一生中需要心脏手术;一半的手术需要在出生后的头六个月内进行。方法:结合从国际数据库中获得的当前结果数据,对文献进行叙述性概述,并与新建立的三级护理中心的方案发展进行比较。结论:先天性心脏手术是一种以恢复双心室循环为目的的再造性手术。自20世纪80年代以来,单阶段初级完全修复已成为中心理念。在大约30%的病例中,生理和解剖原因不允许单次手术修复;这些病人接受分期修复。另外15%的冠心病患者将需要后续的再手术——主要是重新更换不能生长和/或紊乱的假体。由于多学科治疗的进步,在高收入国家,冠心病到成年期的存活率从手术前的不到20%提高到现在的90-95%。治疗冠心病患者是一项终身的承诺。研究可行和生长的假体可以解决目前与再手术相关的重大公共卫生问题。
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引用次数: 1
Clinical features and prognostic analysis of children with medulloblastoma in a single center in China 中国单中心儿童髓母细胞瘤的临床特点及预后分析
Pub Date : 2021-01-01 DOI: 10.21037/pm-21-34
Yan Su, Shuai Zhu, Jing Qin, M. Ge, Yuan-qi Ji, Jian Gong, Tong Yu, Libing Fu, Zhikai Liu, Xiao-li Ma
Background: Medulloblastoma (MB) is the most common malignant pediatric brain tumor. This study systematically summarized the clinical characteristics and prognosis of children with MB respectively. Univariate survival analysis identified age <3 years and the absence of radiotherapy as poor prognostic factors (both P<0.05). Conclusions: Survival outcomes were good among patients with MB (MB) in our center. Young age and the omission of radiotherapy may be predictive of poor outcomes.
背景:髓母细胞瘤是儿童最常见的恶性脑肿瘤。本研究系统总结了小儿MB的临床特点和预后。单因素生存分析发现年龄<3岁和未接受放疗是不良预后因素(P<0.05)。结论:本中心MB患者的生存结局良好。年轻和未接受放射治疗可能预示预后不良。
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引用次数: 0
An attempt at building a database of children using donor human milk in Japan 在日本尝试使用捐赠母乳建立儿童数据库
Pub Date : 2021-01-01 DOI: 10.21037/pm-21-31
Motoichiro Sakurai, Yuko Sakurai, Y. Wada, Yuuki Tani, K. Mizuno
A hospital-dedicated human milk bank was established in Japan at Koto Toyosu Hospital, Showa University in 2014. After a 3-year trial-and-error period, the Japanese Human Milk Bank Association was established in 2017. The supply of donor human milk (DHM) from the Japanese Human Milk Bank Association to various facilities nationwide has increased recently. However, as of 2021, there is only one human milk bank in Japan and the supply is limited. Therefore, there is an urgent need to understand the status of usage of DHM in the neonatal intensive care unit. Moreover, it is globally rare to build a database aimed at understanding the background and prognosis of all children supplied with DHM. In this paper, we have introduced the database and reported on aspects such as the salient points considered in building this database. The fundamental policy of this database included the following: (I) accessibility from the neonatal intensive care unit, (II) a simple input method, (III) reliability and continuity, (IV) safeguarding anonymity, (V) enriched search functionality, and (VI) enabling administration by the person in charge at each facility. In accordance with these six policies, the main items such as patient clinical information, DHM usage amount, and prognosis were set. In addition, the database was built to enable detailed search. The database was completed and became operational in November 2020. The input format was simplified as much as possible by adopting a selection-from-options approach. Enriched search functionality was implemented considering the function as a database in each facility. This database has enabled the proper operation of the human milk bank, and it would likely contribute further to perinatal care outcomes.
2014年,昭和大学东洋医院在日本成立了专门的母乳库。经过3年的试错,日本母乳库协会于2017年成立。最近,日本母乳库协会向全国各地提供的捐赠母乳有所增加。然而,截至2021年,日本只有一家母乳库,供应有限。因此,迫切需要了解DHM在新生儿重症监护室的使用情况。此外,建立一个旨在了解所有接受DHM的儿童的背景和预后的数据库在全球范围内是罕见的。在本文中,我们介绍了该数据库,并报告了在构建该数据库时考虑的要点等方面。该数据库的基本政策包括:(I)新生儿重症监护室的可访问性,(II)简单的输入方法,(III)可靠性和连续性,(IV)保护匿名性,(V)丰富的搜索功能,以及(VI)允许每个设施的负责人进行管理。根据这六项政策,设置了患者临床信息、DHM使用量和预后等主要项目。此外,建立数据库是为了进行详细搜索。该数据库已于2020年11月建成并投入使用。通过采用从选项中选择的方法,尽可能简化了输入格式。实现了丰富的搜索功能,将该功能视为每个设施中的数据库。这个数据库使母乳库能够正常运作,它可能会进一步促进围产期护理的结果。
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引用次数: 0
Bilirubin neurotoxicity: a narrative review on long lasting, insidious, and dangerous effects 胆红素神经毒性:对长期、潜伏和危险影响的叙述性回顾
Pub Date : 2021-01-01 DOI: 10.21037/pm-21-37
D. Brites, Rui F. M. Silva
Instituto de Investigação do Medicamento (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Lisbon, Portugal; Departamento de Ciências Farmacêuticas e do Medicamento, Faculdade de Farmácia, Universidade de Lisboa, Lisbon, Portugal Contributions: (I) Conception and design: Both authors; (II) Administrative support: None; (III) Provision of study materials or patients: None; (IV) Collection and assembly of data: Both authors; (V) Data analysis and interpretation: None; (VI) Manuscript writing: Both authors; (VII) Final Approval of manuscript: Both authors. Correspondence to: Dora Brites. Faculdade de Farmácia, Universidade de Lisboa, Lisbon, Portugal. Email: dbrites@ff.ulisboa.pt.
葡萄牙里斯本里斯本里斯本大学农场学院医学研究所;葡萄牙里斯本里斯本里斯本大学农场医学部贡献:(I)概念和设计:两位作者;(II) 行政支持:无;(III) 提供研究材料或患者:无;(IV) 数据收集和汇编:两位作者;(V) 数据分析和解释:无;(VI) 手稿写作:两位作者;(VII) 手稿的最终批准:两位作者。通信:多拉英国人。里斯本大学药学院,葡萄牙里斯本。电子邮件:dbrites@ff.ulisboa.pt.
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引用次数: 1
Children’s mental health at times of disasters 灾难发生时儿童的心理健康
Pub Date : 2021-01-01 DOI: 10.21037/PM-20-85
K. Olness
: About 40 million children were displaced by disasters in 2020. Displacements associated with natural disasters may be relatively short. Those associated with war and terrorism may continue for a lifetime. Most children experience acute psychologic distress when there is a sudden, unexpected move, regardless of the cause. Depending on pre-existing personality factors, family support, length of displacement and prior trauma, children may develop long term mental health problems, including post traumatic stress disorder (PTSD). Early identification of psychologic distress and appropriate care of affected children can facilitate resilience and reduce long term problems. Persons who help children in the aftermath of disasters should be prepared to provide basic needs of children, help parents (including provision of respite time), screen for psychologic distress in children and parents, use a trauma informed approach in speaking with children, and provide safe play and recreation opportunities. They should also be aware of cultural differences and practices in their development of programs. This paper provides information about types of disasters, international humanitarian law, types of mental health issues experienced by children in disaster situations, screening tools that may be helpful in assessment of mental health issues, and acute interventions that may reduce long term psychological trauma. Relief workers should recognize that they may also be a risk for psychologic distress related to the tragic situations they experience as well as to their own fatigue. There is a great need for more training of relief workers about the mental health issues of children who experience disasters and for training to prevent mental health distress in relief workers.
:2020年,约有4000万儿童因灾害而流离失所。与自然灾害有关的流离失所可能相对较短。那些与战争和恐怖主义有关的行为可能会持续一生。无论是什么原因,当发生突然、意外的举动时,大多数孩子都会经历严重的心理困扰。根据先前存在的人格因素、家庭支持、流离失所时间和先前的创伤,儿童可能会出现长期的心理健康问题,包括创伤后应激障碍(PTSD)。早期发现心理困扰并对受影响的儿童进行适当的护理可以促进恢复力并减少长期问题。灾后帮助儿童的人员应做好准备,提供儿童的基本需求,帮助父母(包括提供休息时间),筛查儿童和父母的心理困扰,在与儿童交谈时采用创伤知情的方法,并提供安全的玩耍和娱乐机会。他们还应该意识到文化差异和他们在项目开发中的做法。本文提供了有关灾害类型、国际人道主义法、儿童在灾害情况下经历的心理健康问题类型、可能有助于评估心理健康问题的筛查工具以及可能减少长期心理创伤的急性干预措施的信息。救援人员应该认识到,他们也可能有心理痛苦的风险,这与他们所经历的悲惨情况以及他们自己的疲劳有关。迫切需要对救援人员进行更多关于经历灾难的儿童心理健康问题的培训,并进行培训以防止救援人员出现心理健康问题。
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引用次数: 0
期刊
Pediatric medicine (Hong Kong, China)
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