Pub Date : 2023-01-01DOI: 10.1007/978-1-0716-3175-1
{"title":"Hemostasis and Thrombosis: Methods and Protocols","authors":"","doi":"10.1007/978-1-0716-3175-1","DOIUrl":"https://doi.org/10.1007/978-1-0716-3175-1","url":null,"abstract":"","PeriodicalId":76372,"journal":{"name":"Progress in hemostasis and thrombosis","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90522583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vitronectin is a multifunctional glycoprotein present in blood and in the extracellular matrix. It binds glycosaminoglycans, collagen, plasminogen and the urokinase-receptor, and also stabilizes the inhibitory conformation of plasminogen activation inhibitor-1. By its localization in the extracellular matrix and its binding to plasminogen activation inhibitor-1, vitronectin can potentially regulate the proteolytic degradation of this matrix. In addition, vitronectin binds to complement, to heparin and to thrombin-antithrombin III complexes, implicating its participation in the immune response and in the regulation of clot formation. The biological functions of vitronectin can be modulated by proteolytic enzymes, and by exo- and ecto-protein kinases present in blood. Vitronectin contains an RGD sequence, through which it binds to the integrin receptor alpha v beta 3, and is involved in the cell attachment, spreading and migration. Antibodies against alpha v beta 3 or synthetic peptides containing an RGD sequence are now being tested as therapeutic agents in the treatment of human cancers, bone diseases (e.g. osteoporosis) and in pathological disorders which involve angiogenesis.
玻璃体粘连蛋白是一种存在于血液和细胞外基质中的多功能糖蛋白。它结合糖胺聚糖、胶原蛋白、纤溶酶原和尿激酶受体，并稳定纤溶酶原活化抑制剂-1的抑制构象。通过其在细胞外基质中的定位和与纤溶酶原激活抑制剂-1的结合，玻璃体连接蛋白可以潜在地调节该基质的蛋白水解降解。此外，玻璃体粘连蛋白与补体、肝素和凝血酶-抗凝血酶III复合物结合，暗示其参与免疫反应和凝块形成的调节。玻璃体粘连蛋白的生物学功能可由蛋白水解酶以及血液中的外、外蛋白激酶调节。Vitronectin含有一个RGD序列，通过该序列与整合素受体α v β 3结合，参与细胞的附着、扩散和迁移。针对α v β 3或含有RGD序列的合成肽的抗体目前正在作为治疗人类癌症、骨病(如骨质疏松症)和涉及血管生成的病理性疾病的治疗剂进行测试。
{"title":"Vitronectin.","authors":"B. Tomasini, D. Mosher","doi":"10.32388/nys258","DOIUrl":"https://doi.org/10.32388/nys258","url":null,"abstract":"Vitronectin is a multifunctional glycoprotein present in blood and in the extracellular matrix. It binds glycosaminoglycans, collagen, plasminogen and the urokinase-receptor, and also stabilizes the inhibitory conformation of plasminogen activation inhibitor-1. By its localization in the extracellular matrix and its binding to plasminogen activation inhibitor-1, vitronectin can potentially regulate the proteolytic degradation of this matrix. In addition, vitronectin binds to complement, to heparin and to thrombin-antithrombin III complexes, implicating its participation in the immune response and in the regulation of clot formation. The biological functions of vitronectin can be modulated by proteolytic enzymes, and by exo- and ecto-protein kinases present in blood. Vitronectin contains an RGD sequence, through which it binds to the integrin receptor alpha v beta 3, and is involved in the cell attachment, spreading and migration. Antibodies against alpha v beta 3 or synthetic peptides containing an RGD sequence are now being tested as therapeutic agents in the treatment of human cancers, bone diseases (e.g. osteoporosis) and in pathological disorders which involve angiogenesis.","PeriodicalId":76372,"journal":{"name":"Progress in hemostasis and thrombosis","volume":"10 1","pages":"269-305"},"PeriodicalIF":0.0,"publicationDate":"2020-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47584349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.1007/978-3-319-09312-3_21
T. Deloughery
{"title":"Stroke and Peripheral Vascular Disease","authors":"T. Deloughery","doi":"10.1007/978-3-319-09312-3_21","DOIUrl":"https://doi.org/10.1007/978-3-319-09312-3_21","url":null,"abstract":"","PeriodicalId":76372,"journal":{"name":"Progress in hemostasis and thrombosis","volume":"169 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74866980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.1007/978-3-319-09312-3_23
T. Deloughery
{"title":"Other Parenteral Anticoagulants","authors":"T. Deloughery","doi":"10.1007/978-3-319-09312-3_23","DOIUrl":"https://doi.org/10.1007/978-3-319-09312-3_23","url":null,"abstract":"","PeriodicalId":76372,"journal":{"name":"Progress in hemostasis and thrombosis","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78697325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.1007/978-3-030-19330-0_30
M. Daughety, B. S. Bannow
{"title":"Hemostasis and Thrombosis in Pregnancy","authors":"M. Daughety, B. S. Bannow","doi":"10.1007/978-3-030-19330-0_30","DOIUrl":"https://doi.org/10.1007/978-3-030-19330-0_30","url":null,"abstract":"","PeriodicalId":76372,"journal":{"name":"Progress in hemostasis and thrombosis","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72918837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.1007/978-3-030-19330-0_29
J. Shatzel
{"title":"Bleeding and Thrombosis in Cancer Patients","authors":"J. Shatzel","doi":"10.1007/978-3-030-19330-0_29","DOIUrl":"https://doi.org/10.1007/978-3-030-19330-0_29","url":null,"abstract":"","PeriodicalId":76372,"journal":{"name":"Progress in hemostasis and thrombosis","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86523318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.1007/978-3-319-09312-3_13
T. Deloughery
{"title":"Non-blood Product Agents for Bleeding Disorders","authors":"T. Deloughery","doi":"10.1007/978-3-319-09312-3_13","DOIUrl":"https://doi.org/10.1007/978-3-319-09312-3_13","url":null,"abstract":"","PeriodicalId":76372,"journal":{"name":"Progress in hemostasis and thrombosis","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88950307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.1007/978-3-030-19330-0_31
B. S. Samuelson Bannow
{"title":"Hemorrhage and Thrombosis in Women","authors":"B. S. Samuelson Bannow","doi":"10.1007/978-3-030-19330-0_31","DOIUrl":"https://doi.org/10.1007/978-3-030-19330-0_31","url":null,"abstract":"","PeriodicalId":76372,"journal":{"name":"Progress in hemostasis and thrombosis","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88957788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.1007/978-3-030-19330-0_10
T. Deloughery
{"title":"Cardiac Bypass and Ventricular Assist Devices/ECMO","authors":"T. Deloughery","doi":"10.1007/978-3-030-19330-0_10","DOIUrl":"https://doi.org/10.1007/978-3-030-19330-0_10","url":null,"abstract":"","PeriodicalId":76372,"journal":{"name":"Progress in hemostasis and thrombosis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85663986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.1007/978-3-319-09312-3_3
T. Deloughery
{"title":"Bleeding Disorders: A General Approach","authors":"T. Deloughery","doi":"10.1007/978-3-319-09312-3_3","DOIUrl":"https://doi.org/10.1007/978-3-319-09312-3_3","url":null,"abstract":"","PeriodicalId":76372,"journal":{"name":"Progress in hemostasis and thrombosis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80352141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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