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Automated Detection of 3D Landmarks for the Elimination of Non-Biological Variation in Geometric Morphometric Analyses. 用于消除几何形态测量分析中非生物变异的3D地标自动检测。
Pub Date : 2015-06-01 DOI: 10.1109/CBMS.2015.86
D Aneja, S R Vora, E D Camci, L G Shapiro, T C Cox

Landmark-based morphometric analyses are used by anthropologists, developmental and evolutionary biologists to understand shape and size differences (eg. in the cranioskeleton) between groups of specimens. The standard, labor intensive approach is for researchers to manually place landmarks on 3D image datasets. As landmark recognition is subject to inaccuracies of human perception, digitization of landmark coordinates is typically repeated (often by more than one person) and the mean coordinates are used. In an attempt to improve efficiency and reproducibility between researchers, we have developed an algorithm to locate landmarks on CT mouse hemi-mandible data. The method is evaluated on 3D meshes of 28-day old mice, and results compared to landmarks manually identified by experts. Quantitative shape comparison between two inbred mouse strains demonstrate that data obtained using our algorithm also has enhanced statistical power when compared to data obtained by manual landmarking.

基于地标的形态计量学分析被人类学家、发育和进化生物学家用来理解形状和大小的差异。在颅骨中)在标本群之间。标准的劳动密集型方法是研究人员手动在3D图像数据集上放置地标。由于地标识别受制于人类感知的不准确性,地标坐标的数字化通常是重复的(通常不止一个人),并使用平均坐标。为了提高研究人员之间的效率和可重复性,我们开发了一种算法来定位CT小鼠半下颌骨数据上的地标。该方法在28天龄小鼠的三维网格上进行了评估,并将结果与专家手动识别的地标进行了比较。对两种近交系小鼠的形状进行定量比较,结果表明,与手工标记数据相比,本文算法获得的数据具有更强的统计能力。
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引用次数: 14
Lyria PACS: A Case Study Saves Ten Million Dollars in a Brazilian Hospital Lyria PACS:巴西一家医院的案例研究节省了一千万美元
Pub Date : 2015-01-01 DOI: 10.1109/CBMS.2015.87
D. F. Carvalho, J. A. Guerrero, P. M. A. Marques, Alessandra Alaniz Macedo
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引用次数: 0
A Multicriteria Method for Cervical Tumor Segmentation in Positron Emission Tomography 一种多准则的正电子发射断层扫描子宫颈肿瘤分割方法
Pub Date : 2014-05-27 DOI: 10.1109/CBMS.2014.52
Andre Luis Resende Monteiro, A. Machado, Marcelo Henrique Mamede Lewer
Accurate delineation of tumors is a fundamental requirement for proper planning and subsequent cancer treatment. In this paper, we propose to model the process of tumor segmentation as a multicriteria decision making problem, considering the information embedded in both Positron Emission Tomography (PET) and Computed tomography (CT) images. A set of images of cervical tumors were semi-automated segmented and the results compared with a manual delineation. The results show that using a multiple criteria approach in the segmentation process can improve sensitivity, and the utilization of both PET and CT images may be a factor for improving precision.
准确描述肿瘤是正确规划和后续癌症治疗的基本要求。在本文中,我们提出将肿瘤分割过程建模为一个多准则决策问题,同时考虑到正电子发射断层扫描(PET)和计算机断层扫描(CT)图像中嵌入的信息。对一组宫颈肿瘤图像进行了半自动分割,并与人工分割结果进行了比较。结果表明,在分割过程中采用多准则方法可以提高灵敏度,同时利用PET和CT图像可能是提高精度的一个因素。
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引用次数: 5
Classifying Craniosynostosis with a 3D Projection-Based Feature Extraction System. 利用基于三维投影的特征提取系统对颅畸形进行分类。
Pub Date : 2014-05-01 DOI: 10.1109/CBMS.2014.63
Irma Lam, Michael Cunningham, Matthew Speltz, Linda Shapiro

Craniosynostosis, a disorder in which one or more fibrous joints of the skull fuse prematurely, causes skull deformity and is associated with increased intracranial pressure and developmental delays. Although clinicians can easily diagnose craniosynostosis and can classify its type, being able to quantify the condition is an important problem in craniofacial research. While several papers have attempted this quantification through statistical models, the methods have not been intuitive to biomedical researchers and clinicians who want to use them. The goal of this work was to develop a general platform upon which new quantification measures could be developed and tested. The features reported in this paper were developed as basic shape measures, both single-valued and vector-valued, that are extracted from a single plane projection of the 3D skull. This technique allows us to process images that would otherwise be eliminated in previous systems due to poor resolution, noise or imperfections on their CT scans. We test our new features on classification tasks and also compare their performance to previous research. In spite of its simplicity, the classification accuracy of our new features is significantly higher than previous results on head CT scan data from the same research studies.

颅骨融合症是一种颅骨的一个或多个纤维关节过早融合的疾病,会导致颅骨畸形,并与颅内压增高和发育迟缓有关。虽然临床医生可以很容易地诊断出颅骨融合症并对其类型进行分类,但如何量化这种疾病是颅面研究中的一个重要问题。虽然已有多篇论文尝试通过统计模型进行量化,但这些方法对于想要使用它们的生物医学研究人员和临床医生来说并不直观。这项工作的目标是开发一个通用平台,在此基础上开发和测试新的量化方法。本文报告的特征是作为基本形状测量方法开发的,包括单值和向量值,均从三维头骨的单一平面投影中提取。这项技术使我们能够处理那些在以前的系统中由于分辨率低、噪声或 CT 扫描不完美而被剔除的图像。我们在分类任务中测试了我们的新特征,并将其性能与之前的研究进行了比较。尽管我们的新特征非常简单,但其分类准确率却明显高于之前在相同研究的头部 CT 扫描数据上的结果。
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引用次数: 0
Computer-Based Coding of Occupation Codes for Epidemiological Analyses. 流行病学分析职业代码计算机编码。
Pub Date : 2014-05-01 DOI: 10.1109/CBMS.2014.79
Daniel E Russ, Kwan-Yuet Ho, Calvin A Johnson, Melissa C Friesen

Mapping job titles to standardized occupation classification (SOC) codes is an important step in evaluating changes in health risks over time as measured in inspection databases. However, manual SOC coding is cost prohibitive for very large studies. Computer based SOC coding systems can improve the efficiency of incorporating occupational risk factors into large-scale epidemiological studies. We present a novel method of mapping verbatim job titles to SOC codes using a large table of prior knowledge available in the public domain that included detailed description of the tasks and activities and their synonyms relevant to each SOC code. Job titles are compared to our knowledge base to find the closest matching SOC code. A soft Jaccard index is used to measure the similarity between a previously unseen job title and the knowledge base. Additional information such as standardized industrial codes can be incorporated to improve the SOC code determination by providing additional context to break ties in matches.

将职称映射到标准化职业分类(SOC)代码是评估检查数据库中测量的健康风险随时间变化的重要步骤。然而,手动SOC编码对于非常大的研究来说成本过高。基于计算机的SOC编码系统可以提高将职业危险因素纳入大规模流行病学研究的效率。我们提出了一种将逐字职位名称映射到SOC代码的新方法,该方法使用公共领域中可用的大量先验知识表,其中包括与每个SOC代码相关的任务和活动及其同义词的详细描述。职位名称与我们的知识库进行比较,以找到最接近的匹配SOC代码。软Jaccard指数用于衡量以前未见过的职位与知识库之间的相似性。其他信息,如标准化工业代码,可以通过提供额外的上下文来打破匹配中的联系,以改善SOC代码的确定。
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引用次数: 16
The role of medical data analytics in reducing health fraud and improving clinical and financial outcomes 医疗数据分析在减少医疗欺诈和改善临床和财务结果方面的作用
Pub Date : 2013-06-20 DOI: 10.1109/CBMS.2013.6627755
R. B. Rao
Consider the following healthcare trends: (1) There is a tremendous increase in the amount of patient, life sciences and process data in electronic form, fueled by advances in healthcare IT technology, and health reform legislation. (2) The amount of medical information (e.g., evidence-based knowledge) and published knowledge is said to be doubling every few years. (3) There is an explosion in the number of available therapies and diagnostic options for patient care, often enabling precise targeting of therapy to disease conditions. In this talk we will discuss these trends and some of the reasons why, despite these advances, healthcare is facing a crisis: namely, there is a steady unsustainable increase in medical costs without a corresponding improvement of patient outcomes. We believe that analysis of clinical, life sciences and medical process data can play a key role in tackling these fundamental challenges. Two technology advances, in particular, can play a key role: cloud computing and mobility will make it possible to analyze vast amounts of data and quickly deliver useful information to clinicians, consumers and researchers at the point where it can have the most impact. Some of this is already happening today, with medical records being analyzed to reduce fraud, waste and abuse, improve patient outcomes, and to improve compliance with standards of care and policy guidelines. We conclude the talk with a glimpse of a future where medical systems could be continually analyzed for optimizing healthcare costs and outcomes.
考虑以下医疗保健趋势:(1)由于医疗保健IT技术的进步和医疗改革立法的推动,电子形式的患者、生命科学和流程数据的数量急剧增加。(2)医学信息(如循证知识)和已发表知识的数量据说每隔几年就翻一番。(3)可用于病人护理的治疗方法和诊断选择的数量呈爆炸式增长,通常能够针对疾病状况进行精确的治疗。在这次演讲中,我们将讨论这些趋势,以及尽管取得了这些进步,医疗保健仍面临危机的一些原因:即,医疗费用持续增长,而患者的治疗效果却没有相应改善。我们相信,对临床、生命科学和医疗过程数据的分析可以在应对这些基本挑战方面发挥关键作用。特别是两项技术进步可以发挥关键作用:云计算和移动性将使分析大量数据成为可能,并在影响最大的时候迅速向临床医生、消费者和研究人员提供有用的信息。其中一些已经在今天发生,通过分析医疗记录来减少欺诈、浪费和滥用,改善患者的治疗效果,并改善对护理标准和政策指导方针的遵守。我们以对未来医疗系统可以不断分析以优化医疗成本和结果的一瞥来结束谈话。
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引用次数: 13
Bayesian networks to answer challenging neuroscience questions 贝叶斯网络来回答具有挑战性的神经科学问题
Pub Date : 2013-06-20 DOI: 10.1109/CBMS.2013.6627754
P. Larrañaga, C. Bielza
Summary form only given. In this keynote lecture we will show how Bayesian networks can address important neuroscience problems. These problems include: (a) neuroanatomy issues, like modeling and simulation of dendritic trees and classifying neuron types based on morphological features; (b) neurodegenerative diseases, like predicting health-related quality of life in Parkinson's disease, classification of dementia stages in Parkinson's disease and searching for genetic biomarkers in Alzheimer's disease.
只提供摘要形式。在这次主题演讲中,我们将展示贝叶斯网络如何解决重要的神经科学问题。这些问题包括:(a)神经解剖学问题,如树突树的建模和模拟以及基于形态学特征的神经元类型分类;(b)神经退行性疾病,如预测帕金森病患者与健康相关的生活质量,帕金森病患者痴呆阶段的分类,以及寻找阿尔茨海默病的遗传生物标志物。
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引用次数: 1
Why don't engineers and clinicians talk the same language - And what to do about it? 为什么工程师和临床医生说的不是同一种语言?对此该怎么办?
Pub Date : 2013-06-20 DOI: 10.1109/CBMS.2013.6627753
J. Wyatt
In my experience, presentations at AIME, IEEE or EFMI conferences often describe work by academic engineers using patients as a source of data to explore new modelling methods, and few demonstrate convincing solutions to real world clinical problems. One reason for this is that many doctors make themselves inaccessible, so engineers find it hard to engage them in projects. Since healthcare and medical work are very complex, it takes years of exposure to clinicians and healthcare settings for an engineer to understand real-world patient management problems in sufficient detail to help solve them. This means that sometimes, an engineer might believe they have solved the problem, while to a clinician they have only explored an irrelevant simplification of it. Another explanation is that some engineering academics have had their fingers burned by clinicians, who expect the engineer to carry out an everyday system development task with no research payload. Such engineers will become suspicious of engaging too closely with doctors. Cynics might be less fair, observing that since medical research is well funded, there is a tendency for engineers to apply any novel engineering method to a simplified health data as this is more likely to attract funding than applying their method to, say, linguistics data. However, I believe there is a deeper explanation of why so few bioengineering projects seem to bear clinically digestible fruit: there are fundamental differences in motivation, research focus and research methods between engineering and healthcare research domains, and in the kind of problems they address. For example, the engineering approaches used in the Virtual Physiological Human programme mainly involve data mining and modelling, while clinicians emphasise using psychological, social or other theories to understand and formalise a complex problem first, then use empirical testing to find out whether a theory-based solution works - the evidence based approach. It is clearly unhelpful for engineers to criticise doctors as being poor collaborators in multidisciplinary projects, just as it is for doctors to criticise engineers. So, the aim of this talk is to move beyond name calling to explore common ground constructively and to provoke useful reflection and discussion, both within and across these disciplines. This talk will therefore explore some of the similarities and differences between engineering and healthcare as research disciplines, their respective approaches to problem solving and attempt to build bridges between these two very different worlds. In conclusion, unless we describe the features of this uneasy stand-off between engineers and clinicians, confront it head on and provoke debate, it looks set to continue. This will reduce productivity on both sides and limit the enormous scientific, economic and social benefits that novel, clinically appropriate and collaboratively engineered systems can generate.
根据我的经验,在AIME, IEEE或EFMI会议上的演讲经常描述学术工程师使用患者作为数据来源来探索新的建模方法的工作,很少有令人信服的解决方案来解决现实世界的临床问题。其中一个原因是,许多医生不愿与人接触,因此工程师很难让他们参与项目。由于医疗保健和医疗工作非常复杂,工程师需要多年接触临床医生和医疗保健环境,才能充分详细地了解现实世界中的患者管理问题,从而帮助解决这些问题。这意味着,有时候,工程师可能会认为他们已经解决了问题,而对临床医生来说,他们只是探索了一个无关紧要的简化。另一种解释是,一些工程学者已经被临床医生烫伤了,他们希望工程师在没有研究负载的情况下执行日常系统开发任务。这些工程师会对与医生过于密切的接触产生怀疑。愤世嫉俗者可能就不那么公平了,他们观察到,由于医学研究得到了充足的资助,工程师们倾向于将任何新颖的工程方法应用于简化的健康数据,因为这比将他们的方法应用于语言学数据更有可能吸引资金。然而,我相信有一个更深层次的解释,为什么如此少的生物工程项目似乎产生临床可消化的成果:在动机、研究重点和研究方法上,工程和医疗保健研究领域之间存在根本差异,以及它们所解决的问题类型。例如,在虚拟生理人项目中使用的工程方法主要涉及数据挖掘和建模,而临床医生强调首先使用心理学、社会或其他理论来理解和形式化一个复杂的问题,然后使用经验测试来找出基于理论的解决方案是否有效——基于证据的方法。工程师批评医生在多学科项目中合作不佳显然是无益的,就像医生批评工程师一样。所以,这次演讲的目的是超越谩骂,建设性地探索共同点,并在这些学科内部和学科之间引发有益的反思和讨论。因此,本讲座将探讨工程和医疗保健作为研究学科之间的一些异同,他们各自解决问题的方法,并试图在这两个截然不同的世界之间建立桥梁。总之,除非我们描述工程师和临床医生之间这种令人不安的对峙的特点,正面面对它并引发辩论,否则这种对峙似乎将继续下去。这将降低双方的生产力,并限制新颖的、临床适用的和协作设计的系统所能产生的巨大的科学、经济和社会效益。
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引用次数: 0
AudioSense: Enabling Real-time Evaluation of Hearing Aid Technology In-Situ. AudioSense:实现助听器技术的实时评估。
Pub Date : 2013-01-01 DOI: 10.1109/CBMS.2013.6627783
Syed Shabih Hasan, Farley Lai, Octav Chipara, Yu-Hsiang Wu

AudioSense integrates mobile phones and web technology to measure hearing aid performance in real-time and in-situ. Measuring the performance of hearing aids in the real world poses significant challenges as it depends on the patient's listening context. AudioSense uses Ecological Momentary Assessment methods to evaluate both the perceived hearing aid performance as well as to characterize the listening environment using electronic surveys. AudioSense further characterizes a patient's listening context by recording their GPS location and sound samples. By creating a time-synchronized record of listening performance and listening contexts, AudioSense will allow researchers to understand the relationship between listening context and hearing aid performance. Performance evaluation shows that AudioSense is reliable, energy-efficient, and can estimate Signal-to-Noise Ratio (SNR) levels from captured audio samples.

AudioSense集成了移动电话和网络技术,实时和原位测量助听器的性能。在现实世界中测量助听器的性能具有重大挑战,因为它取决于患者的听力环境。AudioSense使用生态瞬时评估方法来评估感知助听器的性能以及使用电子调查来表征听力环境。AudioSense通过记录患者的GPS位置和声音样本进一步表征患者的听力环境。通过创建听力表现和听力环境的时间同步记录,AudioSense将使研究人员能够了解听力环境和助听器性能之间的关系。性能评估表明,AudioSense是可靠的、节能的,并且可以从捕获的音频样本中估计信噪比(SNR)水平。
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引用次数: 26
Inexpensive Monocular Pico-Projector-based Augmented Reality Display for Surgical Microscope. 廉价的手术显微镜单目微投影仪增强现实显示器。
Pub Date : 2012-01-01 DOI: 10.1109/CBMS.2012.6266298
Chen Shi, Brian C Becker, Cameron N Riviere

This paper describes an inexpensive pico-projector-based augmented reality (AR) display for a surgical microscope. The system is designed for use with Micron, an active handheld surgical tool that cancels hand tremor of surgeons to improve microsurgical accuracy. Using the AR display, virtual cues can be injected into the microscope view to track the movement of the tip of Micron, show the desired position, and indicate the position error. Cues can be used to maintain high performance by helping the surgeon to avoid drifting out of the workspace of the instrument. Also, boundary information such as the view range of the cameras that record surgical procedures can be displayed to tell surgeons the operation area. Furthermore, numerical, textual, or graphical information can be displayed, showing such things as tool tip depth in the work space and on/off status of the canceling function of Micron.

本文介绍了一种廉价的基于微投影仪的增强现实(AR)手术显微镜显示器。该系统是为Micron设计的,Micron是一种主动手持式手术工具,可以消除外科医生的手部震颤,以提高显微手术的准确性。使用AR显示器,可以将虚拟线索注入显微镜视图中,以跟踪Micron尖端的运动,显示所需的位置,并指示位置误差。通过帮助外科医生避免游离于器械的工作空间之外,提示可以用来保持高水平的手术表现。此外,可以显示记录手术过程的摄像机的视野范围等边界信息,以告诉外科医生手术区域。此外,还可以显示数字、文本或图形信息,显示工作空间中的刀尖深度和Micron取消功能的开/关状态。
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引用次数: 9
期刊
Proceedings. IEEE International Symposium on Computer-Based Medical Systems
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