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Machine Learning and Gene Editing at the Helm of a Societal Evolution. 机器学习和基因编辑引领社会进化。
Pub Date : 2024-03-04 eCollection Date: 2024-03-01
Sana Zakaria, Timothy Marler, Mark Cabling, Suzanne Genc, Artur Honich, Mann Virdee, Sam Stockwell

The integration of artificial intelligence (AI) and biotechnology, whilst in its infancy, presents significant opportunities and risks, and proactive policy is needed to manage these emerging technologies. Whilst AI continues to have significant and broad impact, its relevance and complexity magnify when integrated with other emerging technologies. The confluence of Machine Learning (ML), a subset of AI, with gene editing (GE) in particular can foster substantial benefits as well as daunting risks that range from ethics to national security. These complex technologies have implications for multiple sectors, ranging from agriculture and medicine to economic competition and national security. Consideration of technology advancements and policies in different geographic regions, and involvement of multiple organisations further confound this complexity. As the impact of ML and GE expands, forward looking policy is needed to mitigate risks and leverage opportunities. Thus, this study explores the technological and policy implications of the intersection of ML and GE, with a focus on the United States (US), the United Kingdom (UK), China, and the European Union (EU). Analysis of technical and policy developments over time and an assessment of their current state have informed policy recommendations that can help manage beneficial use of technology advancements and their convergence, which can be applied to other sectors. This study is intended for policymakers to prompt reflection on how to best approach the convergence of the two technologies. Technical practitioners may also find it valuable as a resource to consider the type of information and policy stakeholders engage with.

人工智能(AI)与生物技术的融合虽然处于起步阶段,但也带来了巨大的机遇和风险,因此需要制定积极的政策来管理这些新兴技术。虽然人工智能将继续产生重大而广泛的影响,但当它与其他新兴技术相结合时,其相关性和复杂性将进一步放大。机器学习(ML)是人工智能的一个子集,它与基因编辑(GE)的结合尤其能带来巨大的利益,同时也会带来从伦理道德到国家安全的巨大风险。这些复杂的技术对农业、医药、经济竞争和国家安全等多个领域都有影响。考虑到不同地理区域的技术进步和政策,以及多个组织的参与,进一步加剧了这种复杂性。随着 ML 和 GE 影响的扩大,需要制定前瞻性政策来降低风险和利用机遇。因此,本研究以美国(US)、英国(UK)、中国和欧盟(EU)为重点,探讨了 ML 和 GE 交叉领域的技术和政策影响。随着时间的推移,对技术和政策发展的分析以及对其现状的评估为政策建议提供了依据,这些建议有助于管理技术进步及其融合的有益利用,并可应用于其他部门。本研究报告旨在帮助政策制定者思考如何以最佳方式实现两种技术的融合。技术从业人员可能也会发现,本研究作为一种资源,对于考虑利益相关者参与的信息和政策类型很有价值。
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引用次数: 0
The Road to Reintegration: Status and Continuing Support of the U.S. Air Force's Wounded, Ill, and Injured. 重返社会之路:美国空军伤病员的状况和持续支持。
Pub Date : 2024-03-04 eCollection Date: 2024-03-01
Carra S Sims, Christine Anne Vaughan, John A Hamm, Brent Anderson, Angela Clague

The U.S. Air Force asked RAND Project AIR FORCE (PAF) to help assess the well-being of its wounded members and the quality of services provided to facilitate their recovery and reintegration. RAND PAF fielded a survey in the fall of 2016 to assess wounded airmen's functioning in the domains of physical health, mental health, interpersonal relationships, unemployment, and financial status, as well as their utilization and perceptions of Air Force nonmedical programs for wounded airmen. The authors of this study invited all 713 wounded airmen enrolled in the Air Force Wounded Warrior program to complete the survey, and 270 airmen (38 percent) completed it. One-third of airmen reported difficulty obtaining care for physical or mental health conditions, and one-quarter expressed dissatisfaction with coordination of care. Similar proportions of airmen reported barriers to care for physical and mental health conditions. Difficulty scheduling appointments was the most commonly endorsed barrier for both types of conditions. Small but notable proportions of airmen reported potential social support deficits, unemployment, and financial problems. For many of the Air Force's programs for wounded airmen, over 80 percent of program users reported overall program satisfaction. The authors recommend that the Air Force consider focusing on improving care coordination, increasing health care system capacity, continuing employment assistance, and improving marketing of programs with low uptake.

美国空军请兰德公司的 "空军项目"(PAF)帮助评估其伤员的福祉以及为促进其康复和重返社会而提供的服务质量。RAND PAF 在 2016 年秋季进行了一项实地调查,以评估受伤空军人员在身体健康、心理健康、人际关系、失业和财务状况等领域的功能,以及他们对空军为受伤空军人员提供的非医疗项目的利用情况和看法。这项研究的作者邀请所有参加空军 "受伤勇士 "计划的 713 名受伤飞行员完成调查,有 270 名飞行员(38%)完成了调查。三分之一的飞行员表示在获得身体或心理健康护理方面存在困难,四分之一的飞行员对护理协调表示不满。报告在身体和精神健康状况护理方面遇到障碍的飞行员比例相似。难以安排预约是这两类疾病最常见的障碍。报告潜在社会支持不足、失业和财务问题的空军人员比例虽小,但也很明显。对于空军的许多受伤飞行员项目,超过 80% 的项目用户对项目总体表示满意。作者建议空军考虑将重点放在改善护理协调、提高医疗保健系统能力、继续提供就业援助以及改善参与率较低项目的营销方面。
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引用次数: 0
Letter from the Editor. 编辑来信
Pub Date : 2024-03-04 eCollection Date: 2024-03-01
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引用次数: 0
Data Collection and Sharing for Pathogen Surveillance: Making Sense of a Fragmented Global System. 病原体监测的数据收集与共享:理顺支离破碎的全球系统。
Pub Date : 2024-03-04 eCollection Date: 2024-03-01
Sarah Parkinson, Jessica Dawney, Avery Adams, Ben Senator

RAND Europe was commissioned by the Novo Nordisk Foundation to conduct a study on pathogen surveillance and current initiatives. The study aims to provide an overview of the pathogen surveillance space internationally and the stakeholders involved, as well as to understand the strengths and weaknesses of different initiatives, the challenges of pathogen surveillance and how they have been addressed, and how data has been used to inform public health decision making. To do this, a scoping review of pathogen surveillance initiatives was conducted, and ten case studies were developed and selected for further review following a workshop attended by the Novo Nordisk Foundation and RAND Europe study team. Interviews were conducted with individuals involved in pathogen surveillance initiatives to gather additional information to develop case studies, and expert interviews addressed gaps in the pathogen surveillance space and models that would be helpful in filling these gaps.

兰德欧洲公司受诺和诺德基金会委托,对病原体监控和当前举措进行研究。该研究旨在提供国际病原体监控领域和相关利益方的概况,并了解不同举措的优缺点、病原体监控面临的挑战和如何应对这些挑战,以及如何利用数据为公共卫生决策提供信息。为此,诺和诺德基金会和兰德欧洲研究团队召开了一次研讨会,对病原体监控措施进行了一次范围界定审查,并制定和选择了十项案例研究,以作进一步审查。与参与病原体监控计划的人员进行了访谈,以收集更多信息来编写案例研究,专家访谈则探讨了病原体监控领域的差距以及有助于填补这些差距的模式。
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引用次数: 0
Identifying Strategies for Strengthening the Health Care Workforce in the Commonwealth of Virginia. 确定加强弗吉尼亚州卫生保健人员队伍的战略。
Pub Date : 2024-03-04 eCollection Date: 2024-03-01
Megan Andrew, Brian Briscombe, Raffaele Vardavas, Nazia Wolters, Nabeel Qureshi, Wilson Nham, Mahshid Abir

Like the United States as a whole, Virginia faces a significant shortage of health care workers in nursing, primary care, and behavioral health. If current trends persist, these shortages will increase across Virginia. The authors of this study identify interventions that can help the Virginia Health Workforce Development Authority (VHWDA) address these health care workforce shortages. To accomplish this goal, they applied an analytic framework to existing or potential interventions for retaining, recruiting, and improving the structural efficiency of the nursing, primary care, and behavioral health workforces in Virginia. In this study, they highlight which interventions VHWDA should prioritize based on its desired outcomes and policy goals.

与整个美国一样,弗吉尼亚州在护理、初级保健和行为保健方面也面临着医护人员严重短缺的问题。如果目前的趋势持续下去,弗吉尼亚州各地的短缺情况将会加剧。本研究的作者确定了可以帮助弗吉尼亚州卫生劳动力发展局(VHWDA)解决这些医护人员短缺问题的干预措施。为了实现这一目标,他们运用分析框架对弗吉尼亚州现有或潜在的干预措施进行了分析,以留住、招聘和提高护理、初级保健和行为健康工作队伍的结构效率。在这项研究中,他们强调了弗吉尼亚州妇女发展局应根据其预期成果和政策目标优先考虑哪些干预措施。
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引用次数: 0
Artificial Intelligence-Based Student Activity Monitoring for Suicide Risk: Considerations for K-12 Schools, Caregivers, Government, and Technology Developers. 基于人工智能的学生自杀风险活动监控:K-12 学校、护理人员、政府和技术开发人员的考虑因素。
Pub Date : 2024-03-04 eCollection Date: 2024-03-01
Lynsay Ayer, Benjamin Boudreaux, Jessica Welburn Paige, Pierrce Holmes, Tara Laila Blagg, Sapna J Mendon-Plasek

In response to the widespread youth mental health crisis, some kindergarten-through-12th-grade (K-12) schools have begun employing artificial intelligence (AI)-based tools to help identify students at risk for suicide and self-harm. The adoption of AI and other types of educational technology to partially address student mental health needs has been a natural forward step for many schools during the transition to remote education. However, there is limited understanding about how such programs work, how they are implemented by schools, and how they may benefit or harm students and their families. To assist policymakers, school districts, school leaders, and others in making decisions regarding the use of these tools, the authors address these knowledge gaps by providing a preliminary examination of how AI-based suicide risk monitoring programs are implemented in K-12 schools, how stakeholders perceive the effects that the programs are having on students, and the potential benefits and risks of such tools. Using this analysis, the authors also offer recommendations for school and district leaders; state, federal, and local policymakers; and technology developers to consider as they move forward in maximizing the intended benefits and mitigating the possible risks of AI-based suicide risk monitoring programs.

为了应对普遍存在的青少年心理健康危机,一些幼儿园到十二年级(K-12)的学校已经开始采用基于人工智能(AI)的工具来帮助识别有自杀和自残风险的学生。采用人工智能和其他类型的教育技术来部分满足学生的心理健康需求,是许多学校在向远程教育过渡过程中自然而然迈出的一步。然而,人们对这些项目如何运作、学校如何实施以及它们对学生及其家庭是有利还是有害的了解还很有限。为了帮助政策制定者、学区、学校领导等就这些工具的使用做出决策,作者针对这些知识空白,对 K-12 学校如何实施基于人工智能的自杀风险监控项目、利益相关者如何看待这些项目对学生的影响以及这些工具的潜在益处和风险进行了初步研究。通过分析,作者还为学校和学区领导、州、联邦和地方政策制定者以及技术开发者提出了建议,供他们在推进基于人工智能的自杀风险监控项目时参考,最大限度地发挥其预期效益并降低其可能存在的风险。
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引用次数: 0
Potential Changes to Veterans' Benefits Under the Major Richard Star Act: Veterans' Issues in Focus. 重大理查德-斯塔法案》下退伍军人福利的潜在变化:退伍军人问题聚焦。
Pub Date : 2023-12-20 eCollection Date: 2023-12-01
Stephanie Rennane

Retired service members with a service-connected disability cannot always receive their full retirement pay and disability benefits because of rules against "double-dipping" from federal funding sources. Veterans' advocates have long argued that the current law is unfair and that it denies disabled veterans the full compensation that they have earned from their military service. New legislation would drop the offset that reduces retirement pay for some disabled veterans. If the Major Richard Star Act is signed into law, what would change for disabled veterans, and how many would actually see an increase in their compensation?

由于联邦资金来源禁止 "双重浸透 "的规定,因公致残的退役军人不能总是全额领取退役金和残疾津贴。退伍军人权益倡导者长期以来一直认为,现行法律不公平,剥夺了伤残退伍军人因服兵役而获得的全部补偿。新的立法将取消减少部分伤残退伍军人退休工资的抵消。如果《理查德少校之星法案》签署成为法律,伤残退伍军人会有哪些变化?
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引用次数: 0
Assessing Technology Platforms for Global Health Engagement to Support Integration of Efforts Across Geographic Combatant Commands. 评估全球卫生参与的技术平台,以支持跨地域作战司令部的工作整合。
Pub Date : 2023-12-20 eCollection Date: 2023-12-01
Padmaja Vedula, Trupti Brahmbhatt, Jonathan Tran, Chandler Sachs

Global health engagement (GHE) is an integral part of the cooperation efforts of the U.S. Department of Defense (DoD) and the geographic combatant commands (GCCs) with partner nations and provides support in training and preparing their military and civilian health systems. These activities encompass a wide spectrum of engagements-military-to-military, military-to-civilian, and multilateral-and support joint missions of humanitarian aid and disaster response, deterrence, access and presence, counterterrorism, and homeland defense. Global health engagements and activities require extensive planning, funding, and resource allocation within the GCCs and component commands. For a continuously growing breadth of GHE and the need to support joint exercises with partner military and civilian medical professionals for partner capacity-building, GHE also requires a robust information technology infrastructure. In this study, the authors assess the technology and process requirements to support the life cycle of GHE activities and assessments-from planning to evaluation-and the information- and knowledge-sharing needs of the GHE community. To do so, they conducted a literature review related to GHE activities, funding sources, and stakeholders; the evolution of technology solutions to support GHE; systems in use by GHE practitioners; and technology solutions in the market, focusing particularly on cloud infrastructure and services and cloud service providers. They held discussions with GHE subject-matter experts to document and analyze GHE technology platform requirements. And they assessed the available and planned platforms according to their features, enhancements, support and maintenance, data integration, interoperability, and future road maps.

全球卫生参与(GHE)是美国国防部(DoD)和地域作战司令部(GCCs)与伙伴国合作努力的一个组成部分,并为其军事和民事卫生系统的培训和准备提供支持。这些活动包括军方对军方、军方对民间和多边等多种参与方式,并支持人道主义援助和救灾、威慑、准入和存在、反恐和国土防卫等联合任务。全球卫生参与和活动需要全球合作理事会和各司令部进行广泛的规划、筹资和资源分配。由于全球健康教育的范围不断扩大,而且需要支持与合作伙伴的军事和民事医疗专业人员进行联合演习,以促进合作伙伴的能力建设,因此全球健康教育还需要强大的信息技术基础设施。在本研究中,作者评估了支持全球健康教育活动和评估生命周期(从规划到评估)的技术和流程需求,以及全球健康教育团体的信息和知识共享需求。为此,他们进行了一次文献综述,内容涉及全球健康教育活动、资金来源和利益相关者;支持全球健康教育的技术解决方案的演变;全球健康教育从业人员使用的系统;以及市场上的技术解决方案,尤其侧重于云基础设施和服务以及云服务提供商。他们与全球热教育主题专家进行了讨论,以记录和分析全球热教育技术平台需求。他们还根据现有和计划中的平台的功能、增强功能、支持和维护、数据集成、互操作性和未来路线图对这些平台进行了评估。
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引用次数: 0
A Brief Overview of Emerging Vaccine Technologies for Pandemic Preparedness. 用于防范大流行病的新兴疫苗技术简介。
Pub Date : 2023-12-20 eCollection Date: 2023-12-01
Annette Prieto, Robert Huang, Christopher A Eusebi, Melissa Shostak

Over the past two decades, pandemic preparedness has proven to be critical to health, national, and economic security. Now, countries are investing billions of dollars in various pandemic preparedness tools, such as vaccines and broad-spectrum medical countermeasures (MCM), to address the threats arising from outbreaks. These tools not only offer protection against naturally occurring and accidental biological incidents but can also help provide some protection against deliberate biological attacks. Furthermore, pandemic preparedness has substantial economic implications for both the public and private sectors because of its connection with the biotechnology industry, an important component of the worldwide economy. With so many aspects of pandemic preparedness tied to public health, national security, and economic competition, understanding the key technology and policy trends of the major country stakeholders in this space provides valuable insights into pandemic preparedness gaps and ways of addressing them. This study provides a brief characterization of the trends and strategic implications associated with specific aspects of pandemic preparedness in the United States, China, and Russia. The authors discuss both technical and policy aspects of vaccine concepts and technologies, broad-spectrum MCM, and immunization facilitation.

在过去二十年里,大流行病防备工作已被证明对健康、国家和经济安全至关重要。现在,各国正在投资数十亿美元用于各种大流行病防备工具,如疫苗和广谱医疗对策(MCM),以应对疫情爆发带来的威胁。这些工具不仅能防范自然发生的和意外的生物事件,还能在一定程度上防范蓄意的生物袭击。此外,大流行病防备对公共和私营部门都有重大的经济影响,因为它与生物技术产业有关,而生物技术产业是全球经济的重要组成部分。由于大流行病防备的许多方面都与公共卫生、国家安全和经济竞争息息相关,因此了解该领域主要国家利益相关者的关键技术和政策趋势,可为了解大流行病防备差距和解决这些差距的方法提供有价值的见解。本研究简要介绍了美国、中国和俄罗斯在大流行病防备特定方面的趋势和战略意义。作者讨论了疫苗概念和技术、广谱 MCM 以及免疫促进的技术和政策方面。
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引用次数: 0
The Impact of State Voting Processes in the 2020 Election: Estimating the Effects on Voter Turnout, Voting Method, and the Spread of COVID-19. 2020 年大选中各州投票程序的影响:估算对投票率、投票方法和 COVID-19 传播的影响》(Estimating the Effects on Voter Turnout, Voting Method, and the Spread of COVID-19)。
Pub Date : 2023-12-20 eCollection Date: 2023-12-01
Samuel Absher, Jennifer Kavanagh

Leading up to the 2020 general election, state election boards grew concerned that the coronavirus disease 2019 (COVID-19) pandemic might drive voters away from the polls or that crowded polling stations would spread the virus and lead to a wave of new cases, hospitalizations, and deaths. In an effort to safely conduct the 2020 general election, many states changed their voting laws by implementing automatic voter registration, removing excuse requirements for absentee ballots, and expanding early voting windows. These changes, meant to encourage turnout and protect public health, were expensive to implement, politically contentious, or both. But did the changes have the desired effects? This study examines the impact of voting laws on voter turnout and choice of voting method in the 2020 election and the effects of in-person voting on the spread of COVID-19.

在 2020 年大选之前,各州选举委员会越来越担心 2019 年冠状病毒病(COVID-19)大流行可能会使选民远离投票站,或者拥挤的投票站会传播病毒并导致新病例、住院和死亡浪潮。为了安全举行 2020 年大选,许多州修改了投票法,实施了选民自动登记,取消了缺席投票的借口要求,并扩大了提前投票窗口。这些旨在鼓励选民投票和保护公众健康的改革,实施起来成本高昂,政治上争议不断,或两者兼而有之。但这些变化是否达到了预期效果?本研究探讨了投票法对 2020 年选举中选民投票率和投票方式选择的影响,以及亲自投票对 COVID-19 传播的影响。
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引用次数: 0
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Rand health quarterly
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