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Towards Understanding Contemporary Gambling Advertising in Sub-Saharan Africa. 对撒哈拉以南非洲当代赌博广告的理解。
Pub Date : 2024-12-09 eCollection Date: 2024-12-01 DOI: 10.1002/puh2.70017
Emmanuel Badu

Gambling advertising has become ubiquitous in sub-Saharan Africa influencing social norms and attitudes towards gambling. The delay or failure of governments to effectively regulate gambling advertising poses a significant threat to public health. This article provides contemporary insights into gambling advertising, its forms, mechanics and influence on gambling behaviour. It provides contextual understanding to policy-makers, health advocates and public health actors, including a call to action for effective regulation. With sub-Saharan Africa becoming important to the gambling industry for market growth and profits, there is the need for public health actors to instigate advocacy for strong regulations and enforcement of gambling advertising.

赌博广告在撒哈拉以南非洲无处不在,影响着社会规范和对赌博的态度。政府延迟或未能有效管制赌博广告对公众健康构成重大威胁。这篇文章提供了当代的见解赌博广告,它的形式,机制和赌博行为的影响。它为决策者、卫生倡导者和公共卫生行为者提供了上下文理解,包括呼吁采取行动进行有效监管。随着撒哈拉以南非洲在博彩业的市场增长和利润方面变得越来越重要,公共卫生行为体有必要倡导对赌博广告实施强有力的法规和执法。
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引用次数: 0
Burnout Among Labor and Birth Providers in Northern Tanzania: A Mixed-Methods Study. 坦桑尼亚北部劳动力和分娩提供者的职业倦怠:一项混合方法研究。
Pub Date : 2024-12-05 eCollection Date: 2024-12-01 DOI: 10.1002/puh2.70014
Virginie Marchand, Melissa H Watt, Linda M Minja, Mariam L Barabara, Olivia R Hanson, Janeth Mlay, Maya J Stephens, Blandina T Mmbaga, Susanna R Cohen

Background: Burnout, characterized by emotional exhaustion, depersonalization, and a diminished sense of accomplishment, is a serious problem among healthcare workers. Burnout negatively impacts provider well-being, patient outcomes, and healthcare systems globally and is especially worrisome in settings with shortages of healthcare workers and resources.

Methods: This study explores the experience of burnout among labor and delivery (L&D) providers in Tanzania, using three data sources. A structured assessment of burnout was collected at four timepoints from a sample of 60 L&D providers in 6 clinics. The same providers participated in an interactive group activity from which we drew observational prevalence data. Finally, we conducted in-depth interviews (IDIs) with 15 providers to further explore their experience of burnout.

Results: Prior to any introduction to the concept, 18% of respondents met criteria for burnout. Immediately after a discussion and activity on burnout, 62% of providers met criteria. One and 3 months later, 29% and 33% of providers met criteria, respectively. In IDIs, participants saw the lack of understanding of burnout as the cause for low baseline rates and attributed the subsequent decrease in burnout to newly acquired coping strategies. The activity helped them realize they were not alone in their experience of burnout. High patient load, low staffing, limited resources, and low pay emerged as contributing factors.

Conclusion: A lack of exposure to the concept of burnout leads to providers being unaware of the issue as a collective burden. Therefore, burnout remains rarely discussed and not addressed, thus continuing to impact provider and patient health.

背景:职业倦怠,其特征是情绪耗竭,人格解体,成就感减少,是一个严重的问题在医护人员。职业倦怠对医疗服务提供者的幸福感、患者的治疗效果和全球医疗保健系统都有负面影响,在医疗工作者和资源短缺的情况下尤其令人担忧。方法:本研究利用三个数据来源,探讨坦桑尼亚分娩服务提供者的职业倦怠体验。从6个诊所的60名L&D提供者的样本中,在四个时间点收集了倦怠的结构化评估。同样的提供者参加了一个互动式小组活动,从中我们得出了观察性患病率数据。最后,我们对15名医疗服务提供者进行了深度访谈(IDIs),以进一步探讨他们的职业倦怠经历。结果:在引入这个概念之前,18%的受访者符合职业倦怠的标准。在关于倦怠的讨论和活动之后,62%的医疗服务提供者立即达到了标准。1个月和3个月后,分别有29%和33%的提供者符合标准。在idi中,参与者认为缺乏对倦怠的理解是基线率低的原因,并将随后的倦怠减少归因于新获得的应对策略。这项活动帮助他们意识到,他们并不是唯一一个经历过精疲力竭的人。高病人负荷、低人员、有限的资源和低工资成为了影响因素。结论:缺乏对倦怠概念的了解导致提供者没有意识到这个问题是一种集体负担。因此,倦怠仍然很少被讨论,也没有得到解决,从而继续影响提供者和患者的健康。
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引用次数: 0
Determination of Iodine Concentration in Commonly Consumed Salt and Its Potential Impact on Household Consumers: An Examination and Assessment of Consumed Salt. 常用食盐中碘浓度的测定及其对家庭消费者的潜在影响:食用食盐的检验与评价。
Pub Date : 2024-12-02 eCollection Date: 2024-12-01 DOI: 10.1002/puh2.70012
Md Shahedul Islam, Mohammad Asadul Habib, Mohammad Anwar Ul Alam, Oumma Halima, Nusrat Parvin, Md Rezaul Karim, Abdur Rahman Shanna, Rifat Jahan Romel, Abdur Rahman Sakib, Mohammad Ariful Islam

Introduction: Iodine deficiency disorder (IDD) can lead to health issues as it is necessary for metabolic functions. This study investigated the iodine content of commonly consumed salt and the potential impact on daily iodine requirements and IDDs.

Methods: A cross-sectional survey was employed using multistage cluster sampling among 240 households, dividing them into eight clusters from four stratified areas. The sampled salts were analyzed using the World Health Organization's iodometric titration method.

Results: The study revealed that most salt samples from the studied brands had an iodine content within the Bangladesh Standards and Testing Institution (BSTI) recommended range of 20-50 ppm, with two exceptions. The study found that most socioeconomic groups in cities, towns, and semirural areas meet their daily iodine requirements at over 100%. At the same time, many rural homes, regardless of income, fail to meet these requirements. However, the study found iodized salt in 97.9% of all surveyed households. Although 48.3% of unions, that is, rural respondents, was knowledgeable about the existence of iodized salt, 66.7% of respondents was not aware of the health benefits of iodized salt. Surprisingly, 63.3% of the town's household members and 61.7% of the rural population still consume raw salt. Additionally, 79.6% of individuals reported having no IDDs. However, only 44.2% of thyroid patients used iodine supplements.

Conclusion: Although salt usage and consumption practices are satisfactory, there are still a few concerns about the 100% iodization of branded and raw salts. As a result, many households need help to satisfy their daily iodine requirements.

碘缺乏症(IDD)可导致健康问题,因为它是代谢功能所必需的。本研究调查了常食用盐的碘含量及其对每日碘需要量和碘缺乏量的潜在影响。方法:采用多阶段整群抽样的横断面调查方法,从4个分层区将240户家庭分为8个整群。使用世界卫生组织的碘量滴定法对样品进行了分析。结果:研究显示,大多数食盐样品的碘含量在孟加拉国标准和检测机构(BSTI)建议的20- 50ppm范围内,只有两个例外。该研究发现,城市、城镇和半农村地区的大多数社会经济群体的每日碘需求量超过100%。与此同时,许多农村家庭,无论收入如何,都无法满足这些要求。然而,该研究发现97.9%的被调查家庭都有加碘盐。尽管48.3%的工会,即农村应答者知道加碘盐的存在,但66.7%的应答者不知道加碘盐的健康益处。令人惊讶的是,该镇63.3%的家庭成员和61.7%的农村人口仍在食用生盐。此外,79.6%的人报告没有idd。然而,只有44.2%的甲状腺患者使用碘补充剂。结论:尽管盐的使用和消费习惯令人满意,但品牌盐和生盐的100%加碘仍然存在一些问题。因此,许多家庭需要帮助来满足每日的碘需求。
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引用次数: 0
Malnutrition Risk Among Hospitalized Patients With Type 2 Diabetes Mellitus and Its Association With Hospital Length. 2型糖尿病住院患者营养不良风险及其与住院时间的关系
Pub Date : 2024-11-27 eCollection Date: 2024-12-01 DOI: 10.1002/puh2.70011
Philemon Kwizera, Reverien Niyomwungeri, Omar Gatera, Harriet Gyamfuah Adu-Amoah, Jeannine Ahishakiye

Background: Estimating malnutrition risk among hospitalized patients is challenging, yet critical due to its association with adverse outcomes such as prolonged hospital stays, increased mortality, impaired wound healing, depression, and increased hospital costs. This research study aims to evaluate the risk of malnutrition among Type 2 diabetic hospitalized patients and its impact on the patient's length of stay in two tertiary hospitals based in Kigali.

Method: In this retrospective cross-sectional study, 300 adult hospitalized Type 2 diabetic patients from Kigali's tertiary hospitals were enrolled between January 2021 and October 2022. Data collected include demographics, anthropometrics, serum albumin, and length of hospital stay. The nutrition risk index was used to determine malnutrition risk.

Results: Overall, 55.3% of hospitalized Type 2 diabetes patients was found to be at risk of malnutrition on the basis of the nutrition risk index. Gender distribution showed no significant difference (p = 0.724), with 56.6% females and 54.5% males at risk. Significant associations were found with age (r = 0.018, p = 0.017), hypertension as comorbidity (r = -0.169, p = 0.004), hospital stay duration (r = 0.139, p = 0.002), and blood glucose levels (r = -0.087, p = 0.001).

Conclusion: A study finds high malnutrition risk in hospitalized Type 2 diabetes patients, linked to longer stays and poor outcomes. Early malnutrition screening, proper nutrition support, and a multidisciplinary care team are crucial for improved clinical care and cost-effectiveness.

背景:估计住院患者的营养不良风险具有挑战性,但由于其与住院时间延长、死亡率增加、伤口愈合受损、抑郁和住院费用增加等不良后果相关,因此评估营养不良风险至关重要。本研究旨在评估2型糖尿病住院患者营养不良的风险及其对患者在基加利两家三级医院住院时间的影响。方法:在这项回顾性横断面研究中,在2021年1月至2022年10月期间,从基加利三级医院招募了300名住院的成年2型糖尿病患者。收集的数据包括人口统计学、人体测量学、血清白蛋白和住院时间。采用营养风险指数确定营养不良风险。结果:总体而言,根据营养风险指数,55.3%的住院2型糖尿病患者存在营养不良风险。性别分布差异无统计学意义(p = 0.724),女性为56.6%,男性为54.5%。与年龄(r = 0.018, p = 0.017)、高血压合并症(r = -0.169, p = 0.004)、住院时间(r = 0.139, p = 0.002)和血糖水平(r = -0.087, p = 0.001)存在显著相关性。结论:一项研究发现,住院的2型糖尿病患者营养不良风险高,与住院时间长和预后差有关。早期营养不良筛查、适当的营养支持和多学科护理团队对于改善临床护理和成本效益至关重要。
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引用次数: 0
Community Water Fluoridation a Cost-Benefit-Risk Consideration. 社区用水氟化:成本-效益-风险的考虑。
Pub Date : 2024-11-27 eCollection Date: 2024-12-01 DOI: 10.1002/puh2.70009
Bill Osmunson, Griffin Cole

For over 70 years, the addition of fluoride to public water as community water fluoridation (CWF or fluoridation) with intent to prevent dental caries continues to be controversial, and risks are seldom included in monetary evaluations. Published operational costs and benefits of fluoridation are used, whereas published and clinical experience treating dental fluorosis are utilized to estimate treatment costs of patient-perceived dental fluorosis and lost wages from lower IQ (intelligence quotient). Published estimated caries averted, less operational costs at $8 PPPY (per person per year) were used, compensation for functional and cosmetic dental fluorosis $126 PPPY, and lower earnings from presumed harm of developmental neurotoxicity estimated at $438 PPPY. Net loss from CWF is estimated at $556 PPPY, although some individuals will have significantly more or less loss. Previous economic evaluations of fluoridation have estimated caries averted and costs of operations; however, few evaluations include the costs of treating harm. Fluoridation is not cost-effective if the cost of harm is included. Alternatives for the prevention of dental caries should be promoted, and the cessation of fluoridation is indicated.

70多年来,将氟化物作为社区水氟化(CWF或氟化)添加到公共水中以预防龋齿的做法一直存在争议,其风险很少被纳入货币评估。使用已公布的氟化操作成本和效益,而使用已公布的治疗氟牙症的临床经验来估计患者认为氟牙症的治疗成本和较低智商(智商)造成的工资损失。采用了已公布的估计避免龋齿,减少了(每人每年)8美元的运营费用,功能性和美容性氟牙症的补偿为126美元,发育性神经毒性损害的收入较低,估计为438美元。CWF的净损失估计为每年556元,虽然有些人的损失或多或少。以前对氟化的经济评价估计了避免的龋齿和操作费用;然而,很少有评估包括治疗伤害的费用。如果将危害成本算在内,氟化处理是不符合成本效益的。应推广预防龋齿的替代方法,并建议停止氟化。
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引用次数: 0
Depression and Its Determinants Among Patients With Sickle Cell Disease: A Cross-Sectional Study. 镰状细胞病患者的抑郁及其决定因素:一项横断面研究
Pub Date : 2024-11-25 eCollection Date: 2024-12-01 DOI: 10.1002/puh2.70010
Bhuwan Dahit, Madhusudan Subedi, Ajay Kumar Rajbhandari, Amit Arjyal, Data Ram Adhikari, Padam Kanta Dahal

Background: Depression among patients with sickle cell disease (SCD) is crucial as it is often underdiagnosed and undertreated. Therefore, this study aimed to determine the prevalence of depression and to identify its determinants.

Methods: This cross-sectional study was conducted in the Bardiya district of Nepal, based on registered cases of SCD. Depression was measured using the validated Nepalese version of the Beck Depression Inventory (BDI). A random sample of 358 participants with SCD aged >13 years was included in the study. Descriptive and inferential statistics were applied to sociodemographic, clinical and psychological variables. Logistic regression analysis was performed for bivariate analysis. Variables with a p value of less than 0.05 were subjected to final multivariate logistic regression.

Results: The prevalence of depression was 36.31% among patients with SCD, age (p = 0.0178), education (p = 0.0178) and sociodemographic status (p = 0.0328) were strongly associated. Factors such as patients aged 40-49 years (adjusted odds ratio [AOR] = 3.05), complications due to SCD (AOR = 1.86) and genetic counselling group (AOR = 4.72) had higher chances of experiencing depression compared to their relative counterparts. However, patients with lower middle-class economic status, who experience pain crisis, with moderate self-esteem and who experience discrimination were 52%, 83%, 58% and 58% less likely to have depression compared to their respective counterparts, respectively.

Conclusions: Depression was prevalent in patients with SCD, and multiple sociodemographic, clinical and psychological factors were strongly associated. This warrants the urgent need for early diagnosis and treatment of depression among participants with SCD.

背景:镰状细胞病(SCD)患者的抑郁症是至关重要的,因为它经常被误诊和治疗不足。因此,本研究旨在确定抑郁症的患病率,并确定其决定因素。方法:这项横断面研究是在尼泊尔的Bardiya地区进行的,基于登记的SCD病例。使用经验证的尼泊尔版贝克抑郁量表(BDI)测量抑郁症。该研究随机抽取了358名年龄在10至13岁之间的SCD患者。描述性和推断性统计应用于社会人口学、临床和心理变量。双变量分析采用Logistic回归分析。p值小于0.05的变量进行最后的多元逻辑回归。结果:SCD患者抑郁患病率为36.31%,年龄(p = 0.0178)、文化程度(p = 0.0178)、社会人口状况(p = 0.0328)与抑郁相关。40-49岁患者(调整优势比[AOR] = 3.05)、SCD并发症(AOR = 1.86)和遗传咨询组(AOR = 4.72)等因素发生抑郁的几率高于相关人群。然而,中产阶级经济地位较低的患者、经历过疼痛危机的患者、中度自尊的患者和经历过歧视的患者患抑郁症的可能性分别比相应人群低52%、83%、58%和58%。结论:抑郁症在SCD患者中普遍存在,与多种社会人口学、临床和心理因素密切相关。这证明了早期诊断和治疗SCD参与者抑郁症的迫切需要。
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引用次数: 0
Identifying Individual and Household Level Predictors of Undernutrition Among 6-59 Months Children in Bangladesh: A Multivariate Approach. 确定孟加拉国6-59个月儿童营养不良的个人和家庭水平预测因素:一种多变量方法。
Pub Date : 2024-10-30 eCollection Date: 2024-12-01 DOI: 10.1002/puh2.70007
Oumma Halima, Abira Nowar, Md Hafizul Islam, Akibul Islam Chowdhury, Kazi Turjaun Akhter, Nazma Shaheen

Introduction: Globally malnutrition is considered one of the greatest threats to public health, particularly in low- and middle-income countries. The present study examined the extent of undernutrition and the associated determinants among children aged 6-59 months in Bangladesh using data from the Nutrition Survey of Bangladesh (NSB), 2017-18.

Methods: The sampling frame of NSB 2017-18 was specified by a 30 (locations) × 30 (households) cluster approach where 20 locations were from rural areas and the other 10 were from urban areas. Out of the sampled households, 566 children aged between 6 and 59 months were included in the analysis. Determinants of three anthropometric measures, weight-for-age (stunting), weight-for-height (wasting), and weight-for-age (underweight), were analyzed using a multiple logistic regression model.

Result: The prevalence of stunting, underweight, and wasting of children was 34.5%, 40.6%, and 20.1%, respectively. Although the child's age, family size, cleanliness of the residential area, and food insecurity were significant determinants of malnutrition, inadequate and low-quality protein consumption strongly predicted the development of underweight and stunting in infants and children. The odds of being stunted were 2 times (adjusted odds ratio [AOR]: 2.02, 95% confidence interval [CI]: 1.17-3.46; p = 0.011) and underweight was almost 2.5 times (AOR: 2.41; 95% CI: 1.27-4.56; p < 0.01) higher, respectively, among children who consumed inadequate amounts of protein.

Conclusion: Because the percentage of children from wealthy families was relatively low in the present study, cleanliness of residential areas, food insecurity, and inadequate protein intake are likely to be key drivers of malnutrition in Bangladesh, which might be significantly reduced with better coverage of preventive nutrition programs.

导言:在全球范围内,营养不良被认为是对公共卫生的最大威胁之一,特别是在低收入和中等收入国家。本研究使用2017-18年孟加拉国营养调查(NSB)的数据,调查了孟加拉国6-59个月儿童的营养不良程度和相关决定因素。方法:采用30(地点)× 30(户)聚类方法确定NSB 2017-18年的抽样框架,其中农村20个,城镇10个。在抽样家庭中,566名年龄在6至59个月之间的儿童被纳入分析。使用多元logistic回归模型分析了三种人体测量指标的决定因素,即年龄体重比(发育迟缓)、身高体重比(消瘦)和年龄体重比(体重不足)。结果:儿童发育迟缓、体重不足和消瘦的发生率分别为34.5%、40.6%和20.1%。虽然儿童的年龄、家庭规模、居住区的清洁度和粮食不安全是营养不良的重要决定因素,但不足和低质量的蛋白质消费强烈地预示着婴儿和儿童体重不足和发育迟缓的发展。发育不良的几率为2倍(调整优势比[AOR]: 2.02, 95%可信区间[CI]: 1.17-3.46;p = 0.011)和体重过轻的比例接近2.5倍(AOR: 2.41;95% ci: 1.27-4.56;p结论:由于本研究中来自富裕家庭的儿童比例相对较低,因此居住区的清洁、食品不安全和蛋白质摄入不足可能是孟加拉国营养不良的主要驱动因素,如果预防性营养计划的覆盖率提高,可能会大大减少营养不良。
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引用次数: 0
The Interplay of Tobacco Farming and Tobacco Control: Exploring Socioeconomic and Health Dynamics in Malawi. 烟草种植和烟草控制的相互作用:探索马拉维的社会经济和健康动态。
Pub Date : 2024-10-30 eCollection Date: 2024-12-01 DOI: 10.1002/puh2.70008
Chimwemwe Ngoma, Sahan Lungu, George N Chidimbah Munthali, Martha Shantel Mwase

Tobacco farming and tobacco control are closely inter-related issues, particularly in developing countries that are heavily reliant on tobacco farming like Malawi. This commentary explores the relationship among tobacco farming, economic sustainability, and public health, focusing on the context of Malawi as one of the major tobacco producers in Africa. Malawi's economy is significantly dependent on tobacco farming, yet the country also struggles with smoking-related health risks, creating a dilemma between socioeconomic and public health considerations. The commentary highlights the lack of empirical evidence regarding the socioeconomic implications of tobacco control measures on tobacco farming in the country. Moreover, despite the country's economic dependence on tobacco farming, a majority of cigarettes consumed domestically are imported, demonstrating the complexity of Malawi's tobacco industry. On public health implications, the article highlights the disease and death burden that is a result of tobacco smoking, underscoring the need for tobacco control measures. The article further draws insights from tobacco end-game strategies in other countries and proposes a comprehensive approach to tobacco control. However, the article notes Malawi's limited financial resources and healthcare infrastructure to implement traditional tobacco control measures and highlights an emphasis on tobacco harm reduction, a third pillar of the Framework Convention on Tobacco Control. The article also advocates for an emphasis on alternative livelihood opportunities for smallholder tobacco farmers in Malawi.

烟草种植和烟草控制是密切相关的问题,特别是在马拉维等严重依赖烟草种植的发展中国家。本评论探讨烟草种植、经济可持续性和公共卫生之间的关系,重点关注马拉维作为非洲主要烟草生产国之一的背景。马拉维的经济严重依赖烟草种植,但该国也在与吸烟相关的健康风险作斗争,在社会经济和公共卫生考虑之间造成了两难境地。该评论强调缺乏关于烟草控制措施对该国烟草种植的社会经济影响的经验证据。此外,尽管该国经济依赖烟草种植,但国内消费的大部分卷烟都是进口的,这表明马拉维烟草业的复杂性。关于公共卫生影响,文章强调了吸烟造成的疾病和死亡负担,强调了采取烟草控制措施的必要性。文章进一步借鉴了其他国家的烟草终局战略,并提出了一种全面的烟草控制方法。然而,这篇文章指出,马拉维实施传统烟草控制措施的财政资源和卫生保健基础设施有限,并强调强调减少烟草危害,这是《烟草控制框架公约》的第三个支柱。这篇文章还提倡强调马拉维小烟农的替代生计机会。
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引用次数: 0
Current State and Challenges of Local Production of Vaccines in Nigeria. 尼日利亚当地疫苗生产的现状和挑战。
Pub Date : 2024-10-10 eCollection Date: 2024-12-01 DOI: 10.1002/puh2.70006
Obi Peter Adigwe, Godspower Onavbavba, Olajide Joseph Adebola, Anthony Ayeke, Saheed Ekundayo Sanyaolu, Kenneth Anene Agu

Background: Vaccination protects the population against infectious diseases and reduces their transmissibility. Potentials exist for local production of vaccines in Nigeria, as a means of addressing public health needs. However, challenges exist in certain critical aspects which limit development in this area. This study aimed at evaluating the challenges of local vaccines' manufacturing in Nigeria from the perspectives of relevant stakeholders.

Methods: This was a cross-sectional study. A structured questionnaire was used for data collection. The data obtained from the study were analysed descriptively.

Results: More than half of the study participants (55.5%) agreed that significant gaps exist with respect to access to vaccines in Nigeria. Only about one-quarter of the respondents (25.8%) were of the view that relevant legislative frameworks exist to support government funding in the area of vaccine production. One-third of the participants (32.3%) expressed confidence in the availability of trained human resources for vaccine production. Close to two-thirds of the respondents (61.7%) expressed dissatisfaction regarding the current funding for vaccine research and development, and a similar proportion (65.2%) were of the opinion that a lack of local manufacturing capacity contributed to the sub-optimal access to vaccines. Moreover, two-thirds (62.3%) disagreed that Nigeria was prepared for future pandemics.

Conclusion: Ill-suited policies, sub-optimal infrastructure, and inadequate research and development funding, are some factors which the study identified as contributory to the lack of access to vaccines in Nigeria. There is a need to improve incentives, infrastructural development and build human resource capacity for vaccine research and development to enhance local production in Nigeria.

背景:疫苗接种可以保护人群免受传染病的侵害,并减少其传播。尼日利亚有可能在当地生产疫苗,作为满足公共卫生需求的一种手段。然而,在某些关键方面存在着挑战,限制了这一领域的发展。这项研究旨在从相关利益攸关方的角度评估尼日利亚当地疫苗生产面临的挑战。方法:采用横断面研究。数据收集采用结构化问卷。从研究中获得的数据进行了描述性分析。结果:一半以上的研究参与者(55.5%)同意尼日利亚在获得疫苗方面存在重大差距。只有约四分之一的答复者(25.8%)认为存在支持政府在疫苗生产领域提供资金的相关立法框架。三分之一的与会者(32.3%)表示有信心获得训练有素的疫苗生产人力资源。近三分之二的答复者(61.7%)对目前用于疫苗研发的资金表示不满,同样比例的答复者(65.2%)认为,缺乏当地制造能力导致疫苗获得不理想。此外,三分之二(62.3%)的人不认为尼日利亚为未来的流行病做好了准备。结论:不合适的政策、次优的基础设施和研发资金不足是研究确定的导致尼日利亚缺乏疫苗获取的一些因素。有必要改善激励措施、基础设施发展和建立疫苗研发的人力资源能力,以加强尼日利亚的当地生产。
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引用次数: 0
A Landscaping Assessment and Call-to-Action to Improve Access to Novel Reserve Antibiotics in 14 Low- and Middle-Income Countries. 在14个低收入和中等收入国家改善新型储备抗生素可及性的环境评估和行动呼吁。
Pub Date : 2024-10-10 eCollection Date: 2024-12-01 DOI: 10.1002/puh2.70005
Fabrizio Motta, Summiya Nizamuddin, Ejaz Khan, Tracie Muraya, Silvio Vega, Joseph Fadare, Shaffi F Koya, Maria Virginia Villegas, Faisal Sultan, Tara Lumley, Rahul Dwivedi, Lauren Jankelowitz, Jennifer Cohn

Background: Antimicrobial resistance (AMR) presents a significant global mortality burden which particularly affects the low- and middle-income countries (LMICs). Enhancing diagnostics to identify drug-resistant infections and improving appropriate access to novel Reserve antibiotics in LMICs can address AMR-related morbidity, mortality and healthcare costs. This article characterizes the AMR landscape across 14 LMICs and describes an introductory pathway for novel Reserve antibiotics.

Methods: This mixed-method study was completed in 14 LMICs in Africa, the Americas, Asia and Europe through a combination of qualitative interviews with physicians and public health experts (PHEs), and a quantitative survey of physicians, supported by an assessment of secondary materials relating to antibiotic introduction and AMR burden.

Results: A total of 54 physicians and 17 PHEs were interviewed, and 209 physicians participated in the survey. Top unmet needs across public and private settings were as follows: access to new antibiotics to better manage drug-resistant infections; affordability; adequate safety profile for prescribed antibiotics. Access to diagnostics and antibiotic susceptibility testing was noted as a barrier, with large tertiary and private centres experiencing better access. Implementation of antibiotic stewardship programmes was variable and limited by insufficient funding, shortage of infectious disease physicians, poor AMR education and lack of restrictions to limit antibiotic use. Antibiotic access varies by sector, centre type, location and strength of individual state procurement systems. In particular, private sector facilities have better access to Reserve products. In most countries, most Reserve antibiotics included in WHO's Essential Medicines List (EML) were not included in national EMLs or not registered in countries.

Conclusion: This study has helped to identify common barriers and pathways to Reserve antibiotic access, irrespective of the level of preparedness of countries. The data offer insights into possible solutions to improve access and highlight opportunities to strengthen access pathways and expedite access, for example, by identifying priority antibiotics based on national public health need. A six-step introductory pathway for novel Reserve antibiotics is described.

背景:抗菌素耐药性(AMR)是一个重大的全球死亡率负担,尤其影响低收入和中等收入国家(LMICs)。在中低收入国家,加强诊断以确定耐药感染并改善对新型储备抗生素的适当获取,可以解决与抗生素耐药性相关的发病率、死亡率和医疗费用问题。本文描述了14个低收入国家的抗菌素耐药性情况,并描述了新型储备抗生素的入门途径。方法:这项混合方法研究在非洲、美洲、亚洲和欧洲的14个低收入国家完成,通过对医生和公共卫生专家(phe)的定性访谈和对医生的定量调查相结合,并通过评估与抗生素引入和抗菌素耐药性负担有关的二手材料。结果:共访谈54名医生和17名专科医生,参与调查的医生209名。公共和私人环境中未满足的主要需求如下:获得新的抗生素以更好地管理耐药感染;负担能力;处方抗生素有足够的安全性。获得诊断和抗生素敏感性测试被认为是一个障碍,大型三级和私营中心的获得情况较好。抗生素管理方案的执行情况各不相同,受到资金不足、传染病医生短缺、抗生素耐药性教育不力和缺乏限制抗生素使用的限制等因素的限制。抗生素获取因部门、中心类型、地点和各州采购系统的强度而异。特别是,私营部门设施更容易获得储备产品。在大多数国家,列入世卫组织基本药物清单(EML)的大多数储备抗生素未列入国家基本药物清单或未在国家注册。结论:本研究有助于确定储备抗生素获取的共同障碍和途径,无论各国的准备水平如何。这些数据提供了对改善获取的可能解决办法的见解,并突出了加强获取途径和加快获取的机会,例如根据国家公共卫生需求确定重点抗生素。描述了一种新型储备抗生素的六步入门途径。
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Public health challenges
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