Novel autoantibodies are described which react with renal podocytes. These antibodies were found in 9 patients (2 with renal disease, 2 with liver disease, 2 with rheumatic disease, 1 with achalasia, 1 with carcinoma of the pancreas and 1 with anemia). Colocalization studies with double immunofluorescence and confocal laser scanning microscopy using monoclonal antibodies against the 44 kD podocyte protein showed a similar fluorescence pattern for both antibodies. The target antigens remain unclear.
{"title":"[Autoantibodies against podocytes of the kidney glomerulus].","authors":"W B Storch","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Novel autoantibodies are described which react with renal podocytes. These antibodies were found in 9 patients (2 with renal disease, 2 with liver disease, 2 with rheumatic disease, 1 with achalasia, 1 with carcinoma of the pancreas and 1 with anemia). Colocalization studies with double immunofluorescence and confocal laser scanning microscopy using monoclonal antibodies against the 44 kD podocyte protein showed a similar fluorescence pattern for both antibodies. The target antigens remain unclear.</p>","PeriodicalId":75925,"journal":{"name":"Immunitat und Infektion","volume":"23 1","pages":"25-6"},"PeriodicalIF":0.0,"publicationDate":"1995-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18701469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The macrorestriction analysis of bacterial genomes is a method that is generally applicable to the typing of bacteria. The chromosome is cleaved with a restriction endonuclease that cuts infrequently and subsequently separated by pulsed-field gel electrophoresis. The fragment pattern defines the genotype of the strain. The relatedness of strains is evaluated from the similarity of the fragment patterns. The quantitative comparison of fragment patterns allows the definition of the infrasubspecific rank of a clone. Macrorestriction analysis is a sensitive and specific method to trace the origin and spread of infections and to analyse the clonal structure of bacterial populations.
{"title":"[Theory and practice of macrorestriction analysis for the clonal analysis of pathogens].","authors":"U Römling, R Fislage, B Tümmler","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The macrorestriction analysis of bacterial genomes is a method that is generally applicable to the typing of bacteria. The chromosome is cleaved with a restriction endonuclease that cuts infrequently and subsequently separated by pulsed-field gel electrophoresis. The fragment pattern defines the genotype of the strain. The relatedness of strains is evaluated from the similarity of the fragment patterns. The quantitative comparison of fragment patterns allows the definition of the infrasubspecific rank of a clone. Macrorestriction analysis is a sensitive and specific method to trace the origin and spread of infections and to analyse the clonal structure of bacterial populations.</p>","PeriodicalId":75925,"journal":{"name":"Immunitat und Infektion","volume":"23 1","pages":"4-8"},"PeriodicalIF":0.0,"publicationDate":"1995-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18701473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Underestimated threat to adults: diphtheria and polio].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75925,"journal":{"name":"Immunitat und Infektion","volume":"23 1","pages":"III-IV"},"PeriodicalIF":0.0,"publicationDate":"1995-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18701464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[One time therapy with fosfomycin-trometamol successful with uncomplicated cystitis].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75925,"journal":{"name":"Immunitat und Infektion","volume":"23 1","pages":"V"},"PeriodicalIF":0.0,"publicationDate":"1995-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18701465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In nearly 60% of men over 50 years of age, dermato-/polymyositis is induced by malignancies. Till now, 9 patients with melanoma-induced dermatomyositis have been reported in the literature. Here we report on a patient suffering from classic pelvic and pectoral girdle proximal weakness, typical heliotrope rash, increased serum CPK values, and biopsy-proven myositis, who died from metastasizing melanoma one year later.
{"title":"[Dermatomyositis as a complication of a metastatic melanoma-- case report and review of the literature].","authors":"C Lersch, R Fuchs, H Frank, W Schepp","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In nearly 60% of men over 50 years of age, dermato-/polymyositis is induced by malignancies. Till now, 9 patients with melanoma-induced dermatomyositis have been reported in the literature. Here we report on a patient suffering from classic pelvic and pectoral girdle proximal weakness, typical heliotrope rash, increased serum CPK values, and biopsy-proven myositis, who died from metastasizing melanoma one year later.</p>","PeriodicalId":75925,"journal":{"name":"Immunitat und Infektion","volume":"23 1","pages":"23-4"},"PeriodicalIF":0.0,"publicationDate":"1995-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18701468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Report of the DIN-Working committee E10 \"Chemotherapeutic research methods\"].","authors":"A C Rodloff","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75925,"journal":{"name":"Immunitat und Infektion","volume":"23 1","pages":"III"},"PeriodicalIF":0.0,"publicationDate":"1995-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18701463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The influence of anticellular antibodies on reading and interpretation of Chlamydia-specific antibodies was investigated with selected sera in three commercial tests before and after absorption with noninfected cells. In two tests using C.trachomatis-L2-infected BGM- and L 929 cells, respectively, several sera could not be evaluated by unspecific reactions. The test system using only elementary bodies of C.trachomatis L2 showed no unspecific reactions.
{"title":"[Comparison of serological tests for Chlamydia with particular emphasis on anticellular antibodies].","authors":"A Oehme, M Heinsch","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The influence of anticellular antibodies on reading and interpretation of Chlamydia-specific antibodies was investigated with selected sera in three commercial tests before and after absorption with noninfected cells. In two tests using C.trachomatis-L2-infected BGM- and L 929 cells, respectively, several sera could not be evaluated by unspecific reactions. The test system using only elementary bodies of C.trachomatis L2 showed no unspecific reactions.</p>","PeriodicalId":75925,"journal":{"name":"Immunitat und Infektion","volume":"22 6","pages":"218-21"},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18822029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A Voss, W J Melchers, P van den Hurk, K A Bergman, P E Verweij, J F Meis
Between end December 1993 and end January 1994 a cluster of children infected/colonized with Enterobacter cloacae was seen in the neonatal intensive care unit of the University Hospital Nijmegen. The results of the epidemiological investigation are reported, which was aimed to differentiate between a random cluster of endogenously acquired Enterobacter strains and those possibly acquired exogenously via cross-infection. 5 isolates of the 7 patients were available for fingerprinting using interrepeat PCR. According to the fingerprint pattern, 4 of these isolates were identical, thereby suggesting cross-infection among the children. 3 neonates were colonized/infected with genotypically different isolates, suggesting that the infection/colonization developed endogenously. A control strain isolated from a patient at another ward showed the same genotype as the outbreak isolates. The transmission took probably place through one of the surgeons who, among all possible health care workers, were the only professional group treating patients in both units.
{"title":"[Fingerprinting with the polymerase chain reaction: confirmation of a Enterobacter cloacae epidemic in a neonatal intensive care unit].","authors":"A Voss, W J Melchers, P van den Hurk, K A Bergman, P E Verweij, J F Meis","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Between end December 1993 and end January 1994 a cluster of children infected/colonized with Enterobacter cloacae was seen in the neonatal intensive care unit of the University Hospital Nijmegen. The results of the epidemiological investigation are reported, which was aimed to differentiate between a random cluster of endogenously acquired Enterobacter strains and those possibly acquired exogenously via cross-infection. 5 isolates of the 7 patients were available for fingerprinting using interrepeat PCR. According to the fingerprint pattern, 4 of these isolates were identical, thereby suggesting cross-infection among the children. 3 neonates were colonized/infected with genotypically different isolates, suggesting that the infection/colonization developed endogenously. A control strain isolated from a patient at another ward showed the same genotype as the outbreak isolates. The transmission took probably place through one of the surgeons who, among all possible health care workers, were the only professional group treating patients in both units.</p>","PeriodicalId":75925,"journal":{"name":"Immunitat und Infektion","volume":"22 6","pages":"214-7"},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18822028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Campylobacter fetus subsp. fetus in a patient with liver cirrhosis].","authors":"G Beckmann, R Leimbeck, B Sonnenschein","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75925,"journal":{"name":"Immunitat und Infektion","volume":"22 6","pages":"III"},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18822093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Sepsis--septicemia--sepsis syndrome].","authors":"P M Shah","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75925,"journal":{"name":"Immunitat und Infektion","volume":"22 6","pages":"199"},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18822101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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