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Percutaneous Nephrolithotomy under Ultrasound Guidance in Patients with Renal Calculi and Autosomal Dominant Polycystic Kidney Disease: A Report of 11 Cases. 超声引导下经皮肾镜取石术治疗肾结石合并常染色体显性多囊肾病11例报告
IF 1.4 Q3 UROLOGY & NEPHROLOGY Pub Date : 2017-01-01 Epub Date: 2017-02-21 DOI: 10.1155/2017/3483172

Nephrolithiasis accelerates the renal failure in the patients with ADPKD. In order to evaluate the role of percutaneous nephrolithotomy in management of calculus in these patients, 11 patients with autosomal dominant polycystic kidney disease and renal stones were included in the study. Two patients had bilateral renal stones. All patients were treated by percutaneous nephrolithotomy under ultrasound guidance. 13 percutaneous nephrolithotomy procedures were performed in 1 stage by the urology team under ultrasound guidance. 5 people received second operation with flexible nephroscopy in lateral position. The success rate and morbidity and mortality of the technique and hospital stay were recorded. Results. The puncture procedure was fully successful in all cases. The renal function improved in these patients. 5 patients had moderate fever after the surgery. 5 patients received flexible nephroscopy to take out the residual calculi. 2 persons had ESWL therapy after the surgery. Conclusion. PCNL is an ideal, safe, and effective method to remove the stones from those patients with no definite increase in the risk of complication. The outcome and stone-free rate are satisfactory comparable to the PCNL in the patients without ADPKD.

肾结石加速ADPKD患者肾功能衰竭。为了评估经皮肾镜取石术在这些患者结石治疗中的作用,我们纳入了11例常染色体显性多囊肾病和肾结石患者。2例患者有双侧肾结石。所有患者均行超声引导下经皮肾镜取石术。泌尿外科小组在超声引导下分一期行13例经皮肾镜取石术。5例患者行侧位柔性肾镜第二次手术。记录手术成功率、发病率、死亡率及住院时间。结果。穿刺过程在所有病例中都是完全成功的。这些患者的肾功能得到改善。5例术后出现中热。5例行柔性肾镜取出残余结石。2例术后行体外冲击波碎石治疗。结论。PCNL是一种理想、安全、有效的结石取出方法,没有明显增加并发症的风险。与无ADPKD患者的PCNL相比,结果和无结石率令人满意。
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引用次数: 5
The Persistence of Silodosin Monotherapy and the Reasons for Withdrawal from Treatment of Previously Untreated Japanese Patients with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia. 西洛多辛单药治疗的持续性和先前未治疗的日本下尿路症状提示良性前列腺增生患者退出治疗的原因
IF 1.4 Q3 UROLOGY & NEPHROLOGY Pub Date : 2017-01-01 Epub Date: 2017-06-13 DOI: 10.1155/2017/4842025

Objectives: The persistence of silodosin and the reasons for withdrawal from treatment of previously untreated Japanese patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH) were evaluated in real-life clinical practice.

Methods: A total of 81 previously untreated Japanese patients diagnosed with LUTS/BPH were treated with silodosin monotherapy and prospectively followed for 4 years. The persistence rate was estimated using the Kaplan-Meier method. If silodosin had to be terminated or a patient did not come to the hospital, the reason was determined.

Results: The 6-month, 1-year, 2-year, 3-year, and 4-year persistence rates were 63.0%, 56.8%, 50.6%, 44.4%, and 35.8%, respectively. The most frequent reason (22.2%) for withdrawal was symptom resolution. After silodosin treatment, the international prostate symptom score and the quality of life index were significantly improved and maintained for 4 years.

Conclusions: 35.8% of previously untreated Japanese patients continued silodosin for 4 years. Many patients terminated silodosin for various reasons, the most frequent of which was symptom resolution. The effects of silodosin were maintained when the patients continued treatment.

Trial registration: This study was approved by the institutional review board of Hokkaido Prefectural Esashi Hospital (number 2007-2) and was registered in a public trial registry (UMIN000026910).

目的:在现实生活的临床实践中评估西洛多辛的持久性和先前未经治疗的日本患者下尿路症状提示良性前列腺增生(LUTS/BPH)的停药原因。方法:共有81例未经治疗的诊断为LUTS/BPH的日本患者接受西洛多辛单药治疗,前瞻性随访4年。使用Kaplan-Meier法估计持续率。如果西洛多辛必须终止或患者没有来医院,则确定原因。结果:6个月、1年、2年、3年、4年的持续率分别为63.0%、56.8%、50.6%、44.4%、35.8%。停药最常见的原因是症状缓解(22.2%)。西洛多辛治疗后,国际前列腺症状评分和生活质量指数均有明显改善,并维持4年。结论:35.8%先前未接受治疗的日本患者继续使用西洛多辛4年。许多患者因各种原因停用西洛多辛,其中最常见的是症状缓解。西洛多辛的作用在患者继续治疗时保持不变。试验注册:本研究已获得北海道县立Esashi医院机构审查委员会批准(编号2007-2),并已在公共试验登记处注册(UMIN000026910)。
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引用次数: 1
Recent Pathophysiological Aspects of Peyronie's Disease: Role of Free Radicals, Rationale, and Therapeutic Implications for Antioxidant Treatment-Literature Review. 佩罗尼病的最新病理生理方面:自由基的作用、原理和抗氧化治疗的治疗意义-文献综述。
IF 1.4 Q3 UROLOGY & NEPHROLOGY Pub Date : 2017-01-01 Epub Date: 2017-07-04 DOI: 10.1155/2017/4653512

Peyronie's disease (PD) is a chronic inflammation of tunica albuginea of the corpora cavernosa that causes an inelastic plaque resulting in penis deformation. Although its etiology is not completely known, there is general consensus that PD is genetically transmitted and secondary to penile trauma. In recent years, numerous studies demonstrated the role played by oxidative stress in PD pathogenesis, and other studies have described successful use of antioxidants in PD treatment. Oxidative stress is an integral part of this disease, influencing its progression. In the early stages of PD, the inflammatory infiltrate cells produce high quantities of free radicals and proinflammatory and profibrotic cytokines, with consequent activation of transcription factor NF-κB. While conservative therapies commonly used in the early stages of PD include oral substances (Potaba, tamoxifen, colchicine, and vitamin E), intralesional treatment (verapamil, interferon, steroids, and more recently collagenase clostridium histolyticum-Xiaflex), and local physical treatment (iontophoresis, extracorporeal shock wave therapy, and penile extender), the significant results obtained by emerging treatments with the antioxidants cited in this article suggest these therapeutic agents interfere at several levels with the disease's pathogenetic mechanisms. Antioxidants therapy outcomes are interesting for good clinical practice and also confirm the fundamental role played by oxidative stress in PD.

佩罗尼氏病(PD)是一种海绵体白膜的慢性炎症,引起无弹性斑块,导致阴茎变形。虽然其病因尚不完全清楚,但普遍认为PD是遗传遗传的,继发于阴茎创伤。近年来,大量研究证实了氧化应激在PD发病机制中的作用,也有研究成功地将抗氧化剂应用于PD治疗。氧化应激是这种疾病的一个组成部分,影响其进展。在PD的早期阶段,炎症浸润细胞产生大量的自由基和促炎和促纤维化细胞因子,并随之激活转录因子NF-κB。虽然PD早期常用的保守治疗包括口服药物(波他巴、他莫昔芬、水仙花碱和维生素E)、局部治疗(维拉帕米、干扰素、类固醇和最近的胶原酶溶组织梭菌夏弗莱克斯)和局部物理治疗(离子透入、体外冲击波治疗和阴茎延长剂)。本文中引用的抗氧化剂的新兴治疗方法所取得的显著结果表明,这些治疗剂在几个层面上干扰了疾病的发病机制。抗氧化剂治疗的结果对良好的临床实践很有趣,也证实了氧化应激在帕金森病中的基本作用。
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引用次数: 26
Impact on the Quality of Erections after Completing a Low-Intensity Extracorporeal Shock Wave Treatment Cycle on a Group of 710 Patients. 对710例患者完成低强度体外冲击波治疗周期后勃起质量的影响。
IF 1.4 Q3 UROLOGY & NEPHROLOGY Pub Date : 2017-01-01 Epub Date: 2017-12-21 DOI: 10.1155/2017/1843687

Objective: The aim of this study is to evaluate the response to low-intensity extracorporeal shock wave therapy in a group of patients with organic vascular erectile dysfunction.

Materials and methods: This is an observational retrospective study. The researchers reviewed 710 patients with a clinical diagnosis of organic vascular erectile dysfunction (ED) of more than 3-month duration from male sexual health clinics of the Boston Medical Group from 12 cities in Spain and 4 in Mexico. Patients received 5 outpatient shock wave therapy sessions. They were evaluated with the erection hardness score (EHS) before the first session (n = 710), at the end of the last session (n = 710), and one month after the last session (n = 412).

Results: In the first examination, the EHS improved in 43.1% (306/710) of subjects compared to the baseline measurement and ability to penetrate increased from 26.8% to 44% (p < 0.0001). In the second examination, the ability to penetrate was 37.9%, lower than in the first (p=0.042) but higher than the baseline (p=0.0001).

Conclusions: The results suggest that the shock wave therapy with or without concomitant treatments improved the quality of erections in patients with erectile dysfunction treated in specialised male sexual health clinics. This trial is registered with NCT03237143.

目的:本研究的目的是评估低强度体外冲击波治疗一组器质性血管性勃起功能障碍患者的反应。材料与方法:本研究为观察性回顾性研究。研究人员回顾了710名临床诊断为器质性血管性勃起功能障碍(ED)超过3个月的患者,这些患者来自波士顿医疗集团的男性性健康诊所,分别来自西班牙的12个城市和墨西哥的4个城市。患者接受5次门诊冲击波治疗。在第一次治疗前(n = 710)、最后一次治疗结束时(n = 710)和最后一次治疗后一个月(n = 412)对他们进行勃起硬度评分(EHS)评估。结果:第一次检查时,与基线测量相比,43.1%(306/710)的受试者EHS改善,穿透能力从26.8%提高到44% (p < 0.0001)。第二次检查穿透能力为37.9%,低于第一次检查(p=0.042),但高于基线(p=0.0001)。结论:冲击波治疗联合或不联合治疗可改善在男性专业性健康诊所治疗的勃起功能障碍患者的勃起质量。该试验注册号为NCT03237143。
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引用次数: 8
Incidence of Urethral Stricture in Patients with Adult Acquired Buried Penis. 成人获得性隐伏阴茎患者尿道狭窄的发生率。
IF 1.4 Q3 UROLOGY & NEPHROLOGY Pub Date : 2017-01-01 Epub Date: 2017-03-30 DOI: 10.1155/2017/7056173

Introduction. Concealed-buried penis is an acquired condition associated with obesity, challenging to both manage and repair. Urethral stricture is a more common disorder with multiple etiologies. Lichen sclerosus is a significant known cause of urethral stricture, implicated in up to 30%. We hypothesize that patients with buried penis have a higher rate of urethral stricture and lichen sclerosus than the general population. Methods. We retrospectively reviewed a single surgeon's (CM) case logs for patients presenting with a buried penis. All patients were evaluated for urethral stricture with cystoscopy or retrograde urethrogram either prior to or at the time of repair for buried penis. Those that had surgical repair or biopsy were reviewed for presence of lichen sclerosus. Results. 39 patients met inclusion criteria. Of these, 13 (33%) had associated stricture disease. The location of the strictures was bulbar urethra (38%), penile urethra (15%), and meatus or fossa navicularis (62%). Five patients had lichen sclerosus and urethral stricture disease, while 3 had lichen sclerosus without stricture. 11/13 stricture patients were treated. Six underwent dilation, 3 underwent meatotomy, and 2 underwent urethroplasty. No significant recurrences of stricture were seen. Conclusion. Patients with a concealed penis are more likely than the general population to have a urethral stricture and/or LS. Patients presenting with concealed penis should also be evaluated for a urethral stricture.

介绍。隐伏性阴茎是一种与肥胖相关的获得性疾病,对治疗和修复都具有挑战性。尿道狭窄是一种更常见的疾病,有多种病因。地衣硬化症是尿道狭窄的一个重要的已知原因,涉及高达30%。我们假设阴茎埋藏患者尿道狭窄和硬化衣的发生率高于一般人群。方法。我们回顾性地回顾了一位外科医生(CM)的病例记录,为患者提出了一个埋藏的阴茎。所有患者在进行埋藏阴茎修复术前或修复术时均通过膀胱镜检查或逆行尿道造影评估尿道狭窄。那些手术修复或活检检查是否存在硬化地衣。结果:39例患者符合纳入标准。其中13例(33%)伴有狭窄性疾病。狭窄部位依次为球尿道(38%)、阴茎尿道(15%)、舟状窝或鼻道(62%)。合并硬化地衣合并尿道狭窄5例,合并硬化地衣无尿道狭窄3例。11/13例狭窄患者接受治疗。6例行扩张术,3例行切肉术,2例行尿道成形术。未见明显的狭窄复发。结论。隐蔽性阴茎患者比一般人群更容易发生尿道狭窄和/或LS。出现隐蔽性阴茎的患者也应检查是否有尿道狭窄。
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引用次数: 23
The Effect of Obesity and Increased Waist Circumference on the Outcome of Laparoscopic Nephrectomy. 肥胖和腰围增加对腹腔镜肾切除术疗效的影响
IF 1.4 Q3 UROLOGY & NEPHROLOGY Pub Date : 2017-01-01 Epub Date: 2017-01-22 DOI: 10.1155/2017/3941727

Introduction. The prevalence of obesity is increasing worldwide. Obesity can be determined by body mass index (BMI); however waist circumference (WC) is a better measure of central obesity. This study evaluates the outcome of laparoscopic nephrectomy on patients with an abnormal WC. Methods. A WC of >88 cm for women and >102 cm for men was defined as obese. Data collected included age, gender, American Society of Anaesthesiologists (ASA) score, renal function, anaesthetic duration, surgery duration, blood loss, complications, and duration of hospital stay. Results. 144 patients were assessed; 73 (50.7%) of the patients had abnormal WC for their gender. There was no difference between the groups for conversion to open surgery, number of ports used, blood loss, and complications. Abnormal WC was associated with a longer median anaesthetic duration, 233 min, IQR (215-265) versus 204 min, IQR (190-210), p = 0.0022, and operative duration, 178 min, IQR (160-190) versus 137 min, IQR (128-162), p < 0.0001. Patients with an abnormal WC also had a longer inpatient stay, p = 0.0436. Conclusion. Laparoscopic nephrectomy is safe in obese patients. However, obese patients should be informed that their obesity prolongs the anaesthetic duration and duration of the surgery and is associated with a prolonged recovery.

介绍肥胖在世界范围内的流行率正在上升。肥胖可以通过体重指数(BMI)来确定;然而,腰围(WC)是衡量中心性肥胖的更好指标。本研究评估腹腔镜肾切除术对WC异常患者的疗效。方法。>88的WC 女性为cm,>102 cm的男性被定义为肥胖。收集的数据包括年龄、性别、美国麻醉师协会(ASA)评分、肾功能、麻醉持续时间、手术持续时间、失血、并发症和住院时间。后果对144名患者进行了评估;73例(50.7%)患者的WC存在性别异常。两组之间在转为开放手术、使用端口数量、失血和并发症方面没有差异。WC异常与中位麻醉持续时间较长有关,233 最小IQR(215–265)与204 min,IQR(190–210),p=0.0022,手术持续时间,178 最小IQR(160–190)与137 最小IQR(128–162),p<0.0001。WC异常的患者住院时间也更长,p=0.0436。结论腹腔镜肾切除术对肥胖患者是安全的。然而,应告知肥胖患者,他们的肥胖会延长麻醉持续时间和手术持续时间,并与长期康复有关。
{"title":"The Effect of Obesity and Increased Waist Circumference on the Outcome of Laparoscopic Nephrectomy.","authors":"D B Hennessey, E M Bolton, A Z Thomas, R P Manecksha, T H Lynch","doi":"10.1155/2017/3941727","DOIUrl":"10.1155/2017/3941727","url":null,"abstract":"<p><p><i>Introduction</i>. The prevalence of obesity is increasing worldwide. Obesity can be determined by body mass index (BMI); however waist circumference (WC) is a better measure of central obesity. This study evaluates the outcome of laparoscopic nephrectomy on patients with an abnormal WC. <i>Methods</i>. A WC of >88 cm for women and >102 cm for men was defined as obese. Data collected included age, gender, American Society of Anaesthesiologists (ASA) score, renal function, anaesthetic duration, surgery duration, blood loss, complications, and duration of hospital stay. <i>Results</i>. 144 patients were assessed; 73 (50.7%) of the patients had abnormal WC for their gender. There was no difference between the groups for conversion to open surgery, number of ports used, blood loss, and complications. Abnormal WC was associated with a longer median anaesthetic duration, 233 min, IQR (215-265) versus 204 min, IQR (190-210), <i>p</i> = 0.0022, and operative duration, 178 min, IQR (160-190) versus 137 min, IQR (128-162), <i>p</i> < 0.0001. Patients with an abnormal WC also had a longer inpatient stay, <i>p</i> = 0.0436. <i>Conclusion</i>. Laparoscopic nephrectomy is safe in obese patients. However, obese patients should be informed that their obesity prolongs the anaesthetic duration and duration of the surgery and is associated with a prolonged recovery.</p>","PeriodicalId":7490,"journal":{"name":"Advances in Urology","volume":"2017 1","pages":"3941727"},"PeriodicalIF":1.4,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42530590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do Routine Preoperative and Intraoperative Urine Cultures Benefit Pediatric Vesicoureteral Reflux Surgery? 术前和术中常规尿培养对小儿膀胱输尿管反流手术有益吗?
IF 1.4 Q3 UROLOGY & NEPHROLOGY Pub Date : 2017-01-01 Epub Date: 2017-04-11 DOI: 10.1155/2017/3197869

Objective. To determine if routine preoperative and intraoperative urine cultures (UCx) are necessary in pediatric vesicoureteral (VUR) reflux surgery by identifying their association with each other, preoperative symptoms, and surgical outcomes. Materials and Methods. A retrospective review of patients undergoing ureteral reimplant(s) for primary VUR at a tertiary academic medical center between years 2000 and 2014 was done. Preoperative UCx were defined as those within 30 days before surgery. A positive culture was defined as >50,000 colony forming units of a single organism. Results. A total of 185 patients were identified and 87/185 (47.0%) met inclusion criteria. Of those, 39/87 (45%) completed a preoperative UCx. Only 3/39 (8%) preoperative cultures returned positive, and all of those patients were preoperatively symptomatic. No preoperatively asymptomatic patients had positive preoperative cultures. Intraoperative cultures were obtained in 21/87 (24.1%) patients; all were negative. No associations were found between preoperative culture results and intraoperative cultures or between culture result and postoperative complications. Conclusions. In asymptomatic patients, no associations were found between the completion of a preoperative or intraoperative UCx and surgical outcomes, suggesting that not all patients may require preoperative screening. Children presenting with symptoms of urinary tract infection (UTI) prior to ureteral reimplantation may benefit from preoperative UCx.

目标。通过确定患儿膀胱输尿管(VUR)反流手术术前和术中常规尿培养(UCx)是否必要,确定两者之间、术前症状和手术结果的相关性。材料与方法。回顾性分析了2000年至2014年在某三级学术医疗中心接受输尿管再植术治疗原发性VUR的患者。术前UCx定义为术前30天内的UCx。阳性培养定义为单个生物体的集落形成单位>50,000。结果。共纳入185例患者,其中87/185(47.0%)符合纳入标准。其中,39/87(45%)完成了术前UCx。只有3/39(8%)患者术前培养阳性,且所有患者术前均有症状。术前无症状患者无术前培养阳性。术中培养21/87 (24.1%);都是负面的。术前培养结果与术中培养结果或培养结果与术后并发症之间无关联。结论。在无症状的患者中,未发现术前或术中UCx检查的完成与手术结果之间的关联,这表明并非所有患者都需要术前筛查。在输尿管再植前出现尿路感染(UTI)症状的儿童可能受益于术前UCx。
{"title":"Do Routine Preoperative and Intraoperative Urine Cultures Benefit Pediatric Vesicoureteral Reflux Surgery?","authors":"Daniel R Hettel,&nbsp;Bradley C Gill,&nbsp;Audrey C Rhee","doi":"10.1155/2017/3197869","DOIUrl":"https://doi.org/10.1155/2017/3197869","url":null,"abstract":"<p><p><i>Objective</i>. To determine if routine preoperative and intraoperative urine cultures (UCx) are necessary in pediatric vesicoureteral (VUR) reflux surgery by identifying their association with each other, preoperative symptoms, and surgical outcomes. <i>Materials and Methods</i>. A retrospective review of patients undergoing ureteral reimplant(s) for primary VUR at a tertiary academic medical center between years 2000 and 2014 was done. Preoperative UCx were defined as those within 30 days before surgery. A positive culture was defined as >50,000 colony forming units of a single organism. <i>Results</i>. A total of 185 patients were identified and 87/185 (47.0%) met inclusion criteria. Of those, 39/87 (45%) completed a preoperative UCx. Only 3/39 (8%) preoperative cultures returned positive, and all of those patients were preoperatively symptomatic. No preoperatively asymptomatic patients had positive preoperative cultures. Intraoperative cultures were obtained in 21/87 (24.1%) patients; all were negative. No associations were found between preoperative culture results and intraoperative cultures or between culture result and postoperative complications. <i>Conclusions</i>. In asymptomatic patients, no associations were found between the completion of a preoperative or intraoperative UCx and surgical outcomes, suggesting that not all patients may require preoperative screening. Children presenting with symptoms of urinary tract infection (UTI) prior to ureteral reimplantation may benefit from preoperative UCx.</p>","PeriodicalId":7490,"journal":{"name":"Advances in Urology","volume":"2017 ","pages":"3197869"},"PeriodicalIF":1.4,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/3197869","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34980302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Study of Testicular Structure in Fetuses with Prune Belly Syndrome. 梅干腹综合征胎儿睾丸结构的研究。
IF 1.4 Q3 UROLOGY & NEPHROLOGY Pub Date : 2017-01-01 Epub Date: 2017-05-21 DOI: 10.1155/2017/3254980

Purpose: To compare the structure of the testis in fetuses with prune belly syndrome (PBS) to normal controls.

Materials and methods: We studied 6 testes obtained from 3 fetuses with PBS and 14 testes from 7 male fetuses. The testicular specimens were cut into 5-μm thick sections and stained with hematoxylin and eosin (HE), to observe the seminiferous tubules; Weigert's solution to observe elastic fibers; and picrosirius red to observe collagen. The images were captured with an Olympus BX51 microscope and Olympus DP70 camera. The stereological analysis was done with the Image Pro and Image J programs. Means were statistically compared using the Mann-Whitney U test (p < 0.005).

Results: Quantitative analysis documented no differences (p = 0.4) in number of seminiferous tubules (ST) in PBS testes (mean = 8.87%, SD = 1.59), when compared to the control (mean = 11.4%, SD = 2.99) and no differences (p = 0.8) in diameter of ST in PBS testes (mean = 52.85 μm, SD = 1.58) when compared to the control group (mean = 53.17 μm, SD = 1.55), but we did observe a lower number (p = 0.0002) of Leydig cells in the PBS testes (mean = 67.03% and SD = 3.697) when compared to the control group (mean = 90.1% and SD = 2.986).

Conclusions: Our study showed a lower concentration of Leydig cells in the triad syndrome fetuses.

目的:比较梅干腹综合征(PBS)胎儿与正常对照组的睾丸结构。材料和方法:我们研究了3例PBS胎儿的6个睾丸和7例男性胎儿的14个睾丸。取睾丸标本切成5 μm厚的切片,苏木精和伊红(HE)染色,观察精小管;威格特溶液观察弹性纤维;并以小天狼星红观察胶原蛋白。图像由奥林巴斯BX51显微镜和奥林巴斯DP70相机拍摄。利用Image Pro和Image J程序进行立体分析。均值比较采用Mann-Whitney U检验(p < 0.005)。结果:定量分析显示,PBS组睾丸精管数量(平均8.87%,SD = 1.59)与对照组(平均11.4%,SD = 2.99)比较,差异无统计学意义(p = 0.4); PBS组睾丸精管直径(平均52.85 μm, SD = 1.58)与对照组(平均53.17 μm, SD = 1.55)比较,差异无统计学意义(p = 0.8);但我们确实观察到PBS组睾丸间质细胞数量(平均67.03%,SD = 3.697)低于对照组(平均90.1%,SD = 2.986), p = 0.0002。结论:我们的研究表明,三联症胎儿的间质细胞浓度较低。
{"title":"Study of Testicular Structure in Fetuses with Prune Belly Syndrome.","authors":"Luciano A Favorito,&nbsp;Suelen F Costa,&nbsp;Waldemar S Costa,&nbsp;Rodrigo Vieiralves,&nbsp;Fabio O Bernardo,&nbsp;Francisco J B Sampaio","doi":"10.1155/2017/3254980","DOIUrl":"https://doi.org/10.1155/2017/3254980","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the structure of the testis in fetuses with prune belly syndrome (PBS) to normal controls.</p><p><strong>Materials and methods: </strong>We studied 6 testes obtained from 3 fetuses with PBS and 14 testes from 7 male fetuses. The testicular specimens were cut into 5-<i>μ</i>m thick sections and stained with hematoxylin and eosin (HE), to observe the seminiferous tubules; Weigert's solution to observe elastic fibers; and picrosirius red to observe collagen. The images were captured with an Olympus BX51 microscope and Olympus DP70 camera. The stereological analysis was done with the Image Pro and Image J programs. Means were statistically compared using the Mann-Whitney <i>U</i> test (<i>p</i> < 0.005).</p><p><strong>Results: </strong>Quantitative analysis documented no differences (<i>p</i> = 0.4) in number of seminiferous tubules (ST) in PBS testes (mean = 8.87%, SD = 1.59), when compared to the control (mean = 11.4%, SD = 2.99) and no differences (<i>p</i> = 0.8) in diameter of ST in PBS testes (mean = 52.85 <i>μ</i>m, SD = 1.58) when compared to the control group (mean = 53.17 <i>μ</i>m, SD = 1.55), but we did observe a lower number (<i>p</i> = 0.0002) of Leydig cells in the PBS testes (mean = 67.03% and SD = 3.697) when compared to the control group (mean = 90.1% and SD = 2.986).</p><p><strong>Conclusions: </strong>Our study showed a lower concentration of Leydig cells in the triad syndrome fetuses.</p>","PeriodicalId":7490,"journal":{"name":"Advances in Urology","volume":"2017 ","pages":"3254980"},"PeriodicalIF":1.4,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/3254980","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35084062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Does Leaving the Biopsy Needle in Povidone-Iodine Solution Reduce Infective Complications after Biopsy? 将活检针留在聚维酮碘溶液中是否能减少活检后的感染并发症?
IF 1.4 Q3 UROLOGY & NEPHROLOGY Pub Date : 2016-12-20 DOI: 10.1155/2016/6841837
Aim. The aim of this study is to evaluate whether leaving the biopsy needle used during prostate needle biopsy in 10% povidone-iodine (betadine) solution affects the infectious complications forming after biopsy. Material and Method. This study retrospectively evaluated the data of 176 patients with prostate biopsy performed between December 2012 and April 2014. Patients in Group 1 (n = 89) were given ofloxacin as a prophylactic antibiotic before biopsy. Patients in Group 2 (n = 87) had the biopsy needle left in povidone-iodine solution for 1 minute before each use, in addition to antibiotic prophylaxis. The two groups were compared in terms of infective complications developing after biopsy. Results were analyzed using the Mann–Whitney U test and Fisher's exact test. Results. The distribution of infective complications after biopsy according to group was as follows. Group 1, not using betadine, had 15.7% fever, 13.5% hospital stay, 12.4% urinary retention, 10.1% prostatitis, and 5.6% sepsis. The distribution of the same complications in Group 2 using betadine was identified as 5.7% fever, 4.6% hospital stay, 3.4% urinary retention, 2.3% prostatitis, and 0% sepsis. The use of betadine was found to significantly reduce the infectious complications after biopsy compared to the control group (p < 0.05). Conclusion. At the end of this study leaving the prostate needle in povidone-iodine solution before each use during prostate biopsy was found to reduce the infective complications and hospital stay after biopsy.
的目标。本研究的目的是评估前列腺穿刺活检时使用的活检针留在10%聚维酮碘(倍他定)溶液中是否会影响活检后形成的感染性并发症。材料和方法。本研究回顾性评估了2012年12月至2014年4月期间176例前列腺活检患者的数据。第一组患者(89例)在活检前给予氧氟沙星作为预防性抗生素。2组患者(n = 87)除抗生素预防外,每次使用前将活检针留在聚维酮碘溶液中1分钟。比较两组活检后发生的感染并发症。使用Mann-Whitney U检验和Fisher精确检验对结果进行分析。结果。各组活检后感染并发症分布如下:1组未使用倍他定,发热15.7%,住院13.5%,尿潴留12.4%,前列腺炎10.1%,败血症5.6%。使用倍他定组2相同并发症的分布为5.7%发热,4.6%住院,3.4%尿潴留,2.3%前列腺炎,0%脓毒症。与对照组相比,使用倍他定可显著减少活检后感染并发症(p < 0.05)。结论。在本研究结束时,发现前列腺活检期间每次使用前将前列腺针留在聚维酮碘溶液中可减少感染并发症和活检后的住院时间。
{"title":"Does Leaving the Biopsy Needle in Povidone-Iodine Solution Reduce Infective Complications after Biopsy?","authors":"Erdal Benli, A. Çırakoğlu, Ercan Ogreden, Y. Çetinkol, M. Çalgın, A. Ayyıldız, A. Yüce","doi":"10.1155/2016/6841837","DOIUrl":"https://doi.org/10.1155/2016/6841837","url":null,"abstract":"Aim. The aim of this study is to evaluate whether leaving the biopsy needle used during prostate needle biopsy in 10% povidone-iodine (betadine) solution affects the infectious complications forming after biopsy. Material and Method. This study retrospectively evaluated the data of 176 patients with prostate biopsy performed between December 2012 and April 2014. Patients in Group 1 (n = 89) were given ofloxacin as a prophylactic antibiotic before biopsy. Patients in Group 2 (n = 87) had the biopsy needle left in povidone-iodine solution for 1 minute before each use, in addition to antibiotic prophylaxis. The two groups were compared in terms of infective complications developing after biopsy. Results were analyzed using the Mann–Whitney U test and Fisher's exact test. Results. The distribution of infective complications after biopsy according to group was as follows. Group 1, not using betadine, had 15.7% fever, 13.5% hospital stay, 12.4% urinary retention, 10.1% prostatitis, and 5.6% sepsis. The distribution of the same complications in Group 2 using betadine was identified as 5.7% fever, 4.6% hospital stay, 3.4% urinary retention, 2.3% prostatitis, and 0% sepsis. The use of betadine was found to significantly reduce the infectious complications after biopsy compared to the control group (p < 0.05). Conclusion. At the end of this study leaving the prostate needle in povidone-iodine solution before each use during prostate biopsy was found to reduce the infective complications and hospital stay after biopsy.","PeriodicalId":7490,"journal":{"name":"Advances in Urology","volume":"2016 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2016-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/6841837","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64492677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Quality of Health Information on the Internet for Urolithiasis on the Google Search Engine 在谷歌搜索引擎上的互联网尿石症健康信息质量
IF 1.4 Q3 UROLOGY & NEPHROLOGY Pub Date : 2016-12-04 DOI: 10.1155/2016/8243095
Purpose. To compare the quality of health information on the Internet for keywords related to urolithiasis, to assess for difference in information quality across four main Western languages, and to compare the source of sponsorship in these websites. Methods. Health On the Net (HON) Foundation principles were utilised to determine quality information. Fifteen keywords related to urolithiasis were searched on the Google search engine. The first 150 websites were assessed against the HON principles and the source of sponsorship determined. Results. A total of 8986 websites were analysed. A proportion of HON-accredited websites for individual search terms range between 2.5% and 12.0%. The first 50 websites were more likely to be HON-positive compared to websites 51–100 and 101–150. French websites searched were more likely to be HON-positive whereas German websites were less likely to be HON-positive than English websites. There was no statistically significant difference between the rate of HON-positive English and Spanish websites. The three main website sponsors were from government/educational sources (40.2%), followed by commercial (29.9%) and physician/surgeon sources (18.6%). Conclusions. Health information on most urolithiasis websites was not validated. Nearly one-third of websites in this study have commercial sponsorship. Doctors should recognise the need for more reliable health websites for their patients.
目的。比较互联网上与尿石症相关的关键字健康信息的质量,评估四种主要西方语言的信息质量差异,并比较这些网站的赞助来源。方法。利用网上健康(HON)基金会的原则来确定信息的质量。在谷歌搜索引擎上搜索了15个与尿石症相关的关键词。前150个网站已根据“诚信原则”进行评估,并确定赞助来源。结果。共分析了8986个网站。个别搜索词的非牟利网站比例在2.5%至12.0%之间。与51-100和101-150网站相比,前50个网站更有可能是阳性的。法国网站更有可能是阳性的,而德国网站比英语网站更不可能是阳性的。英语和西班牙语网站的非阳性率无统计学差异。三个主要的网站赞助商来自政府/教育机构(40.2%),其次是商业机构(29.9%)和内科/外科医生(18.6%)。结论。大多数尿石症网站上的健康信息没有得到验证。在这项研究中,近三分之一的网站有商业赞助。医生应该认识到需要为他们的病人提供更可靠的健康网站。
{"title":"Quality of Health Information on the Internet for Urolithiasis on the Google Search Engine","authors":"D. Chang, R. Abouassaly, N. Lawrentschuk","doi":"10.1155/2016/8243095","DOIUrl":"https://doi.org/10.1155/2016/8243095","url":null,"abstract":"Purpose. To compare the quality of health information on the Internet for keywords related to urolithiasis, to assess for difference in information quality across four main Western languages, and to compare the source of sponsorship in these websites. Methods. Health On the Net (HON) Foundation principles were utilised to determine quality information. Fifteen keywords related to urolithiasis were searched on the Google search engine. The first 150 websites were assessed against the HON principles and the source of sponsorship determined. Results. A total of 8986 websites were analysed. A proportion of HON-accredited websites for individual search terms range between 2.5% and 12.0%. The first 50 websites were more likely to be HON-positive compared to websites 51–100 and 101–150. French websites searched were more likely to be HON-positive whereas German websites were less likely to be HON-positive than English websites. There was no statistically significant difference between the rate of HON-positive English and Spanish websites. The three main website sponsors were from government/educational sources (40.2%), followed by commercial (29.9%) and physician/surgeon sources (18.6%). Conclusions. Health information on most urolithiasis websites was not validated. Nearly one-third of websites in this study have commercial sponsorship. Doctors should recognise the need for more reliable health websites for their patients.","PeriodicalId":7490,"journal":{"name":"Advances in Urology","volume":"2016 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2016-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/8243095","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64556907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
期刊
Advances in Urology
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