Pub Date : 2016-04-12DOI: 10.24061/1727-4338.XV.2.56.2016.10
P. Hamet, D. Malo, J. Tremblay
{"title":"Genetic basis of increased sensitivity to environmental stress in hypertension.","authors":"P. Hamet, D. Malo, J. Tremblay","doi":"10.24061/1727-4338.XV.2.56.2016.10","DOIUrl":"https://doi.org/10.24061/1727-4338.XV.2.56.2016.10","url":null,"abstract":"","PeriodicalId":76154,"journal":{"name":"Methods and achievements in experimental pathology","volume":"15 1","pages":"27-46"},"PeriodicalIF":0.0,"publicationDate":"2016-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68976964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The relationships between emotional status, neurohormonal control and the cardiovascular function are reviewed. In the first part of this paper, we reviewed (1) the pathways between brain and heart, physiology of the defense reaction and the role of the autonomic nervous system in the mediation of the effects of stress; (2) the cardiac manifestations of emotional stress, and (3) the role of stress and the influence of circadian variations in the occurrence and development of myocardial ischemia, myocardial infarction and sudden death. In the second part, we discussed the relationship between behavior, coronary heart disease and particularly the role of the so-called type A behavior and hostility. Finally, we emphasize the importance of life-style changes to improve the prognosis of coronary disease and to limit the progression and ultimately to cause a regression of atherosclerosis. Thus, it appears that a transdisciplinary approach associating cardiologists, neuroscientists and behavior scientists will help to devise more effective strategies for the prevention and early therapy of cardiovascular disease.
{"title":"The effects of stress, emotion, and behavior on the heart.","authors":"A Pasternac, M Talajic","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The relationships between emotional status, neurohormonal control and the cardiovascular function are reviewed. In the first part of this paper, we reviewed (1) the pathways between brain and heart, physiology of the defense reaction and the role of the autonomic nervous system in the mediation of the effects of stress; (2) the cardiac manifestations of emotional stress, and (3) the role of stress and the influence of circadian variations in the occurrence and development of myocardial ischemia, myocardial infarction and sudden death. In the second part, we discussed the relationship between behavior, coronary heart disease and particularly the role of the so-called type A behavior and hostility. Finally, we emphasize the importance of life-style changes to improve the prognosis of coronary disease and to limit the progression and ultimately to cause a regression of atherosclerosis. Thus, it appears that a transdisciplinary approach associating cardiologists, neuroscientists and behavior scientists will help to devise more effective strategies for the prevention and early therapy of cardiovascular disease.</p>","PeriodicalId":76154,"journal":{"name":"Methods and achievements in experimental pathology","volume":"15 ","pages":"47-57"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12926517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Implication of brain corticosteroid receptor diversity for the adaptation syndrome concept.","authors":"E R de Kloet, M Joëls, M Oitzl, W Sutanto","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76154,"journal":{"name":"Methods and achievements in experimental pathology","volume":"14 ","pages":"104-32"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13103551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stress modulation of learning and memory processes.","authors":"D De Wied, G Croiset","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76154,"journal":{"name":"Methods and achievements in experimental pathology","volume":"15 ","pages":"167-99"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12827616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L Rappaport, F Contard, I Dubus, B Swynghedauw, J L Samuel
{"title":"Stress-induced proto-oncogenes in the myocardium.","authors":"L Rappaport, F Contard, I Dubus, B Swynghedauw, J L Samuel","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76154,"journal":{"name":"Methods and achievements in experimental pathology","volume":"15 ","pages":"84-103"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12998368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Role of interleukins in the stress response.","authors":"C Rivier","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76154,"journal":{"name":"Methods and achievements in experimental pathology","volume":"14 ","pages":"63-79"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13103553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stress and catecholamines.","authors":"O Kuchel","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76154,"journal":{"name":"Methods and achievements in experimental pathology","volume":"14 ","pages":"80-103"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13103554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L D Van de Kar, K D Richardson-Morton, P A Rittenhouse
{"title":"Stress: neuroendocrine and pharmacological mechanisms.","authors":"L D Van de Kar, K D Richardson-Morton, P A Rittenhouse","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76154,"journal":{"name":"Methods and achievements in experimental pathology","volume":"14 ","pages":"133-73"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12847649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Physiologic stress results in significant alterations in the release of multiple cytokines. Increased production of interleukin-1 (IL-1) occurs following hemorrhage and thermal injury. Hemorrhage, accidental trauma and burns are followed by decreased interleukin-2 (IL-2) generation. Production of interleukin-3 (IL-3) and interleukin-5 (IL-5) is diminished following hemorrhage. Gamma-interferon release appears to be increased following hemorrhage. Stress secondary to infection is accompanied by marked elevations in serum levels of tumor necrosis factor (TNF), which contribute to hypotension and physiologic instability in this setting. Alterations in cytokine release probably play important roles in mediating alterations in immunologic, hemodynamic and cardiorespiratory function known to occur following physiologic stress. The production of all cytokines so far examined is altered by stress. Increased generation of IL-1, and probably of TNF and IL-6, contributes to the acute-phase reaction and hypermetabolic response which accompanies injury, burns, hemorrhage, and overwhelming infection. Severe immunosuppression, involving both T and B cell function, and contributing to the increased incidence of infection after injury may result, at least in part, from the multiple actions of stress-induced alterations in interleukin release. T cell activation is clearly affected by injury-induced decreases in IL-2, IL-3, and IFN-gamma release. Similarly, the depressed generation of systemic and mucosal antibodies to bacterial antigens following injury may be affected by alterations in the production of cytokines affecting B cell function, namely IL-1, IL-2, IL-3, IL-5 and IFN-gamma.(ABSTRACT TRUNCATED AT 250 WORDS)
{"title":"Effects of stress on cytokine production.","authors":"E Abraham","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Physiologic stress results in significant alterations in the release of multiple cytokines. Increased production of interleukin-1 (IL-1) occurs following hemorrhage and thermal injury. Hemorrhage, accidental trauma and burns are followed by decreased interleukin-2 (IL-2) generation. Production of interleukin-3 (IL-3) and interleukin-5 (IL-5) is diminished following hemorrhage. Gamma-interferon release appears to be increased following hemorrhage. Stress secondary to infection is accompanied by marked elevations in serum levels of tumor necrosis factor (TNF), which contribute to hypotension and physiologic instability in this setting. Alterations in cytokine release probably play important roles in mediating alterations in immunologic, hemodynamic and cardiorespiratory function known to occur following physiologic stress. The production of all cytokines so far examined is altered by stress. Increased generation of IL-1, and probably of TNF and IL-6, contributes to the acute-phase reaction and hypermetabolic response which accompanies injury, burns, hemorrhage, and overwhelming infection. Severe immunosuppression, involving both T and B cell function, and contributing to the increased incidence of infection after injury may result, at least in part, from the multiple actions of stress-induced alterations in interleukin release. T cell activation is clearly affected by injury-induced decreases in IL-2, IL-3, and IFN-gamma release. Similarly, the depressed generation of systemic and mucosal antibodies to bacterial antigens following injury may be affected by alterations in the production of cytokines affecting B cell function, namely IL-1, IL-2, IL-3, IL-5 and IFN-gamma.(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":76154,"journal":{"name":"Methods and achievements in experimental pathology","volume":"14 ","pages":"45-62"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13103552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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