{"title":"Morphology of myocardial infarction.","authors":"M Cantin, A Leone","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76154,"journal":{"name":"Methods and achievements in experimental pathology","volume":"10 ","pages":"244-84"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18094430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The polypeptide hormone-producing neuroendocrine cells and their tumors: an immunohistochemical analysis.","authors":"R A DeLellis, H J Wolfe","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76154,"journal":{"name":"Methods and achievements in experimental pathology","volume":"10 ","pages":"190-220"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17191370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chromosome markers in human cancers.","authors":"A Kessous","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76154,"journal":{"name":"Methods and achievements in experimental pathology","volume":"10 ","pages":"138-61"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18094428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tracer and marker techniques in the microscopic study of skeletal muscles.","authors":"G Karpati, S Carpenter, S Pena","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76154,"journal":{"name":"Methods and achievements in experimental pathology","volume":"10 ","pages":"101-37"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17244236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evidence and appraisal of adverse reactions to drugs and other preparations used in hospital practice: detection, validation, outlook for the future.","authors":"J S Campbell, N Z Mikhael, E Napke","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76154,"journal":{"name":"Methods and achievements in experimental pathology","volume":"10 ","pages":"221-43"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18094429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The cytoskeletal proteins, actin, myosin, tubulin, dynein, and their associated proteins, are discussed selectively with regards to their biochemical and structural properties. Particular emphasis is placed on the comparison of non-muscle proteins to their muscle counterparts, and on the various mechanisms for regulating actin polymerization, actin-myosin interaction, and tubulin polymerization. This review as well as the bibliography accompanying it is selective. An attempt is made to stress the most recent findings and to emphasize those areas which appear to hold the greatest promise for future research.
{"title":"The cytoskeleton and cell movement: general considerations.","authors":"R S Adelstein, S P Scordilis, J A Trotter","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The cytoskeletal proteins, actin, myosin, tubulin, dynein, and their associated proteins, are discussed selectively with regards to their biochemical and structural properties. Particular emphasis is placed on the comparison of non-muscle proteins to their muscle counterparts, and on the various mechanisms for regulating actin polymerization, actin-myosin interaction, and tubulin polymerization. This review as well as the bibliography accompanying it is selective. An attempt is made to stress the most recent findings and to emphasize those areas which appear to hold the greatest promise for future research.</p>","PeriodicalId":76154,"journal":{"name":"Methods and achievements in experimental pathology","volume":"8 ","pages":"1-41"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11372832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The cytoskeleton and cell division.","authors":"J W Sanger, J M Sanger","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76154,"journal":{"name":"Methods and achievements in experimental pathology","volume":"8 ","pages":"110-42"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11578052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Smooth muscle antoantibodies are found in high titre in some patients with chronic active hepatitis, and in lower titres in a number of other liver diseases and certain viral infections. They are directed at contractile proteins of the actomyosin group, and anti-actin activity appears to predominate. Whether occurring in disease affecting the liver or in other conditions, smooth muscle antibody production is thought to be stimulated when contractile proteins of non-muscle cells become immunogenic as a result of changes induced in the cells by viral infection or by other unknown causes of derangement of cytoskeletal structure.
{"title":"Contractile proteins as autoantigens.","authors":"E J Holborow","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Smooth muscle antoantibodies are found in high titre in some patients with chronic active hepatitis, and in lower titres in a number of other liver diseases and certain viral infections. They are directed at contractile proteins of the actomyosin group, and anti-actin activity appears to predominate. Whether occurring in disease affecting the liver or in other conditions, smooth muscle antibody production is thought to be stimulated when contractile proteins of non-muscle cells become immunogenic as a result of changes induced in the cells by viral infection or by other unknown causes of derangement of cytoskeletal structure.</p>","PeriodicalId":76154,"journal":{"name":"Methods and achievements in experimental pathology","volume":"9 ","pages":"244-60"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11577974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Several lines of evidence point to the existence of unpolymerised actin in non-muscle cells. Ultrastructural examination reveals both a variety of actin filament bundles and actin in a controversial organisational state. Arguments are cited that this material, which at least in part is found close to the plasma membrane, represents unpolymerised actin rather than a random array of single actin filaments. The rearrangement of actin filament bundles during the cell cycle, and in response to experimental manipulation, suggests a turnover of filaments by a polymerisation-depolymerisation cycle. Extracts made from non-muscle cells under conditions where muscle actin would polymerise still contain appreciable fractions of monomeric actin. Studies on purified polymerisation-resistant actin from a variety of sources reveal the presence of a small protein which binds specifically to actin and prevents polymerisation. In the last section of the article, we expand the idea that this auxiliary protein is a central control element in the regulated exchange between non-polymerised and polymerised actin in vivo.
{"title":"The unpolymerised form of actin in non-muscle cells.","authors":"U Lindberg, L Carlsson, F Markey, L E Nyström","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Several lines of evidence point to the existence of unpolymerised actin in non-muscle cells. Ultrastructural examination reveals both a variety of actin filament bundles and actin in a controversial organisational state. Arguments are cited that this material, which at least in part is found close to the plasma membrane, represents unpolymerised actin rather than a random array of single actin filaments. The rearrangement of actin filament bundles during the cell cycle, and in response to experimental manipulation, suggests a turnover of filaments by a polymerisation-depolymerisation cycle. Extracts made from non-muscle cells under conditions where muscle actin would polymerise still contain appreciable fractions of monomeric actin. Studies on purified polymerisation-resistant actin from a variety of sources reveal the presence of a small protein which binds specifically to actin and prevents polymerisation. In the last section of the article, we expand the idea that this auxiliary protein is a central control element in the regulated exchange between non-polymerised and polymerised actin in vivo.</p>","PeriodicalId":76154,"journal":{"name":"Methods and achievements in experimental pathology","volume":"8 ","pages":"143-70"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11578053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The role of microfilaments and microtubules comprising the cytoskeleton and cytomusculature in embryonic development is discussed. The cytomusculature, as microfilaments, is evident in both the unfertilized and fertilized egg and probably plays a role in sperm incorporation, cortical contractions, and cytokinesis. The cytoskeleton, in the form of microtubules, appears after fertilization in the form of the sperm aster and the mitotic apparatus. The cytoskeleton and cytomusculature play a decisive role in shape changes of individual cells responsible for gastrulation, neurulation, and morphogenesis of other epithelial sheets. Several developmental defects, such as spina bifida, may be related to malfunctioning of the cytoskeleton or cytomusculature. The putative role of microfilaments and microtubules in cell shape changes during embryogenesis can best be, at least initially, inferred from careful ultrastructural observations.
{"title":"The cytoskeleton and cytomusculature in embryogenesis--an overview.","authors":"D R Burgess, T E Schroeder","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The role of microfilaments and microtubules comprising the cytoskeleton and cytomusculature in embryonic development is discussed. The cytomusculature, as microfilaments, is evident in both the unfertilized and fertilized egg and probably plays a role in sperm incorporation, cortical contractions, and cytokinesis. The cytoskeleton, in the form of microtubules, appears after fertilization in the form of the sperm aster and the mitotic apparatus. The cytoskeleton and cytomusculature play a decisive role in shape changes of individual cells responsible for gastrulation, neurulation, and morphogenesis of other epithelial sheets. Several developmental defects, such as spina bifida, may be related to malfunctioning of the cytoskeleton or cytomusculature. The putative role of microfilaments and microtubules in cell shape changes during embryogenesis can best be, at least initially, inferred from careful ultrastructural observations.</p>","PeriodicalId":76154,"journal":{"name":"Methods and achievements in experimental pathology","volume":"8 ","pages":"171-89"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11578055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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