Pub Date : 2024-09-13DOI: 10.1152/ajpheart.00603.2024
Emilia Entcheva, Matthew W. Kay
American Journal of Physiology-Heart and Circulatory Physiology, Ahead of Print.
美国生理学杂志-心脏与循环生理学》，提前出版。
{"title":"Extracellular matrix components halt peripheral nerve regeneration after myocardial infarction","authors":"Emilia Entcheva, Matthew W. Kay","doi":"10.1152/ajpheart.00603.2024","DOIUrl":"https://doi.org/10.1152/ajpheart.00603.2024","url":null,"abstract":"American Journal of Physiology-Heart and Circulatory Physiology, Ahead of Print. <br/>","PeriodicalId":7640,"journal":{"name":"American Journal of Physiology - Heart and Circulatory Physiology","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142187277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
American Journal of Physiology-Heart and Circulatory Physiology, Ahead of Print.
美国生理学杂志-心脏与循环生理学》，提前出版。
{"title":"The dual-edged role of SIRT1 in energy metabolism and cardiovascular disease","authors":"Redemptor Zhou, Kaleb Barnes, Savannah Gibson, Natasha Fillmore","doi":"10.1152/ajpheart.00001.2024","DOIUrl":"https://doi.org/10.1152/ajpheart.00001.2024","url":null,"abstract":"American Journal of Physiology-Heart and Circulatory Physiology, Ahead of Print. <br/>","PeriodicalId":7640,"journal":{"name":"American Journal of Physiology - Heart and Circulatory Physiology","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142187299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-13DOI: 10.1152/ajpheart.00545.2024
Karthi Sreedevi, Alexey V. Zaitsev, Abigail Doku, Rebekah Thomas, Amina James, Sara Do, Mei Zhang, Meghan W Sedovy, Xinyan Leng, Clare L. Dennison, Scott R. Johnstone, Jonathan A. Kirk, Zhen Yan, Junco S. Warren
American Journal of Physiology-Heart and Circulatory Physiology, Ahead of Print.
美国生理学杂志-心脏与循环生理学》，提前出版。
{"title":"Adeno-associated virus mediated gene delivery of Perm1 enhances cardiac contractility in mice","authors":"Karthi Sreedevi, Alexey V. Zaitsev, Abigail Doku, Rebekah Thomas, Amina James, Sara Do, Mei Zhang, Meghan W Sedovy, Xinyan Leng, Clare L. Dennison, Scott R. Johnstone, Jonathan A. Kirk, Zhen Yan, Junco S. Warren","doi":"10.1152/ajpheart.00545.2024","DOIUrl":"https://doi.org/10.1152/ajpheart.00545.2024","url":null,"abstract":"American Journal of Physiology-Heart and Circulatory Physiology, Ahead of Print. <br/>","PeriodicalId":7640,"journal":{"name":"American Journal of Physiology - Heart and Circulatory Physiology","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142187297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-13DOI: 10.1152/ajpheart.00565.2024
Hiroe Toba, Shinji Takai
American Journal of Physiology-Heart and Circulatory Physiology, Ahead of Print.
美国生理学杂志-心脏与循环生理学》，提前出版。
{"title":"Exploring the roles of SPARC as a proinflammatory factor and its potential as a novel therapeutic target against cardiovascular disease","authors":"Hiroe Toba, Shinji Takai","doi":"10.1152/ajpheart.00565.2024","DOIUrl":"https://doi.org/10.1152/ajpheart.00565.2024","url":null,"abstract":"American Journal of Physiology-Heart and Circulatory Physiology, Ahead of Print. <br/>","PeriodicalId":7640,"journal":{"name":"American Journal of Physiology - Heart and Circulatory Physiology","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142187278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-13DOI: 10.1152/ajpheart.00562.2024
Filip Mjörnstedt, Rebecka Wilhelmsson, Marcus Ulleryd, Maria Hammarlund, Göran Bergström, Anders Gummesson, Maria E Johansson
American Journal of Physiology-Heart and Circulatory Physiology, Ahead of Print.
美国生理学杂志-心脏与循环生理学》，提前出版。
{"title":"The alpha7 nicotinic acetylcholine receptor agonist PHA 568487 dampens inflammation in PBMCs from patients with newly discovered coronary artery disease.","authors":"Filip Mjörnstedt, Rebecka Wilhelmsson, Marcus Ulleryd, Maria Hammarlund, Göran Bergström, Anders Gummesson, Maria E Johansson","doi":"10.1152/ajpheart.00562.2024","DOIUrl":"https://doi.org/10.1152/ajpheart.00562.2024","url":null,"abstract":"American Journal of Physiology-Heart and Circulatory Physiology, Ahead of Print. <br/>","PeriodicalId":7640,"journal":{"name":"American Journal of Physiology - Heart and Circulatory Physiology","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142187279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-13DOI: 10.1152/ajpheart.00459.2024
Bryan M. Kistner, Yanna Tian, Elizabeth S. Douglas, Kathleen M. Caron
American Journal of Physiology-Heart and Circulatory Physiology, Ahead of Print.
美国生理学杂志-心脏与循环生理学》，提前出版。
{"title":"Cardiac lymphatics undergo distinct remodeling during hypertrophic and non-hypertrophic pregnancy","authors":"Bryan M. Kistner, Yanna Tian, Elizabeth S. Douglas, Kathleen M. Caron","doi":"10.1152/ajpheart.00459.2024","DOIUrl":"https://doi.org/10.1152/ajpheart.00459.2024","url":null,"abstract":"American Journal of Physiology-Heart and Circulatory Physiology, Ahead of Print. <br/>","PeriodicalId":7640,"journal":{"name":"American Journal of Physiology - Heart and Circulatory Physiology","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142187298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-13DOI: 10.1152/ajpheart.00606.2024
Saurabh S. Thosar, Leandro C. Brito
American Journal of Physiology-Heart and Circulatory Physiology, Ahead of Print.
美国生理学杂志-心脏与循环生理学》，提前出版。
{"title":"Partial Sleep Restriction and Blood Pressure During Exercise: Surprising Findings and Future Directions","authors":"Saurabh S. Thosar, Leandro C. Brito","doi":"10.1152/ajpheart.00606.2024","DOIUrl":"https://doi.org/10.1152/ajpheart.00606.2024","url":null,"abstract":"American Journal of Physiology-Heart and Circulatory Physiology, Ahead of Print. <br/>","PeriodicalId":7640,"journal":{"name":"American Journal of Physiology - Heart and Circulatory Physiology","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142187276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-13DOI: 10.1152/ajpheart.00413.2024
Madison D. Williams, Joshua S. Morgan, Michael T. Bullock, Cere E. Poovey, Michael E. Wisniewski, Jake T. Francisco, Jerry A. Barajas-Nunez, Amira M. Hijazi, Drew Theobald, Srinivas Sriramula, Kyle D. Mansfield, Nathan A. Holland, David A. Tulis
American Journal of Physiology-Heart and Circulatory Physiology, Ahead of Print.
美国生理学杂志-心脏与循环生理学》，提前出版。
{"title":"pH-sensing GPR68 inhibits vascular smooth muscle cell proliferation through Rap1A","authors":"Madison D. Williams, Joshua S. Morgan, Michael T. Bullock, Cere E. Poovey, Michael E. Wisniewski, Jake T. Francisco, Jerry A. Barajas-Nunez, Amira M. Hijazi, Drew Theobald, Srinivas Sriramula, Kyle D. Mansfield, Nathan A. Holland, David A. Tulis","doi":"10.1152/ajpheart.00413.2024","DOIUrl":"https://doi.org/10.1152/ajpheart.00413.2024","url":null,"abstract":"American Journal of Physiology-Heart and Circulatory Physiology, Ahead of Print. <br/>","PeriodicalId":7640,"journal":{"name":"American Journal of Physiology - Heart and Circulatory Physiology","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142187300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Contextualization of observed racial differences in biomarkers to avoid racial essentialism","authors":"Francois G. Rollin, Shub S. Agrawal, Alex P. Galloway, Colin Washington","doi":"10.1152/ajpheart.00168.2024","DOIUrl":"https://doi.org/10.1152/ajpheart.00168.2024","url":null,"abstract":"American Journal of Physiology-Heart and Circulatory Physiology, Volume 326, Issue 6, Page H1550-H1551, June 2024. <br/>","PeriodicalId":7640,"journal":{"name":"American Journal of Physiology - Heart and Circulatory Physiology","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141195361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-03DOI: 10.1152/ajpheart.00130.2024
Natasha G. Boyes, M. Rafique Khan, Adam M.S Luchkanych, Rory A. Marshall, Idris Bare, Tony Haddad, Sherif Abdalla, Ibrahim Al-Mouaiad Al-Azem, Cameron J. Morse, Alexander Zhai, Haissam Haddad, Darcy D. Marciniuk, T. Dylan Olver, Corey R. Tomczak
Background: Patients with heart failure with reduced ejection fraction (HFrEF) have exaggerated sympathoexcitation and impaired peripheral vascular conductance. Evidence demonstrating consequent impaired functional sympatholysis is limited in HFrEF. This study aimed to determine the magnitude of reduced limb vascular conductance during sympathoexcitation and whether functional sympatholysis would abolish such reductions in HFrEF. Methods: Twenty patients with HFrEF and 22 age-matched controls performed the cold pressor test (left foot 2-min in -0.5[1] °C water) alone (CPT) and with right handgrip exercise (EX+CPT). Right forearm vascular conductance (FVC), forearm blood flow (FBF), and mean arterial pressure (MAP) were measured. Results: Patients with HFrEF had greater decreases in %ΔFVC and %ΔFBF during CPT (both P<0.0001) but not EX+CPT (P=0.449, P=0.199) compared to controls, respectively. %ΔFVC and %ΔFBF decreased from CPT to EX+CPT in patients with HFrEF (both P<0.0001) and controls (P=0.018, P=0.015), respectively. MAP increased during CPT and EX+CPT in both groups (all P<0.0001). MAP was greater in controls compared to patients with HFrEF during EX+CPT (P=0.025) but not CPT (P=0.209). Conclusions: Acute sympathoexcitation caused exaggerated peripheral vasoconstriction and reduced peripheral blood flow in patients with HFrEF. Handgrip exercise abolished sympathoexcitatory-mediated peripheral vasoconstriction and normalized peripheral blood flow in patients with HFrEF. These novel data reveal intact functional sympatholysis in the upper limb and suggest exercise-mediated, local control of blood flow is preserved when cardiac limitations that are cardinal to HFrEF are evaded with dynamic handgrip exercise.
{"title":"Elevated sympathetic-mediated vasoconstriction at rest but intact functional sympatholysis during exercise in heart failure with reduced ejection fraction","authors":"Natasha G. Boyes, M. Rafique Khan, Adam M.S Luchkanych, Rory A. Marshall, Idris Bare, Tony Haddad, Sherif Abdalla, Ibrahim Al-Mouaiad Al-Azem, Cameron J. Morse, Alexander Zhai, Haissam Haddad, Darcy D. Marciniuk, T. Dylan Olver, Corey R. Tomczak","doi":"10.1152/ajpheart.00130.2024","DOIUrl":"https://doi.org/10.1152/ajpheart.00130.2024","url":null,"abstract":"Background: Patients with heart failure with reduced ejection fraction (HFrEF) have exaggerated sympathoexcitation and impaired peripheral vascular conductance. Evidence demonstrating consequent impaired functional sympatholysis is limited in HFrEF. This study aimed to determine the magnitude of reduced limb vascular conductance during sympathoexcitation and whether functional sympatholysis would abolish such reductions in HFrEF. Methods: Twenty patients with HFrEF and 22 age-matched controls performed the cold pressor test (left foot 2-min in -0.5[1] °C water) alone (CPT) and with right handgrip exercise (EX+CPT). Right forearm vascular conductance (FVC), forearm blood flow (FBF), and mean arterial pressure (MAP) were measured. Results: Patients with HFrEF had greater decreases in %ΔFVC and %ΔFBF during CPT (both <i>P</i><0.0001) but not EX+CPT (<i>P</i>=0.449, <i>P</i>=0.199) compared to controls, respectively. %ΔFVC and %ΔFBF decreased from CPT to EX+CPT in patients with HFrEF (both <i>P</i><0.0001) and controls (<i>P</i>=0.018, <i>P</i>=0.015), respectively. MAP increased during CPT and EX+CPT in both groups (all <i>P</i><0.0001). MAP was greater in controls compared to patients with HFrEF during EX+CPT (<i>P</i>=0.025) but not CPT (<i>P</i>=0.209). Conclusions: Acute sympathoexcitation caused exaggerated peripheral vasoconstriction and reduced peripheral blood flow in patients with HFrEF. Handgrip exercise abolished sympathoexcitatory-mediated peripheral vasoconstriction and normalized peripheral blood flow in patients with HFrEF. These novel data reveal intact functional sympatholysis in the upper limb and suggest exercise-mediated, local control of blood flow is preserved when cardiac limitations that are cardinal to HFrEF are evaded with dynamic handgrip exercise.","PeriodicalId":7640,"journal":{"name":"American Journal of Physiology - Heart and Circulatory Physiology","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140830905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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