Recent diagnosis of rheumatoid arthritis (usually within to two years of onset) during which treatment may be more effective and possibly improve the disease course.
最近诊断为类风湿性关节炎(通常在发病两年内)，在此期间治疗可能更有效，并可能改善病程。
{"title":"Early Rheumatoid Arthritis","authors":"","doi":"10.32388/ngciyr","DOIUrl":"https://doi.org/10.32388/ngciyr","url":null,"abstract":"Recent diagnosis of rheumatoid arthritis (usually within to two years of onset) during which treatment may be more effective and possibly improve the disease course.","PeriodicalId":76426,"journal":{"name":"Reumatizam","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69637976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-16DOI: 10.33004/REUMATIZAM-66-1-4
N. Tučkar, Ivka Djaković, I. Šola, M. Mustapić, O. Grgić, V. Kosec
pubic pain frequently accompanies uneventful pregnancies and is a common symptom in pregnancy. still, in some cases, especially when it is associated with walking difficulties, persistent and/or severe pubic pain, and inflammation that can be confirmed by laboratory parameters, it should be taken with additional caution. differential diagnosis should include osteitis pubis, a non-bacterial, self-limited inflammation that leaves no permanent consequences, but also, more importantly, osteomyelitis of the pubic symphysis. This is a rare bacterial infection in pregnancy, important to be diagnosed in time and treated early and properly since it can leave serious long-term complications such as fistulas that require prolonged treatment and sometimes even surgery. a multidisciplinary approach is mandatory to exclude all the other potential causes of pubic pain and make a timely diagnosis of osteomyelitis. We present two patients with pubic pain during pregnancy, with two different diagnoses and treatment options, and a favorable outcome that was the result of a multidisciplinary approach.
{"title":"Osteitis pubis and osteomyelitis pubis in pregnancy – two case reports","authors":"N. Tučkar, Ivka Djaković, I. Šola, M. Mustapić, O. Grgić, V. Kosec","doi":"10.33004/REUMATIZAM-66-1-4","DOIUrl":"https://doi.org/10.33004/REUMATIZAM-66-1-4","url":null,"abstract":"pubic pain frequently accompanies uneventful pregnancies and is a common symptom in pregnancy. still, in some cases, especially when it is associated with walking difficulties, persistent and/or severe pubic pain, and inflammation that can be confirmed by laboratory parameters, it should be taken with additional caution. differential diagnosis should include osteitis pubis, a non-bacterial, self-limited inflammation that leaves no permanent consequences, but also, more importantly, osteomyelitis of the pubic symphysis. This is a rare bacterial infection in pregnancy, important to be diagnosed in time and treated early and properly since it can leave serious long-term complications such as fistulas that require prolonged treatment and sometimes even surgery. a multidisciplinary approach is mandatory to exclude all the other potential causes of pubic pain and make a timely diagnosis of osteomyelitis. We present two patients with pubic pain during pregnancy, with two different diagnoses and treatment options, and a favorable outcome that was the result of a multidisciplinary approach.","PeriodicalId":76426,"journal":{"name":"Reumatizam","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46315481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-01DOI: 10.33004/eumatizam-66-1-6
{"title":"12th Central European Congress of Rheumatology and 20th Annual Congress of the Croatian Society for Rheumatology","authors":"","doi":"10.33004/eumatizam-66-1-6","DOIUrl":"https://doi.org/10.33004/eumatizam-66-1-6","url":null,"abstract":"","PeriodicalId":76426,"journal":{"name":"Reumatizam","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44314074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-01DOI: 10.33004/REUMATIZAM-66-1-5
Ivka Djaković, Vesna Gall, V. Saftić, P. Radulović, N. Bilić, V. Kosec
Osteochondrodysplasias comprise a large, genetically heterogeneous group of disorders characterized by abnormalities of cartilage and bone growth. They are often associated with abnormalities in other organ systems. They are classified as lethal or non-lethal skeletal dysplasias. Thanatophoric dysplasia is the most common form of lethal skeletal dysplasia with an incidence of 0.69 per 10.000 births. Heterozygous achondroplasia is the most common non-lethal dysplasia with an incidence of 0.15 per 10.000 births. We will present two cases of skeletal dysplasia. The first case is the case of lethal osteochondrodysplasia in the fetus of a 41-year-old multiparous woman, who came to our hospital in active preterm labor, in the 33th week of uncontrolled pregnancy. The second case is the case of non-lethal osteochondrodysplasia in the fetus of a 31-year-old multiparous woman. The fetal short femur length was detected in the 30th
{"title":"THE IMPORTANCE OF ANTENATAL ULTRASOUND SCREENING FOR CONGENITAL OSTEOCHONDRODYSPLASIA – TWO CASE REPORTS","authors":"Ivka Djaković, Vesna Gall, V. Saftić, P. Radulović, N. Bilić, V. Kosec","doi":"10.33004/REUMATIZAM-66-1-5","DOIUrl":"https://doi.org/10.33004/REUMATIZAM-66-1-5","url":null,"abstract":"Osteochondrodysplasias comprise a large, genetically heterogeneous group of disorders characterized by abnormalities of cartilage and bone growth. They are often associated with abnormalities in other organ systems. They are classified as lethal or non-lethal skeletal dysplasias. Thanatophoric dysplasia is the most common form of lethal skeletal dysplasia with an incidence of 0.69 per 10.000 births. Heterozygous achondroplasia is the most common non-lethal dysplasia with an incidence of 0.15 per 10.000 births. We will present two cases of skeletal dysplasia. The first case is the case of lethal osteochondrodysplasia in the fetus of a 41-year-old multiparous woman, who came to our hospital in active preterm labor, in the 33th week of uncontrolled pregnancy. The second case is the case of non-lethal osteochondrodysplasia in the fetus of a 31-year-old multiparous woman. The fetal short femur length was detected in the 30th","PeriodicalId":76426,"journal":{"name":"Reumatizam","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41692537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-01DOI: 10.33004/REUMATIZAM-66-1-2
M. Bakula, P. Kilić, M. Cerovec, M. Mayer, B. Anić
treatment of inflammatory rheumatic diseases and control of disease activity have considerably improved after the introduction of biologic therapy over a decade ago. The safety profile of biologic therapy in the preconception period as well as during pregnancy and lactation is neccessary to consider when planning the treatment of young female patients. neither the Food and drug administration agency nor the european Medicines agency have declared biologic therapy safe during pregnancy. Both the european league against rheumatism and the British society for rheumatology proposed guidelines for the treatment of female rheumatology patients during pregnancy and lactation, and the american college of rheumatology is currently developing guidelines for the therapeutic approach during pregnancy. on the other hand, there are numerous publications of pregnancy outcomes in patients treated with biologic therapy, with a small number of adverse effects. We analyzed the modalities of biologic therapy and pregnancy outcomes in patients treated at our department, during planned and unplanned pregnancies. our results do not differ from the literature published to date. among the patients described here, 15 were treated with an inhibitor of tumor necrosis factor-α and one with an il-6 inhibitor during or just before pregnancy. only 2 patients stopped biologic therapy in compliance with the guidelines. of the 16 aforementioned patients, 3 had to undergo medically-induced abortion; one patient because of a severe fetal malformation and the other two patients because they had been treated with conventional disease-modifying antirheumatic drugs, which are contraindicated during pregnancy.
{"title":"Biologic therapy and pregnancy – a tertiary center experience","authors":"M. Bakula, P. Kilić, M. Cerovec, M. Mayer, B. Anić","doi":"10.33004/REUMATIZAM-66-1-2","DOIUrl":"https://doi.org/10.33004/REUMATIZAM-66-1-2","url":null,"abstract":"treatment of inflammatory rheumatic diseases and control of disease activity have considerably improved after the introduction of biologic therapy over a decade ago. The safety profile of biologic therapy in the preconception period as well as during pregnancy and lactation is neccessary to consider when planning the treatment of young female patients. neither the Food and drug administration agency nor the european Medicines agency have declared biologic therapy safe during pregnancy. Both the european league against rheumatism and the British society for rheumatology proposed guidelines for the treatment of female rheumatology patients during pregnancy and lactation, and the american college of rheumatology is currently developing guidelines for the therapeutic approach during pregnancy. on the other hand, there are numerous publications of pregnancy outcomes in patients treated with biologic therapy, with a small number of adverse effects. We analyzed the modalities of biologic therapy and pregnancy outcomes in patients treated at our department, during planned and unplanned pregnancies. our results do not differ from the literature published to date. among the patients described here, 15 were treated with an inhibitor of tumor necrosis factor-α and one with an il-6 inhibitor during or just before pregnancy. only 2 patients stopped biologic therapy in compliance with the guidelines. of the 16 aforementioned patients, 3 had to undergo medically-induced abortion; one patient because of a severe fetal malformation and the other two patients because they had been treated with conventional disease-modifying antirheumatic drugs, which are contraindicated during pregnancy.","PeriodicalId":76426,"journal":{"name":"Reumatizam","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44533932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.33004/reumatizam-66-1-3
Željka Kardum, Jasmin Ahić, Ivana Kovacevic, A. Lukinac, A. Kovač, K. K. stranski, V. Prus
antineutrophil cytoplasmic autoantibody (anca)-associated vasculitis (aav) is a small-vessel vasculitis, characterized by necrotizing inflammation of small vessels and positive ancas. cancas are directed against proteinase-3 (Pr-3) and are specific for granulomatosis with polyangiitis (GPa, formerly known as Wegener’s disease), although their role in the immunopathology of the disease is still unclear. This is why the european medicines agency suggested that canca positivity, in addition to the clinical picture, can be enough for the diagnosis of GPa. Granulomatosis with polyangiitis is characterized by granulomatous inflammation that usually involves the upper and lower respiratory tract, necrotizing vasculitis that affects small and medium-sized vessels, and often rapidly progressive glomerulonephritis. We present a patient with an unusual presentation of canca-associated vasculitis, who presented with arthritis, palpable purpura on legs, and pauci-immune necrotizing glomerulonephritis with highly positive canca antibodies, without any signs or symptoms of airway involvement. although renal-limited anca vasculitis is recognized as a separate entity, our patient also had signs of skin and joint involvement and prominent constitutional symptoms that contributed to the diagnosis of systemic disease. in this paper, we present a patient with an atypical course of GPa, which can also be called a limited form of the disease. an atypical course or limited form belongs to the group of sine syndromes in inflammatory rheumatic diseases, which are not very common, but should be considered in the differential diagnosis. to our knowledge, there are only a few described case reports with a similar presentation.
{"title":"Case report of a patient with cANCA vasculitis without airway involvement","authors":"Željka Kardum, Jasmin Ahić, Ivana Kovacevic, A. Lukinac, A. Kovač, K. K. stranski, V. Prus","doi":"10.33004/reumatizam-66-1-3","DOIUrl":"https://doi.org/10.33004/reumatizam-66-1-3","url":null,"abstract":"antineutrophil cytoplasmic autoantibody (anca)-associated vasculitis (aav) is a small-vessel vasculitis, characterized by necrotizing inflammation of small vessels and positive ancas. cancas are directed against proteinase-3 (Pr-3) and are specific for granulomatosis with polyangiitis (GPa, formerly known as Wegener’s disease), although their role in the immunopathology of the disease is still unclear. This is why the european medicines agency suggested that canca positivity, in addition to the clinical picture, can be enough for the diagnosis of GPa. Granulomatosis with polyangiitis is characterized by granulomatous inflammation that usually involves the upper and lower respiratory tract, necrotizing vasculitis that affects small and medium-sized vessels, and often rapidly progressive glomerulonephritis. We present a patient with an unusual presentation of canca-associated vasculitis, who presented with arthritis, palpable purpura on legs, and pauci-immune necrotizing glomerulonephritis with highly positive canca antibodies, without any signs or symptoms of airway involvement. although renal-limited anca vasculitis is recognized as a separate entity, our patient also had signs of skin and joint involvement and prominent constitutional symptoms that contributed to the diagnosis of systemic disease. in this paper, we present a patient with an atypical course of GPa, which can also be called a limited form of the disease. an atypical course or limited form belongs to the group of sine syndromes in inflammatory rheumatic diseases, which are not very common, but should be considered in the differential diagnosis. to our knowledge, there are only a few described case reports with a similar presentation.","PeriodicalId":76426,"journal":{"name":"Reumatizam","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69480407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Juvenile idiopathic arthritis (JIA) is the most common rheumatic disorder in children and one of the most common causes of part-time or long-term disability. The term juvenile idiopathic arthritis defines the main characteristics of the disease: joint inflammation of unknown origin manifested before the 16th birthday and lasting for more than six weeks. JIA is very rare in infancy, with highest frequency in preschool age. It is not a single disease, but a group of disorders with some common features of different immunopathogenesis and with different clinical manifestations. According to the revised International League of Associations for Rheumatology (ILAR) criteria, JIA is classified into 8 subtypes, but this classification is still a “work in progress“ because with new knowledge gained in genetics and immunology, the classification will obviously have to be changed and refined. New research of the disease pathogenesis is the basis for the development of new and better treatments for JIA. The goal of such treatments is not just to relieve pain, but also to control inflammation and stop irreversible joint damage and long-term disability. Biological agents have significantly improved the disease prognosis.
{"title":"[JUVENILE IDIOPATHIC ARTHRITIS].","authors":"L. Bukovac, M. Perica","doi":"10.1037/e619442012-001","DOIUrl":"https://doi.org/10.1037/e619442012-001","url":null,"abstract":"Juvenile idiopathic arthritis (JIA) is the most common rheumatic disorder in children and one of the\u0000most common causes of part-time or long-term disability. The term juvenile idiopathic arthritis defines the main characteristics\u0000of the disease: joint inflammation of unknown origin manifested before the 16th birthday and lasting for more\u0000than six weeks. JIA is very rare in infancy, with highest frequency in preschool age. It is not a single disease, but a group\u0000of disorders with some common features of different immunopathogenesis and with different clinical manifestations. According\u0000to the revised International League of Associations for Rheumatology (ILAR) criteria, JIA is classified into 8\u0000subtypes, but this classification is still a “work in progress“ because with new knowledge gained in genetics and immunology,\u0000the classification will obviously have to be changed and refined. New research of the disease pathogenesis is the basis\u0000for the development of new and better treatments for JIA. The goal of such treatments is not just to relieve pain, but also\u0000to control inflammation and stop irreversible joint damage and long-term disability. Biological agents have significantly\u0000improved the disease prognosis.","PeriodicalId":76426,"journal":{"name":"Reumatizam","volume":"63 Suppl 1 1","pages":"53-8"},"PeriodicalIF":0.0,"publicationDate":"2017-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43956109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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