Pub Date : 2022-01-01DOI: 10.4168/aard.2022.10.4.195
Seok Min Kim, Ji An Kim, H. Kim, Jong-seo Yoon, Hyun Hee Kim, Y. Chun
{"title":"Development of a house dust mite-induced mouse model for allergen-specific immunotherapy in allergic rhinitis","authors":"Seok Min Kim, Ji An Kim, H. Kim, Jong-seo Yoon, Hyun Hee Kim, Y. Chun","doi":"10.4168/aard.2022.10.4.195","DOIUrl":"https://doi.org/10.4168/aard.2022.10.4.195","url":null,"abstract":"","PeriodicalId":7548,"journal":{"name":"Allergy, Asthma & Respiratory Disease","volume":"25 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89772674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4168/aard.2022.10.2.73
Y. Chun, Minji Kim, Hyo-Bin Kim, Y. Rha, Yang Park, Y. Park, M. Sung, Y. Shin, H. Yum, Kyung-Suk Lee, Yong Ju Lee, H. Jee, B. Choi, S. Choi, Hyun Hee Kim
{"title":"Risk factors and protective factors in pediatric patients with allergic rhinitis","authors":"Y. Chun, Minji Kim, Hyo-Bin Kim, Y. Rha, Yang Park, Y. Park, M. Sung, Y. Shin, H. Yum, Kyung-Suk Lee, Yong Ju Lee, H. Jee, B. Choi, S. Choi, Hyun Hee Kim","doi":"10.4168/aard.2022.10.2.73","DOIUrl":"https://doi.org/10.4168/aard.2022.10.2.73","url":null,"abstract":"","PeriodicalId":7548,"journal":{"name":"Allergy, Asthma & Respiratory Disease","volume":"17 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74353906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4168/aard.2022.10.1.60
Yoo Ri Jo, H. Woo, D. Lim, J. Kim
Kimura disease is characterized by painless subcutaneous masses, usually in the head and neck area as well as serum/tissue eosino-philia and elevated serum IgE levels. Various treatment methods, such as surgical excision, corticosteroids, and radiotherapy, have been suggested, but none of these are considered standard therapy due to high recurrence rates. Dupilumab is a human monoclonal antibody that binds to the alpha subunit of IL-4 receptor for IL-4 and IL-13 and inhibits T helper 2 (Th2) response, which plays an important role in the pathogenesis of allergic diseases, such as atopic dermatitis, asthma, and nasal polyps. Kimura disease has also been shown to increase CD4+Th2 cells and Th2 cytokines. We report a case of a 12-year-old boy who had subcutaneous neck and orbital masses of Kimura disease concurrent with allergic rhinitis, decreased lung function, and IgG subclass deficiency. The masses did not improve with omalizumab or immunomodulatory agents, but resolved with dupilumab. Considering potential side effects of steroids or immunosuppressant agents, dupilumab may be an option for initial treatment with Kimura diseases in children. ( Allergy Asthma Respir Dis 2022;10:60-65 )
{"title":"Dupilumab therapy in a 12-year-old boy with Kimura disease, allergic rhinitis, and IgG3 deficiency","authors":"Yoo Ri Jo, H. Woo, D. Lim, J. Kim","doi":"10.4168/aard.2022.10.1.60","DOIUrl":"https://doi.org/10.4168/aard.2022.10.1.60","url":null,"abstract":"Kimura disease is characterized by painless subcutaneous masses, usually in the head and neck area as well as serum/tissue eosino-philia and elevated serum IgE levels. Various treatment methods, such as surgical excision, corticosteroids, and radiotherapy, have been suggested, but none of these are considered standard therapy due to high recurrence rates. Dupilumab is a human monoclonal antibody that binds to the alpha subunit of IL-4 receptor for IL-4 and IL-13 and inhibits T helper 2 (Th2) response, which plays an important role in the pathogenesis of allergic diseases, such as atopic dermatitis, asthma, and nasal polyps. Kimura disease has also been shown to increase CD4+Th2 cells and Th2 cytokines. We report a case of a 12-year-old boy who had subcutaneous neck and orbital masses of Kimura disease concurrent with allergic rhinitis, decreased lung function, and IgG subclass deficiency. The masses did not improve with omalizumab or immunomodulatory agents, but resolved with dupilumab. Considering potential side effects of steroids or immunosuppressant agents, dupilumab may be an option for initial treatment with Kimura diseases in children. ( Allergy Asthma Respir Dis 2022;10:60-65 )","PeriodicalId":7548,"journal":{"name":"Allergy, Asthma & Respiratory Disease","volume":"39 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77663723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4168/aard.2022.10.3.127
Ju-Young Kim, Y. Jee
{"title":"Is smoking a factor in both the development and exacerbation of asthma?","authors":"Ju-Young Kim, Y. Jee","doi":"10.4168/aard.2022.10.3.127","DOIUrl":"https://doi.org/10.4168/aard.2022.10.3.127","url":null,"abstract":"","PeriodicalId":7548,"journal":{"name":"Allergy, Asthma & Respiratory Disease","volume":"23 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83491312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4168/aard.2022.10.4.189
B. Choi, Hyun Hee Kim, Hyo-Bin Kim, Y. Rha, Yang Park, M. Sung, Y. Shin, H. Yum, Kyung-Suk Lee, Yong Ju Lee, Y. Chun, H. Jee, Minji Kim, Y. Park, S. Choi
{"title":"Smoking exposure and allergic rhinitis in children and adolescents","authors":"B. Choi, Hyun Hee Kim, Hyo-Bin Kim, Y. Rha, Yang Park, M. Sung, Y. Shin, H. Yum, Kyung-Suk Lee, Yong Ju Lee, Y. Chun, H. Jee, Minji Kim, Y. Park, S. Choi","doi":"10.4168/aard.2022.10.4.189","DOIUrl":"https://doi.org/10.4168/aard.2022.10.4.189","url":null,"abstract":"","PeriodicalId":7548,"journal":{"name":"Allergy, Asthma & Respiratory Disease","volume":"25 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81496196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4168/aard.2022.10.3.153
Sang Hong, Chae-Gu Jo, Hyuna Kim, Young-Seok Lee, W. Bae, Jin-A Jung
{"title":"Changes in levels of fractional exhaled and nasal nitric oxide after treatment in allergic rhinitis","authors":"Sang Hong, Chae-Gu Jo, Hyuna Kim, Young-Seok Lee, W. Bae, Jin-A Jung","doi":"10.4168/aard.2022.10.3.153","DOIUrl":"https://doi.org/10.4168/aard.2022.10.3.153","url":null,"abstract":"","PeriodicalId":7548,"journal":{"name":"Allergy, Asthma & Respiratory Disease","volume":"30 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78566127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4168/aard.2022.10.4.229
Hyun Jung Kim, S. K. Park
{"title":"Negative pressure pulmonary edema after endotracheal tube extubation during recovery of general anesthesia in a pediatric patient with cerebral palsy","authors":"Hyun Jung Kim, S. K. Park","doi":"10.4168/aard.2022.10.4.229","DOIUrl":"https://doi.org/10.4168/aard.2022.10.4.229","url":null,"abstract":"","PeriodicalId":7548,"journal":{"name":"Allergy, Asthma & Respiratory Disease","volume":"35 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79751291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4168/aard.2022.10.3.131
S. Yoon, Jae-Woo Jung, So-Young Park, Gun Woo Kim, Kyung-woo Son, Sung-Yoon Kang, H. Park, M. Kang, Joo-Hee Kim, K. Park, Dong Hun Lee, Sae-Hoon Kim, Hyouk-Soo Kwon, Hye‐Ryun Kang, D. Suh
{"title":"Management of hereditary angioedema in pediatric, pregnant, and breast-feeding patients: An expert opinion","authors":"S. Yoon, Jae-Woo Jung, So-Young Park, Gun Woo Kim, Kyung-woo Son, Sung-Yoon Kang, H. Park, M. Kang, Joo-Hee Kim, K. Park, Dong Hun Lee, Sae-Hoon Kim, Hyouk-Soo Kwon, Hye‐Ryun Kang, D. Suh","doi":"10.4168/aard.2022.10.3.131","DOIUrl":"https://doi.org/10.4168/aard.2022.10.3.131","url":null,"abstract":"","PeriodicalId":7548,"journal":{"name":"Allergy, Asthma & Respiratory Disease","volume":"93 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79443281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4168/aard.2022.10.1.45
J. Won, Sukyung Kim, Y. Son, J. Cho, T. Y. Jeon, Joungho Han, Yae-Jean Kim, Ji Won Lee, Jihyun Kim, K. Ahn
Recurrent respiratory papillomatosis (RRP) is a chronic disease related to human papillomavirus infection. The standard treatment of RRP is surgical resection of the lesion, but due to frequent recurrence, a combination of various adjuvant therapies has been at-tempted. Herein, we present the first case of RRP to whom intravenous cidofovir was administered as an adjuvant therapy in Korea. A 9-year-old boy was admitted due to hoarseness, stridor and breathing difficulty. At 10 months of age, he was diagnosed with RRP in the upper airway and thereafter he had repeatedly undergone surgical removal. During this hospitalization, papilloma was found again from the superior glottis to the inferior glottis and surrounding the trachea at the age of 9 years. In addition, well-defined nodular lesions were newly found on both lung fields, and a pathologic examination revealed a squamous papilloma with high-grade dysplasia, human papilloma virus types 6, 11, and 40 (low-risk type). Because of the frequent recurrence of papilloma in the upper airway as well as lung involvement, he underwent 38 injections of intravenous cidofovir for 2 years. During treatment, the in-tervals required for surgical removal of the mass causing upper airway obstruction were prolonged from an average of 37.3 to 74.6 days without serious side effects. However, intravenous cidofovir treatment had no effect on the lung lesion. This case shows that an intravenous cidofovir administration can be used as an adjuvant therapy in a child with RRP to relieve the upper airway obstruction, although this treatment does not cure the disease. ( Allergy Asthma Respir Dis 2022;10:45-49 )
{"title":"Intravenous cidofovir as an adjuvant therapy for recurrent upper airway papillomatosis with lung involvement in a child","authors":"J. Won, Sukyung Kim, Y. Son, J. Cho, T. Y. Jeon, Joungho Han, Yae-Jean Kim, Ji Won Lee, Jihyun Kim, K. Ahn","doi":"10.4168/aard.2022.10.1.45","DOIUrl":"https://doi.org/10.4168/aard.2022.10.1.45","url":null,"abstract":"Recurrent respiratory papillomatosis (RRP) is a chronic disease related to human papillomavirus infection. The standard treatment of RRP is surgical resection of the lesion, but due to frequent recurrence, a combination of various adjuvant therapies has been at-tempted. Herein, we present the first case of RRP to whom intravenous cidofovir was administered as an adjuvant therapy in Korea. A 9-year-old boy was admitted due to hoarseness, stridor and breathing difficulty. At 10 months of age, he was diagnosed with RRP in the upper airway and thereafter he had repeatedly undergone surgical removal. During this hospitalization, papilloma was found again from the superior glottis to the inferior glottis and surrounding the trachea at the age of 9 years. In addition, well-defined nodular lesions were newly found on both lung fields, and a pathologic examination revealed a squamous papilloma with high-grade dysplasia, human papilloma virus types 6, 11, and 40 (low-risk type). Because of the frequent recurrence of papilloma in the upper airway as well as lung involvement, he underwent 38 injections of intravenous cidofovir for 2 years. During treatment, the in-tervals required for surgical removal of the mass causing upper airway obstruction were prolonged from an average of 37.3 to 74.6 days without serious side effects. However, intravenous cidofovir treatment had no effect on the lung lesion. This case shows that an intravenous cidofovir administration can be used as an adjuvant therapy in a child with RRP to relieve the upper airway obstruction, although this treatment does not cure the disease. ( Allergy Asthma Respir Dis 2022;10:45-49 )","PeriodicalId":7548,"journal":{"name":"Allergy, Asthma & Respiratory Disease","volume":"27 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83523021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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