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[Primary sclerosing cholangitis]. 原发性硬化性胆管炎。
Pub Date : 2012-04-01 DOI: 10.12968/GASN.2012.10.3.8
S. Heggie
Primary sclerosing cholangitis (PSC) is an uncommon, chronic, cholestatic liver disease caused by inflammation and fibrosis that can involve the entire biliary tree (Chapman, 2011). This progressive process destroys both intra and extra hepatic bile ducts, leading to biliary cirrhosis, portal hypertension and hepatic failure. The cause of PSC is unknown but it is closely associated with inflammatory bowel disease, particularly ulcerative colitis (UC), which occurs in approximately 70% of cases. Approximately 5–10% of patients with total UC will have co-existing PSC (Chapman, 2011). PSC is often difficult to diagnose due to the complexity of its symptoms (European Association for the Study of the Liver, 2009). These symptoms include fatigue, intermittent jaundice, weight loss, right upper quadrant abdominal pain and pruritus. Cholangitis, sporadic episodes of inflammation within the biliary tract, often bacterial in nature cause pain, shivers, fever and distress and require immediate antibiotic therapy. Occasionally, more invasive treatment is needed. The clinical course of PSC is variable and there is no curative treatment apart from liver transplant; medical treatment has proven unsuccessful. Folseraas et al (2011) indicated that no treatment has confirmed any delay in progression, but studies are often conflicting (Chapman, 2009; Lindor et al, 2009). Barnabas and Chapman (2012) debated the use of ursodeoxycholic acid for PSC confirming that its role remains unclear. They found that a high dose (28–30 mg/ kg/day) may be harmful, while a low-tomoderate dose may have a carcinogenic protective effect. As diagnostic techniques are advancing rapidly, PSC is being identified earlier (Molodecky et al, 2011). Research is ongoing to try to find a treatment, cure or genetic link for this often debilitating condition. Folseraas et al (2011) state that genome wide studies have consistently identified genetic susceptibility and environmental factors—the relation of these hopefully offer exciting opportunities for transferring knowledge and impending treatment options. UK genome-wide studies are ongoing and recruitment is continuing (UK PSC Genome Study, 2011). The unpredictability of the condition is daunting and the uncertainty of how it will effect day to day life and future plans can bring major concerns and anxiety. Many people living with PSC describe it as very challenging: the itch and pain in particular causing daily stress which can reduce quality of life (Ponsioen, 2011). A decompensated liver can bring about many hurdles. For some, the addition of other related autoimmune conditions and immunosuppression due to prescribed therapy can be immense. As with any condition, an active healthy lifestyle is required. Good nutrition is vital for patients with a liver condition, even more important with associated inflammatory bowel disease. Access to dietary expertize is often limited; however, dieticians Leaper and Hamlin (2012) and the British Liver Trust
原发性硬化性胆管炎(PSC)是一种罕见的慢性胆汁淤积性肝病,由炎症和纤维化引起,可累及整个胆道(Chapman, 2011)。这一渐进过程破坏肝内和肝外胆管,导致胆汁性肝硬化、门脉高压和肝功能衰竭。PSC的病因尚不清楚,但它与炎症性肠病密切相关,特别是溃疡性结肠炎(UC),约70%的病例发生。大约5-10%的完全性UC患者会同时存在PSC (Chapman, 2011)。由于症状复杂,PSC往往难以诊断(欧洲肝脏研究协会,2009年)。这些症状包括疲劳、间歇性黄疸、体重减轻、右上腹部疼痛和瘙痒。胆管炎是胆道内偶发的炎症,通常是细菌性的,引起疼痛、发抖、发烧和不适,需要立即进行抗生素治疗。有时,需要更多的侵入性治疗。PSC的临床病程多变,除肝移植外无根治方法;医学治疗已证明无效。Folseraas等人(2011)指出,没有任何治疗证实有任何进展延迟,但研究结果往往相互矛盾(Chapman, 2009;Lindor et al ., 2009)。Barnabas和Chapman(2012)对熊去氧胆酸在PSC中的使用进行了争论,确认其作用尚不清楚。他们发现,高剂量(28-30毫克/公斤/天)可能有害,而低至中等剂量可能具有致癌保护作用。随着诊断技术的迅速发展,PSC被更早地发现(Molodecky等人,2011)。目前正在进行研究,试图为这种经常使人衰弱的疾病找到治疗、治愈或遗传联系。Folseraas等人(2011)指出,全基因组研究已经一致地确定了遗传易感性和环境因素——它们之间的关系有望为知识的转移和即将到来的治疗方案提供令人兴奋的机会。英国全基因组研究正在进行,招募也在继续(英国PSC基因组研究,2011年)。这种情况的不可预测性令人生畏,它将如何影响日常生活和未来计划的不确定性会带来重大的担忧和焦虑。许多患有PSC的人将其描述为非常具有挑战性的:瘙痒和疼痛尤其会导致日常压力,从而降低生活质量(Ponsioen, 2011)。肝脏失代偿会带来许多障碍。对一些人来说,由于规定的治疗,其他相关的自身免疫性疾病和免疫抑制的增加可能是巨大的。与任何疾病一样,积极健康的生活方式是必需的。良好的营养对肝病患者至关重要,对相关的炎症性肠病患者更是如此。获得饮食专家的机会往往有限;然而,营养师Leaper和Hamlin(2012)和英国肝脏信托基金会(2011)为患有各种肝脏疾病和肝衰竭程度的人提供了极好的信息和建议。护士是提供高效服务和优质护理的关键。胃肠病学和肝病学护士的理想位置是识别患有PSC的患者和/或护理人员,并为他们提供有关其病情、治疗(药理学和非药理学)以及如何应对和生活PSC的策略的指导。PSC支持是一个英国的慈善机构,帮助受PSC影响的人在国内和国际。它们完全由志愿者运营,旨在:“向PSC患者和医学界提供信息和支持”“提高对PSC的认识,PSC支持和器官捐赠”“与参与PSC治疗和研究的人员建立有效的伙伴关系。”GN
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引用次数: 0
[Pancreas divisum].
Pub Date : 2011-07-28 DOI: 10.53347/rid-14471
Y. Sheikh, R. Schubert
Pancreas divisum represents a developmental failure of the ducts of the dorsal and ventral pancreas to fuse during the second month of gestation. It results in separate drainage of the ventrally situated head of the pancreas through the main ampulla of Vater, via the duct of Wirsung, and drainage of the body and tail by the duct of Santorini through the much smaller accessory ampulla. It is a surprisingly frequent congenital abnormali ty present in 4.7-14% of necropsy series and has been demonstrated in 0.3-5.8% of patients undergoing endoscopic retrograde pancreatography (1). The etiologic relationship of pancreas divisum to pancreatitis is unresolved. Cotton and Kizu (2), in 1977, first described an increased incidence of pancreatitis in patients with pancreas divisum. While some investigators have supported pancreas divisum as a cause of acute recurrent pancreatitis (3-5), others have not been able to document such an association (6-8), and there is little evidence to support it as a cause of chronic pancreatitis (9). However , we have recently encountered a patient in whom the clinical course and radiologic and histopathologic findings supported an etiologic relationship between pancreas divisum and chronic pancreatitis.
胰腺分裂代表胰腺背侧和腹侧的导管在妊娠第二个月无法融合。它导致位于腹侧的胰腺头部通过主壶腹,通过Wirsung导管,通过小得多的副壶腹,通过Santorini导管分别引流身体和尾部。它是一种非常常见的先天性异常,出现在4.7-14%的尸检中,在0.3-5.8%的内镜逆行胰腺造影患者中也有发现(1)。胰腺分裂与胰腺炎的病因关系尚不清楚。Cotton和Kizu(2)在1977年首次报道了胰腺分裂患者胰腺炎发病率的增加。虽然一些研究者支持胰腺分裂是急性复发性胰腺炎的原因(3-5),但其他人没有能够证明这种关联(6-8),并且几乎没有证据支持它是慢性胰腺炎的原因(9)。然而,我们最近遇到了一位患者,其临床病程、放射学和组织病理学结果支持胰腺分裂与慢性胰腺炎之间的病因学关系。
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引用次数: 0
Extraosseous Manifestation of Multiple Myeloma with Unusual Appearance in Computed Tomography – Case Report 异象多发性骨髓瘤的骨外表现- 1例报告
Pub Date : 2008-01-01 DOI: 10.1016/j.rontge.2008.03.003
Martina Heckmann , Michael Uder , Aleksandar Grgic , Nicole Adrian , Werner Bautz , Marc Heinrich

Extramedullary localizations at diagnosis or during the course of multiple myeloma are rare. We report on a 70 year old patient, presenting multiple hypoechoic liver lesions during an ultrasound examination. The following contrast-enhanced computed tomography demonstrated hypodense liver lesions with slight contrast enhancement and hyperdense polypoid masses in the wall of the gall bladder as well as a small pericostal tumor. A punch biopsy of the liver and immunohistochemical studies confirmed the diagnosis of extramedullary multiple myeloma. In a follow-up CT five weeks later the liver lesions and the pericostal tumor clearly showed progress, the masses in the gall bladder had developed into a concentric wall-thickening. Additionally, polypoid contrast-enhancing masses in the gastric wall became apparent as well as a hypodense lesion in the spleen.

Radiologists should be aware that multiple myeloma can on rare occasions present as hypodense nodules in the liver or new masses in other organs in CT. Because of the morphologic similarity to metastatic disease, a biopsy may be necessary for definitive diagnosis.

在多发性骨髓瘤的诊断或过程中,髓外定位是罕见的。我们报告一个70岁的病人,在超声检查期间出现多发性低回声肝脏病变。以下增强ct显示低密度肝脏病变伴轻微增强,胆囊壁高密度息肉样肿块及小的腹膜周肿瘤。肝脏穿刺活检和免疫组化检查证实了髓外多发性骨髓瘤的诊断。5周后复查CT,肝脏病变及骨周肿瘤进展明显,胆囊肿块呈同心壁增厚。此外,胃壁息肉样增强肿块和脾脏低密度病变变得明显。放射科医生应该意识到,多发性骨髓瘤在罕见情况下可以在CT上表现为肝脏低密度结节或其他器官的新肿块。由于形态学与转移性疾病相似,活检可能是明确诊断的必要条件。
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引用次数: 13
Differentialdiagnose fokaler Nierenläsionen in CT und MRT 下面是CT和mri微分诊断肾部损伤
Pub Date : 2008-01-01 DOI: 10.1016/j.rontge.2008.03.002
Martina Heckmann , Marc Heinrich , Ulrich Humke , Werner Bautz , Michael Uder

The great majority of renal masses are found incidentally as a result of the use of ultrasonography, computed tomography (CT) and magnetic resonance imaging (MRI). If ultrasonography is not diagnostic CT or MRI should be initiated to differentiate lesions of the kidney that need surgical intervention from those that do not and from those that need follow-up examinations.

Cystic renal masses are characterized by using the Bosniak classification, including category IIF. In solid lesions of the kidney first non-surgical lesions as well as lymphoma, renal infarction and nephritis should be excluded. Identifying fatty components in renal lesions is very important because in angiomyolipoma they are almost always present.

CT and MRI are exellent for tumor detection. Careful evaluation of imaging finding combined with the patient′s history should assist the radiologist in making the proper diagnosis or recommending the appropriate treatment in most cases.

This article provides a review about renal masses, the imaging methods for their evaluation and their characteristic features at CT and MR imaging. Different lesions are demonstrated like xantogranulomatous pyelonephritis, acute pyelonephritis, renal infarction, lymphoma, angiomyolipoma, renal oncocytoma, cystic lesion and polycystic disease the kidney, echinococcosis, renal cystadenoma, metastases, renal cell carcinoma (RCC), and multiple bilateral RCC in patients with Hippel-Lindau-Syndrome.

This article should help to differentiate complex cystic lesions of the kidney by using the Bosniak-classification, especially Bosniak Category IIF. Solid masses should be characterized and the major question to be answered is whether the mass represents a surgical or nonsurgical lesion or if follow-up studies are necessary.

绝大多数肾脏肿块都是通过超声、计算机断层扫描(CT)和磁共振成像(MRI)偶然发现的。如果超声检查不能诊断,则应开始使用CT或MRI来区分需要手术干预的肾脏病变与不需要手术干预的肾脏病变以及需要随访检查的肾脏病变。囊性肾肿块的特征采用Bosniak分类,包括IIF类。在肾脏实性病变中,首先应排除非手术病变以及淋巴瘤、肾梗死和肾炎。鉴别肾脏病变中的脂肪成分是非常重要的,因为在血管平滑肌脂肪瘤中它们几乎总是存在。CT和MRI对肿瘤的检测效果很好。在大多数情况下,仔细评估影像学发现并结合患者的病史应有助于放射科医生做出正确的诊断或推荐适当的治疗。本文就肾脏肿块的影像学诊断方法、CT和MR影像学特点作一综述。希佩尔-林道综合征患者表现为黄疸肉芽肿性肾盂肾炎、急性肾盂肾炎、肾梗死、淋巴瘤、血管平滑肌脂肪瘤、肾嗜酸细胞瘤、肾囊性病变和肾多囊性病变、棘球蚴病、肾囊腺瘤、转移瘤、肾细胞癌(RCC)和双侧多发肾细胞癌。这篇文章应该有助于区分复杂的肾脏囊性病变,通过使用波斯尼亚分类,特别是波斯尼亚分类IIF。应该对实性肿块进行特征描述,需要回答的主要问题是肿块是手术还是非手术病变,或者是否需要进行后续研究。
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引用次数: 10
Hypoxischer Schaden aller tiefen Kerngebiete des Gehirns – ein Fallbericht aus der Computertomographie 还有缺氧对大脑最核心区域的打击
Pub Date : 2008-01-01 DOI: 10.1016/j.rontge.2008.03.006
Siegfried A. Schwab , Gregor Richter , Werner A. Bautz , Michael Uder , Sedat Alibek

Though being inferior to magnetic resonance imaging, computed tomography (CT) of the brain is the most frequently applied imaging modality in the diagnostic workup of acute cerebral Ischaemia.

We report on a case of a comatose 53-year-old man who was brought to the emergency room after cardiopulmonary resuscitation. The CT of the brain showed a diffuse brain oedema with an explicit hypodense demarcation of all deep nuclei.

脑计算机断层扫描(CT)虽然不如磁共振成像,但仍是急性脑缺血诊断中最常用的成像方式。我们报告一例昏迷的53岁男子谁被带到急诊室后心肺复苏。脑部CT显示弥漫性脑水肿,所有深部核明显低密度划分。
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引用次数: 4
EDB+Impressum
Pub Date : 2008-01-01 DOI: 10.1016/S0035-7820(08)00022-0
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引用次数: 0
EDB+Impressum EDB+Impressum
Pub Date : 2008-01-01 DOI: 10.1016/S0035-7820(08)00014-1
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引用次数: 0
Endovaskuläre Versorgung einer traumatischen duralen arterio-venösen Fistel unter Beteiligung der Arteria meningea media und facialer Venen 为严重创伤动脉管纤维化包括动脉纤维化
Pub Date : 2008-01-01 DOI: 10.1016/j.rontge.2006.10.002
Janine Rennert , Marcel Seiz , Christopher Nimsky , Arnd Doerfler

Dural arterio-venous fistulas are rare lesions. Traumatic dural AV-fistulas in particular, are very rare complications of head and neck trauma.

We report on a 59-year old man with a severe facial and head trauma. Initial computed tomography demonstrated a left frontal subdural hematoma, leading to progressive midline shift. Additionally, a complex skull base fracture was present, involving the frontal, temporal and sphenoid bone. A few days after the accident the patient reported a left pulsatile tinnitus. Subsequent selective carotid angiography revealed a high flow dural arterio-venous fistula involving the middle meningeal artery and facial veins. Complete endovascular embolization was performed by a transarterial approach using microparticles and an electrolytically detachable coil resulting in an immediate disappearance of the tinnitus.

Remarkably, this case nicely illustrates possible “dangerous” collateral circulation to the ophthalmic artery–a feature that should be kept in mind during endovascular treatment of this entity.

硬脑膜动静脉瘘是罕见的病变。特别是外伤性硬脑膜静脉瘘,是头颈部创伤非常罕见的并发症。我们报告一位59岁的男性面部和头部严重创伤。最初的计算机断层扫描显示左侧额叶硬膜下血肿,导致进行性中线移位。此外,出现复杂的颅底骨折,涉及额骨、颞骨和蝶骨。事故发生几天后,病人报告了左搏动性耳鸣。随后的选择性颈动脉造影显示高流量硬脑膜动静脉瘘累及中脑膜动脉和面静脉。完全血管内栓塞通过经动脉入路使用微粒和电解可拆卸线圈进行,导致耳鸣立即消失。值得注意的是,本病例很好地说明了眼动脉可能存在的“危险”侧支循环,这是在血管内治疗时应牢记的一个特征。
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引用次数: 3
Kosmetische Ergebnisse nach brusterhaltender, radiologischer Mammakarzinomtherapie bei Patientinnen mit intramammären Seromen 那将会造成丰胸手术
Pub Date : 2008-01-01 DOI: 10.1016/j.rontge.2007.08.001
Jürgen Schultze, Kristina Lössl, Bernhard Kimmig

Introduction

There were 373 patients irradiated after breast conserving carcinoma treatment. A planning computed tomography revealed in 97 of these patients seromas and tissue defects exceeding 2 cm in diameter. The cosmetic results in those patients and the impact of seromas herein had to be evaluated.

Patients and methods

Mean age was 59 years. A quadrant resection was performed in 17,5 percent of the patients, a segmental resection in 27,8 percent and a tumour excision in 54,6 percent. Radiation therapy was applied with the linear accelerator and 6 MeV photons up to a total dose in the residual breast of 50 Gy followed by a boost dose to the former tumour bed of 10 Gy. A distinct evaluation and documentation of therapy related side effects and the resulting cosmesis was done in 51 patients.

Results

In all the examined seroma patients there were moderate acute skin reactions grade 1 to 3. As late effects in 82,3 percent scar indurations were noticed. At the skin 51 percent showed enhanced pigmentation, 68,6 percent atrophia and only 11 percent teleangiectasia. Subcutaneous fibrosis occurred in 56,9 percent of the patients, 78,4 percent of the women had breast asymmetries. In 41,2 percent there were a lymphedema subcutaneously, in 72,5 percent impaired sensibility. The overall cosmetic result documented with a 5 point score was “very good” (score 1) in 19,6 percent and “good” (score 2) in 33,3 percent, 37,3 percent were “satisfactory” (score 3) and 9,8 percent “bad” (score 4) respectively. No “very bad” results (score 5) were seen.

Conclusions

The cosmetic results in the examined group of seroma and hematoma patients were inferior to those reported in the literature. We conclude that postoperative seroma and hematoma have an adverse effect on the resulting cosmesis and that their frequency and extent have to be reduced in future by the responsible surgeons.

介绍373例保乳癌术后放疗。计划计算机断层扫描显示97例患者血清肿和直径超过2厘米的组织缺损。这些患者的美容效果和血清肿的影响必须进行评估。患者与方法平均年龄59岁。17.5%的患者接受了象限切除术,27.8%的患者接受了节段性切除术,54.6%的患者接受了肿瘤切除术。使用线性加速器和6兆电子伏光子进行放射治疗,残余乳房的总剂量为50戈瑞,然后对前肿瘤床的增强剂量为10戈瑞。对51例患者进行了治疗相关副作用和美容的独特评估和记录。结果所有血肿患者均有1 ~ 3级中度急性皮肤反应。在82年的晚期效应中,3%的疤痕硬化被注意到。在皮肤方面,51%的人表现出色素沉着增强,68.6%的人表现出萎缩,只有11%的人表现出毛细血管扩张。皮下纤维化发生在56.9%的患者中,78.4%的女性乳房不对称。41.2%的患者有皮下淋巴水肿,72.5%的患者有敏感性受损。5分记录的整体美容结果分别为“非常好”(1分)19.6%,“好”(2分)33.3%,“满意”(3分)37.3%,“不好”(4分)9.8%。没有“非常糟糕”的结果(5分)。结论血肿、血肿患者的美容效果优于文献报道。我们的结论是,术后血肿和血肿对最终的美容有不良影响,其频率和程度必须在未来由负责任的外科医生减少。
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引用次数: 5
Computertomographische Verlaufsbeobachtungen der spontanen Rückbildung von Portalvenenthrombosen bei akuter Pankreatitis 计算机对急性胰腺炎龙门漩涡的气囊反射作出预测
Pub Date : 2008-01-01 DOI: 10.1016/j.rontge.2008.02.001
Johannes Kirchner , Florian Lorenz , Jasna Vlahovic , Esther Maria Kirchner

Portal vein thrombosis complicating acute pancreatitis is more often diagnosed today due to the improved imaging techniques (computed tomography, ultrasound, nmr). Nevertheless the outcome of recent portal vein thrombosis is ill-known. We report on the computed tomographic findings and clinical course of portal vein thrombosis in two patients suffering from acute pancreatitis. Both patients showed spontaneous recanalization of the thrombosis.

门静脉血栓形成并发急性胰腺炎今天更常诊断由于改进的成像技术(计算机断层扫描,超声,核磁共振)。然而,最近的门静脉血栓形成的结果尚不清楚。我们报告两例急性胰腺炎患者门静脉血栓形成的ct表现和临床病程。两例患者均表现为血栓自发再通。
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引用次数: 0
期刊
Rontgenpraxis; Zeitschrift fur radiologische Technik
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