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American Journal of Gastroenterology最新文献

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Response to Lee. 回应李。
IF 8 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-01 Epub Date: 2024-07-31 DOI: 10.14309/ajg.0000000000002934
Qianjun Zhuang, Yinglian Xiao
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引用次数: 0
Response to Pinnuck and Lynch. 对 Pinnuck 和 Lynch 的回应。
IF 8 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-01 Epub Date: 2024-08-19 DOI: 10.14309/ajg.0000000000002982
Arshdeep Singh, Manjeet Kumar Goyal, Vandana Midha, Ajit Sood
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引用次数: 0
Natural History of Indeterminate Liver Nodules in Patients With Advanced Liver Disease: A Multicenter Retrospective Cohort Study. 晚期肝病患者肝脏不确定结节的自然史:一项多中心回顾性队列研究
IF 8 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-01 Epub Date: 2024-04-30 DOI: 10.14309/ajg.0000000000002827
Amit G Singal, Neehar D Parikh, Kirti Shetty, Steven-Huy Han, Cassie Xie, Jing Ning, Jo Ann Rinaudo, Ashwini Arvind, Anna S Lok, Fasiha Kanwal

Introduction: Indeterminate liver nodules (ILNs) are frequently encountered on diagnostic imaging after positive hepatocellular carcinoma (HCC) surveillance results, but their natural history remains unclear.

Methods: We conducted a multicenter retrospective cohort study among patients with ≥1 newly detected LI-RADS 3 (LR-3) lesion ≥1 cm or LI-RADS 4 (LR-4) lesion of any size (per LI-RADS v2018) between January 2018 and December 2019. Patients were followed with repeat imaging at each site per institutional standard of care. Multivariable Fine-Gray models were used to evaluate associations between potential risk factors and patient-level time-to-HCC diagnosis, with death and liver transplantation as competing risks.

Results: Of 307 patients with ILNs, 208 had LR-3 lesions, 83 had LR-4 lesions, and 16 had both LR-3 and LR-4 lesions. HCC incidence rates for patients with LR-3 and LR-4 lesions were 110 (95% CI 70-150) and 420 (95% CI 310-560) per 1,000 person-year, respectively. In multivariable analysis, incident HCC among patients with LR-3 lesions was associated with older age, thrombocytopenia (platelet count ≤150 ×10 9 /L), and elevated serum alpha-fetoprotein levels. Among those with LR-4 lesions, incident HCC was associated with a maximum lesion diameter >1 cm. Although most patients had follow-up computed tomography or magnetic resonance imaging, 13.7% had no follow-up imaging and another 14.3% had follow-up ultrasound only.

Discussion: ILNs have a high but variable risk of HCC, with 4-fold higher risk in patients with LR-4 lesions than those with LR-3 lesions, highlighting a need for accurate risk stratification tools and close follow-up in this population.

背景:肝脏结节(ILN肝细胞癌(HCC)监测结果阳性后,在诊断成像中经常会遇到不确定肝结节(ILNs),但其自然史仍不清楚:我们在2018年1月至2019年12月期间对新发现≥1个≥1厘米的LI-RADS 3(LR-3)病变或任何大小的LI-RADS 4(LR-4)病变(根据LI-RADS v2018)的患者进行了一项多中心回顾性队列研究。根据机构护理标准,对患者进行随访,并在每个部位重复成像。多变量Fine-Gray模型用于评估潜在风险因素与患者级别的HCC诊断时间之间的关联,死亡和肝移植为竞争风险:在307例ILN患者中,208例为LR-3病变,83例为LR-4病变,16例同时为LR-3和LR-4病变。LR-3和LR-4病变患者的HCC发病率分别为每千人年110例(95%CI 70 - 150)和420例(95%CI 310 - 560)。在多变量分析中,LR-3病变患者中发生的HCC与年龄较大、血小板减少症(血小板计数≤150 x109/L)和血清甲胎蛋白(AFP)水平升高有关。在 LR-4 病变患者中,发生 HCC 与最大病变直径大于 1 厘米有关。虽然大多数患者都进行了CT或MRI随访,但有13.7%的患者没有进行任何随访,另有14.3%的患者仅进行了超声随访:结论:ILN发生HCC的风险较高但不稳定,LR-4病变患者发生HCC的风险是LR-3病变患者的4倍,因此需要对这一人群进行准确的风险分层和密切随访。
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引用次数: 0
End-Stage Achalasia With Megaesophagus Causing Mass Effect Leading to Acute Pericarditis. 终末期食道闭锁伴巨型食道引起的群体效应导致急性心包炎
IF 8 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-01 Epub Date: 2024-04-30 DOI: 10.14309/ajg.0000000000002849
Adam M Jacob, Giancarlo Colón Rosa, Marie L Borum
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引用次数: 0
Correction to: Supplementation With Oral vs Intravenous Iron for Anemia With IBD or Gastrointestinal Bleeding: Is Oral Iron Getting a Bad Rap? 更正:补充口服铁剂与静脉注射铁剂治疗 IBD 或胃肠道出血贫血:口服铁剂是否名不副实?
IF 8 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-01 Epub Date: 2024-07-16 DOI: 10.14309/ajg.0000000000002913
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引用次数: 0
Correction to: Treatment Decision for Locally Resected T1 Colorectal Carcinoma-Verification of the Japanese Guideline Criteria for Additional Surgery Based on Long-Term Clinical Outcomes. 更正:局部切除的 T1 结直肠癌的治疗决策--基于长期临床结果的日本额外手术指南标准的验证。
IF 8 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-01 Epub Date: 2024-08-26 DOI: 10.14309/ajg.0000000000003001
Shiro Oka, Shinji Tanaka, Yoshiki Kajiwara, Shoichi Saito, Yosuke Fukunaga, Manabu Takamatsu, Hiroshi Kawachi, Kinich Hotta, Hiroaki Ikematsu, Motohiro Kojima, Yutaka Saito, Masayoshi Yamada, Yukihide Kanemitsu, Shigeki Sekine, Shinji Nagata, Kazutaka Yamada, Nozomu Kobayashi, Soichiro Ishihara, Yusuke Saitoh, Kenji Matsuda, Kazutomo Togashi, Koji Komori, Megumi Ishiguro, Toshio Kuwai, Takashi Okuyama, Akihiro Ohuchi, Shinobu Ohnuma, Kazuhiro Sakamoto, Tamotsu Sugai, Kenji Katsumata, Hiro-O Matsushita, Hiro-O Yamano, Hirotsugu Eda, Toshio Uraoka, Naohiko Akimoto, Hirotoshi Kobayashi, Kenichi Sugihara, Hideki Ueno
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引用次数: 0
Calendar of Courses, Symposiums and Conferences. 课程、研讨会和会议日历。
IF 8 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-01 DOI: 10.14309/ajg.0000000000003113
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引用次数: 0
2024 CME Information. 2024 CME 信息。
IF 8 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-01 Epub Date: 2024-03-06 DOI: 10.14309/ajg.0000000000002611
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引用次数: 0
A Practical Approach to Subcutaneous Infliximab. 皮下注射英夫利西单抗的实用方法。
IF 8 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-01 Epub Date: 2024-04-13 DOI: 10.14309/ajg.0000000000002844
Jennifer Aoto, Benjamin Click
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引用次数: 0
A Rare Culprit of Massive Gastrointestinal Bleeding: Amoeba. 胃肠道大出血的罕见罪魁祸首:阿米巴
IF 8 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-10-31 DOI: 10.14309/ajg.0000000000003181
Zi-Ru Zhou, Jing Sun, Qunyan Zhou, Xia Li, Xinnong Zou, Qiang Zhan
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引用次数: 0
期刊
American Journal of Gastroenterology
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