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Evaluating Plastic Surgery Resident Satisfaction Globally: Predictors and Recommendations for Training Enhancement. 评估全球整形外科住院医师满意度:全球整形外科住院医师满意度评估:预测因素和加强培训的建议。
IF 2 3区 医学 Q2 SURGERY Pub Date : 2024-12-13 DOI: 10.1007/s00266-024-04588-9
Georgios Karamitros, Heather J Furnas, Sofoklis Goulas

Background: Measures of quality in resident training in plastic and reconstructive surgery (PRS) programs are scarce and often methodologically inconsistent. Our research provides insights from current PRS trainees globally, mapping their training inputs, expected outputs, and recommendations for program improvements.

Methods: A global online survey was conducted among PRS residents across 70 countries to gauge their satisfaction with residency training, capturing training inputs such as the number of surgeries attended and seminars they participated in. We also extracted residents' proposed recommendations for program improvement. We investigated the explanatory role of training inputs, demographics, hospital characteristics, and country income on resident satisfaction and graduate competence.

Results: The analysis incorporated data from 518 PRS residents. On average, residents attended 9.8 surgeries and 1.3 seminars per week. Simultaneously, there was a positive correlation between the perceived level of professional competency and training inputs, particularly seminars attended (p - value = 0.001). Male residents tended to report higher satisfaction (p - value = 0.045) with their training (67%) compared with their female counterparts (58%), while those with family responsibilities also demonstrated slightly higher satisfaction levels.

Conclusions: Our analysis expands the evidence base regarding a "global hunger" for more comprehensive seminar-based and hands-on surgical training. Resident recommendations on program improvement reveal the need to address gaps, particularly in aesthetic surgery training. The development of healthcare business models that allow for aesthetic procedures in training institutions is crucial in the promotion of aesthetic surgery training during residency. Policymakers, program directors, and stakeholders across the world can leverage these findings to formulate policies addressing the weaknesses of training programs.

Level of evidence iii: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

背景:衡量整形和重建外科(PRS)住院医师培训质量的方法很少,而且常常在方法上不一致。我们的研究提供了当前全球PRS学员的见解,绘制了他们的培训投入、预期产出和项目改进建议。方法:在全球70个国家的PRS住院医师中进行了一项在线调查,以评估他们对住院医师培训的满意度,包括他们参加的手术次数和参加的研讨会等培训投入。我们还提取了居民提出的改进方案的建议。我们调查了培训投入、人口统计、医院特征和国家收入对居民满意度和毕业生能力的解释作用。结果:分析纳入了518名PRS居民的数据。住院医师平均每周参加9.8次手术和1.3次讲座。同时,专业能力的感知水平与培训投入之间存在正相关,特别是参加的研讨会(p值= 0.001)。男性住院医生对培训的满意度(67%)高于女性住院医生(58%),而有家庭责任的住院医生的满意度也略高。结论:我们的分析扩大了关于“全球饥饿”的证据基础,以更全面的研讨会为基础和实践外科培训。住院医师对项目改进的建议表明,需要解决差距,特别是在美容手术培训方面。允许在培训机构进行美容手术的医疗保健商业模式的发展对于促进住院医师期间的美容手术培训至关重要。世界各地的政策制定者、项目负责人和利益相关者可以利用这些发现制定政策,解决培训项目的弱点。证据等级iii:本刊要求作者为每篇文章指定证据等级。有关这些循证医学评级的完整描述,请参阅目录或在线作者说明www.springer.com/00266。
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引用次数: 0
Correction: Does the Omission of Cefazolin in Irrigation Solution Affect Outcomes in Prepectoral Direct-to-Implant Breast Reconstruction? 更正:冲洗液中头孢唑林的遗漏是否会影响术前直接植入乳房重建术的结果?
IF 2 3区 医学 Q2 SURGERY Pub Date : 2024-12-13 DOI: 10.1007/s00266-024-04630-w
Jong-Koo Lee, Ji Eun Chung, Jai Kyong Pyon, Kyeong-Tae Lee
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引用次数: 0
Evaluation of the Efficacy of the Combined Therapy of Botulinum Toxin and Hyaluronic Acid Compared to Conservative Intervention in the Treatment of Chronic Peripheral Facial Paralysis of Oncologic Etiology. 肉毒毒素与透明质酸联合治疗肿瘤性慢性周围性面瘫与保守干预的疗效比较。
IF 2 3区 医学 Q2 SURGERY Pub Date : 2024-12-12 DOI: 10.1007/s00266-024-04589-8
Franco Patriani D'Andrea, Cristina Alessi, Cristiane Cárcano, Vanessa Tanaka, Bruno Alvares, Davi Brito, Isabela Alves Guerra, Ricardo Gama, Marcelo Riberto

Background: Neoplasms in the head and neck often lead to peripheral facial paralysis (PFP), impacting facial expression and causing psychological distress. Standard treatments involve physiotherapy, but botulinum toxin type A (BTA) and hyaluronic acid (HA) injections have shown promise in promoting facial symmetry.

Aim: To assess the effectiveness of combined BTA and HA intervention in PFP patients, comparing it to conventional treatment (physiotherapy).

Method: A single-blind, randomized clinical trial at Hospital de Amor de Barretos included 18 patients, with the control group receiving standard therapy and the combined therapy (CT) group receiving BTA and HA. Evaluations utilized the Sunnybrook facial grading scale (SFGS) and Psychosocial Facial Asymmetry Scale (EPAF) questionnaires, along with photographic analysis.

Results: CT significantly improved facial symmetry and psychosocial aspects compared to the control group. The SFGS scores increased by 27 points in CT versus 3 points in the control group, while EPAF scores decreased by 16 points in CT and increased by 1 point in the control group. Photographic analysis showed improved dynamic smiles in CT patients. Functional gains were more evident at 30 days, with continued improvement over four months. Psychosocial scores increased throughout the study. Only two CT patients reported transient issues with drinking and chewing.

Conclusion: The study suggests the positive impact of combined therapy on psychosocial and functional aspects, emphasizing the need for further robust research to determine its therapeutic potential.

Level of evidence ii: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

背景:头颈部肿瘤常导致周围性面瘫(PFP),影响面部表情并引起心理困扰。标准的治疗方法包括物理治疗,但A型肉毒杆菌毒素(BTA)和透明质酸(HA)注射在促进面部对称方面显示出希望。目的:评价BTA与HA联合干预治疗PFP患者的疗效,并与常规治疗(物理治疗)进行比较。方法:18例患者在巴雷托斯医院进行单盲随机临床试验,对照组接受标准治疗,CT组接受BTA和HA联合治疗。评估采用Sunnybrook面部分级量表(SFGS)和心理社会面部不对称量表(EPAF)问卷调查,以及照片分析。结果:与对照组相比,CT显着改善了面部对称性和心理社会方面。SFGS CT评分提高了27分,对照组提高了3分;EPAF CT评分降低了16分,对照组提高了1分。照片分析显示,CT患者的动态微笑有所改善。在30天内,功能改善更为明显,并在4个月内持续改善。在整个研究过程中,心理社会得分不断上升。只有两名CT患者报告了短暂的饮酒和咀嚼问题。结论:该研究提示了联合治疗在心理社会和功能方面的积极影响,强调需要进一步强有力的研究来确定其治疗潜力。证据等级ii:本刊要求作者为每篇文章指定证据等级。有关这些循证医学评级的完整描述,请参阅目录或在线作者说明www.springer.com/00266。
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引用次数: 0
Text-to-Video Models and Sora in Plastic Surgery: Pearls, Pitfalls, and Prospectives. 文本到视频模型和Sora在整形外科:珍珠,陷阱和前景。
IF 2 3区 医学 Q2 SURGERY Pub Date : 2024-12-11 DOI: 10.1007/s00266-024-04583-0
Yuanbo Kang, Sifan Wang, Lin Zhu

After the groundbreaking release of the highly acclaimed chatbot ChatGPT, which revolutionized the field of artificial intelligence (AI) last year, OpenAI has once again astounded the world with the unveiling of their latest generative AI model, Sora, on February 16, 2024. This cutting-edge model has the remarkable ability to generate videos up to a duration of 60 seconds solely through text instructions. With a series of AI-generated contents, such as AI chat, AI drawing, and AI music, emerging one after another, the era of "AI revolution" that had a disruptive impact on modern life has arrived. Meanwhile, AI has made significant achievements in the medical field, especially in diagnosing based on medical imaging. This article briefly describes the development history of text-to-video models and provides a detailed introduction to the Sora model, including its portrayal of the human face and contour, inspiring its potential applications in plastic surgery. It also provides a prospect for other AI-generated content technologies, such as text-to-holography and text-to-material objects.Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

继去年备受好评的聊天机器人ChatGPT的突破性发布后,OpenAI于2024年2月16日发布了最新的生成式人工智能模型Sora,再次震惊了世界。这种尖端的模型具有非凡的能力,可以通过文本指令生成长达60秒的视频。随着人工智能聊天、人工智能绘画、人工智能音乐等一系列人工智能生成的内容相继出现,对现代生活产生颠覆性影响的“人工智能革命”时代已经到来。与此同时,人工智能在医学领域取得了重大成就,特别是在基于医学影像的诊断方面。本文简要介绍了文本到视频模型的发展历史,并详细介绍了Sora模型,包括其对人脸和轮廓的描绘,启发了其在整形外科中的潜在应用。它还为其他人工智能生成的内容技术提供了前景,例如文本到全息和文本到实体对象。证据等级V本刊要求作者为每篇文章指定证据等级。有关这些循证医学评级的完整描述,请参阅目录或在线作者说明www.springer.com/00266。
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引用次数: 0
Evaluation of Perilipin Expression in Centrifuged Fat Grafts on Different Revolutions Per Minute and Duration Combinations. 不同转数/分钟和持续时间组合下离心脂肪移植物中Perilipin表达的评价。
IF 2 3区 医学 Q2 SURGERY Pub Date : 2024-12-11 DOI: 10.1007/s00266-024-04580-3
Alper Eskalen, Eray Işık, Ilkay Ozdemir, Ilknur Keskin, Mustafa Keskin, Naci Karacaoglan

Fat graft applications are one of the most frequently used procedures in reconstructive and aesthetic surgery. Fat graft survival rate is variable and depends on many parameters. Those are the features of recipient area, method of obtaining the fat graft, the procedures applied to the harvest to get pure fat graft and the application techniques. In this study, we aimed to find the optimal revolutions per minute(rpm) and duration to be used in the centrifugation technique, which is one of the most frequently used methods in fat grafting. In our study, we used perilipin protein as a survival marker. Liposuction samples were obtained from 10 Caucasian women individuals; whose age range is between 22 and 29 years without any other reported health problem. Fat grafts from all patients were taken by the same surgical team by the same liposuction procedure. The grafts obtained in our study were divided into 6 different groups, these are A1 group (1 minute-1000 rpm) A2 group (3 minutes-1000 rpm) A3 group (5 minutes-1000 rpm) B1 group (1 minute-3000 rpm) B2 group (3 minutes-3000 rpm) and B3 group (5 minutes-3000 rpm). Perilipin expression measurements were made in the sections taken by immunohistochemistry technique. Three minutes-3000 rpm combination (B2 group) was found to be perilipin stained statistically significantly higher than other combinations. This study seeks to make a notable contribution to the literature by demonstrating the relation between frequently used centrifuge combinations and measuring the expression of perilipin. This protein's role in adipocyte regulation is becoming increasingly apparent.Level of Evidence III This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

脂肪移植应用是重建和美容手术中最常用的程序之一。脂肪移植的存活率是可变的,取决于许多参数。主要包括受体区域的特征、脂肪移植的获取方法、纯脂肪移植采收的步骤和应用技术。在这项研究中,我们的目的是找到离心技术中使用的最佳转数每分钟(rpm)和持续时间,离心技术是脂肪移植中最常用的方法之一。在我们的研究中,我们使用perilipin蛋白作为生存标志物。从10名高加索女性个体中抽取抽脂样本;年龄在22至29岁之间,无其他健康问题。所有患者的脂肪移植由同一手术小组通过相同的吸脂程序进行。我们将移植物分为6组,A1组(1分钟-1000转/分)A2组(3分钟-1000转/分)A3组(5分钟-1000转/分)B1组(1分钟-3000转/分)B2组(3分钟-3000转/分)B3组(5分钟-3000转/分)。采用免疫组化技术对切片进行Perilipin的表达测定。3 min -3000 rpm组(B2组)外周血蛋白染色明显高于其他组。本研究旨在通过展示频繁使用的离心机组合与测量perilipin表达之间的关系,为文献做出显著贡献。这种蛋白在脂肪细胞调节中的作用越来越明显。证据等级III本期刊要求作者为每篇文章指定一个证据等级。有关这些循证医学评级的完整描述,请参阅目录或在线作者说明www.springer.com/00266。
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引用次数: 0
Botulinum Toxin: A Non-surgical Approach for Non-myasthenic Mild-to-Moderate Blepharoptosis Treatment. 肉毒杆菌毒素:非肌无力轻至中度上睑下垂的非手术治疗方法。
IF 2 3区 医学 Q2 SURGERY Pub Date : 2024-12-11 DOI: 10.1007/s00266-024-04584-z
Roberta D'Emilio, Mauro Barone, Riccardo De Bernardis, Rosa Salzillo, Giuseppe Rosati, Maria Grazia Caputo, Salvatore Piero Fundarò, Paolo Persichetti

Introduction: Mild-to-moderate blepharoptosis can be aesthetically displeasing for patients, particularly in cases involving a single eyelid. However, certain patients are reluctant to undergo surgical intervention. Botulinum neurotoxin A (BoNT-A) injection offers a potential solution in such cases.

Material and methods: Patients meeting the following inclusion criteria were included in the study: mild-to-moderate eyelid ptosis of different etiologies (excluding myasthenic disorders), robust activity of the orbicularis oculi muscle, proficiency in Italian language, standardized pre- and postoperative photo-documentation, and signed consent for study participation. A 32-33 Gauge 4-mm needle was employed to inject the BoNT-A in the pretarsal orbicularis muscle. Standardized videos and photos were obtained before the treatment, 2 weeks, 4 weeks, and 24 weeks post-treatment. Outcomes were evaluated by measuring changes in the margin reflex distance-1 (MRD-1) and assessing patient point of view through two subjective questionnaires.

Results: Forty-nine patients were enrolled, 39 females and 10 males, aged between 30 and 88 years old. We observed a significant increase in the MRD-1 after 2 weeks and after 4 weeks compared to the baseline (p < 0.0001), with a mean elevation of the eyelid of 0.71 mm and 0.67 mm respectively. Patients ceased to require furrowing of the frontalis muscle to compensate for the eyelid elevation dysfunction. After 24 weeks, the BoNT-A effect diminished, and the treated eyelid returned to its baseline position. 67.4% of patients reported an improvement with only mild inconvenience in their blepharoptosis, and 16.3% of patients reported a complete improvement. 85.7% of patients expressed the desire to undergo the treatment again.

Conclusions: BoNT-A has demonstrated effectiveness in temporarily managing mild-to-moderate blepharoptosis and may represent a viable option for addressing minor eyelids asymmetries.

Level of evidence ii: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

简介:轻度至中度上睑下垂对患者来说可能是不美观的,特别是在单眼皮的情况下。然而,某些患者不愿接受手术干预。肉毒杆菌神经毒素A (BoNT-A)注射在这种情况下提供了一个潜在的解决方案。材料和方法:符合以下纳入标准的患者被纳入研究:不同病因的轻度至中度眼睑下垂(不包括肌无力疾病),眼轮转肌活动强劲,熟练掌握意大利语,标准化的术前和术后照片记录,并签署了参与研究的同意。采用32-33号4-mm针在睑前轮匝肌内注射BoNT-A。分别于治疗前、治疗后2周、4周、24周采集标准化视频和照片。通过测量边缘反射距离-1 (MRD-1)的变化和通过两份主观问卷评估患者的观点来评估结果。结果:纳入49例患者,其中女性39例,男性10例,年龄30 ~ 88岁。我们观察到与基线相比,2周和4周后MRD-1显著增加(p < 0.0001),眼睑平均升高分别为0.71 mm和0.67 mm。患者不再需要额肌皱褶来补偿眼睑抬高功能障碍。24周后,BoNT-A效果减弱,治疗后的眼睑恢复到基线位置。67.4%的患者报告轻度上睑下垂的改善,16.3%的患者报告完全改善。85.7%的患者表示希望再次接受治疗。结论:BoNT-A已被证明在暂时治疗轻度至中度上睑下垂方面是有效的,并且可能是解决轻微眼睑不对称的可行选择。证据等级ii:本刊要求作者为每篇文章指定证据等级。有关这些循证医学评级的完整描述,请参阅目录或在线作者说明www.springer.com/00266。
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引用次数: 0
Unanticipated Economic Burden of Cosmetic Surgery Tourism: A Single Academic Center's Experience. 整容旅游的意外经济负担:一个学术中心的经验。
IF 2 3区 医学 Q2 SURGERY Pub Date : 2024-12-11 DOI: 10.1007/s00266-024-04516-x
R Patrick Duggan, Ramon L Zapata-Sirvent, Pablo L Padilla, John S Hamati, Annalisa Lopez, Linda G Phillips

Introduction: Cosmetic surgery tourism is a burgeoning field, attracting patients with the possibility of procedures at reduced costs. Patients are often unaware of the potential cost of managing complications, with the cost often passed on to the local healthcare systems. We report our experience at a single academic center which serves as a safety net hospital managing cosmetic surgery tourism patients.

Methods: Cosmetic surgery tourism patient demographics and outcomes were reviewed between March 2020 and September 2021 at our institution.

Results: We identified twenty-four female patients, averaging 35.6 years of age. All patients underwent body contouring procedures, most commonly abdominoplasty (17/24), frequently combined with liposuction or breast augmentation. On average, patients presented 32 days after their operation. All patients utilized emergency department resources, and 20/24 patients were admitted, averaging 5.5 days per admission. Fifteen required an additional procedure, including four who returned to the operating room. Twelve patients traveled internationally for surgery, ten to Mexico and two to the Dominican Republic. Domestically, Miami, Florida, was the most popular destination (8/12).

Conclusion: After developing a complication, patients frequently utilized emergency department resources and often were treated by non-surgeons before arriving at our institution. Surgical tourism continues to place the onus of finding appropriate postoperative care on patients, with their surgeon some hundreds of miles away. Additionally, the unanticipated cost of complications often exceeds the cost of their index procedure.

Level of evidence iv: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

导读:整容旅游是一个新兴的领域,以低廉的费用吸引着患者。患者往往不知道处理并发症的潜在成本,这些成本往往转嫁给当地医疗保健系统。我们报告我们的经验,在一个单一的学术中心,作为一个安全网医院管理美容手术旅游患者。方法:回顾我院2020年3月至2021年9月期间整容旅游患者的人口统计数据和结果。结果:24例女性患者,平均年龄35.6岁。所有患者都进行了身体轮廓手术,最常见的是腹部成形术(17/24),经常结合吸脂或隆胸。患者平均在手术后32天出现。所有患者均利用急诊科资源,20/24患者入院,平均每次入院5.5天。15人需要进行额外的手术,其中4人回到了手术室。12名患者出国接受手术,10名前往墨西哥,2名前往多米尼加共和国。在国内,佛罗里达州的迈阿密是最受欢迎的目的地(8/12)。结论:在发生并发症后,患者经常使用急诊科资源,并经常在来我院之前由非外科医生治疗。手术旅游继续将寻找合适的术后护理的责任推给患者,而他们的外科医生远在数百英里之外。此外,并发症的意外成本往往超过其索引程序的成本。证据等级iv:本刊要求作者为每篇文章指定一个证据等级。有关这些循证医学评级的完整描述,请参阅目录或在线作者说明www.springer.com/00266。
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引用次数: 0
Regenerative Nanofat Membrane Development Process. 再生纳米膜的开发过程。
IF 2 3区 医学 Q2 SURGERY Pub Date : 2024-12-11 DOI: 10.1007/s00266-024-04562-5
Nabil Fakih-Gomez, Roshini Manay, Shahriar Nazari, Lessandro Martins, Cristina Muñoz-Gonzalez

Introduction: Chronic wounds present a significant challenge in clinical practice due to complications like infections and prolonged healing times. Conventional treatments often fall short, necessitating advancements in wound healing strategies. This article introduces a novel approach using a combination of adipose-derived stem cells (ADSCs) from fat and growth factors from platelet-rich fibrin (PRF) to enhance wound healing outcomes.

Methods: The Fakih-Manay fat membrane device was utilized to prepare fat membranes. Microfat was harvested and emulsified to produce nanofat, which was then combined with PRF to create a Nanofat-PRF membrane. The resulting membrane was uniform, versatile, and suture-friendly, making it ideal for various medical and surgical applications.

Results: Between April 2019 and April 2024, 172 patients received treatment using a nanofat membrane. The membrane showed significant improvement in wound healing in various cases including diabetic foot ulcers, cleft palate surgeries, facial dermabrasion, skin necrosis, revision rhinoplasties, and post-cosmetic surgery complications. Postoperative follow-up after healing ranged from 1 to 16 months, showing high patient satisfaction and significant improvements in wound healing and no reported complications.

Conclusion: The nanofat membrane presents a versatile and innovative approach to enhancing healing across a broad range of medical and surgical applications. This study provides the first evidence on the method for creating these membranes, demonstrating their clinical efficacy and safety, with no reported complications over a 5-year period.

Level of evidence iv: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

慢性伤口由于感染和愈合时间延长等并发症,在临床实践中提出了重大挑战。传统的治疗方法往往效果不佳,因此需要在伤口愈合策略方面取得进展。本文介绍了一种利用脂肪来源的脂肪源性干细胞(ADSCs)和富含血小板的纤维蛋白(PRF)的生长因子相结合来提高伤口愈合效果的新方法。方法:采用Fakih-Manay脂肪膜装置制备脂肪膜。收集微脂肪并乳化生成纳米脂肪,然后将其与PRF结合形成纳米脂肪-PRF膜。所得到的膜是均匀的,多功能的,缝合友好的,使其成为各种医学和外科应用的理想选择。结果:2019年4月至2024年4月,172例患者接受了纳米脂肪膜治疗。该膜在糖尿病足溃疡、腭裂手术、面部磨皮、皮肤坏死、鼻整形修复和术后并发症等各种病例的伤口愈合方面均有显著改善。术后随访1 ~ 16个月,患者满意度高,创面愈合明显改善,无并发症报道。结论:纳米脂肪膜提供了一种多功能和创新的方法,可以在广泛的医学和外科应用中增强愈合。这项研究首次证实了这种膜的制备方法,证明了其临床有效性和安全性,在5年的时间里没有出现并发症的报道。证据等级iv:本刊要求作者为每篇文章指定一个证据等级。有关这些循证医学评级的完整描述,请参阅目录或在线作者说明www.springer.com/00266。
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引用次数: 0
Vascular Endothelial Growth Factor Expression of Adipose-Derived Stromal Cells and Adipocytes Initiated from Fat Aspirations. 脂肪源性基质细胞和脂肪细胞的血管内皮生长因子表达。
IF 2 3区 医学 Q2 SURGERY Pub Date : 2024-12-10 DOI: 10.1007/s00266-024-04587-w
Maryana Teufelsbauer, Sandra Stickler, Dennis C Hammond, Gerhard Hamilton

Background: Fat grafting is frequently employed in aesthetic and reconstructive plastic surgery with a low complication rate. However, fat necrosis may occur in dependence of the mode of fat aspiration, processing of the tissue and graft size. Graft survival is critically dependent on the contained adipose-derived stromal cells (ADSCs), adipocyte precursors and their potential for vascular supply. This work investigated the potential role of the expression of vascular endothelial growth factor A (VEGF) and various cytokines by ADSCs and differentiated adipocytes as key factors of fat grafting.

Methods: Adipokine expression of ADSCs and differentiated adipocytes were assessed using Proteome Profiler Arrays that detect 58 relevant proteins.

Results: Collected fat grafts could be categorized according to their adipokine expression into VEGFhigh and VEGFlow ADSCs groups, the former exhibiting higher content of VEGF-related angiopoietin-like 2, nidogen-1/entactin, CCL2/MCP-1 and elevated expression of IGFBPs in association with a fourfold higher VEGF expression. Differentiation of ADSCs into adipocytes increased VEGF concentrations in VEGFlow ADSCs but not in ADSCs exhibiting initial high VEGF concentrations. The adipocytes revealed high expression of HGF, leptin, CCL2/MCP-1, nidogen-1/entactin, M-CSF but lower induction of angiopoietin-like 2.

Conclusion: Half of the ADSCs from fat grafts express high concentrations of VEGF and other adipokines that support angiogenesis and survival of this tissues following transfer. Differentiation of ADSClow cells to adipocytes may make up for the initially low VEGF expression, but this activation is 7-10 days delayed compared to the VEGFhigh ADSC cells and may fail to support angiogenesis from the beginning.

No level assigned: This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors  www.springer.com/00266 .

背景:脂肪移植术是一种并发症发生率较低的美容整形手术。然而,脂肪坏死的发生可能与脂肪吸入方式、组织处理和移植物大小有关。移植物的存活严重依赖于所含的脂肪来源基质细胞(ADSCs)、脂肪细胞前体及其血管供应的潜力。本研究探讨了血管内皮生长因子A (VEGF)及多种细胞因子在ADSCs及分化脂肪细胞中表达作为脂肪移植关键因子的潜在作用。方法:采用检测58种相关蛋白的蛋白质组谱仪阵列(Proteome Profiler Arrays)检测ADSCs和分化脂肪细胞中脂肪因子的表达。结果:收集到的脂肪移植物根据其脂肪因子的表达可分为veghigh和VEGFlow ADSCs组,前者表现出VEGF相关血管生成素样2、nidogen-1/entactin、CCL2/MCP-1含量较高,igfbp表达升高,VEGF表达水平提高4倍。分化为脂肪细胞的ADSCs增加了VEGFlow ADSCs中VEGF的浓度,但在初始VEGF浓度较高的ADSCs中没有。脂肪细胞高表达HGF、瘦素、CCL2/MCP-1、nidogen-1/entactin、M-CSF,低表达血管生成素样2。结论:一半来自脂肪移植的ADSCs表达高浓度的VEGF和其他脂肪因子,支持血管生成和移植后组织的存活。ADSClow细胞向脂肪细胞的分化可能弥补了最初的低VEGF表达,但与VEGF高水平的ADSC细胞相比,这种激活延迟了7-10天,并且可能从一开始就不能支持血管生成。未指定水平:本刊要求作者为每份投稿指定证据水平,以适用循证医学排名。这不包括评论文章、书评和涉及基础科学、动物研究、尸体研究和实验研究的手稿。有关这些循证医学评级的完整描述,请参阅目录或在线作者说明www.springer.com/00266。
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引用次数: 0
Electrocardiographic Early Changes After Abdominoplasty. 腹部成形术后心电图早期变化。
IF 2 3区 医学 Q2 SURGERY Pub Date : 2024-12-10 DOI: 10.1007/s00266-024-04559-0
Ayça Ergan Şahin, Ahmet Anıl Şahin, Serbülent Güzey

Introduction: Abdominoplasty aims to reduce the abdominal excess tissue and tighten the abdominal wall. The tightening of the abdominal wall has structural and habitual consequences on the body, which might have an early effect on electrocardiography (ECG) of the patients through volumetric and pressure changes in thoracic and abdominal cavities. ECG serves as a diagnostic tool for assessing cardiac electrical conductions in routine clinical practice. In this study, we aimed to examine whether abdominoplasty has any discernible effect on early ECG results, with the goal of assessing potential cardiological benefits for the patients undergoing this procedure by comparing pre- and early postoperative ECGs.

Method: Study population included 49 patients who had abdominoplasty. ECG records before the procedure and 12-24 h after the surgery were analyzed retrospectively. Patients had no known cardiac diseases and did not have any diagnosed arrhythmia.

Results: The mean age of the study population was 37.1 ± 8.5. The mean body mass index of the study population was 26.4. The mean weight of total removed abdominal skin tissue was 1057 grams. There were significant changes in ECG of the patients postoperatively. Heart rate was increased, and significant change was found in QRS axis (p < 0.001) and T wave axis (p < 0.001). Atrial conduction parameters such as PR duration (p  < 0.001), Pmax duration (p  =  0.001) and P-wave dispersion (p = 0.003) were significantly changed postoperatively. Ventricular conduction parameters such as QRS duration (p = 0.029), QT interval (p   < 0.001), QTc (p  < 0.001), TPe duration (p < 0.001), TPe / QT (p < 0.001) and TPe / QTc (p < 0.001) ratios were found significantly changed.

Conclusion: Abdominoplasty changes the intra-abdominal pressure in the first 24 h after the surgery, which may impact cardiac conduction. The understanding and recognition of possible early ECG changes is crucial during postoperative follow-up of the patients who undergo abdominoplasty surgery.

Level of evidence i: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

简介:腹部成形术的目的是减少腹部多余组织,收紧腹壁。腹壁收紧对身体有结构性和习惯性的影响,可能通过胸腔和腹腔的容积和压力变化对患者的心电图(ECG)产生早期影响。在常规临床实践中,心电图作为一种评估心脏电导的诊断工具。在这项研究中,我们旨在研究腹部成形术是否对早期心电图结果有任何明显的影响,目的是通过比较术前和术后早期心电图来评估接受该手术的患者的潜在心脏病益处。方法:研究对象为49例腹部成形术患者。回顾性分析术前及术后12-24 h的心电图记录。患者没有已知的心脏疾病,也没有任何诊断出的心律失常。结果:研究人群平均年龄为37.1±8.5岁。研究人群的平均体重指数为26.4。总切除腹部皮肤组织的平均重量为1057克。术后患者心电图有明显变化。结论:腹部成形术改变了术后24 h内腹内压,可能影响心脏传导。了解和识别可能的早期心电图变化在腹部成形术患者的术后随访中是至关重要的。证据等级i:本刊要求作者为每篇文章指定证据等级。有关这些循证医学评级的完整描述,请参阅目录或在线作者说明www.springer.com/00266。
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Aesthetic Plastic Surgery
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