The Nebraska medical journal最新文献

英文中文

Surfactant 表面活性剂

The Nebraska medical journal

Pub Date : 2020-01-01 DOI: 10.1007/978-3-319-52090-2_300382

引用次数: 0

Necrotizing enterocolitis 坏死性小肠结肠炎

The Nebraska medical journal

Pub Date : 2018-09-01 DOI: 10.1093/med/9780198759928.003.0007

J. Puntis

Necrotizing enterocolitis is a common and serous disease predominantly affecting premature newborns, with an incidence, morbidity, and mortality that has remained unchanged for several decades. Around 7% of infants between 500g and 1500g birth weight are affected, with the disease often manifesting with vomiting, bilious aspirates, distended abdomen, and blood in stools around 8–10 days of age. Medical management includes decompression of the gastrointestinal tract via a nasogastric tube, broad-spectrum antibiotics, and bowel ‘rest’ (total parenteral nutrition). Surgical intervention is required for intestinal perforation or ongoing deterioration despite medical management. The pathogenesis is multifactorial and includes genetic predisposition, gastrointestinal immaturity, imbalance in microvascular tone, abnormal intestinal microbiological colonization, and a highly immunoreactive intestinal mucosa. Breast milk feeds appear to confer some degree of protection.

坏死性小肠结肠炎是一种常见的严重疾病，主要影响早产儿，其发病率、发病率和死亡率几十年来一直保持不变。约7%的出生体重在500g至1500g之间的婴儿会受到影响，该病通常在8-10天大时表现为呕吐、胆汁性吸入、腹部膨胀和便血。医疗管理包括通过鼻胃管进行胃肠道减压、广谱抗生素和肠道“休息”(全肠外营养)。手术干预肠穿孔或持续恶化，尽管医疗管理。其发病机制是多因素的，包括遗传易感性、胃肠道不成熟、微血管张力失衡、肠道微生物定植异常和高度免疫反应性肠黏膜。母乳喂养似乎提供了某种程度的保护。

引用次数: 0

"Them" and "us". “他们”和“我们”。

The Nebraska medical journal

Pub Date : 2015-07-30 DOI: 10.4324/9781351302043-3

J. Dunlap

引用次数: 46

Aortic dissection. 主动脉夹层。

The Nebraska medical journal

Pub Date : 2014-01-01 DOI: 10.1055/b-0034-92220

J. Phalen, J. Saigh

ACUTE ASCENDING AORTIC DISSECTION is a serious condition with significant mortality requiring prompt diagnosis and surgical treatment as mortality rates increase hourly without intervention. There are a number of modalities currently used to diagnose aortic dissection, including computed tomography (CT), magnetic resonance imaging (MRI), and transesophageal echocardiography (TEE), each with different strengths and weaknesses in regard to speed, accuracy, and ease of performance. There exists a balance between rapid diagnosis with comprehensive information regarding anatomic detail, vascular branch involvement, false lumen identification, and speed with which the diagnosis can be made to expedite potential surgical treatment. The optimal diagnostic mode for identifying ascending aortic dissection remains controversial. Additionally, the various methods of imaging used to evaluate for aortic dissection all carry potential disadvantages of artifact within the image, complicating the diagnostic process and at times leading to false-positive diagnoses. Managing this balance represents some of the difficulties in identification and treatment of these patients. The authors present a patient who was anesthetized for repair of a suspected ascending aortic dissection based on CT findings, yet subsequent TEE revealed normal anatomy.

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引用次数: 2

Extracorporeal lithotripsy in Nebraska--10 years later. 内布拉斯加州体外碎石术——十年后。

The Nebraska medical journal

Pub Date : 1996-12-01

H K Mardis

引用次数: 0

A survey of post polio syndrome in Nebraska. 内布拉斯加州脊髓灰质炎后综合症的调查。

The Nebraska medical journal

Pub Date : 1996-12-01

D S Diamant, H Hillen

引用次数: 0

Gene testing for cancer susceptibility. 癌症易感性的基因测试。

The Nebraska medical journal

Pub Date : 1996-12-01

G Reiser, G B Schaefer

引用次数: 0

Renal sympathetic nerve discharge mediated by the paraventricular nucleus is altered in STZ induced diabetic rats. STZ诱导的糖尿病大鼠室旁核介导的肾交感神经放电发生改变。

The Nebraska medical journal

Pub Date : 1996-12-01

A Y Reynolds, K Zhang, K P Patel

The purpose of this study was to determine if the renal sympathetic nerve discharge (RSND), mediated by the paraventricular nucleus of the hypothalamus (PVN), is altered in streptozotocin (STZ) induced diabetic rats. Two to three weeks prior to the start of the experiment the diabetic group was treated with a single injection of STZ (65 mg/kg ip) in a 2% solution of cold 0.1 M citrate buffer (pH = 4.5). The control group was injected with the vehicle alone. Bicuculline (BIC) was injected into the PVN in three different doses (0.5, 1.0 & 2.0 nmol) while the RSND was being monitored. BIC is an antagonist of gamma-aminobutyric acid (GABA) which is an inhibitory neurotransmitter that is thought to exert a tonic inhibitory effect on the PVN. Microinjection of BIC produced a significantly lower response of RSND in the diabetic group compared to the control group. Microinjection of BIC produced a 13, 35 and 33% change in RSND in diabetic rats compared to control group in response to 0.5, 1.0, and 2.0 nmol doses, respectively. Mean blood pressure and heart rate were statistically not different between the control and the diabetic groups. However there were tendencies of the blood pressure and heart rate to be blunted upon injection of BIC into PVN in diabetic rats. This study demonstrates that RSND in response to microinjection of BIC in PVN is decreased significantly in anesthetized diabetic rats, indicating that STZ induced diabetic rats have a blunted RSND response to microinjection of BIC. There is also some evidence, although not statistically significant, for a blunted blood pressure and heart rate were diabetics. These findings suggest that there is a reduced endogenous inhibitory influence of GABAergic mechanisms within the PVN involved in regulating renal sympathetic outflow in the diabetic state.

本研究的目的是确定链脲佐菌素(STZ)诱导的糖尿病大鼠由下丘脑室旁核(PVN)介导的肾交感神经放电(RSND)是否发生改变。在实验开始前2 - 3周，糖尿病组在2%的0.1 M柠檬酸盐缓冲液(pH = 4.5)中单次注射STZ (65 mg/kg / ip)。对照组小鼠单独注射载药。将Bicuculline (BIC)以三种不同剂量(0.5、1.0和2.0 nmol)注射到PVN中，同时监测RSND。BIC是γ -氨基丁酸(GABA)的拮抗剂，GABA是一种抑制性神经递质，被认为对PVN具有强直抑制作用。与对照组相比，糖尿病组微量注射BIC对RSND的反应明显较低。与对照组相比，0.5、1.0和2.0 nmol剂量的BIC在糖尿病大鼠的RSND中分别产生了13.35和33%的变化。平均血压和心率在对照组和糖尿病组之间没有统计学差异。在糖尿病大鼠PVN内注射BIC后，血压和心率有钝化的趋势。本研究表明，麻醉后糖尿病大鼠PVN内微注射BIC的RSND明显降低，说明STZ诱导的糖尿病大鼠对微注射BIC的RSND反应减弱。还有一些证据表明，虽然没有统计学意义，但血压和心率变钝的人是糖尿病患者。这些发现表明，在糖尿病状态下，参与调节肾交感神经流出的PVN内gaba能机制的内源性抑制作用降低。

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引用次数: 0

C.A.T.C.H.: Community Access to Coordinated Healthcare. C.A.T.C.H:社区获得协调医疗保健。

The Nebraska medical journal

Pub Date : 1996-12-01

E M Reichenbach, N Clark, P Lopez, D J Loschen

引用次数: 0

Current concepts in Guillain-Barré syndrome. 格林-巴罗综合征的当前概念。

The Nebraska medical journal

Pub Date : 1996-12-01

D A Franco, R M Bashir

引用次数: 0

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