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Proceedings. IEEE International Symposium on Computer-Based Medical Systems最新文献

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Support for Accessibility, Reproducibility and Transparency in a Service-Oriented Gene Expression Analysis Platform 在面向服务的基因表达分析平台中支持可访问性、可重复性和透明性
Pub Date : 2019-06-01 DOI: 10.1109/CBMS.2019.00098
Wilson Daniel da Silva, C. D. Farias
An integrated platform can be used to support the analysis of gene expression data. In principle, this platform should provide support for accessibility, reproducibility and transparency in order to facilitate its use. However, this support varies among different platforms. SemanticSCo consists of an integrated platform that allows the development of a gene expression analysis workflow based on the semiautomatic composition of semantic web services. SemanticSCo provides limited support for accessibility. Further, the platform lacks support for reproducibility and transparency. This paper describes how accessibility was improved and how reproducibility and transparency were introduced into a new version of the platform, called SemanticSCo Web. These improvements facilitate the development, execution and sharing of gene expression analysis workflows.
一个集成的平台可以用来支持基因表达数据的分析。原则上,该平台应支持可访问性、可再现性和透明度,以促进其使用。但是,这种支持在不同的平台之间是不同的。SemanticSCo由一个集成平台组成,该平台允许基于语义web服务的半自动组合开发基因表达分析工作流。semantic为可访问性提供了有限的支持。此外,该平台缺乏对可重复性和透明度的支持。本文描述了如何改进可访问性,以及如何将可再现性和透明性引入到称为semantic Web的新版本平台中。这些改进促进了基因表达分析工作流程的开发、执行和共享。
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引用次数: 0
Non Invasive Live Cell Cycle Monitoring using Quantitative Phase Imaging and Proximal Machine Learning Methods 使用定量相位成像和近端机器学习方法的无创活细胞周期监测
Pub Date : 2019-01-01 DOI: 10.1109/CBMS.2019.00099
P. Pognonec, M. Barlaud, B. Wattellier, T. Pourcher, Yuxiang Zhou, Sherazade Aknoun, M. Yonnet, M. Antonini
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引用次数: 0
STMC: Semantic Tag Medical Concept Using Word2Vec Representation 使用Word2Vec表示的语义标签医学概念
Pub Date : 2018-06-18 DOI: 10.1109/CBMS.2018.00075
I. M. Soriano, J. Castro
In this paper we propose a recognition system of medical concepts from free text clinical reports. Our approach tries to recognize also concepts which are named with local terminology, with medical writing scripts, short words, abbreviations and even spelling mistakes. We consider a clinical terminology ontology (Snomed-CT), as a dictionary of concepts. In a first step we obtain an embedding model using word2vec methodology from a big corpus database of clinical reports. Word vectors are positioned in the vector space such that words that share common contexts in the corpus are located in close proximity to one another in the space, and so the geometrical similarity can be considered a measure of semantic relation. We have considered 615513 emergency clinical reports from the Hospital "Rafael Mendez" in Lorca, Murcia. In these reports there are a lot of local language of the emergency domain, medical writing scripts, short words, abbreviations and even spelling mistakes. With the model obtained we represent the words and sentences as vectors, and by applying cosine similarity we identify which concepts of the ontology are named in the text. Finally, we represent the clinical reports (EHR) like a bag of concepts, and use this representation to search similar documents. The paper illustrates 1) how we build the word2vec model from the free text clinical reports, 2) How we extend the embedding from words to sentences, and 3) how we use the cosine similarity to identify concepts. The experimentation, and expert human validation, shows that: a) the concepts named in the text with the ontology terminology are well recognized, and b) others concepts that are not named with the ontology terminology are also recognized, obtaining a high precision and recall measures.
本文提出了一种基于自由文本临床报告的医学概念识别系统。我们的方法也试图识别用当地术语命名的概念,医学写作脚本,短句,缩写,甚至拼写错误。我们考虑一个临床术语本体(Snomed-CT),作为一个概念词典。在第一步中,我们使用word2vec方法从大型临床报告语料库数据库中获得嵌入模型。词向量被定位在向量空间中,使得语料库中具有共同上下文的词在空间中彼此接近,因此几何相似性可以被认为是语义关系的度量。我们审议了穆尔西亚洛尔卡"拉斐尔·门德斯"医院的615513份紧急临床报告。在这些报告中有大量的应急领域的当地语言,医学写作脚本,短词,缩写,甚至拼写错误。利用得到的模型,我们将单词和句子表示为向量,并通过余弦相似度来识别本体的哪些概念在文本中被命名。最后,我们将临床报告(EHR)表示为概念包,并使用这种表示来搜索类似的文档。本文阐述了1)如何从自由文本临床报告中构建word2vec模型,2)如何将嵌入从单词扩展到句子,以及3)如何使用余弦相似度来识别概念。实验和专家人工验证表明:a)文本中使用本体术语命名的概念被很好地识别,b)其他未使用本体术语命名的概念也被识别,获得了较高的准确率和召回率。
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引用次数: 3
SIPRAD: A Radiotherapy Planning System (RTPS) SIPRAD:放疗计划系统(RTPS)
Pub Date : 2018-06-01 DOI: 10.1109/CBMS.2018.00081
D. F. Carvalho, José Antonio Camacho Guerrero, A. Uscamayta, H. Vale, H. Oliveira
Cancer is one type of lethal disease that needs an immediate diagnosis and treatment, demanding the use of advanced technologies. External Radiotherapy is the most common treatment used in the world. Radiotherapy Planning Systems (RTPS) is a software suite used for delineation of organs and calculation of irradiation doses and is essential to ensure the accuracy of oncologic treatment in clinics and hospitals. This works presents a type of RTPS, named SIPRAD, developed for public hospitals reality in Brazil with the assistance of the doctors. SIPRAD architecture uses a number of management and operational tools for all radiotherapy treatment process. One of the main contributions of this work is its interoperable infrastructure capable of communicating with all health systems and devices. Another contribution is a drawing tool, which is able to perform an automatic contour delineation in organs at risk and tumors volumes. Additionally also extends the use of tomography slices in grayscale images applied in three plans: axial, coronal and sagittal. SIPRAD automatic contour delineation saves up 75% of the time for drawings in three different types of regions body exams. Finally, SIPRAD was tested in a set of oncologic exams provided by the University of Sao Paulo Clinical Hospital (HCRP and HC-USP) in Brazil obtained from patients with different conditions of ethnology, ages, tumor severities and body regions.
癌症是一种需要立即诊断和治疗的致命疾病,需要使用先进的技术。外部放射治疗是世界上最常用的治疗方法。放射治疗计划系统(RTPS)是一套用于描绘器官和计算辐照剂量的软件,对于确保诊所和医院肿瘤治疗的准确性至关重要。本作品介绍了一种名为SIPRAD的RTPS,它是在医生的帮助下根据巴西公立医院的实际情况开发的。SIPRAD架构在所有放射治疗过程中使用许多管理和操作工具。这项工作的主要贡献之一是其可互操作的基础设施,能够与所有卫生系统和设备进行通信。另一个贡献是绘图工具,它能够在危险器官和肿瘤体积中执行自动轮廓描绘。此外,还扩展了在灰度图像中应用三种计划的断层扫描切片:轴向,冠状和矢状。SIPRAD自动轮廓绘制在三种不同类型的区域体检查中节省75%的绘图时间。最后,SIPRAD在巴西圣保罗大学临床医院提供的一套肿瘤学检查(HCRP和HC-USP)中进行测试,这些检查来自不同人种学、年龄、肿瘤严重程度和身体区域的患者。
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引用次数: 2
Laugh and Crying Perception in Patients with Severe and Moderate TBI Using FFT Analysis 重型和中度脑外伤患者笑哭感知的FFT分析
Pub Date : 2017-06-01 DOI: 10.1109/CBMS.2017.11
G. Portnova, K. Gladun
Post-traumatic emotional disorder event is a major cause of slow rehabilitation worldwide. The present study investigates the effects of emotional sound stimulation at different groups of subjects with TBI. At the base of our research strategy, we had used a group with diffuse axonal injury (DAI). We collected three groups of patients: 45 healthy adults, 20 patients with severe TBI and 19 patients with moderate TBI. Neurophysiology trials aim was to determine the processes that accompany emotional changes within traumatic brain damage. We analysed emotional EEG response for crying and laughter in patients with severe TBI, patients with moderate TBI and healthy volunteers. We used FFT analyses to quantify highfrequency HRV and average heart rate. Our results showed that patient with TBI showed higher response to crying compared to laughter, accompanied by slow-wave activity in the right temporal area and higher heart rate variability.
创伤后情绪障碍事件是世界范围内康复缓慢的主要原因。本研究探讨了情绪声刺激对不同组脑外伤患者的影响。在我们研究策略的基础上,我们选择了弥漫性轴索损伤(DAI)组。我们收集了三组患者:45名健康成人,20名重度TBI患者和19名中度TBI患者。神经生理学试验的目的是确定创伤性脑损伤中伴随情绪变化的过程。我们分析了重度脑外伤患者、中度脑外伤患者和健康志愿者哭泣和大笑的情绪脑电图反应。我们使用FFT分析来量化高频HRV和平均心率。我们的研究结果表明,与大笑相比,TBI患者对哭泣表现出更高的反应,并伴有右颞区慢波活动和更高的心率变异性。
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引用次数: 2
Simulation of Spiral Waves and Point Sources in Atrial Fibrillation with Application to Rotor Localization. 心房颤动中螺旋波和点源的仿真及其在转子定位中的应用。
Pub Date : 2017-06-01 Epub Date: 2017-11-13 DOI: 10.1109/CBMS.2017.161
Prasanth Ganesan, Kristina E Shillieto, Behnaz Ghoraani

Cardiac simulations play an important role in studies involving understanding and investigating the mechanisms of cardiac arrhythmias. Today, studies of arrhythmogenesis and maintenance are largely being performed by creating simulations of a particular arrhythmia with high accuracy comparable to the results of clinical experiments. Atrial fibrillation (AF), the most common arrhythmia in the United States and many other parts of the world, is one of the major field where simulation and modeling is largely used. AF simulations not only assist in understanding its mechanisms but also help to develop, evaluate and improve the computer algorithms used in electrophysiology (EP) systems for ablation therapies. In this paper, we begin with a brief overeview of some common techniques used in simulations to simulate two major AF mechanisms - spiral waves (or rotors) and point (or focal) sources. We particularly focus on 2D simulations using Nygren et al.'s mathematical model of human atrial cell. Then, we elucidate an application of the developed AF simulation to an algorithm designed for localizing AF rotors for improving current AF ablation therapies. Our simulation methods and results, along with the other discussions presented in this paper is aimed to provide engineers and professionals with a working-knowledge of application-specific simulations of spirals and foci.

心脏模拟在理解和研究心律失常的机制方面起着重要的作用。今天,心律失常发生和维持的研究主要是通过模拟特定心律失常来进行的,其准确度与临床实验结果相当。心房颤动(AF)是美国和世界上许多其他地区最常见的心律失常,也是大量使用仿真和建模的主要领域之一。AF模拟不仅有助于理解其机制,而且有助于开发、评估和改进用于消融治疗的电生理(EP)系统的计算机算法。在本文中,我们首先简要概述了用于模拟两种主要AF机制-螺旋波(或转子)和点(或焦点)源的一些常用技术。我们特别关注使用Nygren等人的人类心房细胞数学模型的二维模拟。然后,我们阐明了开发的AF模拟在AF转子定位算法中的应用,以改进当前的AF消融治疗。我们的模拟方法和结果,以及本文中提出的其他讨论旨在为工程师和专业人员提供特定应用的螺旋和焦点模拟的工作知识。
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引用次数: 5
Application of Affinity Analysis Techniques on Diagnosis and Prescription Data 亲和分析技术在诊断和处方数据中的应用
Pub Date : 2017-06-01 DOI: 10.1109/CBMS.2017.114
S. Theodora, Varlamis Iraklis
This study performs an Affinity Analysis ondiagnosis and prescription data in order to discover cooccurrencerelationships among diagnosis and pharmaceuticalactive ingredients prescribed to different patient groups. Theanalysis data collected during consecutive visits of 4,473 patients in a 3 years period, focused on patients suffering byhypertension and/or hypercholesterolemia and appliedassociation rule and sequential rule mining techniques. Thefindings have been validated in the specific dataset usingstatistical analysis methods. Association rule mining shows an association between gastrooesophagealreflux and the medicines prescribed forhypertension and heart diseases, which agrees with findings inthe related literature. Another interesting finding, not yet beenreported in related studies is the association between heartdiseases, gastroesophageal reflux and insulin-dependentdiabetes mellitus for patients that have both hypertension andhypercholesterolemia. Apart from the medical findings, which must be subject offurther research we propose a methodology for the analysis ofdata collected from a continuous screening process of a groupof patients. With the use of data mining techniques we are ableto extract and formulate the potential research questions, which are then validated using statistical methods and can alsobe validated in larger population studies.
本研究对诊断和处方数据进行亲和分析,以发现不同患者群体的诊断和药物活性成分之间的共现关系。在3年的时间里,对4473例高血压和/或高胆固醇血症患者的连续就诊数据进行了分析,并应用了关联规则和顺序规则挖掘技术。研究结果已在特定数据集中使用统计分析方法进行验证。关联规则挖掘显示胃食管反流与高血压和心脏病处方药物之间存在关联,这与相关文献的研究结果一致。另一个尚未在相关研究中报道的有趣发现是,对于同时患有高血压和高胆固醇血症的患者,心脏病、胃食管反流和胰岛素依赖性糖尿病之间存在关联。除了需要进一步研究的医学发现之外,我们提出了一种方法,用于分析从一组患者的连续筛选过程中收集的数据。通过使用数据挖掘技术,我们能够提取和制定潜在的研究问题,然后使用统计方法进行验证,也可以在更大的人口研究中进行验证。
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引用次数: 2
A New Ontology-Based Method for Functional Composed Comparison of MicroRNAs 基于本体的microrna功能组成比较新方法
Pub Date : 2015-06-22 DOI: 10.1109/CBMS.2015.55
Mariana Yuri Sasazaki, J. C. Felipe
MicroRNAs (miRNAs) are small non-coding RNA molecules that negatively regulate gene expression, playing critical roles in many relevant biological processes. Since there are no terms of miRNAs annotation in Gene Ontology (GO) nor a database with miRNA functional annotation, the direct computation of functional similarity between miRNAs cannot be done under an established standardized approach. However, a miRNA can be annotated with a set of information, such as if it acts as oncogene or as tumour suppressor, the organism that it belongs, its association with diseases, target genes, proteins and pathological events. This way, the similarity between two miRNAs can be inferred based, for example, in the relative position of their respective target genes in GO. In this study, we propose and evaluate CFSim, a method that uses GO and the disease ontology MeSH to compute miRNAs composed similarity by combining different information related to them. We validated CFSim by examining functional similarity values inferred intra and inter miRNA families, and the results showed that our method is efficient in sense that the functional similarity between miRNAs in the same family was higher compared to other miRNAs from distinct families. Furthermore, in comparison with existing methods for functional similarity, CFSim is more effective in distinguishing miRNA families.
MicroRNAs (miRNAs)是一种非编码小分子RNA,可以负向调节基因表达,在许多相关的生物学过程中发挥关键作用。由于基因本体(Gene Ontology, GO)中没有miRNA注释的术语,也没有miRNA功能注释的数据库,因此无法在既定的标准化方法下直接计算miRNA之间的功能相似性。然而,miRNA可以用一系列信息进行注释,例如它是作为致癌基因还是肿瘤抑制基因,它所属的生物体,它与疾病的关联,靶基因,蛋白质和病理事件。通过这种方式,可以推断出两个mirna之间的相似性,例如,基于它们各自靶基因在氧化石墨烯中的相对位置。在本研究中,我们提出并评估了CFSim,这是一种使用GO和疾病本体MeSH通过组合与它们相关的不同信息来计算mirna组成相似度的方法。我们通过检查miRNA家族内部和家族间推断的功能相似性值来验证CFSim,结果表明我们的方法是有效的,因为同一家族的miRNA之间的功能相似性高于来自不同家族的其他miRNA。此外,与现有的功能相似性方法相比,CFSim在区分miRNA家族方面更有效。
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引用次数: 0
Developing an Educational Medical Game Using AgilePASSI Multi-agent Methodology 使用AgilePASSI多智能体方法开发教育医学游戏
Pub Date : 2015-06-22 DOI: 10.1109/CBMS.2015.81
Vitor Manuel Fragoso Ferreira, J. Carvalho, R. M. Costa, Vera Werneck
Games applied to health education have emerged as a motivational improvement in learning and clinical performance of students from the health care area. Currently, there are several agent oriented methodologies that support the multi-agent systems development. However none are specific to the domain of medical and health education. Agent-oriented development of medical educational games must have special features such working with a multidisciplinary team, have a high degree of user involvement and allow a mutuality of game requirements. Within this context, this paper presents the development of MEDEDUC, an educational systems technology applying agile development through the AGILE-PASSI methodology. This game, which has five levels of difficulty, allows the student to study pulmonology answering questions that explore multimedia presentations. The results of this study stressed the advantages of the agile development methodology game that combines medical theory and multi-agent.
应用于健康教育的游戏已经出现,作为一种动机改进学习和临床表现的学生来自卫生保健领域。目前,有几种面向代理的方法支持多代理系统的开发。但是,没有一个是专门针对医学和卫生教育领域的。面向代理的医学教育游戏开发必须具有特殊的功能,如与多学科团队合作,具有高度的用户参与度,并允许游戏需求的相互性。在此背景下,本文介绍了MEDEDUC的开发,这是一种通过agile - passi方法应用敏捷开发的教育系统技术。这个游戏有五个级别的难度,允许学生学习肺脏学,回答探索多媒体演示的问题。本研究的结果强调了结合医学理论和多agent的敏捷开发方法game的优势。
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引用次数: 3
Electronic Systems Interoperability Study: Based on the Interchange of Hospital Obstetrical Information 基于医院产科信息交换的电子系统互操作性研究
Pub Date : 2015-06-22 DOI: 10.1109/CBMS.2015.57
Z. Reis, J. Gaspar, A. C. Souza, M. S. Junior, Thais Abreu Maia, M. R. Santos
The Obstetric Inpatient Discharge Summary is a document considered essential in the complex care network for health care continuity. AIMS: The study proposes a model for the transmission of clinical information contained in the discharge summary with the aim of exchanging the information between electronic systems and defining standards, allowing the testing of obstetric records interoperability, referring, in particular, to births. METHODS: Information was modeled using the methodology for developing archetypes proposed in the International Standardization Organization 13606 standard. RESULTS: The electronic document was implemented in a university hospital, and the information was divided into two sections, one containing maternal data and the other neonate(s) information. An Electronic Health Record extract in eXtensible Markup Language, containing structured clinical data, will constitute the vector of transmission system from hospital information to primary care units. CONCLUSION: The model proposed is expected to subsidize information semantic persistence, contributing to health care quality.
产科住院病人出院摘要是一份文件,被认为是复杂的保健网络中必不可少的保健连续性。目的:该研究提出了一种传输出院摘要中包含的临床信息的模型,目的是在电子系统和定义标准之间交换信息,允许产科记录互操作性的测试,特别是指分娩。方法:使用国际标准化组织13606标准中提出的开发原型的方法对信息进行建模。结果:某高校医院实施了电子病历,病历信息分为两部分,一部分包含产妇信息,另一部分包含新生儿信息。以可扩展标记语言编写的包含结构化临床数据的电子病历摘录将构成从医院信息到初级保健单位的传输系统的载体。结论:该模型可增强信息语义持久性,提高医疗服务质量。
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引用次数: 4
期刊
Proceedings. IEEE International Symposium on Computer-Based Medical Systems
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