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Effect of Tamoxifen on Ethanol Induced Gastric Ulcer in Rats 他莫昔芬对乙醇性大鼠胃溃疡的影响

Recent trends in pharmaceutical sciences and research

Pub Date : 2021-04-05 DOI: 10.46610/RTPSCR.2021.V03I01.005

Malak M. Eljafari, Al-Asayed R. Al-Attar

Background: Tamoxifen is selective estrogen receptor modulators, used in treatment of breast cancer, some literatures reported its impact on the process of peroxidation. Aim: The aim of this study was to evaluate the effect of tamoxifen on ethanol induced gastric ulcer in rats. Method: Gastric ulcers were induced in Wistar albino rats by oral administration of absolute alcohol (1 ml/200 g). Antiulcer activity of tamoxifen (0.5 and 10 mg/kg, p.o.) was observed and compared to standard drug (omeprazole 20mg/kg, p.o.), the ulcer index, ulcers numbers, lengths, gastric volume and total gastric acidity were evaluated. Histopathology is performed for confirmation. Results: Tamoxifen in 10mg/kg dose produced a highly significant (P<0.001) decrease in ulcer parameters studied compared to ulcer control. While 0.5 mg/kg of tamoxifen produced a less significant (P<0.01) effect on gastric volume when compared to the ulcer group. The anti-ulcer effects of the drug of interest is highly compared to omeprazole was very, surprisingly; the higher dose of tamoxifen produced even a much significant reduction in gastric volume and ulcers length compered to standard drug. Conclusion: Tamoxifen shows significant antiulcer activity against ethanol induced gastric ulcers, and this could possibly related to its antioxidant properties.

背景:他莫昔芬是选择性雌激素受体调节剂，用于治疗乳腺癌，有文献报道其对过氧化过程的影响。目的:探讨他莫昔芬对乙醇性大鼠胃溃疡的影响。方法:口服无水酒精(1 ml/200 g)诱导Wistar白化大鼠胃溃疡，观察他莫昔芬(0.5、10 mg/kg, p.o)的抗溃疡活性，并与标准药物(奥美拉唑20mg/kg, p.o)进行比较，评价其溃疡指数、溃疡数量、长度、胃容积和总胃酸。组织病理学证实。结果:与溃疡对照组相比，他莫昔芬10mg/kg剂量组溃疡参数显著降低(P<0.001)。与溃疡组相比，0.5 mg/kg他莫昔芬对胃容量的影响不显著(P<0.01)。该药的抗溃疡作用是高度感兴趣的，与奥美拉唑相比是非常惊人的;与标准药物相比，高剂量的他莫昔芬甚至能显著减少胃容量和溃疡长度。结论:他莫昔芬对乙醇性胃溃疡具有明显的抗溃疡活性，这可能与其抗氧化作用有关。

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引用次数: 0

Pharmaceutical Management for Subarachnoid Hemorrhage. 蛛网膜下腔出血的药物治疗。

Recent trends in pharmaceutical sciences and research

Pub Date : 2021-01-01

Arnav Barpujari, Chhaya Patel, Rebecca Zelmonovich, Alec Clark, Devan Patel, Kevin Pierre, Kyle Scott, Brandon Lucke Wold

Aneurysmal subarachnoid hemorrhage can have deleterious consequences. Vasospasm, delayed cerebral ischemia, and re-hemorrhage can all cause delayed sequelae. Furthermore, severe headaches are common and require careful modulation of pain medications. Limited treatment options currently exist and are becoming more complex with the rising use of oral anticoagulants needing reversal. In this review, we highlight the current treatment options currently employed and address avenues of future discovery based on emerging preclinical data. Furthermore, we dive into the best treatment approach for managing headaches following subarachnoid hemorrhage. The review is designed to serve as a catalyst for further prospective investigation into this important topic.

动脉瘤性蛛网膜下腔出血会造成有害后果。血管痉挛、延迟性脑缺血和再出血都会造成延迟性后遗症。此外，严重头痛也很常见，需要谨慎使用止痛药物。目前的治疗方案有限，而且随着需要逆转的口服抗凝剂使用量的增加而变得更加复杂。在本综述中，我们将重点介绍目前采用的治疗方案，并根据新出现的临床前数据探讨未来的发现途径。此外，我们还深入探讨了治疗蛛网膜下腔出血后头痛的最佳治疗方法。本综述旨在促进对这一重要课题的进一步前瞻性研究。

引用次数: 0

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