Changes in tension were monitored isometrically on spiral strips of freshly obtained bovine basilar arteries. Ergotamine (E), dihydroergotamine (DHE), methysergide (M) and pizotifen (BC-105) displaced the concentration-response curve for 5-HT in a noncompetitive way and in similar concentration ranges as indicated by the pD' 2(60 min) values of the three ergot alkaloids (E: 9.2, M: 9.1, DHE: 8.8) and the pD' 2(30 min) value (8.9) of BC-105. The ergot alkaloids but not BC-105 also exhibited considerable stimulating activity. The calculated pD2 values were 8.8 for E, 8.6 for DHE and 6.6 for M. Relative to 5-HT (= 1) the intrinsic activities were 0.4, 0.2 and 0.1 for E, DHE and M, respectively. BC-105 was nearly equipotent in antagonizing responses to 5-HT, E and DHE suggesting that both ergot alkaloids act as noncompetitive dualists at the 5-HT receptor. The results suggest that the strong stimulant rather than the blocking activity at the 5-HT receptor of ergotamine may be an important property for its therapeutic efficacy in migrainous attacks.
{"title":"Studies on the 5-HT receptor in vascular smooth muscle.","authors":"E. Müller‐Schweinitzer","doi":"10.1159/000402439","DOIUrl":"https://doi.org/10.1159/000402439","url":null,"abstract":"Changes in tension were monitored isometrically on spiral strips of freshly obtained bovine basilar arteries. Ergotamine (E), dihydroergotamine (DHE), methysergide (M) and pizotifen (BC-105) displaced the concentration-response curve for 5-HT in a noncompetitive way and in similar concentration ranges as indicated by the pD' 2(60 min) values of the three ergot alkaloids (E: 9.2, M: 9.1, DHE: 8.8) and the pD' 2(30 min) value (8.9) of BC-105. The ergot alkaloids but not BC-105 also exhibited considerable stimulating activity. The calculated pD2 values were 8.8 for E, 8.6 for DHE and 6.6 for M. Relative to 5-HT (= 1) the intrinsic activities were 0.4, 0.2 and 0.1 for E, DHE and M, respectively. BC-105 was nearly equipotent in antagonizing responses to 5-HT, E and DHE suggesting that both ergot alkaloids act as noncompetitive dualists at the 5-HT receptor. The results suggest that the strong stimulant rather than the blocking activity at the 5-HT receptor of ergotamine may be an important property for its therapeutic efficacy in migrainous attacks.","PeriodicalId":76420,"journal":{"name":"Research and clinical studies in headache","volume":"31 1","pages":"6-12"},"PeriodicalIF":0.0,"publicationDate":"1978-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77405350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The epidemiology and genetics of migraine.","authors":"D. Ziegler","doi":"10.1159/000401334","DOIUrl":"https://doi.org/10.1159/000401334","url":null,"abstract":"","PeriodicalId":76420,"journal":{"name":"Research and clinical studies in headache","volume":"55 1","pages":"21-33"},"PeriodicalIF":0.0,"publicationDate":"1978-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76724217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cerebral blood flow in migraine without headache.","authors":"J. Marshall","doi":"10.1159/000402438","DOIUrl":"https://doi.org/10.1159/000402438","url":null,"abstract":"","PeriodicalId":76420,"journal":{"name":"Research and clinical studies in headache","volume":"9 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"1978-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83462232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Headache, hypertension and renal disease.","authors":"J. Graham, D. Bana, A. Yap","doi":"10.1159/000402456","DOIUrl":"https://doi.org/10.1159/000402456","url":null,"abstract":"","PeriodicalId":76420,"journal":{"name":"Research and clinical studies in headache","volume":"15 1","pages":"147-54"},"PeriodicalIF":0.0,"publicationDate":"1978-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81696587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The use of cryosurgery applied to the sphenopalatine area (artery and ganglion) plus the superficial temporal and occipital branches of the external carotid artery has proven worthwhile in a majority of patients in whom this procedure has been used since 1968. Experience includes almost 700 procedures in more than 500 patients who have answered to follow-up. The procedure is not a major operation, is repeatable and, until the ideal drug is discovered, offers a better than average change for definite improvement in vascular headache.
{"title":"Cryosurgery of headache.","authors":"N. Cook","doi":"10.1159/000401338","DOIUrl":"https://doi.org/10.1159/000401338","url":null,"abstract":"The use of cryosurgery applied to the sphenopalatine area (artery and ganglion) plus the superficial temporal and occipital branches of the external carotid artery has proven worthwhile in a majority of patients in whom this procedure has been used since 1968. Experience includes almost 700 procedures in more than 500 patients who have answered to follow-up. The procedure is not a major operation, is repeatable and, until the ideal drug is discovered, offers a better than average change for definite improvement in vascular headache.","PeriodicalId":76420,"journal":{"name":"Research and clinical studies in headache","volume":"7 1","pages":"86-101"},"PeriodicalIF":0.0,"publicationDate":"1978-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88833570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stereotactic treatment of head and neck pain.","authors":"P. Gildenberg","doi":"10.1159/000401339","DOIUrl":"https://doi.org/10.1159/000401339","url":null,"abstract":"","PeriodicalId":76420,"journal":{"name":"Research and clinical studies in headache","volume":"02 1","pages":"102-21"},"PeriodicalIF":0.0,"publicationDate":"1978-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85919919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Autogenic biofeedback training appears to be a promising technique for the treatment of migraine headaches, as reflected in the literature reviewed herein and in the data from 21 patients who were followed up for an average of 10 months. Autogenic biogeedback training exemplifies an important trend in psychosomatic medicine, in shifting a major portion of responsibility for treatment process both depends on and facilitates greater understanding on the part of the part of the patient of psychosomatic events relevant to symptom development. Autogenic biofeedback training may also provide a useful tool for investigators exploring the relation between psychology and somatic medicine.
{"title":"Autogenic biofeedback treatment for migraine.","authors":"S. Fahrion","doi":"10.1159/000401336","DOIUrl":"https://doi.org/10.1159/000401336","url":null,"abstract":": Autogenic biofeedback training appears to be a promising technique for the treatment of migraine headaches, as reflected in the literature reviewed herein and in the data from 21 patients who were followed up for an average of 10 months. Autogenic biogeedback training exemplifies an important trend in psychosomatic medicine, in shifting a major portion of responsibility for treatment process both depends on and facilitates greater understanding on the part of the part of the patient of psychosomatic events relevant to symptom development. Autogenic biofeedback training may also provide a useful tool for investigators exploring the relation between psychology and somatic medicine.","PeriodicalId":76420,"journal":{"name":"Research and clinical studies in headache","volume":"13 1","pages":"47-71"},"PeriodicalIF":0.0,"publicationDate":"1978-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84554148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Arteriovenous shunting and migraine.","authors":"P. Saxena","doi":"10.1159/000402449","DOIUrl":"https://doi.org/10.1159/000402449","url":null,"abstract":"","PeriodicalId":76420,"journal":{"name":"Research and clinical studies in headache","volume":"59 2 1","pages":"89-102"},"PeriodicalIF":0.0,"publicationDate":"1978-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90297543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The use of cryosurgery applied to the sphenopalatine area (artery and ganglion) plus the superficial temporal and occipital branches of the external carotid artery has proven worthwhile in a majority of patients in whom this procedure has been used since 1968. Experience includes almost 700 procedures in more than 500 patients who have answered to follow-up. The procedure is not a major operation, is repeatable and, until the ideal drug is discovered, offers a better than average change for definite improvement in vascular headache.
{"title":"Cryosurgery of headache.","authors":"N Cook","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The use of cryosurgery applied to the sphenopalatine area (artery and ganglion) plus the superficial temporal and occipital branches of the external carotid artery has proven worthwhile in a majority of patients in whom this procedure has been used since 1968. Experience includes almost 700 procedures in more than 500 patients who have answered to follow-up. The procedure is not a major operation, is repeatable and, until the ideal drug is discovered, offers a better than average change for definite improvement in vascular headache.</p>","PeriodicalId":76420,"journal":{"name":"Research and clinical studies in headache","volume":"5 ","pages":"86-101"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11875321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Implications of the platelet monoamine oxidase deficit during migraine attacks.","authors":"M Sandler","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76420,"journal":{"name":"Research and clinical studies in headache","volume":"6 ","pages":"65-72"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11925152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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