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Long-Term Outcome and Quality of Life in Patients Treated for Head and Neck Sarcoma during Pediatric Age: Considerations from a Series of 4 Cases 儿童时期头颈部肉瘤患者的长期预后和生活质量:来自一系列4例病例的考虑
Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-03-17 DOI: 10.3390/reports6010016
Martina Buchignani, Arrigo Pellacani, Sara Negrello, M. Di Bartolomeo, M. Cellini, Alessia Pancaldi, Alessandra Buttafoco, C. Migliozzi, L. Iughetti, L. Chiarini, A. Anesi
Pediatric sarcomas are rare malignancies accounting for about 10% of solid tumors in childhood. Sarcomas represent a heterogeneous group of malignancies, especially they include Rhabdomyosarcoma (RMS) and Non-Rhabdomyosarcoma Type Sarcomas (STSNR). Therapeutic management of pediatric sarcomas is challenging. Multidisciplinary approach including chemotherapy, surgery and radiotherapy is the treatment of choice. The correct management of affected patients can be demanding, especially in terms of preserving a good quality of life (QoL). In the present study we described our experience with a series of patients diagnosed with head and neck non-metastatic sarcoma between January 1995 and December 2020, referred to Pediatric Oncology or to Maxillo-Facial Surgery of University Hospital of Modena and Reggio Emilia.The survivors were asked to complete questionnaires on health-related quality of life (HRQoL; PedsQL and EORTC QLQ-H&N 43). We found satisfactory results in terms of global HRQoL; although outstanding issues persist, such as deterioration in masticatory function, and speech. Long-term sequelae of multimodality treatment may lead to both significant aesthetic-functional and psychosocial implications that need to be further investigate during the whole the care pathway.
儿童肉瘤是一种罕见的恶性肿瘤,约占儿童实体瘤的10%。肉瘤是一组异质性恶性肿瘤,尤其包括横纹肌肉瘤(RMS)和非横纹肌肉瘤型肉瘤(STSNR)。小儿肉瘤的治疗管理具有挑战性。包括化疗、手术和放疗在内的多学科方法是首选的治疗方法。对受影响患者的正确管理可能要求很高,尤其是在保持良好生活质量方面。在本研究中,我们描述了1995年1月至2020年12月期间一系列被诊断为头颈部非转移性肉瘤的患者的经验,转诊至儿科肿瘤科或莫德纳和雷焦艾米利亚大学医院的Maxillo面部外科。幸存者被要求填写与健康相关的生活质量问卷(HRQoL;PedsQL和EORTC QLQ-H&N 43)。我们在全球HRQoL方面发现了令人满意的结果;尽管突出的问题仍然存在,如咀嚼功能和言语的恶化。多模式治疗的长期后遗症可能会导致显著的美学功能和心理社会影响,需要在整个护理过程中进一步研究。
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引用次数: 0
Pneumomediastinum, Pneumothorax and Subcutaneous Emphysema - A Rare Form of Presentation for Severe COVID-19 Pneumonia 纵隔肺炎、胸腔肺炎和皮下气肿——严重新冠肺炎肺炎的罕见表现形式
Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-03-16 DOI: 10.11648/j.reports.20230302.11
S. Hasanzadeh, Ali Mehri, K. Ghazvini, Z. Ataee
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引用次数: 0
Paroxysmal Atrial Fibrillation with Rapid Ventricular Response Following COVID-19 Nasopharyngeal Swab: A Case Report COVID-19鼻咽拭子术后阵发性心房颤动伴快速心室反应1例报告
Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-03-15 DOI: 10.3390/reports6010015
M. Viscusi, L. Ambrosio, D. Ricciardi, F. Mangiacapra, A. Nusca, Luca Paolucci, G. Ussia, F. Grigioni
Nasopharyngeal (NP) swab sampling is a simple procedure that has become extremely popular in the coronavirus disease 2019 (COVID-19) era, with hundreds of million specimens collected every day. However, rare but serious complications have been reported following NP swab acquisition. Here we present a case of paroxysmal atrial fibrillation associated with NP specimen collection in a healthy healthcare provider undergoing COVID-19 testing during departmental screening. This response may have been caused by an exaggerated vagal tone triggered by the trigeminocardiac reflex. Less invasive collection methods, such as saliva testing, may be warranted in predisposed individuals.
鼻咽拭子采样是一种简单的程序,在2019冠状病毒病(新冠肺炎)时代变得非常流行,每天采集数亿份样本。然而,NP拭子采集后出现了罕见但严重的并发症。在此,我们介绍了一例在一名健康医疗保健提供者中进行新冠肺炎部门筛查期间检测的与NP样本采集相关的发作性心房颤动病例。这种反应可能是由三叉神经反射触发的迷走神经张力过度引起的。唾液检测等侵入性较小的采集方法可能适用于易感人群。
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引用次数: 0
On the Historical Data Collection and Study of the Culture of Mountain Tai Heaver 论泰山鹤文化的史料收集与研究
Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-03-15 DOI: 10.11648/j.reports.20230301.11
Mingjie Sun
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引用次数: 0
A Rare Case of Malignant Ovarian Germ Cell Tumor: Dysgerminoma and Seminoma in the Same Patient 卵巢恶性生殖细胞瘤1例:异常生殖细胞瘤与精原细胞瘤合并
Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-03-03 DOI: 10.3390/reports6010014
M. Mitranovici, D. Chiorean, S. Turdean, Maria-Cezara Muresan, C. Buicu, R. Moraru, L. Moraru, T. Cotoi, Havva Serap Toru, A. Apostol, C. Mǎrginean, Ion Petre, Ioan Emilian Oală, Viviana Ivan, O. Cotoi
Ovarian malignant germ cell tumors (OMGCTs) represent a rare type of malignant tumors composed of primitive germ cells that often originate from dysgenetic gonads and are frequently associated with hermaphroditism. Such tumors occur more frequently in adolescents or young adults, and their etiopathogenic mechanism is not well established. We report the case of a 20-year-old female with ovarian dysgenesis and female phenotype. A laparoscopic surgery was performed, and ovotestis was discovered. To achieve a histopathological examination, right oophorectomy was performed, which confirmed the diagnosis of dysgerminoma. In the case of hermaphroditism, mixed germ cell tumors can develop, leading to a more aggressive evolution with bilateral malignancy of the gonads, which requires the removal of both ovotestis. The patient was recalled. A histopathological examination revealed a seminoma, so laparoscopic left oophorectomy was performed. The management of this type of diagnosis primarily involves surgery, minimally invasive interventions being preferred. Not all pathologic conditions are readily identifiable by means of exploratory laparoscopy, as in our patient’s case. We consider that the optimal solution for these patients would be the preservation of fertility via egg donation and embryo transfer; the survival rate of such patients being 97–100%, if the tumor is diagnosed at an early age.
卵巢恶性生殖细胞瘤(omgct)是一种罕见的恶性肿瘤,由原始生殖细胞组成,通常起源于性腺发育不良,通常与雌雄同体有关。此类肿瘤多见于青少年或青壮年,其发病机制尚不明确。我们报告的情况下,20岁的女性卵巢发育不良和女性表型。进行了腹腔镜手术,发现了卵睾丸。为了完成组织病理学检查,我们进行了右卵巢切除术,确诊为生殖细胞异常瘤。在雌雄同体的情况下,混合生殖细胞肿瘤可以发展,导致双侧性腺恶性肿瘤的更积极的进化,这需要切除两个卵睾丸。病人被召回。组织病理学检查显示精原细胞瘤,因此进行腹腔镜左卵巢切除术。这种类型诊断的处理主要涉及手术,微创干预是首选。并不是所有的病理状况都很容易通过腹腔镜探查来识别,就像我们的病人一样。我们认为这些患者的最佳解决方案是通过卵子捐赠和胚胎移植来保存生育能力;如果在早期诊断出肿瘤,这类患者的生存率为97-100%。
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引用次数: 0
Favorable Outcome and Safety of Neoadjuvant Trastuzumab Emtansine (T-DM1) in a HER2-Positive Early Breast Cancer Patient with Severe Renal Disease on Hemodialysis Ineligible for Conventional Chemotherapy: A Case Report 新辅助曲妥珠单抗Emtansine (T-DM1)治疗her2阳性早期乳腺癌伴严重肾脏疾病的血液透析不适合常规化疗患者的良好结局和安全性:1例报告
Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-03-02 DOI: 10.3390/reports6010013
Suman Kalyan Natarajan, Joice Crystal Danansezhian, Vipul R. Thummar, P. Mehta
Breast cancer is the leading cause of cancer-related death among women worldwide. It is the most common malignancy in middle-age and elderly women already suffering from other comorbidities, such as chronic kidney disease (CKD). Being a heterogeneous disease, it has variable subtype-specific outcomes and responses towards treatment. Patients with human epidermal growth factor receptor 2 (HER2) overexpression are treated with anti-HER2-targeted drugs. With the advent of newer drugs, the usage of HER2 blockade and chemotherapy in the neoadjuvant treatment of HER2-positive early breast cancer management helps to increase the probability of achieving pathological complete response. We herein present a case of a patient with breast cancer with long-standing CKD and on maintenance hemodialysis where treatment with conventional chemotherapy regimens was a concern and managed with an antibody–drug conjugate (ADC), namely T-DM1, in a neoadjuvant setting. The patient showed a favorable outcome, and the tolerance of T-DM1 in this patient was predictable. This is a first-of-its-kind case report, where T-DM1 was used in a neoadjuvant setting for a patient on simultaneous hemodialysis.
乳腺癌是全世界妇女癌症相关死亡的主要原因。它是中老年妇女中最常见的恶性肿瘤,已经患有其他合并症,如慢性肾病(CKD)。作为一种异质性疾病,它具有可变的亚型特异性结果和对治疗的反应。人表皮生长因子受体2 (HER2)过表达的患者可以使用抗HER2靶向药物进行治疗。随着新药的出现,在HER2阳性早期乳腺癌管理的新辅助治疗中,使用HER2阻断和化疗有助于提高达到病理完全缓解的概率。我们在此报告一例患有长期CKD的乳腺癌患者,并进行维持性血液透析,其传统化疗方案是一个问题,并在新辅助设置中使用抗体-药物偶联物(ADC),即T-DM1进行治疗。患者表现出良好的结果,并且该患者的T-DM1耐受性是可预测的。这是首例此类病例报告,其中T-DM1用于同时进行血液透析的患者的新辅助设置。
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引用次数: 0
The Durability and Efficacy of Cryopreserved Human Umbilical Cord Tissue Allograft for the Supplementation of Cartilage Defects Associated with the Sacroiliac Joint: A Case Series 低温保存的人脐带同种异体组织移植治疗骶髂关节软骨缺损的耐久性和有效性:一个病例系列
Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-03-02 DOI: 10.3390/reports6010012
A. Lai, Jon Shou, Steve A. Traina, Tyler C. Barrett
This Institutional Review Board (IRB)-approved retrospective observational protocol aims to report the safety and efficacy of birth tissue allografts applied in 38 patients with treatment-resistant sacroiliac (SI) joint pain. The research methodology consisted of an observational recording of the Numeric Pain Rating Scale (NPRS) and the Western Ontario and McMaster Universities Arthritis Index (WOMAC), which measure pain, stiffness, and physical function. No adverse events or adverse reactions were observed in the 38 patients. Statistically significant improvements in NPRS and WOMAC scores of the affected SI joint were reported after 90 days. The observational data suggests that Wharton’s jelly allograft applications are safe, minimally invasive, and efficacious. They may present an alternative to surgery for patients who fail conservative and procedural management of pain originating from chondral cartilage degeneration of the SI joint.
这项机构审查委员会(IRB)批准的回顾性观察性方案旨在报告38例难治性骶髂(SI)关节疼痛患者使用同种异体组织移植的安全性和有效性。研究方法包括数值疼痛评定量表(NPRS)和西安大略和麦克马斯特大学关节炎指数(WOMAC)的观察记录,测量疼痛、僵硬和身体功能。38例患者无不良事件或不良反应。90天后,受影响SI关节的NPRS和WOMAC评分有统计学意义的改善。观察数据表明,沃顿的果冻异体移植应用是安全、微创和有效的。对于因骶髂关节软骨退变引起的疼痛,保守和程序性治疗失败的患者,它们可能是手术的替代选择。
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引用次数: 0
A Possible New Diagnostic Method for Early Diagnosis of Cryptococcus Infection in Lymphoma Patient Co-Infected with SARS-CoV-2 SARS-CoV-2合并淋巴瘤患者隐球菌感染早期诊断的可能新方法
Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-03-01 DOI: 10.3390/reports6010011
M. Colosimo, S. Nisticò, F. Quintieri, A. De Luca, P. Minchella, L. Gallelli
A Cryptococcus subspecies, neoformans, represents the most pathogenic infection for humans, particularly in immunocompromised hosts (e.g., cancer patients, drug users). In the present study, we described a 67-year old woman with non-Hodgkin lymphoma who developed an infectious disease sustained by Cryptococcus neoformans. Biochemical data documented a decrease in lymphocytes count while clinical evaluation was suggestive on meningeal infection. The microbiological analysis of the serum, using a dilution pattern through the CrAg lateral flow assay (Immy, Norman, OK 73069, USA) detected the antigen of Cryptococcus (dilution 1/1280), and a treatment with liposomal amphotericin B (3 mg/kg id) plus flucytosine (100 mg/kg per day orally in four divided doses) were started, showing an improvement of symptoms. This case report suggests that an antigen dilution can be used to perform a rapid diagnosis and to quickly start the pharmacological treatment.
隐球菌亚种,新生隐球菌,是人类最具致病性的感染,特别是在免疫功能低下的宿主(如癌症患者、吸毒者)中。在本研究中,我们描述了一位67岁的非霍奇金淋巴瘤女性,她发展为一种由新型隐球菌持续的传染病。生化数据显示淋巴细胞计数减少,而临床评估提示脑膜感染。血清的微生物学分析,使用稀释模式通过CrAg横向流动试验(Immy, Norman, OK 73069, USA)检测隐球菌抗原(稀释1/1280),并开始用脂质体两性霉素B (3mg /kg)加氟胞嘧啶(100mg /kg每天口服四次)治疗,显示症状改善。本病例报告提示抗原稀释可用于进行快速诊断并迅速开始药物治疗。
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引用次数: 0
Scanning Electron Microscopy of Conjunctival Scraping: Our Experience in the Diagnosis of Infectious Keratitis with Negative Culture Tests 结膜刮削扫描电镜:培养阴性诊断感染性角膜炎的经验
Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-02-27 DOI: 10.3390/reports6010010
M. Troisi, Salvatore Del Prete, Salvatore Troisi, Daniela Marasco, C. Costagliola
65 consecutive patients with presumed microbial keratitis and negative culture tests for bacteria and fungi obtained by corneal curettage were evaluated. All patients had undergone local broad spectrum antibiotic therapy for at least 5 days with no clinical improvement. After 48–72 h of wash-out they underwent scraping of the superior tarsal conjunctiva for cytological examination of cellular morphology in Scanning Electron Microscopy (SEM). The presence of pathogenic microorganisms was detected with this method in 62 of these patients, towards which specific therapy was carried out. Clinical improvement and eradication of microorganisms previously detected by SEM examination were observed in all positive patients over a time between 10 and 49 days. In three patients, no microorganisms were detected, but the presence of inflammatory cells (eosinophils and mast cells) or dry eye findings. This method could be useful to detect the presence of non-isolated microorganisms at common culture tests. The resolution of the infectious keratitis and the eradication of the pathogens at the subsequent cytological examination of cellular morphology in Scanning Electron Microscopy support the validity of the proposed method.
对65例连续的假定为微生物性角膜炎的患者进行评估,并对通过角膜刮除术获得的细菌和真菌培养测试呈阴性。所有患者均接受了局部广谱抗生素治疗至少5天,临床无任何改善。冲洗48–72小时后,刮除睑板上结膜,用扫描电子显微镜(SEM)对细胞形态进行细胞学检查。用这种方法在其中62名患者中检测到病原微生物的存在,并对其进行了特异性治疗。在10至49天的时间内,在所有阳性患者中观察到先前通过SEM检查检测到的微生物的临床改善和根除。在三名患者中,没有检测到微生物,但存在炎症细胞(嗜酸性粒细胞和肥大细胞)或干眼症。该方法可用于在普通培养试验中检测非分离微生物的存在。在随后的扫描电子显微镜细胞形态学细胞学检查中,感染性角膜炎的解决和病原体的根除支持了所提出方法的有效性。
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引用次数: 1
The Risk of the Development of Secondary Post-Traumatic Stress Disorder among Pediatric Health Care Providers: A Systematic Review 继发性创伤后应激障碍在儿科卫生保健提供者中的发展风险:一项系统综述
Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-02-23 DOI: 10.3390/reports6010009
N. Rigas, A. Soldatou, M. Dagla, C. Nanou, E. Antoniou
Background: Secondary PTSD is defined as the natural, consequential behaviors and emotions that result from knowledge about a traumatic event experienced by a significant other deriving from working with suffering individuals. Pediatric health providers with symptoms of PTSD report problems with relationships and general life dissatisfaction as well as and anxiety, depression and burnout syndrome. Aim: The aim of this systematic review was to estimate the risk of developing secondary PTSD among pediatric health care providers as well as all additional contributing factors. In more detail, we investigated the PTSD symptomatology between pediatric health care providers and the extent to which parameters such as the job, gender, department and other factors had an impact on the mental health status of pediatric health care providers. Methodology: We searched all published English papers in PubMed, Google Scholar and the Cochrane Library from September to November 2022. We excluded reviews, systematic reviews and meta-analyses as well as letters to editors. From a total of 748 papers, we included only 12 research articles that met the admission criteria. Results: According to our results, the prevalence of secondary PTSD ranges from 13% to 94%. Burnout, nurses, the female gender, intensive care units, past traumatic life events and a psychiatric history identified as factors contributing to the development of secondary PTSD. Conclusions: Health policy-makers should take the specificity in the working environment of the pediatric sector seriously into consideration, especially emergency departments.
背景:继发性创伤后应激障碍被定义为一种自然的、后果性的行为和情绪,这种行为和情绪是由于对另一个重要的人在与痛苦的人共事时所经历的创伤事件的了解而产生的。有创伤后应激障碍症状的儿科保健提供者报告说,他们存在人际关系问题、普遍生活不满以及焦虑、抑郁和倦怠综合征。目的:本系统综述的目的是评估儿科医疗服务提供者患继发性创伤后应激障碍的风险以及所有其他促成因素。更详细地说,我们调查了儿科医疗服务提供者之间的创伤后应激障碍症状,以及工作、性别、部门和其他因素等参数对儿科医疗服务提供商心理健康状况的影响程度。方法:我们搜索了2022年9月至11月在PubMed、Google Scholar和Cochrane图书馆发表的所有英文论文。我们排除了评论、系统评论和荟萃分析以及给编辑的信件。在总共748篇论文中,我们只收录了12篇符合录取标准的研究文章。结果:根据我们的研究结果,继发性PTSD的患病率在13%到94%之间。倦怠、护士、女性、重症监护室、过去的创伤生活事件和精神病史被确定为导致继发性创伤后应激障碍发展的因素。结论:卫生政策制定者应认真考虑儿科工作环境的特殊性,尤其是急诊科。
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引用次数: 0
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