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Advances in dermatology最新文献

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Genomic Analysis of Melanocytic Neoplasia 黑色素细胞瘤的基因组分析
Pub Date : 2005-01-01 DOI: 10.1016/j.yadr.2005.04.002
Jürgen Bauer MD , Boris Bastian MD
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引用次数: 14
Neonatal Violaceous Skin Lesions: Expanding the Differential of the “Blueberry Muffin Baby” 新生儿紫色皮肤病变:扩大“蓝莓松饼宝宝”的鉴别
Pub Date : 2005-01-01 DOI: 10.1016/j.yadr.2005.07.003
Kristen E. Holland MD (Clinical Instructor/Pediatric Dermatology Fellow) , Sheila S. Galbraith MD (Assistant Professor, Medical College of Wisconsin,) , Beth A. Drolet MD (Associate Professor, Medical College of Wisconsin)
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引用次数: 14
Advances in Inherited Epidermolysis Bullosa 遗传性大疱性表皮松解症的研究进展
Pub Date : 2005-01-01 DOI: 10.1016/j.yadr.2005.07.002
Josephine Chu McAllister AB (Medical Student) , M. Peter Marinkovich MD (Associate Professor of Dermatology, Attending Physician)
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引用次数: 10
Index 指数
Pub Date : 2005-01-01 DOI: 10.1016/S0882-0880(05)00025-8
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引用次数: 0
Narrowband Ultraviolet B Therapy for Psoriasis and Other Skin Disorders 窄带紫外线B治疗银屑病和其他皮肤病
Pub Date : 2005-01-01 DOI: 10.1016/j.yadr.2005.03.001
Joseph M. Kist MD (Clinical-Educator Fellow) , Abby S. Van Voorhees MD (Assistant Professor of Dermatology)
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引用次数: 16
New Drugs, New Rashes: Update on Cutaneous Drug Reactions 新的药物,新的皮疹:皮肤药物反应的最新进展
Pub Date : 2005-01-01 DOI: 10.1016/j.yadr.2005.03.002
Susan Burgin MD (Ronald O. Perelman Department of Dermatology)
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引用次数: 4
Cutaneous Appendage Tumors: Familial Cylindromatosis and Associated Tumors Update 皮肤附属物肿瘤:家族性圆柱状瘤病和相关肿瘤最新进展
Pub Date : 2005-01-01 DOI: 10.1016/j.yadr.2005.06.005
Fangru Lian MD (Fellow) , Clay J. Cockerell MD (Clinical Professor of Dermatology and Pathology, Director)
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引用次数: 19
Contributors 贡献者
Pub Date : 2005-01-01 DOI: 10.1016/S0882-0880(05)00023-4
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引用次数: 0
Contact allergens of the year. 一年中的接触过敏原。
Pub Date : 2004-01-01
Christen M Mowad
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引用次数: 0
Evidence-based evaluation of immunomodulatory therapy for the cutaneous manifestations of lupus. 免疫调节疗法对狼疮皮肤表现的循证评价。
Pub Date : 2004-01-01
Michelle Heath, Gregory J Raugi

This literature review revealed an unexpected paucity of data derived from adequately powered, randomized, controlled trials to guide evidence-based treatment of the cutaneous manifestations of lupus. Lupus erythematosus is characterized by spontaneous fluctuations in disease activity. This characteristic may serve to explain some of the contradictions in published evidence and cautions us not to rely too heavily on data derived from inadequately powered studies, small uncontrolled case series, or individual case reports, which are additionally subject to publication bias. Clearly, there is a pressing need to conduct adequately powered clinical research studies to fill these gaps in our knowledge. There also is a need for controlled trials to assess drug safety in patients with SLE. Much of the data regarding side-effect profiles of the immunomodulatory drugs has been compiled in patients receiving organ transplantation or chemotherapy for malignant diseases and extrapolated to patients with lupus. Given that there is often a substantial overlap in symptoms related to drug toxicity and to lupus erythematosus, careful studies should be conducted to assess the safety and toxicities of both established and newer medical therapies, especially those whose efficacy is supported only by small trials and case reports. Table 4 summarizes the results of our literature review. For each drug, we give the highest level of data we found, both for the treatment of lupus erythematosus in general and for the treatment of the cutaneous manifestation of lupus in particular.

这篇文献综述揭示了一个意想不到的缺乏数据,这些数据来源于足够有力的、随机的、对照的试验,以指导狼疮皮肤表现的循证治疗。红斑狼疮的特点是疾病活动的自发波动。这一特点可能有助于解释已发表证据中的一些矛盾,并提醒我们不要过分依赖来自不充分的研究、小型非控制病例系列或个别病例报告的数据,这些数据也会受到发表偏倚的影响。显然,迫切需要进行充分有力的临床研究来填补我们知识中的这些空白。还需要进行对照试验来评估SLE患者的药物安全性。许多关于免疫调节药物副作用的数据是在接受器官移植或恶性疾病化疗的患者中收集的,并推断为狼疮患者。鉴于与药物毒性和红斑狼疮相关的症状往往存在大量重叠,应进行仔细的研究,以评估现有和较新的医学疗法的安全性和毒性,特别是那些仅由小型试验和病例报告支持疗效的疗法。表4总结了我们文献综述的结果。对于每一种药物,我们都给出了我们发现的最高水平的数据,无论是对红斑狼疮的一般治疗还是对红斑狼疮皮肤表现的治疗。
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引用次数: 0
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Advances in dermatology
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