Zeitschrift fur Morphologie und Anthropologie最新文献

Tagraxofusp, a CD123-based-targeted immunotherapy, was recently approved to treat blastic plasmacytoid dendritic cell neoplasm (BPDCN) with excellent response. Also, a subset of BPDCN shows resistance to tagraxofusp. These resistant cases continue to express CD123, which forms the basis of the continued utility of tagraxofusp in newer combination chemotherapies to overcome resistance in BPDCN. Herein, we report a case of an elderly male with BPDCN that achieved complete remission on initial primary treatment with tagraxofusp. However, BPDCN relapsed after 1.5 years while on treatment, with loss of CD123 expression. At relapse, the neoplasm was comprehensively immunophenotyped by flow cytometry (performed on both peripheral blood and bone marrow specimen) and by immunohistochemical evaluation of the bone marrow clot section. The neoplasm at relapse was diagnostic of BPDCN with a lack of CD123 expression. This case highlights a potential limitation of current and upcoming tagraxofusp-based multidrug therapies, at least in a subset of refractory BPDCN. We believe our report will serve as a sentinel to incite future investigations involving alternate resistance mechanisms in BDPCN.

Body size, expressed as height or stature, is an important determinant of many other biological variables. Thus, it is surprising that many textbooks portray a wrong picture of Neanderthal height as being "very short" or "just over 5 feet". Based on 45 long bones from maximally 14 males and 7 females, Neanderthals' height averages between 164 and 168 (males) resp. 152 to 156 cm (females). This height is indeed 12-14 cm lower than the height of post-WWII Europeans, but compared to Europeans some 20,000 or 100 years ago, it is practically identical or even slightly higher. Considering the body build of Neanderthals, new body weight estimates show that they are only slightly above the cm/weight or the Body Mass Index of modern Americans or Canadians. The calculation of the relative surface area (approximately 240-244 cm2/kg) is very low and supports earlier findings of a morphological and anatomical thermoregulatory adaptation to a cold climate in the Neanderthals.

Seven skulls from the Vörs-Papkert B Cemetery were analysed according to the facial reconstruction method of KOLLMANN and GERASIMOV. The degree of expression of sex, metric data of the skull, morphological characteristics of the skull and characteristics of the reconstructed face are presented for each of the skulls.

This paper examines patterns of sexual dimorphism within the Spanish hominid Hispanopithecus. The inclusion of this genus within the Hominidae suggests that extant male and female great ape sexually specific characters are appropriate features for determining the sex of these fossil hominids. It is shown that Hispanopithecus has a distinct sexually dimorphic pattern from that observed in the extant great apes. It is also demonstrated that H. laietanus and H. crusafonti each have a distinct sex pattern from each other. This result further supports the dual species hypothesis.

Adolescent growth of foot length (FL) and stature were investigated in a sample of 586 children living in the Ogi area of Saga Prefecture Japan, who were traced longitudinally from 6.5 to 17.5 years of age. FL growth and its relationship to height were analyzed using the JPA2 model and the Optimal Kernel Method to fit the serial data of stature and FL. The results demonstrated that there was clear peak growth velocity (PGV) during the adolescent growth period of FL for most of the children; before 11.5 years of age there was no essential difference in mean foot length between girls and boys; the completion of FL growth was on average two years earlier than that of stature and two and a half years after the appearance of the peak height velocity (PHV); girls completed the FL growth two years earlier than boys; the longer the growth period for FL or the larger the value of FL at an early age the bigger the adult foot length; the foot grew in synchrony with the body as a whole.

161 cases of human-brain autopsies (93 Male, 68 Female) were collected from three samples in the Kinai district of Japan. From photographs of the midsagittal plane of each brain, surface areas of the corpus callosum (CC in mm2) and of the medial view of the cerebrum (H in mm2) were measured. The absolute H and CC values from each of the three samples were larger in males than in females, with full overlapping of the male and female ranges for both H and CC values. However, the relative values of CC corrected for H (CC/H) were almost equal between sexes. The relative values for the posterior one-fifth (splenium) of the CC, which were divided by CC or H, were slightly higher in females than in males in each of the three samples, but without statistical significance. This trend was also found in the relative values for the posterior one-third of the CC and in the relative values for region, meaning the posterior one-fifth of the CC subtracted from the posterior one-third of the CC (isthmus), but not in the relative values for the anterior one-fifth (genu) of the CC.