The state of the art of oxygen delivery to ambulatory patients has evolved remarkably in the past 20 years. Oxygen is established as both safe and effective to use in selected patients with advanced chronic obstructive pulmonary disease. It has clearly been shown to extend life and to improve the quality of life in many patients. It is likely that further advances will make oxygen more suitable, acceptable, and perhaps less costly for a growing number of patients with progressive chronic respiratory diseases marked by hypoxemia and organ system damage.