Pub Date : 2020-01-01DOI: 10.18772/26180197.2019.V1N2A2
M. Mkandawire, M. Davies, G. Paget, P. Mosiane, S. Naicker
{"title":"A Profile of Minimal Change Nephropathy in Adults at the Witwatersrand Academic Complex (2001–2010)","authors":"M. Mkandawire, M. Davies, G. Paget, P. Mosiane, S. Naicker","doi":"10.18772/26180197.2019.V1N2A2","DOIUrl":"https://doi.org/10.18772/26180197.2019.V1N2A2","url":null,"abstract":"","PeriodicalId":75326,"journal":{"name":"Wits journal of clinical medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77076220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.18772/26180197.2020.V2N1A3
Sunday Sofola-Orukotan, F. Motara, A. Bentley, A. Laher
{"title":"First-episode Seizures amongst Adult Patients Presenting to an Academic Hospital Emergency Department – A Preliminary Report","authors":"Sunday Sofola-Orukotan, F. Motara, A. Bentley, A. Laher","doi":"10.18772/26180197.2020.V2N1A3","DOIUrl":"https://doi.org/10.18772/26180197.2020.V2N1A3","url":null,"abstract":"","PeriodicalId":75326,"journal":{"name":"Wits journal of clinical medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73305232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.18772/26180197.2020.v2n3a6
{"title":"Wits Journal Clinical Medicine Comments Feature Lessons I have learnt from COVID-19","authors":"","doi":"10.18772/26180197.2020.v2n3a6","DOIUrl":"https://doi.org/10.18772/26180197.2020.v2n3a6","url":null,"abstract":"","PeriodicalId":75326,"journal":{"name":"Wits journal of clinical medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89219239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.18772/26180197.2019.v1n3a4
M. Davies
{"title":"Murder in the Cathedral: Antibodies and the Limits of Transplantation","authors":"M. Davies","doi":"10.18772/26180197.2019.v1n3a4","DOIUrl":"https://doi.org/10.18772/26180197.2019.v1n3a4","url":null,"abstract":"","PeriodicalId":75326,"journal":{"name":"Wits journal of clinical medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81393914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.18772/26180197.2019.v1n1a6
{"title":"Bert Myburgh Research Forum","authors":"","doi":"10.18772/26180197.2019.v1n1a6","DOIUrl":"https://doi.org/10.18772/26180197.2019.v1n1a6","url":null,"abstract":"","PeriodicalId":75326,"journal":{"name":"Wits journal of clinical medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81614149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.18772/26180197.2019.v1n3a01
S. Tager, M. Veller
{"title":"Bridging the Gap – The Wits Donald Gordon Medical Centre Story","authors":"S. Tager, M. Veller","doi":"10.18772/26180197.2019.v1n3a01","DOIUrl":"https://doi.org/10.18772/26180197.2019.v1n3a01","url":null,"abstract":"","PeriodicalId":75326,"journal":{"name":"Wits journal of clinical medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78553368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.18772/26180197.2019.v1n3a1
J. Strong, P. Gaylard, H. Maher, J. Botha
{"title":"Acute Cellular Rejection in Paediatric Liver Transplants: Does a Living Donor Ameliorate the Risk of Rejection in Our Patients? A Retrospective Review at Wits Donald Gordon Medical Centre, South Africa","authors":"J. Strong, P. Gaylard, H. Maher, J. Botha","doi":"10.18772/26180197.2019.v1n3a1","DOIUrl":"https://doi.org/10.18772/26180197.2019.v1n3a1","url":null,"abstract":"","PeriodicalId":75326,"journal":{"name":"Wits journal of clinical medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76164004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.18772/26180197.2019.v1n1a2
M. Shehu, Manga Pravin
Background: A significant number of patients with acute coronary syndrome (ACS) are reported to suffer from anaemia. However, data relating to anaemia and clinical outcomes in patients presenting with ACS, particularly in Africa, are scarce. This study thus aimed to assess the prevalence of anaemia and its association with clinical characteristics and in-hospital mortality in patients presenting with ACS to a large urban public hospital in South Africa. Methods: The study is a retrospective analysis of patients 18 years and above admitted with a diagnosis of ACS to the Charlotte Maxeke Johannesburg Hospital (CMJAH) over a two-and-a-half-year period between January 2010 and June 2012. Data on clinical characteristics, blood chemistry including haemoglobin (Hb) level, therapies received and in-hospital mortality was collected. Results: A total of 431 ACS patients fulfilled the diagnostic criteria for ACS during the review period. The majority were males (72.2%) with a mean age of 58 ± 12.4 years. Anaemia was found to be present in 18.8% of all patients. Patients with anaemia were found to be significantly older, more likely to be female, have hypertension or diabetes and were more likely to be in a higher Killip functional class as compared to those not having anaemia. Anaemic patients were also less likely to receive optimal medical therapy for ACS (60.5% vs. 72.7%, p < 0.001). Killip class ≥3 (p < 0.001), atrial fibrillation (p < 0.045) and haemoglobin (Hb) < 11.4 g/dl (p < 0.0001) were significantly associated with mortality. However, only Hb of <11.4 g/dl was found to be an independent predictor of mortality and had more than fourfold increased risk compared to those with normal Hb (CI – 1.393–13.041; RR – 4.262; p < 0.011). Conclusion: Anaemia was present in almost one-fifth of patients presenting with ACS. Furthermore it was significantly associated with diabetes, hypertension, older age, female sex and Killip class ≥3. Anaemic patients were also less likely to receive optimal medical therapy. Importantly, a haemoglobin level <11.4 g/dl was found to be an independent predictor of mortality. Simple serial measurement of Hb is recommended in patients presenting with ACS and should be incorporated into the risk stratification of patients with ACS.
{"title":"The Impact of Anaemia in Patients with Acute Coronary Syndrome","authors":"M. Shehu, Manga Pravin","doi":"10.18772/26180197.2019.v1n1a2","DOIUrl":"https://doi.org/10.18772/26180197.2019.v1n1a2","url":null,"abstract":"Background: A significant number of patients with acute coronary syndrome (ACS) are reported to suffer from anaemia. However, data relating to anaemia and clinical outcomes in patients presenting with ACS, particularly in Africa, are scarce. This study thus aimed to assess the prevalence of anaemia and its association with clinical characteristics and in-hospital mortality in patients presenting with ACS to a large urban public hospital in South Africa. Methods: The study is a retrospective analysis of patients 18 years and above admitted with a diagnosis of ACS to the Charlotte Maxeke Johannesburg Hospital (CMJAH) over a two-and-a-half-year period between January 2010 and June 2012. Data on clinical characteristics, blood chemistry including haemoglobin (Hb) level, therapies received and in-hospital mortality was collected. Results: A total of 431 ACS patients fulfilled the diagnostic criteria for ACS during the review period. The majority were males (72.2%) with a mean age of 58 ± 12.4 years. Anaemia was found to be present in 18.8% of all patients. Patients with anaemia were found to be significantly older, more likely to be female, have hypertension or diabetes and were more likely to be in a higher Killip functional class as compared to those not having anaemia. Anaemic patients were also less likely to receive optimal medical therapy for ACS (60.5% vs. 72.7%, p < 0.001). Killip class ≥3 (p < 0.001), atrial fibrillation (p < 0.045) and haemoglobin (Hb) < 11.4 g/dl (p < 0.0001) were significantly associated with mortality. However, only Hb of <11.4 g/dl was found to be an independent predictor of mortality and had more than fourfold increased risk compared to those with normal Hb (CI – 1.393–13.041; RR – 4.262; p < 0.011). Conclusion: Anaemia was present in almost one-fifth of patients presenting with ACS. Furthermore it was significantly associated with diabetes, hypertension, older age, female sex and Killip class ≥3. Anaemic patients were also less likely to receive optimal medical therapy. Importantly, a haemoglobin level <11.4 g/dl was found to be an independent predictor of mortality. Simple serial measurement of Hb is recommended in patients presenting with ACS and should be incorporated into the risk stratification of patients with ACS.","PeriodicalId":75326,"journal":{"name":"Wits journal of clinical medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90807441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.18772/26180197.2019.v1n2a4
Charity Phokontsi, M. Muteba, P. Motshabi-Chakane
{"title":"Intraoperative Usage of Blood Products in Patients Undergoing Cardiac Surgery on Cardiopulmonary Bypass","authors":"Charity Phokontsi, M. Muteba, P. Motshabi-Chakane","doi":"10.18772/26180197.2019.v1n2a4","DOIUrl":"https://doi.org/10.18772/26180197.2019.v1n2a4","url":null,"abstract":"","PeriodicalId":75326,"journal":{"name":"Wits journal of clinical medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80487326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.18772/26180197.2019.v1n3a3
Adam A Mohamed, A. Kazee
{"title":"Public–Private Partnerships in Liver Transplantation: A Novel Approach to Equitable Health-care Delivery","authors":"Adam A Mohamed, A. Kazee","doi":"10.18772/26180197.2019.v1n3a3","DOIUrl":"https://doi.org/10.18772/26180197.2019.v1n3a3","url":null,"abstract":"","PeriodicalId":75326,"journal":{"name":"Wits journal of clinical medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87269698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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