S A Pitts, O O Olomolaiye, C J Elson, C I Westacott, J L Bidwell
{"title":"Identification of a rare Bg/II polymorphism in the promoter region of the human TNF receptor type I (p55) gene.","authors":"S A Pitts, O O Olomolaiye, C J Elson, C I Westacott, J L Bidwell","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77121,"journal":{"name":"European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics","volume":"25 2-3","pages":"271-2"},"PeriodicalIF":0.0,"publicationDate":"1998-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20535463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A novel NlaIII polymorphism in the human IL-6 promoter.","authors":"O Olomolaiye, N A Wood, J L Bidwell","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77121,"journal":{"name":"European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics","volume":"25 2-3","pages":"267"},"PeriodicalIF":0.0,"publicationDate":"1998-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20535460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S A Pitts, O O Olomolaiye, C J Elson, C I Westacott, J L Bidwell
{"title":"An MspA1 I polymorphism in exon 1 of the human TNF receptor type I (p55) gene.","authors":"S A Pitts, O O Olomolaiye, C J Elson, C I Westacott, J L Bidwell","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77121,"journal":{"name":"European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics","volume":"25 2-3","pages":"269-70"},"PeriodicalIF":0.0,"publicationDate":"1998-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20535462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"12th European Histocompatibility Conference. Strasbourg, France, 25-27 March 1998. Abstracts.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77121,"journal":{"name":"European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics","volume":"25 Suppl 1 ","pages":"1-71"},"PeriodicalIF":0.0,"publicationDate":"1998-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20622544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1998-01-01DOI: 10.1111/j.1744-313x.1998.tb01156.x
K. Poulton, L. Kennedy, J. Ross, W. Thomson, J. Mbanya, W. Ollier
Several recently reported HLA-DPB1 alleles have only been identified in a single family or individuals and are of unknown distribution world-wide. Many new DPB1 alleles appear to arise as a result of gene conversion-like events, which may localize variant DPB1 alleles to the population in which they were first identified. Using two SSOP-based typing methods in parallel, we have identified HLA-DPB1*6301 in an individual from rural Cameroon which has previously only been reported in a family of Mexican-American origin. The presence of DPB1*6301 was confirmed by sequence-based typing of exon 2.
{"title":"A study of HLA-DPB1 phenotypes reveals DPB1*6301 in a rural population from Cameroon.","authors":"K. Poulton, L. Kennedy, J. Ross, W. Thomson, J. Mbanya, W. Ollier","doi":"10.1111/j.1744-313x.1998.tb01156.x","DOIUrl":"https://doi.org/10.1111/j.1744-313x.1998.tb01156.x","url":null,"abstract":"Several recently reported HLA-DPB1 alleles have only been identified in a single family or individuals and are of unknown distribution world-wide. Many new DPB1 alleles appear to arise as a result of gene conversion-like events, which may localize variant DPB1 alleles to the population in which they were first identified. Using two SSOP-based typing methods in parallel, we have identified HLA-DPB1*6301 in an individual from rural Cameroon which has previously only been reported in a family of Mexican-American origin. The presence of DPB1*6301 was confirmed by sequence-based typing of exon 2.","PeriodicalId":77121,"journal":{"name":"European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics","volume":"1 1","pages":"375-7"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84274572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P R Nilsson, S G Marsh, I Joosten, M G Nieuwland, E J Hensen, M C Grosfeld-Stulemeyer, S Mikko, A Gelhaus, G M Schreuder
At the Eleventh International HLA Histocompatibility Workshop, numerous anti-HLA class II monoclonal antibodies (mAb) were tested. For several of the polymorphic mAb, one epitope for binding has been mapped within the antigen-binding site of the class II molecules. Screening of the available bovine DRB3 and DQB exon 2 sequences revealed that some of the key amino acid (AA) motifs of these epitopes were present in cattle as well, and the question was raised whether this sharing of key AA motifs might cause interspecies cross-reactivity. Eight polymorphic anti-HLA class II mAb (seven anti-HLA DRB1 and one anti-HLA DQB) were selected for analysis of their reactivity towards bovine lymphocytes. In addition, the monomorphic anti-HLA class II mAb, 7.5.10.1, was selected for analysis, as this mAb was described to detect class II polymorphism in cattle. Flow cytometry and lymphocyte microcytotoxicity testing revealed that five of the polymorphic anti-HLA mAb were reactive with bovine lymphocytes. Furthermore, the anti-bovine reactivity of 7.5.10.1 was confirmed. These findings were supported by biochemical analysis. The anti-bovine reaction of the anti-HLA mAb did not correspond with the expected reaction, which was based on the presence of the AA, postulated to be responsible for recognition. Therefore, we suggest that the patterns of reactivity of the anti-HLA mAb are not always determined by one epitope.
{"title":"The specificity of anti-HLA class II monoclonal antibodies in cattle.","authors":"P R Nilsson, S G Marsh, I Joosten, M G Nieuwland, E J Hensen, M C Grosfeld-Stulemeyer, S Mikko, A Gelhaus, G M Schreuder","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>At the Eleventh International HLA Histocompatibility Workshop, numerous anti-HLA class II monoclonal antibodies (mAb) were tested. For several of the polymorphic mAb, one epitope for binding has been mapped within the antigen-binding site of the class II molecules. Screening of the available bovine DRB3 and DQB exon 2 sequences revealed that some of the key amino acid (AA) motifs of these epitopes were present in cattle as well, and the question was raised whether this sharing of key AA motifs might cause interspecies cross-reactivity. Eight polymorphic anti-HLA class II mAb (seven anti-HLA DRB1 and one anti-HLA DQB) were selected for analysis of their reactivity towards bovine lymphocytes. In addition, the monomorphic anti-HLA class II mAb, 7.5.10.1, was selected for analysis, as this mAb was described to detect class II polymorphism in cattle. Flow cytometry and lymphocyte microcytotoxicity testing revealed that five of the polymorphic anti-HLA mAb were reactive with bovine lymphocytes. Furthermore, the anti-bovine reactivity of 7.5.10.1 was confirmed. These findings were supported by biochemical analysis. The anti-bovine reaction of the anti-HLA mAb did not correspond with the expected reaction, which was based on the presence of the AA, postulated to be responsible for recognition. Therefore, we suggest that the patterns of reactivity of the anti-HLA mAb are not always determined by one epitope.</p>","PeriodicalId":77121,"journal":{"name":"European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics","volume":"24 3","pages":"211-23"},"PeriodicalIF":0.0,"publicationDate":"1997-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20169134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nomenclature for factors of the HLA system, update March 1997.","authors":"S G Marsh","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77121,"journal":{"name":"European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics","volume":"24 3","pages":"239-40"},"PeriodicalIF":0.0,"publicationDate":"1997-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20169138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nomenclature for factors of the HLA system, update January/February 1997.","authors":"S G Marsh","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77121,"journal":{"name":"European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics","volume":"24 3","pages":"237"},"PeriodicalIF":0.0,"publicationDate":"1997-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20169137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"11th European Congress on Histocompatibility. Budapest, Hungary, 2-5 April, 1997. Abstracts.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77121,"journal":{"name":"European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics","volume":"24 Suppl 1 ","pages":"1-132"},"PeriodicalIF":0.0,"publicationDate":"1997-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20083118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J G Bodmer, S G Marsh, E D Albert, W F Bodmer, R E Bontrop, D Charron, B Dupont, H A Erlich, R Fauchet, B Mach, W R Mayr, P Parham, T Sasazuki, G M Schreuder, J L Strominger, A Svejgaard, P I Terasaki
{"title":"Nomenclature for factors of the HLA system, 1996.","authors":"J G Bodmer, S G Marsh, E D Albert, W F Bodmer, R E Bontrop, D Charron, B Dupont, H A Erlich, R Fauchet, B Mach, W R Mayr, P Parham, T Sasazuki, G M Schreuder, J L Strominger, A Svejgaard, P I Terasaki","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77121,"journal":{"name":"European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics","volume":"24 2","pages":"105-51"},"PeriodicalIF":0.0,"publicationDate":"1997-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20054281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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