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Research publications - Association for Research in Nervous and Mental Disease最新文献

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Human studies on the biological basis of reinforcement. A neuroendocrine perspective. 人类对强化生物学基础的研究。神经内分泌的观点。
Research publications - Association for Research in Nervous and Mental Disease
Pub Date : 1992-01-01
J H Mendelson, N K Mello, S K Teoh, S E Lukas, W Phipps, J Ellingboe, S L Palmieri, I Schiff
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引用次数: 0
Epidemiological trends and implications for understanding the nature of addiction. 流行病学趋势及其对理解成瘾本质的影响。
Research publications - Association for Research in Nervous and Mental Disease
Pub Date : 1992-01-01
D B Kandel
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引用次数: 0
Neurological complications of substance abuse. 药物滥用的神经系统并发症。
Research publications - Association for Research in Nervous and Mental Disease
Pub Date : 1992-01-01
J C Brust
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引用次数: 0
Advances in understanding the vulnerability to alcoholism. 对酗酒易感性的理解取得进展。
Research publications - Association for Research in Nervous and Mental Disease
Pub Date : 1992-01-01
M A Schuckit
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引用次数: 0
The search for the genetic defects in Huntington's disease and familial Alzheimer's disease. 寻找亨廷顿氏病和家族性阿尔茨海默病的遗传缺陷。
Research publications - Association for Research in Nervous and Mental Disease
Pub Date : 1991-01-01
J F Gusella
{"title":"The search for the genetic defects in Huntington's disease and familial Alzheimer's disease.","authors":"J F Gusella","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76423,"journal":{"name":"Research publications - Association for Research in Nervous and Mental Disease","volume":"69 ","pages":"75-83"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12988500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in medical genetics in the past 30 years. 过去30年医学遗传学的进展。
Research publications - Association for Research in Nervous and Mental Disease
Pub Date : 1991-01-01
V A McKusick
{"title":"Advances in medical genetics in the past 30 years.","authors":"V A McKusick","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76423,"journal":{"name":"Research publications - Association for Research in Nervous and Mental Disease","volume":"69 ","pages":"1-18"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13160918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetics of manic depressive illness: current status and evolving concepts. 躁狂抑郁症的遗传学:现状和演变的概念。
Research publications - Association for Research in Nervous and Mental Disease
Pub Date : 1991-01-01
M Baron

The bipolar affective spectrum is clinically heterogeneous and genetically complex. Current methods for assessment and analysis of familial traits with variable phenotypic expression and unclear mode of inheritance are reviewed. Recent evidence for a major gene localized on the X-chromosome is presented and other linkage findings are discussed. The limitations and prospects of psychiatric genetics are discussed in the light of recent advances in diagnostic nomenclature, statistical genetic techniques, and molecular biology. Methodological uncertainties notwithstanding, the powerful new techniques in genetic research portend well for unraveling the genetics of bipolar affective illness.

双相情感谱系在临床上具有异质性和遗传复杂性。综述了目前评价和分析具有可变表型表达和遗传方式不明确的家族性性状的方法。最近的证据表明，一个主要的基因定位在x染色体和其他连锁发现进行了讨论。根据诊断命名法、统计遗传技术和分子生物学的最新进展，讨论了精神病学遗传学的局限性和前景。尽管方法上存在不确定性，但基因研究中强大的新技术预示着解开双相情感疾病遗传学的良好前景。
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引用次数: 0
Genetics of Alzheimer's disease. 阿尔茨海默病的遗传学。
Research publications - Association for Research in Nervous and Mental Disease
Pub Date : 1991-01-01
M F Folstein, A Warren
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引用次数: 0
The psychopathology of Huntington's disease. 亨廷顿舞蹈病的精神病理学。
Research publications - Association for Research in Nervous and Mental Disease
Pub Date : 1991-01-01
S E Folstein

Our findings suggest that HD can cause psychiatric disorder in two ways. First, by the direct action of the gene on striatal neurons, and second, by the indirect effect of the disordered family environment on the children, regardless of whether they have inherited the HD gene. The gene and the environment created by the gene caused different psychiatric disorders. The correlates of conduct disorder in HD correspond to those expected from principles already established by psychiatric research. The association of affective disorder and HD suggests two hypotheses: (a) affective disorder is part of a subcortical triad and will be present whenever there is subcortical (striatal) pathology and (b) functional affective disorder may be an example of a subcortical disorder with abnormalities of mood, memory, and movement and emerging indications of striatal pathology.

我们的研究结果表明，HD可以通过两种方式导致精神障碍。首先，基因对纹状体神经元的直接作用，其次，不管孩子是否遗传了HD基因，紊乱的家庭环境对孩子的间接影响。这种基因和它所创造的环境导致了不同的精神疾病。HD患者行为障碍的相关关系与精神病学研究已经建立的原则相一致。情感性障碍和HD的关联提出了两种假设:(a)情感性障碍是皮层下三联征的一部分，只要有皮层下(纹状体)病理就会出现;(b)功能性情感性障碍可能是皮层下障碍的一个例子，伴有情绪、记忆和运动异常，并出现纹状体病理的迹象。
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引用次数: 0
Down syndrome and the trisomy 16 mouse: impact of gene imbalance on brain development and aging. 唐氏综合症和16三体小鼠:基因失衡对大脑发育和衰老的影响。
Research publications - Association for Research in Nervous and Mental Disease
Pub Date : 1991-01-01
J T Coyle, M L Oster-Granite, R Reeves, C Hohmann, P Corsi, J Gearhart
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引用次数: 0
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