Erin Warshaw, An Liu, Kelly Jerstad, Gina Lee, Kathleen Larson, April Farrell, Jacqueline Bailey, Dave Nelson
Objective: The primary objective of this double-blind randomized, pilot study was to evaluate whether previously prepared stored patches may be as effective as freshly prepared patches are for detecting contact allergy.
Methods: Two sets of 62 nonaqueous allergens were applied to participants' upper backs. One set was freshly prepared, and the second set was previously prepared and stored for an average of 6 weeks. Right or left back location for each set was randomly assigned. The primary outcome assessment compared the proportions of fresh and strong reactions in pairs with complete discordance (negative on one side and 1+, 2+, or 3+ on the other side).
Results: In 71 patients enrolled, there were 169 positive reactions. Concordance (any combination of a 1+, 2+, or 3+ reaction on both sides) was found in 63% of pairs (95% CI: 55.4, 70.0). Of the 25 pairs with complete discordance, there was no statistically significant difference between the rate of positive reactions for fresh and stored patches.
Conclusion: Pilot evidence suggests that stored patches may be effective in detecting the majority of allergic contact reactions. Larger studies are needed to evaluate antigen-specific effects as well as effects of varying lengths of antigen storage.
{"title":"Pilot evaluation of a convenient and cost-effective method of patch testing.","authors":"Erin Warshaw, An Liu, Kelly Jerstad, Gina Lee, Kathleen Larson, April Farrell, Jacqueline Bailey, Dave Nelson","doi":"10.2310/6620.2003.38748","DOIUrl":"https://doi.org/10.2310/6620.2003.38748","url":null,"abstract":"<p><strong>Objective: </strong>The primary objective of this double-blind randomized, pilot study was to evaluate whether previously prepared stored patches may be as effective as freshly prepared patches are for detecting contact allergy.</p><p><strong>Methods: </strong>Two sets of 62 nonaqueous allergens were applied to participants' upper backs. One set was freshly prepared, and the second set was previously prepared and stored for an average of 6 weeks. Right or left back location for each set was randomly assigned. The primary outcome assessment compared the proportions of fresh and strong reactions in pairs with complete discordance (negative on one side and 1+, 2+, or 3+ on the other side).</p><p><strong>Results: </strong>In 71 patients enrolled, there were 169 positive reactions. Concordance (any combination of a 1+, 2+, or 3+ reaction on both sides) was found in 63% of pairs (95% CI: 55.4, 70.0). Of the 25 pairs with complete discordance, there was no statistically significant difference between the rate of positive reactions for fresh and stored patches.</p><p><strong>Conclusion: </strong>Pilot evidence suggests that stored patches may be effective in detecting the majority of allergic contact reactions. Larger studies are needed to evaluate antigen-specific effects as well as effects of varying lengths of antigen storage.</p>","PeriodicalId":7612,"journal":{"name":"American journal of contact dermatitis : official journal of the American Contact Dermatitis Society","volume":"14 1","pages":"15-20"},"PeriodicalIF":0.0,"publicationDate":"2003-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24181135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patients with reactions to topical products may be eliciting a physical urticaria, dermographism, by rubbing. These reactions may be misinterpreted as allergic, and three cases demonstrating this phenomenon were reviewed. All patients with reactions to topical products due to dermographism improved with counseling and antihistamine therapy. Repeat open application testing confirmed the safety of previously suspect medications in two of the three cases, preventing unnecessary changes in the medication regimens and inaccurate diagnoses of medication allergy. We observe that intolerance to topical medications due to dermographism can usually be managed without extensive testing or treatment.
{"title":"Intolerance to topical products may be due to dermographism.","authors":"Kalman L Watsky, Thomas McGovern","doi":"10.2310/6620.2003.38772","DOIUrl":"https://doi.org/10.2310/6620.2003.38772","url":null,"abstract":"Patients with reactions to topical products may be eliciting a physical urticaria, dermographism, by rubbing. These reactions may be misinterpreted as allergic, and three cases demonstrating this phenomenon were reviewed. All patients with reactions to topical products due to dermographism improved with counseling and antihistamine therapy. Repeat open application testing confirmed the safety of previously suspect medications in two of the three cases, preventing unnecessary changes in the medication regimens and inaccurate diagnoses of medication allergy. We observe that intolerance to topical medications due to dermographism can usually be managed without extensive testing or treatment.","PeriodicalId":7612,"journal":{"name":"American journal of contact dermatitis : official journal of the American Contact Dermatitis Society","volume":"14 1","pages":"35-6"},"PeriodicalIF":0.0,"publicationDate":"2003-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24181139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Patch testing with the shoe series may be useful for the diagnosis of shoe contact dermatitis.
Objective: The aim of the study was to verify the usefulness of the shoe series and the association of fungal infection with positive results in the shoe series.
Methods: A total of 140 patients with suspected shoe contact dermatitis underwent patch testing with the standard series and shoe series; 41 underwent mycologic examination.
Results: Positive results in the shoe series were noted in 58 patients (41.4%). The most common allergens were potassium dichromate (27.2%), nickel sulfate (11.9%), Kathon CG (10.9%), and 4-tert-butylphenol formaldehyde resin (8.7%). Of the 41 patients with suspected tinea pedis, 13 (32%) had positive mycologic findings and 9 (69.2%) also had a positive response to the shoe series. Of the patients with a negative result on mycologic examination, only 10 (35.7%) had a positive result in the shoe series.
Conclusion: Our study indicates that all patients with foot dermatitis should undergo patch testing with the shoe series. Positive results in the shoe series seem to be more prevalent in patients with a fungal infection.
{"title":"Shoe contact dermatitis in Israel.","authors":"Akiva Trattner, Yoshef Farchi, Michael David","doi":"10.2310/6620.2003.38745","DOIUrl":"https://doi.org/10.2310/6620.2003.38745","url":null,"abstract":"<p><strong>Background: </strong>Patch testing with the shoe series may be useful for the diagnosis of shoe contact dermatitis.</p><p><strong>Objective: </strong>The aim of the study was to verify the usefulness of the shoe series and the association of fungal infection with positive results in the shoe series.</p><p><strong>Methods: </strong>A total of 140 patients with suspected shoe contact dermatitis underwent patch testing with the standard series and shoe series; 41 underwent mycologic examination.</p><p><strong>Results: </strong>Positive results in the shoe series were noted in 58 patients (41.4%). The most common allergens were potassium dichromate (27.2%), nickel sulfate (11.9%), Kathon CG (10.9%), and 4-tert-butylphenol formaldehyde resin (8.7%). Of the 41 patients with suspected tinea pedis, 13 (32%) had positive mycologic findings and 9 (69.2%) also had a positive response to the shoe series. Of the patients with a negative result on mycologic examination, only 10 (35.7%) had a positive result in the shoe series.</p><p><strong>Conclusion: </strong>Our study indicates that all patients with foot dermatitis should undergo patch testing with the shoe series. Positive results in the shoe series seem to be more prevalent in patients with a fungal infection.</p>","PeriodicalId":7612,"journal":{"name":"American journal of contact dermatitis : official journal of the American Contact Dermatitis Society","volume":"14 1","pages":"12-4"},"PeriodicalIF":0.0,"publicationDate":"2003-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24181134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bryan E Anderson, Christopher J Miller, David R Adams
The stinging nettle (Urtica dioica) is a common weed that can cause a wide range of cutaneous reactions. Contact with the hairs or spines on the stems and leaves of the stinging nettle causes the release of several biologically active substances. The released chemicals act to cause itching, dermatitis, and urticaria within moments of contact. Extracts from the stinging nettle may provide therapeutic value for some inflammatory medical conditions. There is no standard treatment for stinging nettle dermatitis.
{"title":"Stinging nettle dermatitis.","authors":"Bryan E Anderson, Christopher J Miller, David R Adams","doi":"10.2310/6620.2003.38719","DOIUrl":"https://doi.org/10.2310/6620.2003.38719","url":null,"abstract":"<p><p>The stinging nettle (Urtica dioica) is a common weed that can cause a wide range of cutaneous reactions. Contact with the hairs or spines on the stems and leaves of the stinging nettle causes the release of several biologically active substances. The released chemicals act to cause itching, dermatitis, and urticaria within moments of contact. Extracts from the stinging nettle may provide therapeutic value for some inflammatory medical conditions. There is no standard treatment for stinging nettle dermatitis.</p>","PeriodicalId":7612,"journal":{"name":"American journal of contact dermatitis : official journal of the American Contact Dermatitis Society","volume":"14 1","pages":"44-6"},"PeriodicalIF":0.0,"publicationDate":"2003-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24181644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Label dermatitis.","authors":"N. Veien","doi":"10.2310/6620.2003.38449","DOIUrl":"https://doi.org/10.2310/6620.2003.38449","url":null,"abstract":"","PeriodicalId":7612,"journal":{"name":"American journal of contact dermatitis : official journal of the American Contact Dermatitis Society","volume":"66 1","pages":"104"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75077079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luis Conde-Salazar, Ruud Valks, María Antonia Pastor, María Elena Gatica, R. Núñez, Berta Perez Tato, C. Iglesias, Manuela Cuevas
A 35-year-old man presented with a 2-month history of intensely pruritic excoriated and crusted linear lesions on the dorsa of the left hand and left forearm (Fig 1). The patient had worked in construction for 2 years, and his job consisted mainly in covering the facades of buildings with cement. The patient was right-handed and used a black rubber glove as a protective measure only on his left hand (Fig 2). He reported that the lesions resolved partially during holidays and weekends and clearly flared in association with his work. There was no history of atopic dermatitis, drug use, or intolerance to metals, rubber, or fruits. On physical examination, linear excoriations with crusts were observed on the dorsa of the left hand, extending to the ventral and dorsal aspects of the forearm, involving the whole area that was in contact with the glove. Lichenified erythematous plaques and excoriations on the dorsal surface of the metacarpophalangeal joints and scaly lesions on the dorsal surfaces of the fingers were also present. On the palm, only discrete hyperkeratosis was seen. The right hand and forearm were free of lesions. He complained of intense pruritus when wearing the rubber glove and admitted to continuous scratching to relieve his discomfort, inducing the linear and excoriated lesions. Treatment with topical corticosteroids was initiated, with progressive resolution of the lesions.
{"title":"Dermatitis artefacta?","authors":"Luis Conde-Salazar, Ruud Valks, María Antonia Pastor, María Elena Gatica, R. Núñez, Berta Perez Tato, C. Iglesias, Manuela Cuevas","doi":"10.2310/6620.2003.38517","DOIUrl":"https://doi.org/10.2310/6620.2003.38517","url":null,"abstract":"A 35-year-old man presented with a 2-month history of intensely pruritic excoriated and crusted linear lesions on the dorsa of the left hand and left forearm (Fig 1). The patient had worked in construction for 2 years, and his job consisted mainly in covering the facades of buildings with cement. The patient was right-handed and used a black rubber glove as a protective measure only on his left hand (Fig 2). He reported that the lesions resolved partially during holidays and weekends and clearly flared in association with his work. There was no history of atopic dermatitis, drug use, or intolerance to metals, rubber, or fruits. On physical examination, linear excoriations with crusts were observed on the dorsa of the left hand, extending to the ventral and dorsal aspects of the forearm, involving the whole area that was in contact with the glove. Lichenified erythematous plaques and excoriations on the dorsal surface of the metacarpophalangeal joints and scaly lesions on the dorsal surfaces of the fingers were also present. On the palm, only discrete hyperkeratosis was seen. The right hand and forearm were free of lesions. He complained of intense pruritus when wearing the rubber glove and admitted to continuous scratching to relieve his discomfort, inducing the linear and excoriated lesions. Treatment with topical corticosteroids was initiated, with progressive resolution of the lesions.","PeriodicalId":7612,"journal":{"name":"American journal of contact dermatitis : official journal of the American Contact Dermatitis Society","volume":"118 1","pages":"93-4"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88034729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lidocaine hydrochloride.","authors":"Christine L. Mackley, J. Marks","doi":"10.2310/6620.2003.11748","DOIUrl":"https://doi.org/10.2310/6620.2003.11748","url":null,"abstract":"","PeriodicalId":7612,"journal":{"name":"American journal of contact dermatitis : official journal of the American Contact Dermatitis Society","volume":"360 1","pages":"221-3"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76461124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Procedures for supplying fragrance information to dermatologists.","authors":"Glen Roberts, Matthias Vey","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7612,"journal":{"name":"American journal of contact dermatitis : official journal of the American Contact Dermatitis Society","volume":"13 4","pages":"206-7"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22157430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lisa Garner, Jere Guin, William James, James A Yiannias
{"title":"Coping with negative test results in patch testing.","authors":"Lisa Garner, Jere Guin, William James, James A Yiannias","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7612,"journal":{"name":"American journal of contact dermatitis : official journal of the American Contact Dermatitis Society","volume":"13 4","pages":"203-5"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22157429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clothing tag pruritus.","authors":"John Zenian","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7612,"journal":{"name":"American journal of contact dermatitis : official journal of the American Contact Dermatitis Society","volume":"13 4","pages":"209-10"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22157433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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