A clinical study was designed to determine whether the lower solute load after intravenous injection of nonionic contrast medium (CM) produced significant changes in nephrographic and pyelographic quality. For equal iodine doses (300 mg I/kg), the lower solute load of nonionic CM produced better nephrogram and pyelogram scores than ionic CM or nonionic CM with mannitol, both of which had higher solute loads. The higher scores associated with nonionic CM were statistically significant for the pyelogram phase but not for the nephrogram phase. These observations were matched by lesser changes in urinary osmolality and higher urinary iodine concentrations with the nonionic CM.
{"title":"Influence of contrast media osmolality on intravenous urographic quality.","authors":"I Lovett, I Benn, G Benness, B Doust","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A clinical study was designed to determine whether the lower solute load after intravenous injection of nonionic contrast medium (CM) produced significant changes in nephrographic and pyelographic quality. For equal iodine doses (300 mg I/kg), the lower solute load of nonionic CM produced better nephrogram and pyelogram scores than ionic CM or nonionic CM with mannitol, both of which had higher solute loads. The higher scores associated with nonionic CM were statistically significant for the pyelogram phase but not for the nephrogram phase. These observations were matched by lesser changes in urinary osmolality and higher urinary iodine concentrations with the nonionic CM.</p>","PeriodicalId":75861,"journal":{"name":"Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband","volume":"128 ","pages":"105-7"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13711721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recent developments in nonionic contrast media.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75861,"journal":{"name":"Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband","volume":"128 ","pages":"1-240"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13711131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A dose of 0.3 g I/kg iotrolan yields much better opacification of the renal parenchyma in dogs (n = 6, intraindividual comparison) than sodium diatrizoate or iopromide, and imaging of the urinary tract is practically equally as good. The plasma iodine levels of all three agents 2 minutes after the bolus injections are 3 mg/ml and the half-lives in the blood are 8 to 10 minutes. The injection of iotrolan causes the hematocrit value to drop by maximum 3.8% 10 minutes after the injection, and corresponding figure after iopromide is 10.8% and that for sodium diatrizoate at 4 minutes is 18.9%. In a further study in dogs (n = 4, intraindividual comparison; dose 0.6 g I/kg) it was found that in the period 10 to 240 minutes after a bolus injection of iotrolan or iopamidol the iodine concentration in the urine was 1.5 to 2 times higher after iotrolan than after iopamidol. Iopamidol causes much higher urinary flow than iotrolan, especially in the first 20 minutes after injection. The properties of iotrolan described here appear to indicate that this novel nonionic, dimeric contrast medium has certain advantages over the monomeric, ionic and nonionic agents for urographic indications.
0.3 g I/kg剂量的碘曲兰在犬肾实质的混浊程度(n = 6，个体间比较)要比异位钠或碘丙胺好得多，而且泌尿道的成像效果几乎一样好。三种药物在大剂量注射后2分钟血浆碘水平均为3mg /ml，在血液中的半衰期为8 ~ 10分钟。注射碘曲兰可使红细胞压积值在注射后10分钟最大下降3.8%，注射碘丙胺后的红细胞压积值为10.8%，注射后4分钟的红细胞压积值为18.9%。在对狗的进一步研究中(n = 4)，个体间比较;剂量0.6 g /kg)，结果发现，在静脉注射碘曲兰或iopamidol后10 ~ 240分钟内，碘曲兰后尿碘浓度比iopamidol后高1.5 ~ 2倍。依帕美多尔引起的尿流量比碘曲兰高得多，特别是在注射后的前20分钟。这里所描述的碘曲兰的特性似乎表明，这种新型的非离子、二聚体造影剂在泌尿学适应症方面比单体、离子和非离子造影剂具有一定的优势。
{"title":"Experimental urography in dogs: diagnostic quality and pharmacokinetic behavior of iotrolan in comparison to nonionic and ionic, monomeric contrast media.","authors":"C Nauert, W Mützel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A dose of 0.3 g I/kg iotrolan yields much better opacification of the renal parenchyma in dogs (n = 6, intraindividual comparison) than sodium diatrizoate or iopromide, and imaging of the urinary tract is practically equally as good. The plasma iodine levels of all three agents 2 minutes after the bolus injections are 3 mg/ml and the half-lives in the blood are 8 to 10 minutes. The injection of iotrolan causes the hematocrit value to drop by maximum 3.8% 10 minutes after the injection, and corresponding figure after iopromide is 10.8% and that for sodium diatrizoate at 4 minutes is 18.9%. In a further study in dogs (n = 4, intraindividual comparison; dose 0.6 g I/kg) it was found that in the period 10 to 240 minutes after a bolus injection of iotrolan or iopamidol the iodine concentration in the urine was 1.5 to 2 times higher after iotrolan than after iopamidol. Iopamidol causes much higher urinary flow than iotrolan, especially in the first 20 minutes after injection. The properties of iotrolan described here appear to indicate that this novel nonionic, dimeric contrast medium has certain advantages over the monomeric, ionic and nonionic agents for urographic indications.</p>","PeriodicalId":75861,"journal":{"name":"Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband","volume":"128 ","pages":"82-7"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13712018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This article reports on the use of iotrolan--a new contrast medium and the first dimeric, nonionic, hexaiodinated, water-soluble preparation--in hysterosalpingography. This randomized, double-blind study compared an ionic and a nonionic monomeric preparation. The better results were achieved with iotrolan. Its unusual lack of local irritation and its high contrast quality, especially definition of contrast, merit particular mention.
{"title":"Hysterosalpingography with a new contrast medium.","authors":"G Wolf, P Fitzal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This article reports on the use of iotrolan--a new contrast medium and the first dimeric, nonionic, hexaiodinated, water-soluble preparation--in hysterosalpingography. This randomized, double-blind study compared an ionic and a nonionic monomeric preparation. The better results were achieved with iotrolan. Its unusual lack of local irritation and its high contrast quality, especially definition of contrast, merit particular mention.</p>","PeriodicalId":75861,"journal":{"name":"Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband","volume":"128 ","pages":"190-4"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13712283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The fate of iotrolan in the body is determined by its physicochemical characteristics and biologic inertness. Iotrolan is distributed in the extracellular space after intravenous or intracisternal injections. No absorption occurred after oral administration. Iotrolan is eliminated almost exclusively by renal excretion in an unmetabolized form. The results found are very similar to those published for other x-ray contrast agents used in uroangiography.
{"title":"Tissue distribution and excretion of iotrolan after intravenous and suboccipital injections in animals.","authors":"H J Weinmann, P Scholz, W Mützel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The fate of iotrolan in the body is determined by its physicochemical characteristics and biologic inertness. Iotrolan is distributed in the extracellular space after intravenous or intracisternal injections. No absorption occurred after oral administration. Iotrolan is eliminated almost exclusively by renal excretion in an unmetabolized form. The results found are very similar to those published for other x-ray contrast agents used in uroangiography.</p>","PeriodicalId":75861,"journal":{"name":"Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband","volume":"128 ","pages":"206-10"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13712287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Radiology of the esophagus.","authors":"D N Hüpscher","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75861,"journal":{"name":"Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband","volume":"127 ","pages":"1-121"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14028316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Computerized tomography of the petrous bone. With magnetic resonance tomography].","authors":"O Köster","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75861,"journal":{"name":"Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband","volume":"129 ","pages":"1-92"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14040701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Digital subtraction angiography].","authors":"E Gmelin, I P Arlart","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75861,"journal":{"name":"Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband","volume":"126 ","pages":"1-192"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14023600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Field control films for ultra-hard x-rays].","authors":"G Breitling, L M Ahlemann","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75861,"journal":{"name":"Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband","volume":"125 ","pages":"214-9"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14015152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Radiotherapeutic indications in non-Hodgkin's lymphoma (nodal form)].","authors":"B Steidle","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75861,"journal":{"name":"Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband","volume":"125 ","pages":"220-7"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14015154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号