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STUDY OF THE DISTRIBUTION OF STRESSES IN THE ELEMENTS OF THE STERNO-COSTAL COMPLEX AND METAL PLATES IN THE CASE OF MINIMALLY INVASIVE CORRECTION OF THE FUNNEL-SHAPED DEFORMATION OF THE CHEST ACCORDING TO NUSS 根据nuss微创矫正胸部漏斗形变形时胸骨-肋复合构件及金属板应力分布的研究
Pub Date : 2023-10-18 DOI: 10.15674/0030-59872023328-35
Vlasii Pylypko, Anatolii Levytskyi, Mykhailo Karpinsky, Olena Karpinska, Olexander Yaresko
In severe forms, funnel-shaped chest deformity (FSCD) requires surgical correction. The method of choice is the Nuss operation and its modifications. Objective. To study the changes that occur in the stressed-deformed state of the chest model and the fixator under different methods of its implementation during the minimally invasive correction of FSCD according to Nuss. Material and methods. 4 schemes of FSCD correction were modeled: 1 — alignment with one retrosternal plate with transverse stabilizers, the point of entry and exit of the fixator is located parasternal at the level of the bone-cartilage transition, the fixator on the sides of the chest ends at the level of the front axillary line; 2 — sternal plate with transverse stabilizers, the point of entry and exit is located at the level of the front armpit line, the fixator ends at the level of the middle armpit line; 3 — the use of a double plate with transverse bars that connect the plates with the help of screws with medial conduction; 4 — a double plate with transverse slats, which connect the plates with the help of screws with lateral guidance. The models were loaded with a distributed force of 100 N applied to the sternum. The results. When using FSCD correction schemes, the maximum level of stress occurs in the metal plates, because they bear the main loads from the sternum, which tries to return to its original position after correction. The same reason causes the highest level of stress among the elements of the skeleton in the sternum. Conclusions. Under the conditions of using any FSCD correction scheme, the maximum stress level occurs in the metal plates, sternum, fifth and sixth ribs, which are in direct contact with the plates. The use of long plates with lateral points leads to a slight decrease in stress values in all elements of the model. The «Bridge» fastener allows you to significantly reduce the level of stress, both in the plates themselves and in the elements of the skeleton due to an increase in their contact area.
在严重的情况下,漏斗状胸部畸形(FSCD)需要手术矫正。选择的方法是努斯手术及其修正。目标。根据Nuss研究FSCD微创矫正过程中不同实施方法下胸部模型及固定架受力变形状态的变化。材料和方法。模拟了4种FSCD矫正方案:1 -采用带横向稳定器的一个胸骨后钢板对准,固定架的进出点位于胸骨旁的骨-软骨过渡水平,胸部两侧的固定架末端位于前腋窝线水平;2 -胸骨板带横向稳定器,进出点位于腋窝前线水平,固定架止于腋窝中线水平;3 -使用带横杆的双板,借助螺钉内侧传导连接板;4 -带横向板条的双板,通过带横向导向的螺钉将板连接起来。这些模型在胸骨上施加了100牛的分布力。结果。当使用FSCD校正方案时,最大的应力水平发生在金属板上,因为它们承受来自胸骨的主要载荷,胸骨在校正后试图返回其原始位置。同样的原因导致骨骼各部分中压力最大的是胸骨。结论。在使用任何FSCD校正方案的情况下,最大应力水平发生在与板直接接触的金属板,胸骨,第五和第六肋骨。使用带侧点的长板导致模型中所有元素的应力值略有下降。由于接触面积的增加,“桥”紧固件可以显着降低板本身和骨架元素的应力水平。
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引用次数: 0
HISTOLOGICAL STRUCTURE OF THE RAT FEMURS AFTER FILLING OF DEFECTS IN THE DISTAL METAPHYSIS WITH 3D-PRINTED IMPLANTS BASED ON POLYLACTIDE AND TRICALCIUM PHOSPHATE IN COMBINATION WITH MESENCHYMAL STROMAL CELLS 基于聚乳酸和磷酸三钙结合间充质间质细胞的3d打印植入物填充远端干骺端缺损后大鼠股骨的组织学结构
Pub Date : 2023-10-18 DOI: 10.15674/0030-59872023343-50
Nataliya Ashukina, Nazar Gontar, Zinaida Danуshchuk, Olga Nikolchenko, Yaryna Kaliyuzhna
Polylactide (PLA) frameworks printed on a 3D printer are used for filling the bone defects. The osteotropic properties of 3D-PLA can be improved by combining with tricalcium phosphate (TCP) and mesenchymal stromal cells (MSCs). Objective. Study the reconstruction in the rat femurs after implanting 3D-printed implants based on PLA and TCP (3D-I) in combination with cultured allogeneic MSCs into defects in the distal metaphysis. Methods. 48 white laboratory rats (age 5–6 months) were used, which were randomly divided into groups: Control — 3D-I; Experiment-I — 3D-I, saturated MSCs; Experiment II — 3D-I, with injection of 0.1‒0.2 ml of medium with MSCs into the area of surgical intervention 7 days after implantation. 15, 30 and 90 days after the operation, histological (with histomorphometry) studies were conducted. Results. The area of 3D-I decreased with time in all groups and connective and bone tissues formed in different ratios. 15 days after the surgery, in the Experiment-I group, the area of the connective tissue was 1.9 and 1.6 times greater (p<0.001) in comparison to the Control and Experiment II; 30 days it was greater 1.6 times (p < 0.001) and 1.4 times (p=0.001), respectively. 30 days after the surgery, the area of newly formed bone in the Experiment-I group was 2.2 times (p < 0.001) less than in the Control. On the contrary, in the Experiment-II, the area of newly formed bone was 1.5 and 3.3 times greater (p < 0.001) compared to Experiment-I and Control, respectively. Conclusions. The studied 3D-I with time after their implantation into the metaphyseal defects of the rats’ femurs are replaced by connective and bone tissues. The use of 3D-I, saturated MSCs, 15 and 30 days after the surgery, caused excessive formation of connective tissue and slower bone formation. Local injection of MSCs 7 days after the implantation of 3D-I caused to the formation of a larger area of newly bone 30th day after surgery compared to 3D-I alone and 3D-I with MSCs.
在3D打印机上打印聚乳酸(PLA)框架用于填充骨缺损。3D-PLA与磷酸三钙(TCP)和间充质基质细胞(MSCs)结合可提高其成骨性能。目标。研究基于PLA和TCP (3D-I)的3d打印假体与培养的异体间充质干细胞联合植入远端干骺端缺损后大鼠股骨的重建。方法:选用5 ~ 6月龄实验用白色大鼠48只,随机分为对照组- 3D-I组;实验- 1 - 3d - 1,饱和MSCs;实验II - 3D-I,植入7天后在手术介入区注射0.1-0.2 ml含MSCs的培养基。术后15、30、90天进行组织学(组织形态学)研究。结果。各组3D-I面积均随时间减少,结缔组织和骨组织形成比例不同。术后15天,实验一组结缔组织面积分别比对照组和实验二组大1.9倍和1.6倍(p < 0.001);30天则增加了1.6倍(p;0.001)和1.4倍(p=0.001)。术后30 d,实验一组新生骨面积为对照组的2.2倍(p <0.001)小于对照组。相反,在实验- ii中,新形成骨的面积增加了1.5倍和3.3倍(p <0.001),分别与实验1和对照组相比。结论。所研究的3D-I植入大鼠股骨干骺端缺损后,随时间推移被结缔组织和骨组织所取代。术后15天和30天使用3D-I,饱和MSCs,导致结缔组织过度形成,骨形成缓慢。植入3D-I后第7天局部注射MSCs,术后第30天新生骨的形成面积比单独使用3D-I和3D-I结合MSCs大。
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引用次数: 0
Principles of pharmacological therapy of comorbid diseases in patients with orthopedic pathology 骨科病理患者合并症的药物治疗原则
Pub Date : 2023-09-11 DOI: 10.15674/0030-59872020464-71.
Nataliya Prytula, Inga Fedotova, Iryna Korzh
Comorbidity is one of the leading problems in clinical practice. Interaction of diseases, involutive processes of natural aging and pathomorphosis of drugs significantly change clinical picture and course of the disease, the nature and severity of complications, limit or complicate the treatment and diagnostic process. Objective. To analyze current information on available recommendations for the treatment of comorbid diseases in patients with orthopedic pathology. Materials. An overview of the recommendations of the European Society of Cardiology, European Society of Hypertension, European Society for Vascular Surgery, Ukrainian Gastroenterological Association and American Diabetes Association for the period 2017–2019 is presented. Results. The first stage in the treatment of arterial hypertension is the lifestyle optimization, and the initial therapy of most patients with hypertension should be a combination of two drugs. Management of patients with lower extremity artery disease is associated with an increased risk of any cardiovascular events. Therefore, preventive measures are of particular importance. Gastropathies induced by non-steroidal anti-inflammatory drugs are widespread in orthopedic practice. In the prevention of their occurrence, a well-chosen gastroprotective therapy is important. Once the diagnosis of diabetes is made, lifestyle modification should be started immediately along with the start of pharmacotherapy. Metformin remains the first-line drug for treatment, drugs of other groups can be prescribed when there are contraindications to metformin. In the treatment of neuropathic pain in diabetes or pre-diabetes, only pharmacological treatment strategies are effective. Conclusions. In most cases, a number of comorbidities with timely diagnosis and compliance with the algorithms of medical care can be corrected and treated. Properly selected conservative therapy can reduce the risk of peri- and postoperative complications.
合并症是临床实践中的主要问题之一。疾病的相互作用、自然衰老的相互影响过程和药物的病理形态显著地改变了疾病的临床表现和病程、并发症的性质和严重程度,限制或复杂化了治疗和诊断过程。目标。分析骨科病理患者共病治疗的现有建议信息。材料。概述了欧洲心脏病学会、欧洲高血压学会、欧洲血管外科学会、乌克兰胃肠病学协会和美国糖尿病协会在2017-2019年期间的建议。结果。动脉高血压治疗的第一阶段是生活方式的优化,大多数高血压患者的初始治疗应该是两种药物的联合治疗。下肢动脉疾病患者的管理与任何心血管事件的风险增加相关。因此,预防措施尤为重要。非甾体类抗炎药引起的胃病在骨科实践中很普遍。为了预防它们的发生,精心选择的胃保护疗法是重要的。一旦诊断出糖尿病,应立即开始改变生活方式,同时开始药物治疗。二甲双胍仍是治疗的一线药物,其他组有二甲双胍禁忌症时可开药。在糖尿病或糖尿病前期神经性疼痛的治疗中,只有药物治疗策略是有效的。结论。在大多数情况下,一些合并症的及时诊断和遵守的算法的医疗保健可以纠正和治疗。选择适当的保守治疗可以减少围手术期和术后并发症的发生。
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引用次数: 0
DIAGNOSTIC CAPABILITIES OF ULTRASOUND EXAMINATION OF THE KNEE JOINT AT THE CURRENT STAGE (LITERATURE REVIEW) 膝关节超声检查在现阶段的诊断能力(文献综述)
Pub Date : 2023-06-27 DOI: 10.15674/0030-598720232101-109
O. Baburkina, Oleg Ovchynnikov, Maryna Bludova
Ultrasound examination (ultrasound) of the knee joint left is one of the main methods of diagnosing its diseases and injuries, which are constantly improved thanks to the use of more accurate diagnostic equipment. Objection. Analyze modern scientific and practical information regarding the possibilities of ultrasound examination of the knee joint and determine pathological changes in its tissues, for the diagnosis of which this technique can be used. Methods. Selected and analyzed scientific articles for the last 6 years, in which the use of knee joint ultrasound is given from the Google search engine, scientific metrics databases PubMed, Medline and other relevant sources scientific and medical information. Results. Analyzed modern literature on the use of knee joint ultrasound in medical practice. Defined orthopedic pathological diseases and areas of the knee joint which investigated by ultrasound. This technique is used for diagnosis of gonarthrosis, synovitis, assessment blood circulation and fluid in the knee joint, Backer's cyst, neoplasms, pathology of menisci, injuries and inflammations ligaments, tendons and muscles. Most doctors and patients prefer the ultrasound technique due to its mobility, without heartburn, almost complete absence of contraindications to carrying out. Today, this research is necessary and an effective method of diagnosing orthopedic pathology traumatic diseases, including knee joint, both individually and in combination with other methods (radiography, computer tomography, magnetic resonance tomography, etc.). It should be noted that the method ultrasound becomes indispensable in case of contraindications to the procedure magnetic resonance imaging. Conclusions. Ultrasound of the patient of diseases and injuries of the knee joint is modern and effective by the method of express diagnostics and can be used both independently and in combination with other methods of diagnostics of pathological changes in the tissues of this localization.
左膝关节的超声检查是诊断其疾病和损伤的主要方法之一,由于使用了更准确的诊断设备,这一方法不断得到改进。反对分析有关膝关节超声检查可能性的现代科学和实用信息,并确定其组织的病理变化,这项技术可用于诊断。方法。选择并分析了过去6年的科学文章,其中膝关节超声的使用来自谷歌搜索引擎、科学指标数据库PubMed、Medline和其他相关来源的科学和医学信息。后果分析了有关膝关节超声在医学实践中的应用的现代文献。通过超声检查确定膝关节的骨科病理疾病和区域。该技术用于诊断膝关节病、滑膜炎、评估膝关节血液循环和液体、Backer囊肿、肿瘤、半月板病理、损伤和炎症韧带、肌腱和肌肉。大多数医生和患者更喜欢超声波技术,因为它可以移动,没有烧心,几乎完全没有禁忌。今天,这项研究是诊断骨科病理创伤疾病的必要和有效的方法,无论是单独使用还是与其他方法(射线照相、计算机断层扫描、磁共振断层扫描等)结合使用。应注意的是,在磁共振成像程序有禁忌症的情况下,超声方法变得不可或缺。结论。膝关节疾病和损伤患者的超声是现代的,并且通过表达诊断的方法是有效的,并且可以独立使用,也可以与诊断该定位的组织中的病理变化的其他方法结合使用。
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引用次数: 0
DEVELOPMENT OF THE REHABILITATION SYSTEM IN UKRAINE. ORGANIZATIONAL ASPECTS 乌克兰康复系统的发展。组织方面
Pub Date : 2023-06-27 DOI: 10.15674/0030-59872023277-83
O. Sitenko
The war and Russian aggression against Ukraine require government and society long-term extraordinary efforts. It’s not only in the field of the destroyed economy. The primary necessity is to restore a dignified life to every person affected by the war, military or civilian. The fate of each of us, our society, and our country in general will depend on efforts effectiveness in this direction. Objective. To develop and substantiate proposals for a systematic approach to the provision of medical rehabilitation assistance in the country. Results. The principles on which it is expedient to create a system of rehabilitation assistance in Ukraine have been formulated and substantiated. They are the principles of statehood, modernity, science, continuity, phasing and unified tactics, regionalism, specializations, self-rehabilitation. Each principle is briefly described, the experience of the world's leading countries is given. The stateand society role in the rehabilitation process is noted. Proposals. Develop a strategy, concept and government program for creating a rehabilitation assistance system in Ukraine. Provide a construction and equipment of regional rehabilitation centers (RC) within the post-war country renovation program. It has to be used worldwide principles of new hospital’s design and construction regarding the 200 inpatient beds in the unit. To locate RC outside of bigcities, usually. Training of rehabilitation specialists should be provided in various levels medical educational institutions. Modified vehicles to manual control for disable people and training in its use. To prevent the liquidation of Ukrainian Research Prosthetics Institution. To transfer this institution functions and the property complex to Sytenko Institute of Spine and Joint Pathology National Ukrainian Academy of Medical Sciences. To transfer research medical rehabilitation organizer and executor functions to the National Ukrainian Academy of Medical Sciences, in generally.
战争和俄罗斯对乌克兰的侵略需要政府和社会做出长期的非凡努力。这不仅仅是在被摧毁的经济领域。首要的必要性是使每一个受战争影响的人,无论是军人还是平民,恢复有尊严的生活。我们每个人、我们的社会和我们整个国家的命运将取决于朝着这个方向所做的努力的有效性。客观的制定并落实在该国提供医疗康复援助的系统方法的建议。后果在乌克兰建立康复援助制度所依据的原则已经制定并得到证实。它们是国家性、现代性、科学性、连续性、阶段性和统一策略、区域主义、专业化和自我康复的原则。对每一项原则进行了简要的介绍,并给出了世界领先国家的经验。指出了国家和社会在康复过程中的作用。建议书。制定在乌克兰建立康复援助系统的战略、概念和政府计划。在战后国家翻新计划中提供区域康复中心(RC)的建筑和设备。它必须在世界范围内使用新医院的设计和建设原则,即该单元的200张住院床位。通常将RC定位在大城市之外。各级医学教育机构应当对康复专家进行培训。将车辆改装为残疾人手动控制,并对其使用进行培训。防止乌克兰假肢研究所破产。将该机构的职能和财产综合体移交给乌克兰国立医学科学院Sytenko脊柱和联合病理研究所。将研究医疗康复组织者和执行者的职能移交给乌克兰国家医学科学院。
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引用次数: 0
REHABILITATION OF PATIENTS AFTER SURGICAL TREATMENT OF STATIC DEFORMITIES OF THE FOREFOOT 前足静态畸形手术治疗后患者的康复
Pub Date : 2023-06-27 DOI: 10.15674/0030-59872023291-95
D. Prozorovskiy, V. Staude, R. Buznytskiy
Postoperative rehabilitation of patients with hallux valgus is just as important, if not more so, than a technically flawless surgical intervention. Carrying out rehabilitation measures is an integral part of the postoperative period, which must be individual for each patient and depend on the volume and type of surgical intervention, the patient's age, and accompanying pathology. Objective. To improvethe results of the recovery of patients after orthopedic surgical interventions on the front part of the foot due to the developed complex system of postoperative rehabilitation. Methods. The articleprovides an analysis of the results of treatment of 70 patients with transversely spread deformation of the forefoot and hallux valgus 1–2 degrees using different approaches to rehabilitation measuresin the postoperative period. The patients were divided into 2 homogeneous groups by age, gender and degree of hallux valgus. Unlike the control group, manual therapy and myofascial massagetechniques were additionally used in the main group. The results. The results of the treatment were evaluated according to the AOFAS scoring scale for the forefoot, which is generally accepted inthe world. In the preoperative period, the average AOFAS score in the main and control groups was 65.4 and 64.7 points, respectively. 45 days after surgery, the average scores were 74.7 and 74.4 points,respectively. After 60 days, the average score in the main group was 92.1 points, and 82.6 in the control group. 3 months (90 days) after the surgical interventions, the average scores practically coincided in both groups and amounted to 93.7 points in the control group and 95.0 in the main group. The patients of the main group resumed their usual activities after 2 months. after the operation onthe front part of the foot, and the control after 3 months. Conclusions. The use of myofascial massage, manual therapy for mobilizing the metatarsophalangeal and interphalangeal joints of the toes with gymnastics to strengthen not only the stabilizers of the foot, but also to restore the bearing capacity of the girdle of the lower extremities and the stereotype of walking, made it possible to obtainnot only a positive functional result, but also to speed up the recovery compared to the control group per month.
拇外翻患者的术后康复与技术上完美的手术干预同样重要,甚至更重要。实施康复措施是术后阶段的一个组成部分,术后阶段必须针对每个患者,并取决于手术干预的数量和类型、患者的年龄和伴随的病理学。客观的由于复杂的术后康复系统的发展,提高患者在足部前部骨科手术干预后的康复效果。方法。本文分析了70例前足横向伸展变形和拇外翻1-2度患者术后采用不同康复措施的治疗结果。患者按年龄、性别和拇外翻程度分为2组。与对照组不同,主要组额外使用了手法治疗和肌筋膜按摩技术。结果。根据国际公认的前掌AOFAS评分表对治疗结果进行评估。术前,主要组和对照组的平均AOFAS评分分别为65.4分和64.7分。术后45天,平均得分分别为74.7分和74.4分。60天后,主组的平均得分为92.1分,对照组为82.6分。手术干预后3个月(90天),两组的平均得分几乎一致,对照组为93.7分,主组为95.0分。主要组患者在2个月后恢复了正常活动。术后足前部,对照3个月。结论。采用肌筋膜按摩、手法治疗结合体操活动趾跖趾和趾间关节,不仅增强了足部的稳定器,还恢复了下肢束带的承受能力和行走的刻板印象,不仅取得了积极的功能效果,而且与对照组相比每月也能加快恢复速度。
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引用次数: 0
CHONDROSARCOMA IN THE XXI CENTURY 二十一世纪的软骨肉瘤
Pub Date : 2023-06-27 DOI: 10.15674/0030-59872023256-75
O. Vyrva
Chondrosarcoma (CHS) is a rare oncopathology, is the third most common primary bone tumor after multiple myeloma and osteosarcoma. It accounts for about 25 % of the total number of bone sarcomas. CHS mainly affects adults and occurs more often in people older than 40 years, in children and adolescents it is less than 5 % of all cases of primary CHS. The most common CHS sites can be any bone containing cartilage, but most often this tumor is found in pelvis, femur and shoulder bones, and ribs. CHS are divided: by origin (primary and secondary), anatomical site (central — inside the bone marrow canal, peripheral — inside the existing osteochondroma, periosteal — on the bone surface), histological degrees GI-GII-GIII. The WHO classification (2020) includes central normal, secondary peripheral, periosteal, dedifferentiated, mesenchymal and clear-cell CHS. More than 90 % of conventional CHS are tumors of low and medium malignancy degree, with a low potential for metastasis. CHS is caused by mutations in genes that control bone growth and development. The main risk factors are the patientʼs age, previous radiation, genetic factors and predisposition to oncological diseases. Diagnosis of CHS is based on a complex algorithm, which involves collecting the patient's complaints, anamnesis, clarifying clinical symptoms, imaging (X-ray, CT, MRI), histopathological picture. The biopsy conclusion is the most important in establishing the final diagnosis. However, there are several tumors whose histological picture is similar to CHS: enchondroma, chondroblastoma, osteosarcoma, giant cell tumor of bone, dedifferentiated liposarcoma, synovial sarcoma. The CHS treatment protocol is determined based on the results of anamnestic data, imaging, histopathological results, CHS classification, and its final tumor subtype. The «gold standard» remains surgical removal of the tumor. Radiation and chemotherapy don’t play a significant role in the treatment of CHS, but require further study. Targeted and immunotherapy have a certain potential, even with a high degree of CHS resistance to traditional chemotherapy.
软骨肉瘤(CHS)是一种罕见的肿瘤病理,是继多发性骨髓瘤和骨肉瘤之后第三常见的原发性骨肿瘤。约占骨肉瘤总数的25%。CHS主要影响成年人,多发生在40岁以上的人群中,在儿童和青少年中,占所有原发性CHS病例的不到5%。最常见的CHS部位可以是任何含有软骨的骨骼,但最常见的是在骨盆、股骨、肩骨和肋骨。CHS分为:起源(原发性和继发性),解剖部位(中央-在骨髓管内,周围-在现有骨软骨瘤内,骨膜-在骨表面),组织学程度GI-GII-GIII。世卫组织分类(2020年)包括中央正常、继发性外周、骨膜、去分化、间充质和透明细胞CHS。传统CHS 90%以上为中低恶性程度肿瘤,转移潜力低。CHS是由控制骨骼生长和发育的基因突变引起的。主要危险因素是患者的年龄、既往放疗、遗传因素和肿瘤易感性。CHS的诊断是基于一个复杂的算法,包括收集患者的主诉,记忆,澄清临床症状,影像学(x线,CT, MRI),组织病理图片。活检结论是确定最终诊断最重要的。然而,有几种肿瘤的组织学表现与CHS相似:内生性软骨瘤、成软骨细胞瘤、骨肉瘤、骨巨细胞瘤、去分化脂肪肉瘤、滑膜肉瘤。CHS的治疗方案是根据记忆资料、影像学、组织病理学结果、CHS分类及其最终肿瘤亚型的结果来确定的。“金标准”仍然是手术切除肿瘤。放疗和化疗在治疗CHS中的作用不明显,有待进一步研究。靶向和免疫治疗具有一定的潜力,即使CHS对传统化疗的耐药程度很高。
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引用次数: 0
HISTOLOGICAL EVALUATION OF REPARATIVE OSTEOGENESIS IN CRITICAL SIZE FEMORAL BONE DEFECTS IN RATS OF DIFFERENT AGES AFTER INTRODUCTION OF ALLOGRAFTS SATURATED WITH BLOOD PLASMA GROWTH FACTORS 血浆生长因子饱和同种异体移植对不同年龄大鼠股骨缺损修复性成骨的组织学评价
Pub Date : 2023-06-27 DOI: 10.15674/0030-59872023225-32
P. Vorontsov, N. Ashukina, Valentyna Maltseva, Zinaida Danуshchuk, O. Nikolchenko, Kateryna Samoylova
The increase in injuries and gunshot wounds because of the war in Ukraine makes it imperative to find methods for optimizing bone regeneration and filling large-size bone defects. Aim. Study morphological features of reparative osteogenesis when critical size femoral bone defects in rats in the early reproductive and mature stages are filled with allografts saturated with blood plasma growth factors (GF). Methods. Defects (3 × 3 mm) were created in the distal femoral metaphysis of 60 white laboratory rats, 3-months-old (n = 30) and 12-months-old (n = 30). The defects were filled with bone allografts saturated with GF in the two experimental groups (AlloG+GF), and unsaturated bone allografts in the two control groups (AlloG). All groups contained 15 rats of each age. At 14, 28 and 90 days after the surgery, 5 rats from each group were sacrificed, and histological analyses were performed. Results. In the AlloGgroups, excessive formation of connective tissue was observed 14 and 28 days after the surgery, most evident in the 3-monthold rats. In the AlloG+GF groups, bone formation was delayed at 14 days independent of age, while at 28 and 90 days, the area of bone trabeculae did not differ from the values in the AlloG groups. Throughout the experiment, decreases in allograft area (almost all of it was replaced by bone after 90 days) and connective tissue (completely absent in 3-month-old rats after 90 days) were observed in both AlloG+GF groups. The area of bone trabeculae increased in the period from 14 to 28 days. Conclusion. Saturating allografts with blood plasma growth factors facilitates an increase in the rate at which allografts are replaced by bone tissue, independent of the recipient’s age. However, excessive formation of connective tissues in the defect 14 and 28 days after the surgery, especiallyin 3-month-old rats, may negatively affect the mechanical properties of the bone, which should be considered in clinical practice.
乌克兰战争导致的受伤和枪伤增加,迫切需要找到优化骨再生和填充大面积骨缺损的方法。目标研究用富含血浆生长因子(GF)的同种异体移植物填充生殖早期和成熟期大鼠临界大小股骨缺损时修复性成骨的形态学特征。方法。60只3个月大(n=30)和12个月大的白色实验大鼠的股骨远端干骺端产生了3×3mm的缺陷。两个实验组(AlloG+GF)用饱和GF的同种异体骨填充缺损,两个对照组(AlloG)用不饱和同种异体骨填补缺损。所有组均包含每个年龄的15只大鼠。在手术后14、28和90天,每组处死5只大鼠,并进行组织学分析。后果在AlloG组中,手术后14天和28天观察到结缔组织过度形成,在3个月大的大鼠中最为明显。在AlloG+GF组中,骨形成在14天时延迟,与年龄无关,而在28天和90天时,骨小梁面积与AlloG组的值没有差异。在整个实验过程中,在两个AlloG+GF组中都观察到同种异体移植物面积(90天后几乎全部被骨替代)和结缔组织(90天后3个月大的大鼠完全缺失)的减少。骨小梁面积在14~28天增加。结论用血浆生长因子饱和同种异体移植物有助于提高骨组织替代异体移植物的速率,而与受体的年龄无关。然而,手术后14天和28天,特别是3个月大的大鼠,在缺损处过度形成结缔组织,可能会对骨骼的力学性能产生负面影响,临床实践中应考虑这一点。
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引用次数: 0
MISTAKES AND COMPLICATIONS AFTER SURGICAL TREATMENT OF LUMBAR SPONDYLOLISTHESIS. CLINICAL CASE 腰椎滑脱手术治疗后的失误和并发症。临床病例
Pub Date : 2023-06-27 DOI: 10.15674/0030-59872023296-100
Olexandr Chernyshov, Maksym Golbaum
Spondylolisthesis is a pathology of the musculoskeletal system that causes a vertebra to move forward, sideways or backward. Most often, it is treated surgically using transpedicular structures. Objective. To present a clinical case of re-treatment for degenerative lumbar spondylolysis of the LV vertebral body using transpedicular and posterior autografting techniques. Methods. The clinical case of lumbar spine osteochondrosis, spondyloarthritis,posterior transpedicular fusion LV–SI, fracture of the screw in the body of the SI vertebra on the right, and spinal canal stenosis at the level of LV–SI is described. Lower paraparesis. Results. The patient underwent metal removal, decompression of the spinal canal at the level of LV–SI, open reduction of the LV vertebral body, posterior transpedicular fusion of LIV–SI and posterior autografting fusion. The surgical intervention was successful, despite the technical difficulties associated with removing the threaded part of the broken screw. According to the visual analogue scale, the patient had 8 points beforethe operation, which indicates acute pain syndrome, and after that the pain intensity decreased to 4 points. Muscle strength of the right and left lower extremities before surgery was 2 and 2.5 points, respectively, 5 days after surgery, improvement was recorded — 3 points for each limb. From the second day after repeated surgical treatment, the patient showed a significant improvement in muscle sensitivity and strength in both lower extremities.Conclusions. The clinical example of repeated surgery due to the failure of the metal structure and the deterioration of the patient's neurological status highlights the need for postoperative follow-up. Taking into account the percentage of complications after transpedicular spondylodesis, it is necessary tocontinue scientific research to improve the results of surgical treatment of patients with degenerative diseases of the spine.
脊椎滑脱是肌肉骨骼系统的一种病理学,导致脊椎向前、侧向或向后移动。大多数情况下,它是使用经椎弓根结构进行手术治疗的。客观的介绍一例应用经椎弓根和自体后路植骨技术再次治疗退行性LV椎体腰椎峡部裂的临床病例。方法。描述了腰椎骨软骨病、脊椎关节炎、经椎弓根后融合术LV–SI、右侧SI椎体内螺钉骨折和LV–SI水平椎管狭窄的临床病例。下轻瘫。后果患者接受了金属切除、LV–SI水平的椎管减压、LV椎体切开复位、LIV–SI经椎弓根后融合术和自体后移植物融合术。尽管移除断裂螺钉的螺纹部分存在技术困难,但手术干预是成功的。根据视觉模拟量表,患者术前有8分,表示急性疼痛综合征,术后疼痛强度降至4分。术前左右下肢肌力分别为2和2.5分,术后5天,记录改善情况——每肢3分。从反复手术治疗后的第二天起,患者双下肢的肌肉敏感性和力量都有显著改善。结论。由于金属结构失效和患者神经状态恶化而重复手术的临床例子突出了术后随访的必要性。考虑到经椎弓根融合术后并发症的百分比,有必要继续进行科学研究,以提高脊柱退行性疾病患者的手术治疗效果。
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引用次数: 0
Anatolii Feodosijovych Levytskyi 安纳托利亚费奥多西-莱维茨基
Pub Date : 2023-06-27 DOI: 10.15674/0030-598720232110
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引用次数: 0
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Ortopediia travmatologiia i protezirovanie
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